Professor Mary Collins

BSc (Hon) PhD FRACI
Professor of Pharmaceutical Neuroscience
Research Theme Leader, Mental Health

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 8584
Fax +61 2 9351 4391

Biographical details

Professor Mary Collins (Chebib) was awarded her PhD from Griffith University in 1994. After a six-year postdoctoral position at the Department of Pharmacology, she was appointed as Lecturer at the University of Sydney in 2000, Senior Lecturer in 2003, Associate Professor in 2007 and Professor of Pharmaceutical Neuroscience in 2012.

Professor Collins (Chebib) received a number of awards including the ASCEPT Young Investigator Award, RACI Biota Award, entry to Fellow of the Royal Australian Chemical Institute Inc (RACI) (2006), and the University of Sydney Faculty of Pharmacy Higher Degree Supervision Award (2008).

Professor Collins (Chebib) is a member of the Pharmaceutical Subcommittee of the Australian Drug Evaluation Committee for the Therapeutic Goods Administration and associate editor for the journal Amino Acids. She has served as served as Chair of the RACI Biomolecular Chemistry Division and RACI NSW Branch President.

Professor Collins (Chebib) has developed a vigorous research program in the areas of medicinal chemistry and molecular pharmacology focusing on Cys-loop receptors, particularly GABA and nicotinic acetylcholine receptors. Her research focuses on developing subtype selective modulators along with identifying where they bind on the channels. Such studies are essential for drug discovery ventures and for delineating the role each subtype plays in brain physiology and pathophysiology.

Research interests

  • GABA receptors
  • Nicotinic acetylcholine receptors

The rapid advances in molecular biology and genetics have contributed towards the discovery and isolation of a large number of receptors and proteins that may be targets to treat various disease states. My team focuses on studying GABA and nicotinic acetylcholine receptors and their involvement in anxiety, sleep disorders and learning and memory.

Structure-activity relationship (SAR) studies involving structural variations of both the agents and their receptor targets (termed complementary structure-activity studies) play important roles in drug design and development. Of particular focus is the structure-function studies of GABA and nicotinic receptors using site-directed mutagenesis in combination with reactive probes help identify amino acids that are important in the binding and function of receptors. In addition, animal models to evaluate the effects of important ligands establish a link between the in vitro and in vivo effects. Such studies are vital to the discovery of drugs that interact selectively with particular receptor subtypes and in receptors that may have inheritable mutations.

Current projects

  • Identifying the binding sites of flavonoids and other modulators acting on GABAA receptors
  • Design, synthesis and pharmacology of novel GABA receptor agents
  • Flavonoids as anxiolytics, sedatives and sleep agents
  • Identifying the binding sites of novel agents acting on nicotinic acetylcholine receptors

Keywords

Amino acids; Anxiety disorders; Neuropharmacology; Drug design; Molecular biology

Selected grants

2015

  • delta-containing GABA-A receptors as targets for neuroprotection; Collins M, Clarkson A, Balle T, Nicolazzo J, Hanrahan J, Ahring J, Vaughan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • γ-Hydroxybutyric acid (GHB) and α4-containing GABA-A receptors; Collins M, McGregor I, Hunt G, Absalom N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • New positive allosteric modulators of nicotinic acetylcholine receptors for treatment of cognitive impairment in ADHD; Balle T, Collins M, McLeod M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stereotaxic frame; Arnold J, Christie M, Collins M, Sawatari A, Leamey C, Stone J, van Nieuwenhuijzen P, Chan-Ling T, Balle T; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Sydney Neuroscience Network; Balleine B, Absalom N, Braddon-Mitchell D, Callaghan S, Chawla S, Christie M, Collins M, Einfeld S, Grieve S, Haber P, Hanrahan J, Harris A, Hickie I, Kassiou M, Kril J, Meikle S, Morris R, Ramos F, Rong Y, Sue C; DVC Research/Research Network Scheme (SyReNS).
  • Understanding delta-containing GABA-A receptor pharmacology; Collins M; DVC Research/Bridging Support Grant.
  • Allosteric Targets on GABA-A Receptors; Hanrahan J, Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Extrasynaptic GABA-A receptors as novel targets for gamma-Hydroxybutyric acid (GHB); Collins M, Wellendorph P, McGregor I, Hunt G, Brauner-Osborne H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Preparative High-Performance Liquid Chromatography (HPLC); Payne R, Jolliffe K, Hambley T, Kassiou M, Collins M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Structure and dynamidcs of the GABA-C ligand-binding domain; Collins M; DVC Research/Bridging Support Grant.
  • The GABAergic system in eye growth control and myopia; Schmid K, Collins M, Hanrahan J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins M, Johnston G, Young P, Traini D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Elucidating the Mode of Action of Nicotinic Receptor Ligands; Collins M, McLeod M; Australian Research Council (ARC)/Discovery Projects (DP).

