Dr Nial Wheate

BSc(Hons) PhD UNSW
Senior Lecturer, Pharmaceutical Chemistry

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9036 7647
Fax +61 2 9351 4391

Biographical details

Dr Wheate completed a Bachelor of Science degree with 1st class honours from the University of New South Wales whilst at the Australian Defence Force Academy. He then completed a PhD in medicinal chemistry under Prof. J. Grant Collins. Since then he has worked in the School of Biomedical and Health Sciences at the University of Western Sydney (Australia) and the Strathclyde Institute of Pharmacy and Biomedical Science (Scotland) before taking up a position in the Faculty of Pharmacy at the University of Sydney (Australia) in January 2012.

Research interests

Whole of pipeline discovery and development of platinum-based anticancer drugs including: design and synthesis, in vitro and in vivo screening, drug-DNA binding, nanoparticle based delivery, solid state chemistry and co-crystals, toxicology and pharmacokinetics, and dosage formulation.

The drug delivery application of cucurbit[n]urils and their host-guest complexes.

Keywords

Cancer; Drug delivery; Drug design; Pharmaceutics

PhD and master's project opportunities

Selected grants

2013

  • Thermogravimetric Analyser (TGA); Kepert C, D'Alessandro D, Perrier S, Hawkett B, Hibbs D, Wheate N, Harris A, Minett A, Ling C, Kennedy B; DVC Research/Equipment Grant.

Selected publications

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Book Chapters

  • Oun, R., Wheate, N. (2013). Platinum Anticancer Drugs. In Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov (Eds.), Encyclopedia of Metalloproteins, (pp. 1710-1714). United States: Springer Science+Business Media.
  • Hicks, M., Orkey, N., Pisani, M., Collins, J., Wheate, N., Aldrich-Wright, J. (2012). Using Spectroscopic Techniques to Examine Drug-DNA Interactions. In Meni Wanunu and Yitzhak Tor (Eds.), Methods for Studying Nucleic Acid/Drug Interactions, (pp. 3-42). United States: CRC Press.

