Professor Kim Chan

BPharm (Medal) NDMC Taipei PhD DSc Syd
Associate Dean (Research)
Professor, Pharmaceutics (Advanced Drug Delivery)

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 3054
Fax +61 2 9351 4391

Biographical details

Hak-Kim Chan, Professor in Pharmaceutics is leading the Advanced Drug Delivery Group at the Faculty of Pharmacy. He graduated from the National Defense Medical Center (BPharm, University Medal 1983), University of Sydney (PhD 1988 and DSc 2009), was a postdoc at the University of Minnesota in 1988-89 and a scientist at Genentech Inc in 1992–95.

Research interests

Professor Chan is a world leader in respiratory drug delivery. Over a decade since joining the University of Sydney, he has developed a leading research program on aerosol drug delivery, ranging from in vitro, ranging from powder production by novel processes, particle engineering and aerosol formulation, to scintigraphic imaging of lung deposition and clinical outcome. He played a pivotal role in the development of Aridol™ (inhaled mannitol for diagnosis of asthma), which was approved by the FDA in the United States, 14 European Union countries, Singapore, Malaysia, South Korea, Australia and New Zealand. He has more than 280 scientific publications on pharmaceutical formulation and drug delivery (including 175 original research papers, 45 book chapters and reviews and 40 full-length conference articles, with over 5,000 citations and H-index of 38) and holds seven patents in these areas.

Associations

Professor Chan is an executive editor of Advanced Drug Delivery Reviews and on the editorial advisory boards of various pharmaceutical journals, including PharmaceuticalResearch and International Journal of Pharmaceutics. He was appointed to the Subcommittee on Pharmaceutical Aerosol Standards for the Australian Therapeutic Goods Administration in 1996–97, and served as a member (2007–08) on the in vitro – in vivo correlation subgroup of the International Pharmaceutical Aerosol Consortium on Regulation and Science in Washington DC. He is a Fellow of the American Association of Pharmaceutical Scientists (AAPS), Fellow of Royal Australian Chemical Institute (RACI), Chair of the NSW Pharmaceutical Science Group of the RACI, and Vice President of the Asian Federation for Pharmaceutical Sciences.

Keywords

Cystic fibrosis; Influenza; Tuberculosis; Asthma; Chronic obstructive pulmonary disease

Selected grants

2014

  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel inhalation formulation of colistin and combination therapy against Gram-negative 'superbugs'; Chan H, Zhou Q, Li J, Fouras A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Phase 1 clinical trial: Inhaled rifapentine for rapid treatment of tuberculosis; Chan H, McLachlan A, Chan J, Parumasivam T; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • Eradicating pulmonary tuberculosis using multi-functional inhalable particles; Prud’homme R, Chan H; DVC Research/International Research Collaboration Award (IRCA).
  • nanoIR - nanoscale bioimaging with continuous mapping of chemical and physical properties; Gomes V, Dehghani F, Gan Y, Chang L, Jabbarzadeh-Khoei A, McKenzie D, Hanaor D, Zhou F, Chrzanowski W, Braet F, Bilek M, Chan H, Perrier S, O'Neill G, Ammit A, Brand-Miller J, McEwan A, Hawkett B, Kondyurin A, Li Q, Burgess J, Li Z; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Improving subunit vaccines against tuberculosis for pulmonary delivery; Britton W, West N, Payne R, Chan H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • WITEC Alpha 300R High Throughput Microscope - Confocal Raman Microscope; Traini D, Young P, Murray M, Dehghani F, Chan H, Oliver B, Holst J; DVC Research/Equipment Grant.

2012

  • Production of nano-composite particles for inhalational delivery of combination drugs; Chan H; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • Aerosol delivery systems of siRNA for the treatment of lung cancer; Chan H; Department of Trade and Investment, Regional Infrastructure and Services (NSW)/Research Support.
  • Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms; Chan H, Yang R; Australian Research Council (ARC)/Discovery Projects (DP).
  • qNano scanning ion occlusion spectroscopy (SIOS); Chrzanowski W, Bebawy M, Dehghani F, Chan H, Rohanizadeh R, Hawkett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Surface Energy Analyser (SEA); Traini D, Young P, Chan H, Rohanizadeh R, Bilek M, Langrish T, Gomes V; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Advanced Focused Ion Beam (FIB) / Scanning Electron Microscopes (SEM) for Nanometre Scale Characterisation and Fabrication; Cairney J, Munroe P, Ringer S, Ferry M, Mai Y, Liao X, McKenzie D, Wenham S, Dzurak A, Stevens-Kalceff M, Spinks G, Dou S, Valanoor N, Liu Z, Proust G, Young D, Braet F, Chan-Ling T, Maschmeyer T, Chan H, Traini D, Swain M, Harris A, Crawford J, Potts D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The effect of electrostatic charge on the plume of pressurised metered dose inhalers; Traini D, Lewis D, Young P, Chan H; Australian Research Council (ARC)/Linkage Projects (LP).
  • Powder Aerolsols for Inahalation; Chan H; DVC Research/Bridging Support Grant.
  • Engineering of composite particles to enhance performance in respiratory drug delivery; Traini D, Saunders M, Young P, Chan H; Australian Research Council (ARC)/Linkage Projects (LP).

2009

  • PSIA Thermal Atomic Force Microscope (AFM), XE-70 SPM system plus Scanning Thermal Microscope; Murray M, Chan H, Traini D; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery; Chan H; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery; Chan H, Foster N, Foster N; Australian Research Council (ARC)/Linkage Projects (LP).
  • Nanoscale Thermal Imaging (SThM); Young P, Traini D, Yang W, Braet F, Chan H; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • Engineering a delivery device and development of a novel formulation for chronic obstructive pulmonary disease and cystic fibrosis; Fletcher D, Crapper J, Young P, Chan H, Traini D; Australian Research Council (ARC)/Linkage Projects (LP).
  • Precision Titration/ Solution Calorimeter accessory for the Tam III Iosthermal calorimeter Calorimet; Chan H, Murray M, Hibbs D, Young P, Traini D, Weiss A, Stewart P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • State of the art high resolution thermal analysis suite for the life and material sciences; Stewart P, Young P, Traini D, Chan H, Murray M, Dehghani F, Hibbs D, Larson I, Warr G, Weiss A; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Mannitol Powders for Assessment of Asthma in Children; Chan H, Young P, Crapper J, Traini D; Australian Research Council (ARC)/Linkage Projects (LP).
  • Discrete simulation of powder dispersion in pharmaceutical aerosol inhalers; Chan H, Yang R, Yang R; Australian Research Council (ARC)/Discovery Projects (DP).

2006

  • Linkage Round 2 2004 - High gravity precipitation of nanoparticles for pulmonary drug delivery; Golding J, Chan H; NanoMaterials Technology Pty Ltd (Singapore)/Project Support.
  • Formulation Of Anti-Inflammatory Aerosols For The Treatment Of Pathogenic Lung Infection; Chan H, Traini D, Young P; Pharmacy Research Trust of NSW/Research Grants Program.
  • University of Sydney - Bridging Support Grant; Chan H; University of Sydney/Bridging Support.
  • Characterising particulate laden flow in the lung airways: from drug delivery to primary anthropogen; Young P, Stewart P, Chan H, Soria J, Honnery D, Thompson B, Larson I; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Molecular Simulation of the Effects of Additives on Generation of Dry Powder Aerosols; Hibbs D, Chan H; University of Sydney/Research & Development.

2005

  • High gravity precipitation of nanoparticles for pulmonary drug delivery; Chan H, Raper J; Australian Research Council (ARC)/Linkage Projects (LP).
  • Particulate Characterisation for Pharmaceutical and Engineering Applications; Coombes A, Amal R, Romagnoli J, Valix M, Langrish T, Stewart P, Yang R, Chan H; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Bronchoprovocation Testing In Children Using Mannitol Powder Aerosols; Chan H, Devadason S, Sly P, Anderson S; National Health and Medical Research Council (NHMRC)/Development Grants.

2004

  • Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery; Chan H, Raper J, Prud'homme R; Australian Research Council (ARC)/Discovery Projects (DP).
  • Synthesis and PET-radiolabelling of inhalation aerosols for lung deposition and disposition studies; Chan H; DVC Research/Research and Development Scheme: Research and Development (R&D).

2003

  • Pharmaceutical Application of a High Gravity Precipitation Process; Chan H, Yun J; Nano Materials Technology Pty Ltd Singapore/BLO Project.

2002

  • Dispersion of pharmaceutical powders as aerosols for inhalation; Chan H, Raper J, Rutland M, Mazumder M; Australian Research Council (ARC)/Discovery Projects (DP).
  • Pharmaceutical Powder Aerosol Delivery: A Lung Deposition Study; Chan H; DVC Research/Research and Development Scheme: Research and Development (R&D).

2001

  • A Novel Aerosol Inhaler by Thermal Liquid Jet Technology; Lennon A, Robertson P, Goodall S, Chan H; Australian Research Council (ARC)/Strategic Partnerships with Industry - Research and Training (SPIRT).
  • An open-label, randomised,three way crossover study to evaluate oropharyngeal & intrapulmonary deposition of 99mTc-DTPA in healthey volunteers following inhalation using different configuration of the second generation AERx system(SLICE); Chan H; Aradigm Corporation/Research Grants.
  • SLICE 01-02 An open-label, two-way crossover study to evaluate oropharyngeal and intrapulmonary deposition of 99mTc-DTPA in healthy volunteers following inhalation using two different versions of a hand-held, all mechanical AERx system (SLICE).; Chan H; Aradigm Corporation/Research Grants.
  • Not known; Chan H, Okikawa J; Aradigm Corporation/Research Grants.

2000

  • Micronisation of poorly water soluble pharmaceuticals; Chan H, Foster M; Australian Research Council (ARC)/Large Research Grants (LRG).
  • An ultrasonic PCA (precipitation with compressed anti-solven) process fo protein powder production; Chan H; Australian Research Council (ARC)/Large Research Grants (LRG).
  • Development of a methodology to quantify lung deposition of radio-labelled MDIs; Chan H; 3M Pharmaceuticals Pty Ltd/Research Support.
  • Fluicaps - proof of concept of research; Tait R, Chan H; Soltec Research Ltd/Research Support.