2006

  • Elucidating the mode of Action of Nicotinic Receptor Ligands; McLeod M, Collins M; Australian Research Council (ARC)/Discovery Projects (DP).
  • GABA modulators for the treatment of anxiety, epilepsy and insomnia; Johnston G, Hanrahan J, Collins M, Mewett K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • ACV1 in human receptors in Oocytes; Collins M, Belyea C, McIntosh D; Metabolic Pharmaceuticals Ltd/Research Grants.
  • University of Sydney - Bridging Support Grant; Collins M; University of Sydney/Bridging Support.

2005

  • Influence of S 24795 on A 42 - 7 interaction; Collins M, Correia A, Small D; Monash University(IRIS Servier)/Shared Research Grants.
  • 7500 Real-time PCR instrument plus software; Roufogalis B, Armour C, Collins M, Ammit A, Murray M, Hughes M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2004

  • The Roboocyte™: A Medium-throughput Secondary Functional Screening Facility.; Collins M, McLeod M, Jamie J, Johnston G; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Cholinergic abnormalities in Alzheimers disease : Identification of novel terapeutic targets; Collins M, Small D, Aquilar M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Incorporation of unnatural amino acids into proteins; McLeod M, Collins M; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • Novel agents acting on neuronal nicotinic receptors; McLeod M, Collins M; DVC Research/Bridging Support Grant.
  • Molecular and Materials Structure Network; Turner P, Kepert C, Collins M, Hambley T, Hanrahan J, Kennedy B, Lay P; Australian Research Council (ARC)/Research Networks (ARCRN).
  • Acetylcholinesterase, nicotinic receptors and Alzheimer's disease; Aguilar M, Collins M, Small D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • 2-electrode voltage clamp (2EVC) and assessories; Vandenberg R, Mitrovic A, Cook D, Collins M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Constrained analogs of Gabapentin and Pregabalin; Collins M, O'Connor S, Hanrahan J, Johnston G; Pfizer Pty Ltd/Research Grants.
  • GABA receptor modulation by flavonoids; Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Konica Medical Film Processor SRX-101A; Armour C, Collins M, Hughes M, Ammit A, Roufogalis B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • The Sydney Combinatorial Research Facility; Collins M, Jamie J, Read R; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The effects of anti-psychotics on GABA-A and GABA-C receptor subtypes; Collins M; Rebecca L Cooper/Medical Research Foundation.
  • Synthesis, testing and development of GABA-C antagonists, including cyclopentene phosphinates; Johnston G, Kaufman G, Serry L, Sharp S, Hanrahan J, Collins M; Polychip Pharmaceuticals Pty.Ltd./BLO Project.
  • The pharmacology and physiology of GABA-C receptors; Collins M, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Novel agents acting on neuronal nicotinic acetylcholine receptor subtypes; Collins M; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).
  • Electrode puller, microforge setup and nanolitre injector with microscope and light source; Collins M; Clive & Vera Ramaciotti Foundation/Research Grants.
  • The effects of antipsychotics on recombinant human gaba-a and gaba-c receptor subtypes; Collins M; Rebecca L Cooper/Medical Research Foundation.

2000

  • Novel GABA receptors in rat cerebellum, hippocampus, retina and spinal cord; Johnston G, Collins M, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Flavonoids and GABA receptors; Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • 2-electrode voltage clamp rig with incubator and electrode puller; Collins M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

1999

  • Molecular pharmacology of GABA-C receptor subtypes; Collins M, Johnston G, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]

Journals

  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Collins, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PLoS One, 9(1), 1-16. [More Information]
  • Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Collins, M. (2013). Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. Journal of Biological Chemistry, 288(37), 26521-26532. [More Information]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Collins, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. A C S Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Collins, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]
  • Pan, Y., Gerasimov, M., Kvist, T., Wellendorph, P., Madsen, K., Pera, E., Lee, H., Schousboe, A., Collins, M., Brauner-Osborne, H., et al (2012). (1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction. Journal of Medicinal Chemistry, 55(1), 357-366. [More Information]
  • Absalom, N., Eghorn, L., Villumsen, I., Karim, N., Bay, T., Olsen, J., Knudsen, G., Brauner-Osborne, H., Frølund, B., Clausen, R., Collins, M., et al (2012). (alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(33), 13404-13409. [More Information]
  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Beinat, C., Banister, S., Prehn, S., Doddareddy, M., Hibbs, D., Sako, M., Collins, M., Tran, T., Al-Muhtasib, N., Xiao, Y., Kassiou, M. (2012). Consequences of linker length alteration of the alpha7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(7), 2380-2384. [More Information]
  • Ambrus, J., Halliday, J., Kanizaj, N., Absalom, N., Harpsøe, K., Balle, T., Collins, M., McLeod, M. (2012). Covalent attachment of antagonists to the (alpha)7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chemical Communications, 48(53), 6699-6701. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Cheng, Z., Collins, M., Schmid, K. (2012). Identification of GABA receptors in chick cornea. Molecular Vision, 18, 1107-1114. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Collins, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]
  • Yamamoto, I., Jordan, M., Gavande, N., Doddareddy, M., Collins, M., Hunter, L. (2012). The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptor. Chemical Communications, 48(6), 829-831. [More Information]
  • Xie, A., Yan, J., Yue, L., Feng, F., Mir, F., Abdel-Halim, H., Collins, M., Le Breton, G., Standaert, R., Qian, H., et al (2011). 2-Aminoethyl Methylphosphonate, a Potent and Rapidly Acting Antagonist of GABAA-p1 Receptors. Molecular Pharmacology, 80(6), 965-978. [More Information]
  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Yamamoto, I., Deniau, G., Gavande, N., Collins, M., Johnston, G., O'Hagan, D. (2011). Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Communications, 47(28), 7956-7958. [More Information]
  • Wong, S., Collins, M., Haqshenas, G., Loveland, B., Gowans, E. (2011). Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes. Virology, 412(1), 83-90. [More Information]
  • Hanrahan, J., Collins, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Loscalzo, L., Yow, T., Wasowski, C., Collins, M., Marder, M. (2011). Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to {mu}-opioid receptor and inhibits GIRK1/2 currents. Pharmacology, Biochemistry and Behavior, 99(3), 333-341. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2(1), 11-16. [More Information]
  • Cheng, Z., Collins, M., Schmidt, K. (2011). rho(1) GABA(C) receptors are expressed in fibrous and cartilaginous layers of chick sclera and located on sclera fibroblasts and chondrocytes. Journal of Neurochemistry, 118(2), 281-287. [More Information]
  • Quek, G., Lin, D., Halliday, J., Absalom, N., Ambrus, J., Thompson, A., Lochner, M., Lummis, S., McLeod, M., Collins, M. (2010). Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors. ACS Chemical Neuroscience, 1(12), 796-809. [More Information]
  • Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Halliday, J., Collins, M., McLeod, M. (2010). Synthesis and biological evaluation of a new family of constrained azabicyclic homocholine analogues. Australian Journal of Chemistry: an international journal for chemical science, 63(5), 808-812. [More Information]
  • McIntosh, J., Absalom, N., Collins, M., Belen Elgoyhen, A., Vincler, M. (2009). Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochemical Pharmacology, 78(7), 693-702. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Collins, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • MacRaild, C., Illesinghe, J., vanLierop, B., Townsend, A., Collins, M., Livett, B., Robinson, A., Norton, R. (2009). Structure and Activity of (2,8)-Dicarba-(3,12)-cystino alpha-ImI, an alpha-Conotoxin Containing a Nonreducible Cystine Analogue. Journal of Medicinal Chemistry, 52(3), 755-762. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]
  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Hinton, T., Collins, M., Johnston, G. (2008). Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(1), 402-404. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Collins, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]
  • Carland, J., Johnston, G., Collins, M. (2008). Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European Journal of Pharmacology, 580(1), 27-35. [More Information]
  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Small, D., Maksel, D., Kerr, M., Ng, J., Hou, X., Chu, C., Mehrani, H., Unabia, S., Azari, M., Loiacono, R., Collins, M., et al (2007). The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the a7 nicotinic acetylcholine receptor. Journal of Neurochemistry, 101(6), 1527-1538. [More Information]
  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Halliday, J., Collins, M., Turner, P., McLeod, M. (2006). Double-Mannich annulation of cyclic ketones using N,N-bis(ethoxymethyl) alkylamine reagents. Organic Letters, 8(15), 3399-3401. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Collins, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Crittenden, D., Collins, M., Jordan, M. (2005). A quantitative structure-activity relationship investigation into agonist binding at GABA C receptors. Computational and Theoretical Chemistry, 755, 81-89.
  • Barker, D., Lin, D., Carland, J., Chu, C., Collins, M., Brimble, M., Savage, G., McLeod, M. (2005). Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors. Bioorganic and Medicinal Chemistry, 13(14), 4565-4575. [More Information]
  • Crittenden, D., Collins, M., Jordan, M. (2005). Stabilization of zwitterions in solution: GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(18), 4195-4201. [More Information]
  • Crittenden, D., Kumar, R., Hanrahan, J., Collins, M., Jordan, M. (2005). Stabilization of zwitterions in solution: Phosphinic and phosphonic acid GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(37), 8398-8409. [More Information]
  • Carland, J., Moorhouse, A., Barry, P., Johnston, G., Collins, M. (2004). Charged Residues At The 2' Position Of Human GABAc ρ1 Receptors Invert Ion Selectivity And Influence Open State Probability. Journal of Biological Chemistry, 279(52), 54153-54160.
  • Crittenden, D., Thompson, K., Collins, M., Jordan, M. (2004). Efficiency Considerations In The Construction Of Interpolated Potential Energy Surfaces For The Calculation Of Quantum Observables By Diffusion Monte Carlo. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 121(20), 9844-9854.
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Collins, M. (2004). Gabac Receptor Ion Channel. Clinical and Experimental Pharmacology and Physiology, 31, 800-804.
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Small, D., Fodero, L., Losic, D., Chu, C., Aguilar, M., Martin, L., Collins, M. (2004). Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease. International Journal of Peptide Research and Therapeutics, 10(5-6), 401-404. [More Information]
  • Crittenden, D., Collins, M., Jordan, M. (2004). Stabilization of Zwitterions in Solution: γ-Aminobutyric Acid (GABA). The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 108(1), 203-211.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.
  • Campbell, E., Collins, M., Johnston, G. (2004). The Dietary Flavonoids Apigenin And (-)-Epigallocatechin Gallate Enhance The Positive Modulation By Diazepam Of The Activation By GABA Of Recombinant GABA(A) Receptors. Biochemical Pharmacology, 68(8), 1631-1638. [More Information]
  • Krehan, D., Frølund, B., Ebert, B., Nielsen, B., Krogsgaard-Larsen, P., Johnston, G., Collins, M. (2003). Aza-THIP and related analogues of THIP as GABAc antagonists. Bioorganic and Medicinal Chemistry, 11(23), 4891-4896. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Krehan, D., Frølund, B., Krogsgaard-Larsen, P., Kehler, J., Johnston, G., Collins, M. (2003). Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAc receptor antagonists. Neurochemistry International, 42(7), 561-565.
  • Hanrahan, J., Collins, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.
  • Duke, R., Collins, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.
  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.
  • Collins, M. (2001). Novel agents acting on GABAc receptors: potenial cognitive enhancers. Chemistry in Australia, 69, no 9, 19-21.
  • Collins, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192.

Conferences

  • Collins, M. (2004). GABAC receptor ion channels. Annual Scientific Meeting of ASCEPT 2003, Australia: Blackwell Publishers.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.

Patents

  • Collins, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.

2014

  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Collins, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PLoS One, 9(1), 1-16. [More Information]

2013

  • Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Collins, M. (2013). Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. Journal of Biological Chemistry, 288(37), 26521-26532. [More Information]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Collins, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. A C S Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Collins, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]

2012

  • Pan, Y., Gerasimov, M., Kvist, T., Wellendorph, P., Madsen, K., Pera, E., Lee, H., Schousboe, A., Collins, M., Brauner-Osborne, H., et al (2012). (1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction. Journal of Medicinal Chemistry, 55(1), 357-366. [More Information]
  • Absalom, N., Eghorn, L., Villumsen, I., Karim, N., Bay, T., Olsen, J., Knudsen, G., Brauner-Osborne, H., Frølund, B., Clausen, R., Collins, M., et al (2012). (alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(33), 13404-13409. [More Information]
  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Beinat, C., Banister, S., Prehn, S., Doddareddy, M., Hibbs, D., Sako, M., Collins, M., Tran, T., Al-Muhtasib, N., Xiao, Y., Kassiou, M. (2012). Consequences of linker length alteration of the alpha7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(7), 2380-2384. [More Information]
  • Ambrus, J., Halliday, J., Kanizaj, N., Absalom, N., Harpsøe, K., Balle, T., Collins, M., McLeod, M. (2012). Covalent attachment of antagonists to the (alpha)7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chemical Communications, 48(53), 6699-6701. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Cheng, Z., Collins, M., Schmid, K. (2012). Identification of GABA receptors in chick cornea. Molecular Vision, 18, 1107-1114. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Collins, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]
  • Yamamoto, I., Jordan, M., Gavande, N., Doddareddy, M., Collins, M., Hunter, L. (2012). The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA(C) receptor. Chemical Communications, 48(6), 829-831. [More Information]

2011

  • Xie, A., Yan, J., Yue, L., Feng, F., Mir, F., Abdel-Halim, H., Collins, M., Le Breton, G., Standaert, R., Qian, H., et al (2011). 2-Aminoethyl Methylphosphonate, a Potent and Rapidly Acting Antagonist of GABAA-p1 Receptors. Molecular Pharmacology, 80(6), 965-978. [More Information]
  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Yamamoto, I., Deniau, G., Gavande, N., Collins, M., Johnston, G., O'Hagan, D. (2011). Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Communications, 47(28), 7956-7958. [More Information]
  • Wong, S., Collins, M., Haqshenas, G., Loveland, B., Gowans, E. (2011). Dengue virus PrM/M proteins fail to show pH-dependent ion channel activity in Xenopus oocytes. Virology, 412(1), 83-90. [More Information]
  • Hanrahan, J., Collins, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Loscalzo, L., Yow, T., Wasowski, C., Collins, M., Marder, M. (2011). Hesperidin induces antinociceptive effect in mice and its aglicone, hesperetin, binds to {mu}-opioid receptor and inhibits GIRK1/2 currents. Pharmacology, Biochemistry and Behavior, 99(3), 333-341. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2(1), 11-16. [More Information]
  • Cheng, Z., Collins, M., Schmidt, K. (2011). rho(1) GABA(C) receptors are expressed in fibrous and cartilaginous layers of chick sclera and located on sclera fibroblasts and chondrocytes. Journal of Neurochemistry, 118(2), 281-287. [More Information]

2010

  • Quek, G., Lin, D., Halliday, J., Absalom, N., Ambrus, J., Thompson, A., Lochner, M., Lummis, S., McLeod, M., Collins, M. (2010). Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors. ACS Chemical Neuroscience, 1(12), 796-809. [More Information]
  • Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Halliday, J., Collins, M., McLeod, M. (2010). Synthesis and biological evaluation of a new family of constrained azabicyclic homocholine analogues. Australian Journal of Chemistry: an international journal for chemical science, 63(5), 808-812. [More Information]

2009

  • McIntosh, J., Absalom, N., Collins, M., Belen Elgoyhen, A., Vincler, M. (2009). Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochemical Pharmacology, 78(7), 693-702. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Collins, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • MacRaild, C., Illesinghe, J., vanLierop, B., Townsend, A., Collins, M., Livett, B., Robinson, A., Norton, R. (2009). Structure and Activity of (2,8)-Dicarba-(3,12)-cystino alpha-ImI, an alpha-Conotoxin Containing a Nonreducible Cystine Analogue. Journal of Medicinal Chemistry, 52(3), 755-762. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]