Journals

  • Oun, R., Plumb, J., Wheate, N. (2014). A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol. Journal of Inorganic Biochemistry, 134C, 100-105. [More Information]
  • Apps, M., Johnson, B., Sutcliffe, O., Brown, S., Wheate, N. (2014). Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents. Journal of Visualized Experiments, 87(87), 1-7. [More Information]
  • Rhodes, S., Booth, J., Campbell, L., Blythe, R., Wheate, N., Delibegovic, M. (2014). Evidence for a Role of Executive Functions in Learning Biology. Infant and Child Development (Online), 23(1), 67-83. [More Information]
  • Seif, M., Impelido, M., Apps, M., Wheate, N. (2014). Topical Cream-Based Dosage Forms of the Macrocyclic Drug Delivery Vehicle Cucurbit[6]uril. PLoS One, 9(1), e85361. [More Information]
  • McGinely, N., Plumb, J., Wheate, N. (2013). DNA-based aptamer fails as a simultaneous cancer targeting agent and drug delivery vehicle for a phenanthroline-based platinum(II) complex. Journal of Inorganic Biochemistry, 128, 124-130. [More Information]
  • Wagstaff, A., Brown, S., Holden, M., Craig, G., Plumb, J., Brown, R., Schreiter, N., Chrzanowski, W., Wheate, N. (2012). Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields. Inorganica Chimica Acta, 393, 328-333. [More Information]
  • Craig, G., Brown, S., Lamprou, D., Graham, D., Wheate, N. (2012). Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval? Inorganic Chemistry, 51(6), 3490-3497. [More Information]
  • Brown, S., Trotter, K., Sutcliffe, O., Plumb, J., Waddell, B., Briggs, N., Wheate, N. (2012). Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 41(37), 11330-11339. [More Information]
  • Plumb, J., Venugopal, B., Oun, R., Gomez-Roman, N., Kawazoe, Y., Venkataramanan, N., Wheate, N. (2012). Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect. Metallomics, 4(6), 561-567. [More Information]
  • Brown, S., Plumb, J., Johnston, B., Wheate, N. (2012). Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene. Inorganica Chimica Acta, 393, 182-186. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Wheate, N. (2012). Nanoparticles: the future for platinum drugs or a research red herring? Nanomedicine, 7(9), 1285-1287. [More Information]
  • Alniss, H., Anthony, N., Khalaf, A., Mackay, S., Suckling, C., Waigh, R., Wheate, N., Parkinson, J. (2012). Rationalising sequence selection by ligand assemblies in the DNA minor groove; The case for thiazotropsin A. Chemical Science, 3, 711-722. [More Information]
  • Walker, S., Oun, R., McInnes, F., Wheate, N. (2012). The Potential of Cucurbit[n]urils in Drug Delivery. Israel Journal Of Chemistry, 51(5-6), 616-624. [More Information]
  • Wheate, N., Collins, J. (2011). Multi-nuclear platinum drugs: a new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]
  • Brown, S., Nativo, P., Smith, J., Stirling, D., Edwards, P., Venugopal, B., Flint, D., Plumb, J., Graham, D., Wheate, N. (2010). Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. Journal of the American Chemical Society, 132(13), 4678-4684. [More Information]
  • Wheate, N., Vora, V., Anthony, N., McInnes, F. (2010). Host-guest complexes of the antituberculosis drugs pyrazinamide and isoniazid with cucurbit[7]uril. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 68, 359-367. [More Information]
  • Wheate, N., Patel, N., Sutcliffe, O. (2010). Microwave synthesis of cucurbit[n]urils. Future Medicinal Chemistry, 2(2), 231-236. [More Information]
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2010). Synthesis, Processing and Solid State Excipient Interactions of Cucurbit[6]uril and Its Formulation into Tablets for Oral Drug Delivery. Molecular Pharmaceutics, 7(6), 2166-2172. [More Information]
  • Wheate, N., Walker, S., Craig, G., Oun, R. (2010). The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(35), 8113-8127. [More Information]
  • Kennedy, A., Florence, A., McInnes, F., Wheate, N. (2009). A chemical preformulation study of a host–guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (37), 7695-7700. [More Information]
  • Pisani, M., Wheate, N., Keene, F., Aldrich-Wright, J., Collins, J. (2009). Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs. Journal of Inorganic Biochemistry, 103(3), 373-380. [More Information]
  • Grant, M., Wheate, N., Aldrich-Wright, J. (2009). Diffusion coefficient of cucurbit[n]urils (n = 6 or 7) at various concentrations, temperatures, and pH. Journal of Chemical and Engineering Data, 54(2), 323-326. [More Information]
  • Krause-Heuer, A., Wheate, N., Price, W., Aldrich-Wright, J. (2009). Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators. Chemical Communications, 2009 (10), 1210-1212. [More Information]
  • Wheate, N., Abbott, G., Tate, R., Celements, C., Edrada-Ebel, R., Johnston, B. (2009). Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2μ-dpzm]2+ and its implications for anticancer drug delivery. Journal of Inorganic Biochemistry, 103(3), 448-454. [More Information]
  • Krause-Heuer, A., Grunert, R., Kuhne, S., Buczkowska, M., Wheate, N., le Pevelen, D., Boag, L., Fisher, D., Kasparkova, J., Malina, J., et al (2009). Studies of the Mechanism of Action of Platinum(II) Complexes with Potent Cytotoxicity in Human Cancer Cells. Journal of Medicinal Chemistry, 52(17), 5474-5484. [More Information]
  • Krause-Heuer, A., Wheate, N., Tilby, M., Pearson, D., Ottley, C., Aldrich-Wright, J. (2008). Substituted -Cyclodextrin and Calix[4]arene As Encapsulatory Vehicles for Platinum(II)-Based DNA Intercalators. Inorganic Chemistry, 47, 6880-6888.
  • Wheate, N., Brodie, C., Collins, J., Kemp, S., Aldrich-Wright, J. (2007). DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis. Mini - Reviews in Medicinal Chemistry, 7(6), 627-648. [More Information]
  • Kemp, S., Wheate, N., Collins, J., Ralph, S., Day, A., Higgins, V., Aldrich-Wright, J., Wang, S. (2007). Encapsulation of platinum(II)-based DNA intercalators within cucurbit[6,7,8]urils. Journal of Biological Inorganic Chemistry, 12(7), 969-979. [More Information]
  • Wheate, N., Taleb, R., Krause-Heuer, A., Cook, R., Wang, S., Higgins, V., Aldrich-Wright, J. (2007). Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2007 (43), 5055-5064. [More Information]
  • Yousouf, S., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester. Polyhedron, 26, 318-328. [More Information]
  • Taleb, R., Jaramillo, D., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes. Chemistry: A European Journal, 13, 3177-3186. [More Information]
  • Kemp, S., Wheate, N., Buck, D., Nikac, M., