Dr Nathan Absalom

ARC Research Associate

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 6066

Biographical details

ARC Research Associate

Selected grants

2014

  • γ-Hydroxybutyric acid (GHB) and α4-containing GABA-A receptors; Collins M, McGregor I, Hunt G, Absalom N; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Sydney Neuroscience Network; Balleine B, Absalom N, Braddon-Mitchell D, Callaghan S, Chawla S, Christie M, Collins M, Einfeld S, Grieve S, Haber P, Hanrahan J, Harris A, Hickie I, Kassiou M, Kril J, Meikle S, Morris R, Ramos F, Rong Y, Sue C; DVC Research/Research Network Scheme (SyReNS).

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Indurthi Venkata, D., Pera, E., Kim, H., Chu, C., McLeod, M., McIntosh, J., Absalom, N., Chebib, M. (2014). Presence of multiple binding sites on Alpha9Alpha10 nAChR receptors alludes to stoichiometric-dependent action of the Alpha - conotoxin, Vc1.1. Biochemical Pharmacology, 89(1), 131-140. [More Information]
  • Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Collins, M. (2013). Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. Journal of Biological Chemistry, 288(37), 26521-26532. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Absalom, N., Eghorn, L., Villumsen, I., Karim, N., Bay, T., Olsen, J., Knudsen, G., Brauner-Osborne, H., Frølund, B., Clausen, R., Collins, M., et al (2012). (alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(33), 13404-13409. [More Information]
  • Ambrus, J., Halliday, J., Kanizaj, N., Absalom, N., Harpsøe, K., Balle, T., Collins, M., McLeod, M. (2012). Covalent attachment of antagonists to the (alpha)7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chemical Communications, 48(53), 6699-6701. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Quek, G., Lin, D., Halliday, J., Absalom, N., Ambrus, J., Thompson, A., Lochner, M., Lummis, S., McLeod, M., Collins, M. (2010). Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors. ACS Chemical Neuroscience, 1(12), 796-809. [More Information]
  • McIntosh, J., Absalom, N., Collins, M., Belen Elgoyhen, A., Vincler, M. (2009). Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochemical Pharmacology, 78(7), 693-702. [More Information]
  • Cobbold, J., Anstee, Q., Goldin, R., Williams, H., Matthews, H., North, B., Absalom, N., Thomas, H., Thursz, M., Cox, R., et al (2009). Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. Clinical Science, 116(5), 403-413.
  • Girard, C., Shimomura, K., Proks, P., Absalom, N., Castano, L., de Nanclares, G., Ashcroft, F. (2006). Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes. Pfluegers Archiv: European journal of physiology, 453(3), 323-332. [More Information]
  • Absalom, N., Lewis, T., Schofield, P. (2004). Mechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure. Experimental Physiology, 89(2), 145-153.
  • Absalom, N., Lewis, T., Kaplan, W., Pierce, K., Schofield, P. (2003). Role of Charged Residues in Coupling Ligand Binding and Channel Activation in the Extracellular Domain of the Glycine Receptor. Journal of Biological Chemistry, 278(50), 50151-50157.

2014

  • Indurthi Venkata, D., Pera, E., Kim, H., Chu, C., McLeod, M., McIntosh, J., Absalom, N., Chebib, M. (2014). Presence of multiple binding sites on Alpha9Alpha10 nAChR receptors alludes to stoichiometric-dependent action of the Alpha - conotoxin, Vc1.1. Biochemical Pharmacology, 89(1), 131-140. [More Information]

2013

  • Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Collins, M. (2013). Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. Journal of Biological Chemistry, 288(37), 26521-26532. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]

2012

  • Absalom, N., Eghorn, L., Villumsen, I., Karim, N., Bay, T., Olsen, J., Knudsen, G., Brauner-Osborne, H., Frølund, B., Clausen, R., Collins, M., et al (2012). (alpha)4(beta)(delta) GABAA receptors are high-affinity targets for gamma-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(33), 13404-13409. [More Information]
  • Ambrus, J., Halliday, J., Kanizaj, N., Absalom, N., Harpsøe, K., Balle, T., Collins, M., McLeod, M. (2012). Covalent attachment of antagonists to the (alpha)7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chemical Communications, 48(53), 6699-6701. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]

2011

  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]

2010

  • Quek, G., Lin, D., Halliday, J., Absalom, N., Ambrus, J., Thompson, A., Lochner, M., Lummis, S., McLeod, M., Collins, M. (2010). Identifying the Binding Site of Novel Methyllycaconitine (MLA) Analogs at α4β2 Nicotinic Acetylcholine Receptors. ACS Chemical Neuroscience, 1(12), 796-809. [More Information]

2009

  • McIntosh, J., Absalom, N., Collins, M., Belen Elgoyhen, A., Vincler, M. (2009). Alpha9 nicotinic acetylcholine receptors and the treatment of pain. Biochemical Pharmacology, 78(7), 693-702. [More Information]
  • Cobbold, J., Anstee, Q., Goldin, R., Williams, H., Matthews, H., North, B., Absalom, N., Thomas, H., Thursz, M., Cox, R., et al (2009). Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. Clinical Science, 116(5), 403-413.

2006

  • Girard, C., Shimomura, K., Proks, P., Absalom, N., Castano, L., de Nanclares, G., Ashcroft, F. (2006). Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes. Pfluegers Archiv: European journal of physiology, 453(3), 323-332. [More Information]

2004

  • Absalom, N., Lewis, T., Schofield, P. (2004). Mechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure. Experimental Physiology, 89(2), 145-153.

2003

  • Absalom, N., Lewis, T., Kaplan, W., Pierce, K., Schofield, P. (2003). Role of Charged Residues in Coupling Ligand Binding and Channel Activation in the Extracellular Domain of the Glycine Receptor. Journal of Biological Chemistry, 278(50), 50151-50157.

For support on your academic profile contact .