2008

  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Hinton, T., Collins, M., Johnston, G. (2008). Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(1), 402-404. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Collins, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]
  • Carland, J., Johnston, G., Collins, M. (2008). Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European Journal of Pharmacology, 580(1), 27-35. [More Information]

2007

  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Small, D., Maksel, D., Kerr, M., Ng, J., Hou, X., Chu, C., Mehrani, H., Unabia, S., Azari, M., Loiacono, R., Collins, M., et al (2007). The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the a7 nicotinic acetylcholine receptor. Journal of Neurochemistry, 101(6), 1527-1538. [More Information]

2006

  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Halliday, J., Collins, M., Turner, P., McLeod, M. (2006). Double-Mannich annulation of cyclic ketones using N,N-bis(ethoxymethyl) alkylamine reagents. Organic Letters, 8(15), 3399-3401. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Collins, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.

2005

  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Crittenden, D., Collins, M., Jordan, M. (2005). A quantitative structure-activity relationship investigation into agonist binding at GABA C receptors. Computational and Theoretical Chemistry, 755, 81-89.
  • Barker, D., Lin, D., Carland, J., Chu, C., Collins, M., Brimble, M., Savage, G., McLeod, M. (2005). Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors. Bioorganic and Medicinal Chemistry, 13(14), 4565-4575. [More Information]
  • Collins, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.
  • Crittenden, D., Collins, M., Jordan, M. (2005). Stabilization of zwitterions in solution: GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(18), 4195-4201. [More Information]
  • Crittenden, D., Kumar, R., Hanrahan, J., Collins, M., Jordan, M. (2005). Stabilization of zwitterions in solution: Phosphinic and phosphonic acid GABA analogues. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 109(37), 8398-8409. [More Information]

2004

  • Carland, J., Moorhouse, A., Barry, P., Johnston, G., Collins, M. (2004). Charged Residues At The 2' Position Of Human GABAc ρ1 Receptors Invert Ion Selectivity And Influence Open State Probability. Journal of Biological Chemistry, 279(52), 54153-54160.
  • Crittenden, D., Thompson, K., Collins, M., Jordan, M. (2004). Efficiency Considerations In The Construction Of Interpolated Potential Energy Surfaces For The Calculation Of Quantum Observables By Diffusion Monte Carlo. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 121(20), 9844-9854.
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Collins, M. (2004). Gabac Receptor Ion Channel. Clinical and Experimental Pharmacology and Physiology, 31, 800-804.
  • Collins, M. (2004). GABAC receptor ion channels. Annual Scientific Meeting of ASCEPT 2003, Australia: Blackwell Publishers.
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Small, D., Fodero, L., Losic, D., Chu, C., Aguilar, M., Martin, L., Collins, M. (2004). Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease. International Journal of Peptide Research and Therapeutics, 10(5-6), 401-404. [More Information]
  • Crittenden, D., Collins, M., Jordan, M. (2004). Stabilization of Zwitterions in Solution: γ-Aminobutyric Acid (GABA). The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 108(1), 203-211.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.
  • Campbell, E., Collins, M., Johnston, G. (2004). The Dietary Flavonoids Apigenin And (-)-Epigallocatechin Gallate Enhance The Positive Modulation By Diazepam Of The Activation By GABA Of Recombinant GABA(A) Receptors. Biochemical Pharmacology, 68(8), 1631-1638. [More Information]

2003

  • Krehan, D., Frølund, B., Ebert, B., Nielsen, B., Krogsgaard-Larsen, P., Johnston, G., Collins, M. (2003). Aza-THIP and related analogues of THIP as GABAc antagonists. Bioorganic and Medicinal Chemistry, 11(23), 4891-4896. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Krehan, D., Frølund, B., Krogsgaard-Larsen, P., Kehler, J., Johnston, G., Collins, M. (2003). Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAc receptor antagonists. Neurochemistry International, 42(7), 561-565.
  • Hanrahan, J., Collins, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.

2002

  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Duke, R., Collins, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.

2001

  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.
  • Collins, M. (2001). Novel agents acting on GABAc receptors: potenial cognitive enhancers. Chemistry in Australia, 69, no 9, 19-21.
  • Collins, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192.

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