Selected publications

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Book Chapters

  • Chan, H., Kwok, P. (2013). Novel particle production technologies for inhalation products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 47-62). Chichester, UK: John Wiley & Sons.
  • Kwok, P., Salama, R., Chan, H. (2013). Proteins, peptides, and controlled-release formulations for inhalation. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 121-144). Chichester, UK: John Wiley & Sons.
  • Kwok, P., Chan, H. (2011). Pulmonary Delivery of Peptides and Proteins. In Chris Van der Walle (Eds.), Peptide and Protein Delivery, (pp. 23-46). London, UK: Academic Press Elsevier.
  • Coates, M., Tang, P., Chan, H., Fletcher, D., Raper, J. (2009). Characterization of pharmaceutical aerosols and dry powder inhalers for pulmonary drug delivery. In Sigmund W, El-Shall H, Shah D, Moudgil B (Eds.), Particulate Systems in Nano and Biotechnologies, (pp. 193-222). Boca Raton, USA: CRC Press.
  • Chan, H. (2008). Formulation challenges: protein powders for inhalation. In MJ Rathbone, J Hadgraft, MS Roberts, ME Lane (Eds.), Modified Release Drug Delivery Technology, (pp. 623-636). NY, New York: Informa Healthcare.
  • Kwok, P., Chan, H. (2007). Electrostatic Charge in Pharmaceutical Systems. In James Swarbrick and James C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, (pp. 1535-1547). New York, USA: Marcel Dekker.
  • Tang, P., Chan, H., Raper, J. (2004). Fractal Geometry In Pharmaceutical And Biological Applications - A Review. In James Swarbrick (Eds.), Encyclopaedia of Pharmaceutical Technology, (pp. 1779-1806). New York (on-line): Informa Healthcare.
  • Chan, H. (2003). Formulation challenges: Protein powders for inhalation. In Rathbone, Hadgraft, Roberts (Eds.), Modified-Release Drug Delivery Technology, Vol. 126, (pp. 879-890). United States: Marcel Dekker.

Journals

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Chan, J., Wong, J., Zhou, Q., Leung, S., Chan, H. (2014). Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech, 15(4), 882-897. [More Information]
  • Kwok, P., Chan, H. (2014). Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced Drug Delivery Reviews, 73(C), 83-88. [More Information]
  • Cipolla, D., Wu, H., Eastman, S., Redelmeier, T., Gonda, I., Chan, H. (2014). Development and characterization of an in vitro release assay for liposomal ciprofloxacin for inhalation. Journal of Pharmaceutical Sciences, 103(1), 314-327. [More Information]
  • Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, H. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information]
  • Liang, W., Kwok, P., Chow, M., Tang, P., Mason, A., Chan, H., Lam, J. (2014). Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 64-73. [More Information]
  • Cipolla, D., Wu, H., Gonda, I., Eastman, S., Redelmeier, T., Chan, H. (2014). Modifying the release properties of liposomes toward personalized medicine. Journal of Pharmaceutical Sciences, 103(6), 1851-1862. [More Information]
  • Onoue, S., Yamada, S., Chan, H. (2014). Nanodrugs: pharmacokinetics and safety. International Journal of Nanomedicine, 9(1), 1025-1037. [More Information]
  • Kwok, P., Chan, H. (2014). Nanotechnology versus other techniques in improving drug dissolution. Current Pharmaceutical Design, 20(3), 474-482. [More Information]
  • Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital(®) Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
  • Lee, S., Teo, J., Heng, D., Zhao, Y., Ng, W., Chan, H., Tan, R. (2014). Steroid-decorated antibiotic microparticles for inhaled anti-infective therapy. Journal of Pharmaceutical Sciences, 103(4), 1115-1125. [More Information]
  • Zhou, Q., Gegenbach, T., Denman, J., Yu, H., Li, J., Chan, H. (2014). Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection. The AAPS Journal, 16(1), 37-47. [More Information]
  • Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]
  • Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
  • D’Addio, S., Chan, J., Kwok, P., Benson, B., Prud'homme, R., Chan, H. (2013). Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying. Pharmaceutical Research, 30(11), 2891-2901. [More Information]
  • Tong, Z., Zheng, B., Yang, R., Yu, A., Chan, H. (2013). CFD-DEM investigation of the dispersion mechanisms in commercial dry powder inhalers. Powder Technology, 240, 19-24. [More Information]
  • Zhou, Q., Morton, D., Yu, H., Jacob, J., Wang, J., Li, J., Chan, H. (2013). Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. Journal of Pharmaceutical Sciences, 102(10), 3736-3747. [More Information]
  • Zhou, Q., Tong, Z., Tang, P., Citterio, M., Yang, R., Chan, H. (2013). Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler - A Case Study on Aerolizer® Foradile®. The AAPS Journal, 15(2), 511-522. [More Information]
  • Adi, S., Adi, H., Chan, H., Tong, Z., Yang, R., Yu, A. (2013). Effects of mechanical impaction on aerosol performance of particles with different surface roughness. Powder Technology, 236, 164-170. [More Information]
  • Wong, J., Chan, H., Kwok, P. (2013). Electrostatics in pharmaceutical aerosols for inhalation. Therapeutic Delivery, 4(8). [More Information]
  • Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Adi, S., Heng, J., Tan, R. (2013). High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact. Journal of Aerosol Science, 65, 77-87. [More Information]
  • Cipolla, D., Chan, H. (2013). Inhaled antibiotics to treat lung infection. Pharmaceutical Patent Analyst, 2(5), 647-663. [More Information]
  • Cipolla, D., Gonda, I., Chan, H. (2013). Liposomal formulations for inhalation. Therapeutic Delivery, 4(8), 1047-1072. [More Information]
  • Heng, D., Lee, S., Ng, W., Chan, H., Kwek, J., Tan, R. (2013). Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization. International Journal of Pharmaceutics, 452(1-2), 194-200. [More Information]
  • Kwok, P., Chan, H. (2013). Pulmonary drug delivery. Therapeutic Delivery, 4(8), 877-878. [More Information]
  • Guastella, A., Hickie, I., McGuinness, M., Otis, M., Woods, E., Disinger, H., Chan, H., Chen, T., Banati, R. (2013). Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology, 38(5), 612-625. [More Information]
  • Lee, S., Teo, J., Heng, D., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 275-284. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
  • Syed Muhammad, S., Oubani, H., Abbas, A., Chan, H., Kwok, P., Dehghani, F. (2013). The production of dry powder by the sonocrystallisation for inhalation drug delivery. Powder Technology, 246, 337-344. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
  • Guastella, A., Alvares, G., Hickie, I., Chan, H., Chen, T., Banati, R. (2013). Unitary hormonal models, peripheral markers, and evaluation of response to drug: A response to Weisman and Feldman. Psychoneuroendocrinology, 38, 627-628. [More Information]
  • De Boer, A., Chan, H., Price, R. (2012). A critical view on lactose-based drug formulation and device studies for dry powder inhalation: Which are relevant and what interactions to expect? Advanced Drug Delivery Reviews, 64(3), 257-274. [More Information]
  • Heng, D., Lee, S., Kwek, J., Ng, W., Chan, H., Tan, R. (2012). Assessing the combinatorial influence of climate, formulation and device on powder aerosolization using the Taguchi experimental design. Powder Technology, 226, 253-260. [More Information]
  • D’Addio, S., Chan, J., Kwok, P., Prud'homme, R., Chan, H. (2012). Constant size, variable density aerosol particles by ultrasonic spray freeze drying. International Journal of Pharmaceutics, 427(2), 185-191. [More Information]
  • Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
  • Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807. [More Information]
  • Lam, J., Liang, W., Chan, H. (2012). Pulmonary delivery of therapeutic siRNA. Advanced Drug Delivery Reviews, 64(1), 1-15. [More Information]
  • Fleming, J., Bailey, D., Chan, H., Conway, J., Kuehl, P., Laube, B., Newman, S. (2012). Standardization of Techniques for Using Single-Photon Emission Computed Tomography (SPECT) for Aerosol Deposition Assessment of Orally Inhaled Products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-29-S-51. [More Information]
  • Handayani, D., Meyer, B., Chen, J., Tang, P., Kwok, P., Chan, H., Huang, X. (2012). The comparison of the effect of oat and Shiitake mushroom powder to prevent body weight gain in rats fed high fat diet. Food and Nutrition Sciences, 3(7), 1009-1019. [More Information]
  • Syed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. Journal of Supercritical Fluids, 71, 92-101. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
  • Devadason, S., Chan, H., Haeussermann, S., Kietzig, C., Kuehl, P., Newman, S., Sommerer, K., Taylor, G. (2012). Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-6-S-9. [More Information]
  • Adi, S., Adi, H., Chan, H., Finlay, W., Tong, Z., Yang, R., Yu, A. (2011). Agglomerate strength and dispersion of pharmaceutical powders. Journal of Aerosol Science, 42(4), 285-294. [More Information]
  • Yamasaki, K., Kwok, P., Fukushige, K., Prud'homme, R., Chan, H. (2011). Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former. International Journal of Pharmaceutics, 420(1), 34-42. [More Information]
  • Zhang, J., Wu, L., Chan, H., Watanabe, W. (2011). Formation, characterization, and fate of inhaled drug nanoparticles. Advanced Drug Delivery Reviews, 63(6), 441-455. [More Information]
  • Rojanarat, W., Changsan, N., Tawithong, E., Pinsuwan, S., Chan, H., Srichana, T. (2011). Isoniazid proliposome powders for inhalation-preparation, characterization and cell culture studies. International Journal of Molecular Sciences, 12(7), 4414-4434. [More Information]
  • Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
  • Tang, P., Chan, H., Rajbhandari, D., Phipps, P. (2011). Method to Introduce Mannitol Powder to Intubated Patients to Improve Sputum Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24(1), 1-9. [More Information]
  • Lee, S., Heng, D., Ng, W., Chan, H., Tan, R. (2011). Nano Spray Drying: A Novel Method for Preparing Protein Nanoparticles for Protein Therapy. International Journal of Pharmaceutics, 403(1-2), 192-200. [More Information]
  • Tong, Z., Adi, S., Yang, R., Chan, H., Yu, A. (2011). Numerical investigation of the de-agglomeration mechanisms of fine powders on mechanical impaction. Journal of Aerosol Science, 42, 811-819. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
  • Chan, H., Kwok, P. (2011). Production methods for nanodrug particles using the bottom-up approach. Advanced Drug Delivery Reviews, 63(6), 406-416. [More Information]
  • Syed Muhammad, S., Langrish, T., Tang, P., Adi, H., Chan, H., Kazarian, S., Dehghani, F. (2010). A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388(1-2), 114-122. [More Information]
  • Kumon, M., Kwok, P., Adi, H., Heng, D., Chan, H. (2010). Can low-dose combination products for inhalation be formulated in single crystalline particles? European Journal of Pharmaceutical Sciences, 40(1), 16-24. [More Information]
  • Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
  • Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
  • Kwok, P., Trietsch, S., Kumon, M., Chan, H. (2010). Electrostatic Charge Characteristics of Jet Nebulized Aerosols. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(3), 149-159. [More Information]
  • Kwok, P., Tunsirikongkon, A., Glover, W., Chan, H. (2010). Formation of Protein Nano-Matrix Particles with Controlled Surface Architecture for Respiratory Drug Delivery. Pharmaceutical Research, , 1-9. [More Information]
  • Adi, S., Tong, Z., Chan, H., Yang, R., Yu, A. (2010). Impact angles as an alternative way to improve aerosolisation of powders for inhalation? European Journal of Pharmaceutical Sciences, 41(2), 320-327. [More Information]
  • Tong, Z., Yang, R., Chu, K., Yu, A., Adi, S., Chan, H. (2010). Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow. Chemical Engineering Journal, 164, 432-441. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
  • Cipolla, D., Chan, H., Schuster, J., Farina, D. (2010). Personalizing aerosol medicine: development of delivery systems tailored to the individual. Therapeutic Delivery, 1(5), 667-682. [More Information]
  • Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
  • Weers, J., Bell, J., Chan, H., Cipolla, D., Dunbar, C., Hickey, A., Smith, I. (2010). Pulmonary Formulations: What Remains to be Done? Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(2), S5-S23. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
  • Tang, P., Chan, H., Chiou, H., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud’homme, R., Raper, J. (2009). Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets. International Journal of Pharmaceutics, 367, 51-57. [More Information]
  • Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
  • Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
  • Kwok, P., Chan, H. (2009). Electrostatics of pharmaceutical inhalation aerosols. Journal of Pharmacy and Pharmacology, 61(12), 1587-1599. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
  • Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
  • Tong, Z., Yang, R., Yu, A., Adi, S., Chan, H. (2009). Numerical modelling of the breakage of loose agglomerates of fine particles. Powder Technology, 196(2), 213-221.
  • Changsan, N., Chan, H., Separovic, F., Srichana, T. (2009). Physicochemical Characterization and Stability of Rifampicin Liposome Dry Powder Formulations for Inhalation. Journal of Pharmaceutical Sciences, 98(2), 628-639. [More Information]
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Pure drug nanoparticles in tablets: what are the dissolution limitations? Journal of Nanoparticle Research, , 1-12.
  • Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
  • Tang, P., Chan, H., Raper, J. (2009). Validation of computation method to predict aerodynamic diameter of particles with rough surface. Powder Technology, 192(1), 74-84.
  • Chiou, H., Chan, H., Heng, D., Prud’homme, R., Raper, J. (2008). A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. Journal of Aerosol Science, 39(6), 500-509. [More Information]
  • Yang, R., Yu, A., Choi, S., Coates, M., Chan, H. (2008). Agglomeration of fine particles subjected to centripetal compaction. Powder Technology, 184(1), 122-129.
  • Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2008). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, 97(8), 3356-3366. [More Information]
  • Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model. Langmuir, 24(14), 7538-7544. [More Information]
  • Kwok, P., Noakes, T., Chan, H. (2008). Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 39(3), 211-226. [More Information]
  • Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2008). Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers. International Journal of Pharmaceutics, 349(1/2), 314-322. [More Information]
  • Kwok, P., Chan, H. (2008). Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols. Pharmaceutical Research, 25(2), 277-288. [More Information]
  • Chiou, H., Chan, H., Prud’homme, R., Raper, J. (2008). Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles. Drug Development and Industrial Pharmacy, 34(1), 59-64. [More Information]
  • Newman, S., Chan, H. (2008). In vitro/in vivo comparisons in pulmonary drug delivery. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 21(1), 77-84. [More Information]
  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
  • Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
  • Hu, T., Chiou, H., Chan, H., Chen, J., Yun, J. (2008). Preparation of inhalable salbutamol sulphate using reactive high gravity controlled precipitation. Journal of Pharmaceutical Sciences, 97(2), 944-949. [More Information]
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
  • Tang, P., Fletcher, D., Chan, H., Raper, J. (2008). Simple and cost-effective powder disperser for aerosol particle size measurement. Powder Technology, 187(1), 27-36.
  • Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). What is a suitable dissolution method for drug nanoparticles? Pharmaceutical Research, 25(7), 1696-1701. [More Information]
  • Chan, H. (2008). What is the role of particle morphology in pharmaceutical powder aerosols? Expert Opinion on Drug Delivery, 5(8), 909-914. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
  • Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
  • Heng, D., Tang, P., Cairney, J., Chan, H., Cutler, D., Salama, R., Yun, J. (2007). Focused-ion-beam Milling: A Novel Approach to Probing the Interior of Particles Used for Inhalation Aerosols. Pharmaceutical Research, 24(9), 1608-1617. [More Information]
  • Mitchell, J., Newman, S., Chan, H. (2007). In Vitro and In Vivo Aspects of Cascade Impactor Tests and Inhaler Performance: A Review. AAPS PharmSciTech, 8(4), 110-E1-110-E12.
  • Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
  • Coates, M., Chan, H., Fletcher, D., Chiou, H. (2007). Influence of Mouthpiece Geometry on the Aerosol Delivery Performance of a Dry Powder Inhaler. Pharmaceutical Research, 24(8), 1450-1456. [More Information]
  • Chiou, H., Li, L., Hu, T., Chan, H., Chen, J., Yun, J. (2007). Production of salbutamol sulfate for inhalation by high-gravity controlled antisolvent precipitation. International Journal of Pharmaceutics, 331(1), 93-98. [More Information]
  • Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319.
  • Jouyban, A., Soltanpour, S., Soltani, S., Chan, H., Acree, W. (2007). Solubility prediction of drugs in water-cosolvent mixtures using Abraham solvation parameters. Journal of Pharmacy and Pharmaceutical Sciences, 10(3), 263-277. [More Information]
  • Abbas, A., Srour, M., Tang, P., Chiou, H., Chan, H., Romagnoli, J. (2007). Sonocrystallization of sodium chloride particles for inhalation. Chemical Engineering Science, 62(9), 2445-2453. [More Information]
  • Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
  • Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
  • Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]
  • Chan, H. (2006). Dry powder aerosol delivery systems: current and future research directions. Journal of Aerosol Medicine, 19(1), 21-27. [More Information]
  • Chan, H. (2006). Dry powder aerosol drug delivery-Opportunities for colloid and surface scientists. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 284-285, 50-55. [More Information]
  • Coates, M., Chan, H., Fletcher, D., Raper, J. (2006). Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. Journal of Pharmaceutical Sciences, 95(6), 1382-1392. [More Information]
  • Kwok, P., Collins, R., Chan, H. (2006). Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 37(12), 1671-1682. [More Information]
  • Glover, W., Chan, H., Eberl, S., Daviskas, E., Anderson, S. (2006). Lung Deposition of Mannitol Powder Aerosol in Healthy Subjects. Journal of Aerosol Medicine, 19(4), 522-532. [More Information]
  • Jouyban, A., Khoubnasabjafari, M., Chan, H., Acree, W. (2006). Mathematical representation of solubility of amino acids in binary aqueous-organic solvent mixtures at various temperatures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(9), 789-792.
  • Tang, P., Chan, H., Tam, E., de Gruyter, N., Chan, J. (2006). Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research, 45(12), 4188-4192.
  • Jouyban, A., Chan, H., Chew, N., Khoubnasabjafari, M., Acree, W. (2006). Solubility Prediction of Paracetamol in Binary and Ternary Solvent Mixtures Using Jouyban-Acree Model. Chemical and Pharmaceutical Bulletin, 54(4), 428-431. [More Information]
  • Jouyban, G., Chew, N., Chan, H., Khoubnasabjafari, M., Acree, W. (2006). Solubility prediction of salicylic acid in water-ethanol-propylene glycol mixtures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(4), 318-321. [More Information]
  • Eberl, S., Chan, H., Daviskas, E. (2006). SPECT Imaging for Radioaerosol Deposition and Clearance Studies. Journal of Aerosol Medicine, 19(1), 8-20. [More Information]
  • Issa, F., Kassiou, M., Chan, H., McLeod, M. (2006). Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition. Australian Journal of Chemistry: an international journal for chemical science, 59(1), 53-58.
  • Chan, H., Chiou, H., Kwok, P. (2006). The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005. Expert Opinion on Drug Delivery, 3(1), 163-167. [More Information]
  • Jouyban, A., Chew, N., Chan, H., Sabour, M., Acree, W. (2005). A Unified Cosolvency Model for Calculating Solute Solubility in Mixed Solvents. Chemical and Pharmaceutical Bulletin, 53(6), 634-637. [More Information]
  • Koskela, H., Martens, R., Brannan, J., Anderson, S., Leuppi, J., Chan, H. (2005). Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. Respirology, 10, 442-448. [More Information]
  • Chew, N., Shekunov, B., Tong, H., Chow, A., Savage, C., Wu, J., Chan, H. (2005). Effect of amino acids on the dispersion of disodium cromoglycate powders. Journal of Pharmaceutical Sciences, 94(10), 2289-2300. [More Information]
  • Kwok, P., Glover, W., Chan, H. (2005). Electrostatic charge characteristics of aerosols produced from metered dose inhalers. Journal of Pharmaceutical Sciences, 94(12), 2789-2799. [More Information]
  • Chew, N., Tang, P., Chan, H., Raper, J. (2005). How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical Research. [More Information]
  • Coates, M., Chan, H., Fletcher, D., Raper, J. (2005). Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(9), 1445-1453. [More Information]
  • Daviskas, E., Anderson, S., Gomes, K., Briffa, P., Cochrane, B., Chan, H., Young, I., Rubin, B. (2005). Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum. Respirology, 10(1), 46-56. [More Information]
  • Jouyban, A., Soltani, S., Chan, H., Acree, W. (2005). Modeling acid dissociation constant of analytes in binary solvents at various temperatures using Jouyban-Acree model. Thermochimica acta, 428, 119-123.
  • Jouyban, A., Khoubnasabjafari, M., Chan, H. (2005). Modeling the entrainer effects on solubility of solutes in supercritical carbon dioxide. Chemical and Pharmaceutical Bulletin, 53(3), 290-295. [More Information]
  • Leuppi, J., Tandjung, R., Anderson, S., Stolz, D., Brutsche, M., Bingisser, R., Perruchoud, A., Surber, C., Knoblauch, A., Andersson, M., Chan, H., et al (2005). Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept. Pulmonary Pharmacology and Therapeutics, 18, 83-88. [More Information]
  • Coates, M., Fletcher, D., Chan, H., Raper, J. (2005). The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(6), 923-932. [More Information]
  • Jouyban, A., Soltanpour, S., Chan, H. (2004). A Simple Relationship Between Dielectric Constant Of Mixed Solvents With Solvent Composition And Temperature. International Journal of Pharmaceutics, 269(2), 353-360. [More Information]
  • Koskela, H., Hyvarinen, L., Brannan, J., Chan, H., Anderson, S. (2004). Coughing During Mannitol Challenge Is Associated With Asthma. Chest, 125(6), 1985-1992.
  • Coates, M., Fletcher, D., Chan, H., Raper, J. (2004). Effect Of Design On The Performance Of A Dry Powder Inhaler Using Computational Fluid Dynamics. Part 1: Grid Structure And Mouthpiece Length. Journal of Pharmaceutical Sciences, 93(11), 2863-2876.
  • Chew, N., Reddel, H., Bosnic-Anticevich, S., Chan, H. (2004). Effect Of Mouthpiece Washing On Aerosol Performance Of Cfc-Free Ventolin. Journal of Asthma, 41(7), 721-727.
  • Glover, W., Chan, H. (2004). Electrostatic Charge Characterization Of Pharmaceutical Aerosols Using Electrical Low-Pressure Impaction (Elpi). Journal of Aerosol Science, 35(6), 755-764. [More Information]
  • Chen, J., Zhou, M., Shao, L., Wang, Y., Yun, J., Chew, N., Chan, H. (2004). Feasibility Of Preparing Nanodrugs By High-Gravity Reactive Precipitation. International Journal of Pharmaceutics, 269(1), 267-274. [More Information]
  • Chan, H., Clark, A., Feeley, J., Kuo, M., Lehrman, S., Pikal-Cleland, K., Miller, D., Vehring, R., Lechuga-Ballesteros, D. (2004). Physical Stability Of Salmon Calcitonin Spray-Dried Powders For Inhalation. Journal of Pharmaceutical Sciences, 93(3), 792-804. [More Information]
  • Tang, P., Chan, H., Raper, J. (2004). Prediction Of Aerodynamic Diameter Of Particles With Rough Surfaces. Powder Technology, 147(1-3), 64-78.
  • Jouyban, G., Chan, H., Romero, S., Khoubnasabjafari, M., Bustamante, P. (2004). Solubility prediction in water-ethanol mixtures based on the excess free energy approach using a minimum number of experimental data. Die Pharmazie: an international journal of pharmaceutical sciences, 59(2), 117-120.
  • Jouyban, A., Jabbaribar, F., Chan, H. (2003). An improved empirical model to calculate solute solubility in supercritical carbon dioxide. Die Pharmazie: an international journal of pharmaceutical sciences, 58(6), 396-398.
  • Jouyban, A., Chan, H., Khoubnasabjafari, M., Clark, B. (2003). Calculation of electrophoretic mobility in ternary solvent electrolyte systems. Journal of Pharmaceutical and Biomedical Analysis, 32(2), 203-208.
  • Jouyban, A., Chan, H., Clark, B., Kenndler, E. (2003). Comparison of different algorithms to calculate electrophoretic mobility of analytes as a function of binary solvent composition. Electrophoresis, 24(10), 1596-1602. [More Information]
  • Bustami, R., Chan, H., Sweeney, T., Dehghani, F., Foster, N. (2003). Generation of Fine Powders of Recombinant Human Deoxyribonuclease Using the Aerosol Solvent Extraction System. Pharmaceutical Research, 20(12), 2028-2035.
  • Koskela, H., Taivainen, A., Tukiainen, H., Chan, H. (2003). Inhalation Challenge with Bovine Dander Allergens: Who Needs It? Chest, 124(1), 383-391.
  • Chan, H. (2003). Inhalation drug delivery devices and emerging technologies. Expert Opinion on Therapeutic Patents, 13(9), 1333-1343.
  • Tang, P., Chew, N., Chan, H., Raper, J. (2003). Limitation of Determination of Surface Fractal Dimension Using N2 Adsorption Isotherms and Modified Frenkel-Halsey-Hill Theory. Langmuir, 19(7), 2632-2638.
  • Holzer, K., Anderson, S., Chan, H., Douglass, J. (2003). Mannitol as a Challenge Test to Identify Exercise-induced Bronchoconstriction in Elite Athletes. American Journal of Respiratory and Critical Care Medicine, 167(4), 534-537.
  • Jouyban, A., Grosse, S., Chan, H., Coleman, M., Clark, B. (2003). Mathematical representation of electrophoretic mobility of basic drugs in ternary solvent buffers in capillary zone electrophoresis. Journal of Chromatography A, 994(1-2), 191-198.
  • Chan, H., Chew, N. (2003). Novel alternative methods for the delivery of drugs for the treatment of asthma. Advanced Drug Delivery Reviews, 55(7), 793-805.
  • Jouyban, A., Khoubnasabjafari, M., Chan, H., Altria, K., Clark, B. (2003). Predicting Electrophoretic Mobility of Beta-blockers in a Water-Methanol Based Electrolyte System. Chromatographia, 57(3-4), 191-195. [More Information]
  • Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Responsiveness to Three Bronchial Provocation Tests in Patients with Asthma. Chest, 124(6), 2171-2177.
  • Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Sensitivity and Validity of Three Bronchial Provocation Tests to Demonstrate the Effect of Inhaled Corticosteroids in Asthma. Chest, 124(4), 1341-1349.
  • Jouyban, A., Romero, S., Chan, H., Clark, B., Bustamante, P. (2002). A cosolvency model to predict solubility of drugs at several temperatures from a limited number of solubility measurements. Chemical and Pharmaceutical Bulletin, 50(5), 594-599.
  • Jouyban, A., Chan, H., Barzegar-Jalali, M., Acree, W. (2002). A model to represent solvent effects on the chemical stability of solutes in mixed solvent systems. International Journal of Pharmaceutics, 243(1-2), 167-172.
  • Lam, Y., Bustami, R., Phan, T., Chan, H., Seoarivuc, F. (2002). A solid-state NMR study of protein mobility in lyophilized protein-sugar powders. Journal of Pharmaceutical Sciences, 91(4), 943-951. [More Information]
  • Goodall, S., Chew, N., Chan, H., Auriac, D., Waters, M. (2002). Aerosolization of protein solutions using thermal inkjet technology. Journal of Aerosol Medicine, 15(3), 351-357.
  • Brennan, J., Koskela, H., Anderson, S., Chan, H. (2002). Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology, 7(1), 37-44.
  • Jouyban, A., Grosse, S., Coleman, M., Chan, H., Kenndler, E., Clark, B. (2002). Calculation of electrophoretic mobility in mixed solvent buffers in capillary zone electrophoresis using a mixture response surface method. The Analyst, 127(9), 1118-1192.
  • Chan, H., Eberl, S., Daviskas, E., Constable, C., Young, I. (2002). Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study. Journal of Aerosol Medicine, 15(3), 307-311.
  • Chew, N., Chan, H., Bagster, D., Mukharaiya, J. (2002). Characterization of pharmaceutical powder inhalers: estimation of energy input for powder dispersion and effect of capsule device configuration. Journal of Aerosol Science, 33(7), 999-1008.
  • Chew, N., Chan, H. (2002). Effect of powder polydispersity on aerosol generation. Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 162-168.
  • Daviskas, E., Anderson, S., Eberl, S., Chan, H., Young, I., Seale, J. (2002). Effects of terbutaline in combination with mannitol on mucociliary clearance. European Respiratory Journal, 20, 1423-1429.
  • Jouyban, A., Chan, H., Clark, B., Acree, W. (2002). Mathematical representation of apparent dissociation constants in aqueous -organic solvent mixtures. International Journal of Pharmaceutics, 246(1-2), 135-142.
  • Jouyban, A., Chan, H., Foster, N. (2002). Mathematical representation of solute solubility in supercritical carbon dioxide using empirical expressions. Journal of Supercritical Fluids, 24(1), 19-35.
  • Jouyban, A., Rehman, M., Shekunov, B., Chan, H., Clark, B., York, P. (2002). Solubility prediction in supercritical CO2 using minimum number of experiments. Journal of Pharmaceutical Sciences, 91(5), 1287-1295. [More Information]
  • Jouyban, G., Khoubnasabjafari, M., Chan, H., Clark, B., Acree, W. (2002). Solubility prediction of Anthracene in mixed solvents using a minimum number of experimental data. Chemical and Pharmaceutical Bulletin, 50(1), 21-25.
  • Chew, N., Chan, H. (2002). The role of particle properties in pharmaceutical powder inhalation formulations. Journal of Aerosol Medicine, 15(3), 325-330.
  • Anderson, S., Brannan, J., Chan, H. (2002). Use of aerosols for bronchila provocation testing in the laboratory: Where we have been and where we are going. Journal of Aerosol Medicine, 15(3), 313-324.
  • Chan, H., Eberl, S., Daviskas, E., Constable, C., Young,, I. (2001). Aerosol deposition and clearance measurement: a novel technique using dynamic SPET. European Journal of Nuclear Medicine and Molecular Imaging, 28, 1365-1372.
  • Brannan, J., Chan, H., Seale, J., Anderson, S., Gomes,, K., King,, G. (2001). Fexofenadine decreases sensitivity to and Montelukast improves recovery from inhaled Mannitol. American Journal of Respiratory and Critical Care Medicine, 163(6), 1420-1425.
  • Chew, N., Chan, H. (2001). In vitro aerosol performance and dose uniformity between the Foradile aerolizer and the Oxis turbuhaler. Journal of Aerosol Medicine, 14(4), 495-501.
  • Chan, H., H�gman,, M., L�dvfksd=ttir,, D., Anderson, S., George, S., Hskansson,, L., MerilSinen, P., Hedenstr�m,, H. (2001). Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. Respiratory Physiology and Neurobiology, 124, 141-150.
  • Leuppi, J., Salome, C., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Koskela, H., Anderson, S., Andersson, M. (2001). Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. European Respiratory Journal, 18, 444-450.
  • Jouyban, G., Chan, H., Clark, B., Kenndler, E. (2001). Mathematical representation of electrophoretic mobility in mixed aqueous-methanolic buffers in capillary zone electrophoresis. Journal of Separation Science, 13(8), 346-350.
  • Chew, N., Chan, H. (2001). Pharmaceutical dry powder aerosol delivery. Kona, 19, 46-55.
  • Leuppi, J., Salome, C., Xuan, W., Marks, G., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Anderson, S., Koskela,, H., et al (2001). Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. American Journal of Respiratory and Critical Care Medicine, 163(2), 406-412.
  • Jouyban, G., Dastmalchi, S., Chan, H., Hanaee, J., Javanmard, A., Barzegar-Jalali, M. (2001). Solubility prediction for Furosemide in water-cosolvent mixtures using the minimum number of experiments. Drug Development and Industrial Pharmacy, 27(6), 577-583.
  • Chan, H., Daviskas, E., Anderson, S., Eberl, S., Young,, I. (2001). The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis. Chest, 119(2), 414-421.
  • Chew, N., Chan, H. (2001). Use of solid corrugated particles to enhance powder aerosol performance. Pharmaceutical Research, 18(11), 1570-1577.

Conferences

  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Zhou, Q., Tong, Z., Tang, P., Yang, R., Chan, H. (2013). CFD analysis of the aerosolization of carrier-based dry powder inhaler formulations. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]
  • Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Electrostatic properties of dry powder inhaler formulations: effect of crystallinity. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Liang, W., Kwok, P., Chow, M., Mason, A., Chan, H., Lam, J. (2013). Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Heng, D., Lee, S., Teo, J., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Heng, J., Tan, R. (2013). Visualizing powder de-agglomeration upon impact with simultaneous flowing charge behaviour. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]
  • Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Faua'ad Sed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). Potential technique for the production of micronised lactose crystals by supercritical fluid conditioning. 10th International Symposium on Supercritical Fluids (ISSF) 2012, San Francisco, USA: Elsevier.
  • Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Agglomerate Strength and Aerosol Performance of API-Only Powders. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Does Impact Angle Affect Powder De-Agglomeration in a Model Throat? RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Syed Muhammad, S., Langrish, T., Chan, H., Tang, P., Dehghani, F. (2009). A new method for he production of crystalline microparticle. 9th International Symposium on Supercritical Fluids (ISSF) 2009, Arcachon, France.
  • Kwok, P., Glover, W., Chan, H. (2009). Aerosol Performance of Bovine Serum Albumin Nano-matrices for Inhalation. Asian Federation for Pharmaceutical Sciences (AFPS) 2009 Conference, Japan: Kumamoto University.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Investigating the Unique Dissolution Behaviour of Nanoparticles. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Tang, P., Chan, H., Raper, J. (2009). Prediction of Aerodynamic Diameter of Particles with Corrugated Surface. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Kwok, P., Adi, H., Chan, H. (2009). Protein Nano-Matrices with Controlled Surface Roughness for Inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2009). The Importance of Agglomerate Strength on the Aerosol Performance of Pharmaceutical Dry Powders. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Kwok, P., Chan, H. (2008). Solid Forms and Electrostatic Properties of Salbutamol Sulfate. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
  • Chiou, H., Glover, W., Jun, H., Chan, H., Yun, J. (2007). Metered Dose Inhaler Performance Of High-Gravity Controlled Precipitated Salbutamol Sulfate. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Chan, H. (2007). The Role Of Particle Morphology In Powder Inhalers. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Kwok, P., Chan, H. (2006). Electrostatic charges of metered dose inhaler aerosols sampled from plastic spacers. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Coates, M., Chan, H., Fletcher, D. (2006). Influence of mouthpiece geometry on the performance of a dry powder inhaler. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
  • Chiou, H., Li, L., Chan, H., Hu, T., Chen, R., Yun, J. (2006). Production of salbutamol sulfate powders using high gravity controlled precipitation. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Li, L., Chiou, H., Heng, D., Chan, H., Prud'homme, R., Raper, J. (2006). Studies on nano-pharmaceuticals formulated using confined impinging jets for pulmonary drug delivery. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2006). The Effect of Particle Size of A Powder Dry Aerosol On Lung Deposition. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Tang, P., Chan, H., Raper, J. (2006). Validation of Computation Method to Predict Aerodynamic Diameter of Particles with Rough Surface. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Tang, P., Chan, H., Schneider, C. (2002). Impact of timing valve on the invitro particle size distribution of the Bricanyl Turhuhaler�. Pharmaceutical Science beyond the Genome: Harnessing the Potential, : British Medical Journal Publishing Group.
  • Chew, N., Bosnic-Anticevich, S., Reddel, H., Chan, H., Collis,, L. (2002). Salbutamol sulphate CFC-free metered dose inhalers: effects of washing the inhaler mouthpiece on aerosol performance and potential consequences. TSANZ Annual Scientific Meeting.
  • Chew, N., Chan, H., Bagster, D. (2001). Characterisation of dry powder inhalers: estimation of energy input and effect due to presence of capsule on powder dispersion. Annual Conference, : Ads & Adea.
  • Chew, N., Chan, H. (2001). Determinants for dispersion of powders as aerosols for inhalation. ANZSRS, : World Scientific Publishing.
  • Chew, N., Chan, H. (2001). Effect of the liquid properties on spray performances of thermo-liquid jet technology.
  • Chan, H., Chew, N., Goodall, S. (2001). Particle size estimation of therapeutic aerosols produced by thermal ink jet technology.

Patents

  • Chan, H., Chiou, H., Chen, J., Hu, T., Yun, J. (2006). Inhalable Drug. Patent No. 2006096906. World.
  • Chan, H., Foster, N., Regtop, H., Dehghani, F., Bustami, R. (2006). Synthesis Of Small Particles. Patent No. 2002221320.

Reference Works

  • Chan, H. (2001). Radiolabelling of Pharmaceutical Aerosols and Gamma Scintigraphic Imaging for Lung Deposition. (Vol. 20, pp. 255-268).

2014

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Chan, J., Wong, J., Zhou, Q., Leung, S., Chan, H. (2014). Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech, 15(4), 882-897. [More Information]
  • Kwok, P., Chan, H. (2014). Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced Drug Delivery Reviews, 73(C), 83-88. [More Information]
  • Cipolla, D., Wu, H., Eastman, S., Redelmeier, T., Gonda, I., Chan, H. (2014). Development and characterization of an in vitro release assay for liposomal ciprofloxacin for inhalation. Journal of Pharmaceutical Sciences, 103(1), 314-327. [More Information]
  • Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, H. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information]
  • Liang, W., Kwok, P., Chow, M., Tang, P., Mason, A., Chan, H., Lam, J. (2014). Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 64-73. [More Information]
  • Cipolla, D., Wu, H., Gonda, I., Eastman, S., Redelmeier, T., Chan, H. (2014). Modifying the release properties of liposomes toward personalized medicine. Journal of Pharmaceutical Sciences, 103(6), 1851-1862. [More Information]
  • Onoue, S., Yamada, S., Chan, H. (2014). Nanodrugs: pharmacokinetics and safety. International Journal of Nanomedicine, 9(1), 1025-1037. [More Information]
  • Kwok, P., Chan, H. (2014). Nanotechnology versus other techniques in improving drug dissolution. Current Pharmaceutical Design, 20(3), 474-482. [More Information]
  • Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital(®) Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
  • Lee, S., Teo, J., Heng, D., Zhao, Y., Ng, W., Chan, H., Tan, R. (2014). Steroid-decorated antibiotic microparticles for inhaled anti-infective therapy. Journal of Pharmaceutical Sciences, 103(4), 1115-1125. [More Information]
  • Zhou, Q., Gegenbach, T., Denman, J., Yu, H., Li, J., Chan, H. (2014). Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection. The AAPS Journal, 16(1), 37-47. [More Information]
  • Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]

2013

  • Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • D’Addio, S., Chan, J., Kwok, P., Benson, B., Prud'homme, R., Chan, H. (2013). Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying. Pharmaceutical Research, 30(11), 2891-2901. [More Information]
  • Zhou, Q., Tong, Z., Tang, P., Yang, R., Chan, H. (2013). CFD analysis of the aerosolization of carrier-based dry powder inhaler formulations. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]
  • Tong, Z., Zheng, B., Yang, R., Yu, A., Chan, H. (2013). CFD-DEM investigation of the dispersion mechanisms in commercial dry powder inhalers. Powder Technology, 240, 19-24. [More Information]
  • Zhou, Q., Morton, D., Yu, H., Jacob, J., Wang, J., Li, J., Chan, H. (2013). Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. Journal of Pharmaceutical Sciences, 102(10), 3736-3747. [More Information]
  • Zhou, Q., Tong, Z., Tang, P., Citterio, M., Yang, R., Chan, H. (2013). Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler - A Case Study on Aerolizer® Foradile®. The AAPS Journal, 15(2), 511-522. [More Information]
  • Adi, S., Adi, H., Chan, H., Tong, Z., Yang, R., Yu, A. (2013). Effects of mechanical impaction on aerosol performance of particles with different surface roughness. Powder Technology, 236, 164-170. [More Information]
  • Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Electrostatic properties of dry powder inhaler formulations: effect of crystallinity. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Wong, J., Chan, H., Kwok, P. (2013). Electrostatics in pharmaceutical aerosols for inhalation. Therapeutic Delivery, 4(8). [More Information]
  • Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Adi, S., Heng, J., Tan, R. (2013). High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact. Journal of Aerosol Science, 65, 77-87. [More Information]
  • Cipolla, D., Chan, H. (2013). Inhaled antibiotics to treat lung infection. Pharmaceutical Patent Analyst, 2(5), 647-663. [More Information]
  • Cipolla, D., Gonda, I., Chan, H. (2013). Liposomal formulations for inhalation. Therapeutic Delivery, 4(8), 1047-1072. [More Information]
  • Heng, D., Lee, S., Ng, W., Chan, H., Kwek, J., Tan, R. (2013). Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization. International Journal of Pharmaceutics, 452(1-2), 194-200. [More Information]
  • Chan, H., Kwok, P. (2013). Novel particle production technologies for inhalation products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 47-62). Chichester, UK: John Wiley & Sons.
  • Kwok, P., Salama, R., Chan, H. (2013). Proteins, peptides, and controlled-release formulations for inhalation. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 121-144). Chichester, UK: John Wiley & Sons.
  • Kwok, P., Chan, H. (2013). Pulmonary drug delivery. Therapeutic Delivery, 4(8), 877-878. [More Information]
  • Guastella, A., Hickie, I., McGuinness, M., Otis, M., Woods, E., Disinger, H., Chan, H., Chen, T., Banati, R. (2013). Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology, 38(5), 612-625. [More Information]
  • Liang, W., Kwok, P., Chow, M., Mason, A., Chan, H., Lam, J. (2013). Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Heng, D., Lee, S., Teo, J., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]
  • Lee, S., Teo, J., Heng, D., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 275-284. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Syed Muhammad, S., Oubani, H., Abbas, A., Chan, H., Kwok, P., Dehghani, F. (2013). The production of dry powder by the sonocrystallisation for inhalation drug delivery. Powder Technology, 246, 337-344. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
  • Guastella, A., Alvares, G., Hickie, I., Chan, H., Chen, T., Banati, R. (2013). Unitary hormonal models, peripheral markers, and evaluation of response to drug: A response to Weisman and Feldman. Psychoneuroendocrinology, 38, 627-628. [More Information]
  • Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Heng, J., Tan, R. (2013). Visualizing powder de-agglomeration upon impact with simultaneous flowing charge behaviour. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]

2012

  • De Boer, A., Chan, H., Price, R. (2012). A critical view on lactose-based drug formulation and device studies for dry powder inhalation: Which are relevant and what interactions to expect? Advanced Drug Delivery Reviews, 64(3), 257-274. [More Information]
  • Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Heng, D., Lee, S., Kwek, J., Ng, W., Chan, H., Tan, R. (2012). Assessing the combinatorial influence of climate, formulation and device on powder aerosolization using the Taguchi experimental design. Powder Technology, 226, 253-260. [More Information]
  • D’Addio, S., Chan, J., Kwok, P., Prud'homme, R., Chan, H. (2012). Constant size, variable density aerosol particles by ultrasonic spray freeze drying. International Journal of Pharmaceutics, 427(2), 185-191. [More Information]
  • Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
  • Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807. [More Information]
  • Faua'ad Sed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). Potential technique for the production of micronised lactose crystals by supercritical fluid conditioning. 10th International Symposium on Supercritical Fluids (ISSF) 2012, San Francisco, USA: Elsevier.
  • Lam, J., Liang, W., Chan, H. (2012). Pulmonary delivery of therapeutic siRNA. Advanced Drug Delivery Reviews, 64(1), 1-15. [More Information]
  • Fleming, J., Bailey, D., Chan, H., Conway, J., Kuehl, P., Laube, B., Newman, S. (2012). Standardization of Techniques for Using Single-Photon Emission Computed Tomography (SPECT) for Aerosol Deposition Assessment of Orally Inhaled Products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-29-S-51. [More Information]
  • Handayani, D., Meyer, B., Chen, J., Tang, P., Kwok, P., Chan, H., Huang, X. (2012). The comparison of the effect of oat and Shiitake mushroom powder to prevent body weight gain in rats fed high fat diet. Food and Nutrition Sciences, 3(7), 1009-1019. [More Information]
  • Syed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. Journal of Supercritical Fluids, 71, 92-101. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
  • Devadason, S., Chan, H., Haeussermann, S., Kietzig, C., Kuehl, P., Newman, S., Sommerer, K., Taylor, G. (2012). Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-6-S-9. [More Information]

2011

  • Adi, S., Adi, H., Chan, H., Finlay, W., Tong, Z., Yang, R., Yu, A. (2011). Agglomerate strength and dispersion of pharmaceutical powders. Journal of Aerosol Science, 42(4), 285-294. [More Information]
  • Yamasaki, K., Kwok, P., Fukushige, K., Prud'homme, R., Chan, H. (2011). Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former. International Journal of Pharmaceutics, 420(1), 34-42. [More Information]
  • Zhang, J., Wu, L., Chan, H., Watanabe, W. (2011). Formation, characterization, and fate of inhaled drug nanoparticles. Advanced Drug Delivery Reviews, 63(6), 441-455. [More Information]
  • Rojanarat, W., Changsan, N., Tawithong, E., Pinsuwan, S., Chan, H., Srichana, T. (2011). Isoniazid proliposome powders for inhalation-preparation, characterization and cell culture studies. International Journal of Molecular Sciences, 12(7), 4414-4434. [More Information]
  • Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
  • Tang, P., Chan, H., Rajbhandari, D., Phipps, P. (2011). Method to Introduce Mannitol Powder to Intubated Patients to Improve Sputum Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24(1), 1-9. [More Information]
  • Lee, S., Heng, D., Ng, W., Chan, H., Tan, R. (2011). Nano Spray Drying: A Novel Method for Preparing Protein Nanoparticles for Protein Therapy. International Journal of Pharmaceutics, 403(1-2), 192-200. [More Information]
  • Tong, Z., Adi, S., Yang, R., Chan, H., Yu, A. (2011). Numerical investigation of the de-agglomeration mechanisms of fine powders on mechanical impaction. Journal of Aerosol Science, 42, 811-819. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
  • Chan, H., Kwok, P. (2011). Production methods for nanodrug particles using the bottom-up approach. Advanced Drug Delivery Reviews, 63(6), 406-416. [More Information]
  • Kwok, P., Chan, H. (2011). Pulmonary Delivery of Peptides and Proteins. In Chris Van der Walle (Eds.), Peptide and Protein Delivery, (pp. 23-46). London, UK: Academic Press Elsevier.
  • Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.

2010

  • Syed Muhammad, S., Langrish, T., Tang, P., Adi, H., Chan, H., Kazarian, S., Dehghani, F. (2010). A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388(1-2), 114-122. [More Information]
  • Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Agglomerate Strength and Aerosol Performance of API-Only Powders. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Kumon, M., Kwok, P., Adi, H., Heng, D., Chan, H. (2010). Can low-dose combination products for inhalation be formulated in single crystalline particles? European Journal of Pharmaceutical Sciences, 40(1), 16-24. [More Information]
  • Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
  • Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
  • Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Does Impact Angle Affect Powder De-Agglomeration in a Model Throat? RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Kwok, P., Trietsch, S., Kumon, M., Chan, H. (2010). Electrostatic Charge Characteristics of Jet Nebulized Aerosols. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(3), 149-159. [More Information]
  • Kwok, P., Tunsirikongkon, A., Glover, W., Chan, H. (2010). Formation of Protein Nano-Matrix Particles with Controlled Surface Architecture for Respiratory Drug Delivery. Pharmaceutical Research, , 1-9. [More Information]
  • Adi, S., Tong, Z., Chan, H., Yang, R., Yu, A. (2010). Impact angles as an alternative way to improve aerosolisation of powders for inhalation? European Journal of Pharmaceutical Sciences, 41(2), 320-327. [More Information]
  • Tong, Z., Yang, R., Chu, K., Yu, A., Adi, S., Chan, H. (2010). Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow. Chemical Engineering Journal, 164, 432-441. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
  • Cipolla, D., Chan, H., Schuster, J., Farina, D. (2010). Personalizing aerosol medicine: development of delivery systems tailored to the individual. Therapeutic Delivery, 1(5), 667-682. [More Information]
  • Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
  • Weers, J., Bell, J., Chan, H., Cipolla, D., Dunbar, C., Hickey, A., Smith, I. (2010). Pulmonary Formulations: What Remains to be Done? Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(2), S5-S23. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
  • Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.

2009

  • Syed Muhammad, S., Langrish, T., Chan, H., Tang, P., Dehghani, F. (2009). A new method for he production of crystalline microparticle. 9th International Symposium on Supercritical Fluids (ISSF) 2009, Arcachon, France.
  • Kwok, P., Glover, W., Chan, H. (2009). Aerosol Performance of Bovine Serum Albumin Nano-matrices for Inhalation. Asian Federation for Pharmaceutical Sciences (AFPS) 2009 Conference, Japan: Kumamoto University.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Tang, P., Chan, H., Chiou, H., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud’homme, R., Raper, J. (2009). Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets. International Journal of Pharmaceutics, 367, 51-57. [More Information]
  • Coates, M., Tang, P., Chan, H., Fletcher, D., Raper, J. (2009). Characterization of pharmaceutical aerosols and dry powder inhalers for pulmonary drug delivery. In Sigmund W, El-Shall H, Shah D, Moudgil B (Eds.), Particulate Systems in Nano and Biotechnologies, (pp. 193-222). Boca Raton, USA: CRC Press.
  • Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
  • Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
  • Kwok, P., Chan, H. (2009). Electrostatics of pharmaceutical inhalation aerosols. Journal of Pharmacy and Pharmacology, 61(12), 1587-1599. [More Information]
  • Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
  • Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Investigating the Unique Dissolution Behaviour of Nanoparticles. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
  • Tong, Z., Yang, R., Yu, A., Adi, S., Chan, H. (2009). Numerical modelling of the breakage of loose agglomerates of fine particles. Powder Technology, 196(2), 213-221.
  • Changsan, N., Chan, H., Separovic, F., Srichana, T. (2009). Physicochemical Characterization and Stability of Rifampicin Liposome Dry Powder Formulations for Inhalation. Journal of Pharmaceutical Sciences, 98(2), 628-639. [More Information]
  • Tang, P., Chan, H., Raper, J. (2009). Prediction of Aerodynamic Diameter of Particles with Corrugated Surface. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Kwok, P., Adi, H., Chan, H. (2009). Protein Nano-Matrices with Controlled Surface Roughness for Inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Pure drug nanoparticles in tablets: what are the dissolution limitations? Journal of Nanoparticle Research, , 1-12.
  • Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
  • Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2009). The Importance of Agglomerate Strength on the Aerosol Performance of Pharmaceutical Dry Powders. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
  • Tang, P., Chan, H., Raper, J. (2009). Validation of computation method to predict aerodynamic diameter of particles with rough surface. Powder Technology, 192(1), 74-84.

2008

  • Chiou, H., Chan, H., Heng, D., Prud’homme, R., Raper, J. (2008). A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. Journal of Aerosol Science, 39(6), 500-509. [More Information]
  • Yang, R., Yu, A., Choi, S., Coates, M., Chan, H. (2008). Agglomeration of fine particles subjected to centripetal compaction. Powder Technology, 184(1), 122-129.
  • Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2008). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, 97(8), 3356-3366. [More Information]
  • Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model. Langmuir, 24(14), 7538-7544. [More Information]
  • Kwok, P., Noakes, T., Chan, H. (2008). Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 39(3), 211-226. [More Information]
  • Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2008). Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers. International Journal of Pharmaceutics, 349(1/2), 314-322. [More Information]
  • Kwok, P., Chan, H. (2008). Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols. Pharmaceutical Research, 25(2), 277-288. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Chiou, H., Chan, H., Prud’homme, R., Raper, J. (2008). Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles. Drug Development and Industrial Pharmacy, 34(1), 59-64. [More Information]
  • Chan, H. (2008). Formulation challenges: protein powders for inhalation. In MJ Rathbone, J Hadgraft, MS Roberts, ME Lane (Eds.), Modified Release Drug Delivery Technology, (pp. 623-636). NY, New York: Informa Healthcare.
  • Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Newman, S., Chan, H. (2008). In vitro/in vivo comparisons in pulmonary drug delivery. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 21(1), 77-84. [More Information]
  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
  • Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
  • Hu, T., Chiou, H., Chan, H., Chen, J., Yun, J. (2008). Preparation of inhalable salbutamol sulphate using reactive high gravity controlled precipitation. Journal of Pharmaceutical Sciences, 97(2), 944-949. [More Information]
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
  • Tang, P., Fletcher, D., Chan, H., Raper, J. (2008). Simple and cost-effective powder disperser for aerosol particle size measurement. Powder Technology, 187(1), 27-36.
  • Kwok, P., Chan, H. (2008). Solid Forms and Electrostatic Properties of Salbutamol Sulfate. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). What is a suitable dissolution method for drug nanoparticles? Pharmaceutical Research, 25(7), 1696-1701. [More Information]
  • Chan, H. (2008). What is the role of particle morphology in pharmaceutical powder aerosols? Expert Opinion on Drug Delivery, 5(8), 909-914. [More Information]

2007

  • Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
  • Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
  • Kwok, P., Chan, H. (2007). Electrostatic Charge in Pharmaceutical Systems. In James Swarbrick and James C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, (pp. 1535-1547). New York, USA: Marcel Dekker.
  • Heng, D., Tang, P., Cairney, J., Chan, H., Cutler, D., Salama, R., Yun, J. (2007). Focused-ion-beam Milling: A Novel Approach to Probing the Interior of Particles Used for Inhalation Aerosols. Pharmaceutical Research, 24(9), 1608-1617. [More Information]
  • Mitchell, J., Newman, S., Chan, H. (2007). In Vitro and In Vivo Aspects of Cascade Impactor Tests and Inhaler Performance: A Review. AAPS PharmSciTech, 8(4), 110-E1-110-E12.
  • Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
  • Coates, M., Chan, H., Fletcher, D., Chiou, H. (2007). Influence of Mouthpiece Geometry on the Aerosol Delivery Performance of a Dry Powder Inhaler. Pharmaceutical Research, 24(8), 1450-1456. [More Information]
  • Chiou, H., Glover, W., Jun, H., Chan, H., Yun, J. (2007). Metered Dose Inhaler Performance Of High-Gravity Controlled Precipitated Salbutamol Sulfate. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Chiou, H., Li, L., Hu, T., Chan, H., Chen, J., Yun, J. (2007). Production of salbutamol sulfate for inhalation by high-gravity controlled antisolvent precipitation. International Journal of Pharmaceutics, 331(1), 93-98. [More Information]
  • Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319.
  • Jouyban, A., Soltanpour, S., Soltani, S., Chan, H., Acree, W. (2007). Solubility prediction of drugs in water-cosolvent mixtures using Abraham solvation parameters. Journal of Pharmacy and Pharmaceutical Sciences, 10(3), 263-277. [More Information]
  • Abbas, A., Srour, M., Tang, P., Chiou, H., Chan, H., Romagnoli, J. (2007). Sonocrystallization of sodium chloride particles for inhalation. Chemical Engineering Science, 62(9), 2445-2453. [More Information]
  • Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
  • Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
  • Chan, H. (2007). The Role Of Particle Morphology In Powder Inhalers. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]

2006

  • Chan, H. (2006). Dry powder aerosol delivery systems: current and future research directions. Journal of Aerosol Medicine, 19(1), 21-27. [More Information]
  • Chan, H. (2006). Dry powder aerosol drug delivery-Opportunities for colloid and surface scientists. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 284-285, 50-55. [More Information]
  • Coates, M., Chan, H., Fletcher, D., Raper, J. (2006). Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. Journal of Pharmaceutical Sciences, 95(6), 1382-1392. [More Information]
  • Kwok, P., Collins, R., Chan, H. (2006). Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 37(12), 1671-1682. [More Information]
  • Kwok, P., Chan, H. (2006). Electrostatic charges of metered dose inhaler aerosols sampled from plastic spacers. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Coates, M., Chan, H., Fletcher, D. (2006). Influence of mouthpiece geometry on the performance of a dry powder inhaler. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Chan, H., Chiou, H., Chen, J., Hu, T., Yun, J. (2006). Inhalable Drug. Patent No. 2006096906. World.
  • Glover, W., Chan, H., Eberl, S., Daviskas, E., Anderson, S. (2006). Lung Deposition of Mannitol Powder Aerosol in Healthy Subjects. Journal of Aerosol Medicine, 19(4), 522-532. [More Information]
  • Jouyban, A., Khoubnasabjafari, M., Chan, H., Acree, W. (2006). Mathematical representation of solubility of amino acids in binary aqueous-organic solvent mixtures at various temperatures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(9), 789-792.
  • Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
  • Tang, P., Chan, H., Tam, E., de Gruyter, N., Chan, J. (2006). Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research, 45(12), 4188-4192.
  • Chiou, H., Li, L., Chan, H., Hu, T., Chen, R., Yun, J. (2006). Production of salbutamol sulfate powders using high gravity controlled precipitation. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Jouyban, A., Chan, H., Chew, N., Khoubnasabjafari, M., Acree, W. (2006). Solubility Prediction of Paracetamol in Binary and Ternary Solvent Mixtures Using Jouyban-Acree Model. Chemical and Pharmaceutical Bulletin, 54(4), 428-431. [More Information]
  • Jouyban, G., Chew, N., Chan, H., Khoubnasabjafari, M., Acree, W. (2006). Solubility prediction of salicylic acid in water-ethanol-propylene glycol mixtures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(4), 318-321. [More Information]
  • Eberl, S., Chan, H., Daviskas, E. (2006). SPECT Imaging for Radioaerosol Deposition and Clearance Studies. Journal of Aerosol Medicine, 19(1), 8-20. [More Information]
  • Li, L., Chiou, H., Heng, D., Chan, H., Prud'homme, R., Raper, J. (2006). Studies on nano-pharmaceuticals formulated using confined impinging jets for pulmonary drug delivery. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Issa, F., Kassiou, M., Chan, H., McLeod, M. (2006). Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition. Australian Journal of Chemistry: an international journal for chemical science, 59(1), 53-58.
  • Chan, H., Foster, N., Regtop, H., Dehghani, F., Bustami, R. (2006). Synthesis Of Small Particles. Patent No. 2002221320.
  • Chan, H., Chiou, H., Kwok, P. (2006). The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005. Expert Opinion on Drug Delivery, 3(1), 163-167. [More Information]
  • Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2006). The Effect of Particle Size of A Powder Dry Aerosol On Lung Deposition. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Tang, P., Chan, H., Raper, J. (2006). Validation of Computation Method to Predict Aerodynamic Diameter of Particles with Rough Surface. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.

2005

  • Jouyban, A., Chew, N., Chan, H., Sabour, M., Acree, W. (2005). A Unified Cosolvency Model for Calculating Solute Solubility in Mixed Solvents. Chemical and Pharmaceutical Bulletin, 53(6), 634-637. [More Information]
  • Koskela, H., Martens, R., Brannan, J., Anderson, S., Leuppi, J., Chan, H. (2005). Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. Respirology, 10, 442-448. [More Information]
  • Chew, N., Shekunov, B., Tong, H., Chow, A., Savage, C., Wu, J., Chan, H. (2005). Effect of amino acids on the dispersion of disodium cromoglycate powders. Journal of Pharmaceutical Sciences, 94(10), 2289-2300. [More Information]
  • Kwok, P., Glover, W., Chan, H. (2005). Electrostatic charge characteristics of aerosols produced from metered dose inhalers. Journal of Pharmaceutical Sciences, 94(12), 2789-2799. [More Information]
  • Chew, N., Tang, P., Chan, H., Raper, J. (2005). How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical Research. [More Information]
  • Coates, M., Chan, H., Fletcher, D., Raper, J. (2005). Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(9), 1445-1453. [More Information]
  • Daviskas, E., Anderson, S., Gomes, K., Briffa, P., Cochrane, B., Chan, H., Young, I., Rubin, B. (2005). Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum. Respirology, 10(1), 46-56. [More Information]
  • Jouyban, A., Soltani, S., Chan, H., Acree, W. (2005). Modeling acid dissociation constant of analytes in binary solvents at various temperatures using Jouyban-Acree model. Thermochimica acta, 428, 119-123.
  • Jouyban, A., Khoubnasabjafari, M., Chan, H. (2005). Modeling the entrainer effects on solubility of solutes in supercritical carbon dioxide. Chemical and Pharmaceutical Bulletin, 53(3), 290-295. [More Information]
  • Leuppi, J., Tandjung, R., Anderson, S., Stolz, D., Brutsche, M., Bingisser, R., Perruchoud, A., Surber, C., Knoblauch, A., Andersson, M., Chan, H., et al (2005). Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept. Pulmonary Pharmacology and Therapeutics, 18, 83-88. [More Information]
  • Coates, M., Fletcher, D., Chan, H., Raper, J. (2005). The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(6), 923-932. [More Information]

2004

  • Jouyban, A., Soltanpour, S., Chan, H. (2004). A Simple Relationship Between Dielectric Constant Of Mixed Solvents With Solvent Composition And Temperature. International Journal of Pharmaceutics, 269(2), 353-360. [More Information]
  • Koskela, H., Hyvarinen, L., Brannan, J., Chan, H., Anderson, S. (2004). Coughing During Mannitol Challenge Is Associated With Asthma. Chest, 125(6), 1985-1992.
  • Coates, M., Fletcher, D., Chan, H., Raper, J. (2004). Effect Of Design On The Performance Of A Dry Powder Inhaler Using Computational Fluid Dynamics. Part 1: Grid Structure And Mouthpiece Length. Journal of Pharmaceutical Sciences, 93(11), 2863-2876.
  • Chew, N., Reddel, H., Bosnic-Anticevich, S., Chan, H. (2004). Effect Of Mouthpiece Washing On Aerosol Performance Of Cfc-Free Ventolin. Journal of Asthma, 41(7), 721-727.
  • Glover, W., Chan, H. (2004). Electrostatic Charge Characterization Of Pharmaceutical Aerosols Using Electrical Low-Pressure Impaction (Elpi). Journal of Aerosol Science, 35(6), 755-764. [More Information]
  • Chen, J., Zhou, M., Shao, L., Wang, Y., Yun, J., Chew, N., Chan, H. (2004). Feasibility Of Preparing Nanodrugs By High-Gravity Reactive Precipitation. International Journal of Pharmaceutics, 269(1), 267-274. [More Information]
  • Tang, P., Chan, H., Raper, J. (2004). Fractal Geometry In Pharmaceutical And Biological Applications - A Review. In James Swarbrick (Eds.), Encyclopaedia of Pharmaceutical Technology, (pp. 1779-1806). New York (on-line): Informa Healthcare.
  • Chan, H., Clark, A., Feeley, J., Kuo, M., Lehrman, S., Pikal-Cleland, K., Miller, D., Vehring, R., Lechuga-Ballesteros, D. (2004). Physical Stability Of Salmon Calcitonin Spray-Dried Powders For Inhalation. Journal of Pharmaceutical Sciences, 93(3), 792-804. [More Information]
  • Tang, P., Chan, H., Raper, J. (2004). Prediction Of Aerodynamic Diameter Of Particles With Rough Surfaces. Powder Technology, 147(1-3), 64-78.
  • Jouyban, G., Chan, H., Romero, S., Khoubnasabjafari, M., Bustamante, P. (2004). Solubility prediction in water-ethanol mixtures based on the excess free energy approach using a minimum number of experimental data. Die Pharmazie: an international journal of pharmaceutical sciences, 59(2), 117-120.

2003

  • Jouyban, A., Jabbaribar, F., Chan, H. (2003). An improved empirical model to calculate solute solubility in supercritical carbon dioxide. Die Pharmazie: an international journal of pharmaceutical sciences, 58(6), 396-398.
  • Jouyban, A., Chan, H., Khoubnasabjafari, M., Clark, B. (2003). Calculation of electrophoretic mobility in ternary solvent electrolyte systems. Journal of Pharmaceutical and Biomedical Analysis, 32(2), 203-208.
  • Jouyban, A., Chan, H., Clark, B., Kenndler, E. (2003). Comparison of different algorithms to calculate electrophoretic mobility of analytes as a function of binary solvent composition. Electrophoresis, 24(10), 1596-1602. [More Information]
  • Chan, H. (2003). Formulation challenges: Protein powders for inhalation. In Rathbone, Hadgraft, Roberts (Eds.), Modified-Release Drug Delivery Technology, Vol. 126, (pp. 879-890). United States: Marcel Dekker.
  • Bustami, R., Chan, H., Sweeney, T., Dehghani, F., Foster, N. (2003). Generation of Fine Powders of Recombinant Human Deoxyribonuclease Using the Aerosol Solvent Extraction System. Pharmaceutical Research, 20(12), 2028-2035.
  • Koskela, H., Taivainen, A., Tukiainen, H., Chan, H. (2003). Inhalation Challenge with Bovine Dander Allergens: Who Needs It? Chest, 124(1), 383-391.
  • Chan, H. (2003). Inhalation drug delivery devices and emerging technologies. Expert Opinion on Therapeutic Patents, 13(9), 1333-1343.
  • Tang, P., Chew, N., Chan, H., Raper, J. (2003). Limitation of Determination of Surface Fractal Dimension Using N2 Adsorption Isotherms and Modified Frenkel-Halsey-Hill Theory. Langmuir, 19(7), 2632-2638.
  • Holzer, K., Anderson, S., Chan, H., Douglass, J. (2003). Mannitol as a Challenge Test to Identify Exercise-induced Bronchoconstriction in Elite Athletes. American Journal of Respiratory and Critical Care Medicine, 167(4), 534-537.
  • Jouyban, A., Grosse, S., Chan, H., Coleman, M., Clark, B. (2003). Mathematical representation of electrophoretic mobility of basic drugs in ternary solvent buffers in capillary zone electrophoresis. Journal of Chromatography A, 994(1-2), 191-198.
  • Chan, H., Chew, N. (2003). Novel alternative methods for the delivery of drugs for the treatment of asthma. Advanced Drug Delivery Reviews, 55(7), 793-805.
  • Jouyban, A., Khoubnasabjafari, M., Chan, H., Altria, K., Clark, B. (2003). Predicting Electrophoretic Mobility of Beta-blockers in a Water-Methanol Based Electrolyte System. Chromatographia, 57(3-4), 191-195. [More Information]
  • Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Responsiveness to Three Bronchial Provocation Tests in Patients with Asthma. Chest, 124(6), 2171-2177.
  • Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Sensitivity and Validity of Three Bronchial Provocation Tests to Demonstrate the Effect of Inhaled Corticosteroids in Asthma. Chest, 124(4), 1341-1349.

2002

  • Jouyban, A., Romero, S., Chan, H., Clark, B., Bustamante, P. (2002). A cosolvency model to predict solubility of drugs at several temperatures from a limited number of solubility measurements. Chemical and Pharmaceutical Bulletin, 50(5), 594-599.
  • Jouyban, A., Chan, H., Barzegar-Jalali, M., Acree, W. (2002). A model to represent solvent effects on the chemical stability of solutes in mixed solvent systems. International Journal of Pharmaceutics, 243(1-2), 167-172.
  • Lam, Y., Bustami, R., Phan, T., Chan, H., Seoarivuc, F. (2002). A solid-state NMR study of protein mobility in lyophilized protein-sugar powders. Journal of Pharmaceutical Sciences, 91(4), 943-951. [More Information]
  • Goodall, S., Chew, N., Chan, H., Auriac, D., Waters, M. (2002). Aerosolization of protein solutions using thermal inkjet technology. Journal of Aerosol Medicine, 15(3), 351-357.
  • Brennan, J., Koskela, H., Anderson, S., Chan, H. (2002). Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology, 7(1), 37-44.
  • Jouyban, A., Grosse, S., Coleman, M., Chan, H., Kenndler, E., Clark, B. (2002). Calculation of electrophoretic mobility in mixed solvent buffers in capillary zone electrophoresis using a mixture response surface method. The Analyst, 127(9), 1118-1192.
  • Chan, H., Eberl, S., Daviskas, E., Constable, C., Young, I. (2002). Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study. Journal of Aerosol Medicine, 15(3), 307-311.
  • Chew, N., Chan, H., Bagster, D., Mukharaiya, J. (2002). Characterization of pharmaceutical powder inhalers: estimation of energy input for powder dispersion and effect of capsule device configuration. Journal of Aerosol Science, 33(7), 999-1008.
  • Chew, N., Chan, H. (2002). Effect of powder polydispersity on aerosol generation. Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 162-168.
  • Daviskas, E., Anderson, S., Eberl, S., Chan, H., Young, I., Seale, J. (2002). Effects of terbutaline in combination with mannitol on mucociliary clearance. European Respiratory Journal, 20, 1423-1429.
  • Tang, P., Chan, H., Schneider, C. (2002). Impact of timing valve on the invitro particle size distribution of the Bricanyl Turhuhaler�. Pharmaceutical Science beyond the Genome: Harnessing the Potential, : British Medical Journal Publishing Group.
  • Jouyban, A., Chan, H., Clark, B., Acree, W. (2002). Mathematical representation of apparent dissociation constants in aqueous -organic solvent mixtures. International Journal of Pharmaceutics, 246(1-2), 135-142.
  • Jouyban, A., Chan, H., Foster, N. (2002). Mathematical representation of solute solubility in supercritical carbon dioxide using empirical expressions. Journal of Supercritical Fluids, 24(1), 19-35.
  • Chew, N., Bosnic-Anticevich, S., Reddel, H., Chan, H., Collis,, L. (2002). Salbutamol sulphate CFC-free metered dose inhalers: effects of washing the inhaler mouthpiece on aerosol performance and potential consequences. TSANZ Annual Scientific Meeting.
  • Jouyban, A., Rehman, M., Shekunov, B., Chan, H., Clark, B., York, P. (2002). Solubility prediction in supercritical CO2 using minimum number of experiments. Journal of Pharmaceutical Sciences, 91(5), 1287-1295. [More Information]
  • Jouyban, G., Khoubnasabjafari, M., Chan, H., Clark, B., Acree, W. (2002). Solubility prediction of Anthracene in mixed solvents using a minimum number of experimental data. Chemical and Pharmaceutical Bulletin, 50(1), 21-25.
  • Chew, N., Chan, H. (2002). The role of particle properties in pharmaceutical powder inhalation formulations. Journal of Aerosol Medicine, 15(3), 325-330.
  • Anderson, S., Brannan, J., Chan, H. (2002). Use of aerosols for bronchila provocation testing in the laboratory: Where we have been and where we are going. Journal of Aerosol Medicine, 15(3), 313-324.

2001

  • Chan, H., Eberl, S., Daviskas, E., Constable, C., Young,, I. (2001). Aerosol deposition and clearance measurement: a novel technique using dynamic SPET. European Journal of Nuclear Medicine and Molecular Imaging, 28, 1365-1372.
  • Chew, N., Chan, H., Bagster, D. (2001). Characterisation of dry powder inhalers: estimation of energy input and effect due to presence of capsule on powder dispersion. Annual Conference, : Ads & Adea.
  • Chew, N., Chan, H. (2001). Determinants for dispersion of powders as aerosols for inhalation. ANZSRS, : World Scientific Publishing.
  • Chew, N., Chan, H. (2001). Effect of the liquid properties on spray performances of thermo-liquid jet technology.
  • Brannan, J., Chan, H., Seale, J., Anderson, S., Gomes,, K., King,, G. (2001). Fexofenadine decreases sensitivity to and Montelukast improves recovery from inhaled Mannitol. American Journal of Respiratory and Critical Care Medicine, 163(6), 1420-1425.
  • Chew, N., Chan, H. (2001). In vitro aerosol performance and dose uniformity between the Foradile aerolizer and the Oxis turbuhaler. Journal of Aerosol Medicine, 14(4), 495-501.
  • Chan, H., H�gman,, M., L�dvfksd=ttir,, D., Anderson, S., George, S., Hskansson,, L., MerilSinen, P., Hedenstr�m,, H. (2001). Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. Respiratory Physiology and Neurobiology, 124, 141-150.
  • Leuppi, J., Salome, C., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Koskela, H., Anderson, S., Andersson, M. (2001). Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. European Respiratory Journal, 18, 444-450.
  • Jouyban, G., Chan, H., Clark, B., Kenndler, E. (2001). Mathematical representation of electrophoretic mobility in mixed aqueous-methanolic buffers in capillary zone electrophoresis. Journal of Separation Science, 13(8), 346-350.
  • Chan, H., Chew, N., Goodall, S. (2001). Particle size estimation of therapeutic aerosols produced by thermal ink jet technology.
  • Chew, N., Chan, H. (2001). Pharmaceutical dry powder aerosol delivery. Kona, 19, 46-55.
  • Leuppi, J., Salome, C., Xuan, W., Marks, G., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Anderson, S., Koskela,, H., et al (2001). Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. American Journal of Respiratory and Critical Care Medicine, 163(2), 406-412.
  • Chan, H. (2001). Radiolabelling of Pharmaceutical Aerosols and Gamma Scintigraphic Imaging for Lung Deposition. (Vol. 20, pp. 255-268).
  • Jouyban, G., Dastmalchi, S., Chan, H., Hanaee, J., Javanmard, A., Barzegar-Jalali, M. (2001). Solubility prediction for Furosemide in water-cosolvent mixtures using the minimum number of experiments. Drug Development and Industrial Pharmacy, 27(6), 577-583.
  • Chan, H., Daviskas, E., Anderson, S., Eberl, S., Young,, I. (2001). The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis. Chest, 119(2), 414-421.
  • Chew, N., Chan, H. (2001). Use of solid corrugated particles to enhance powder aerosol performance. Pharmaceutical Research, 18(11), 1570-1577.

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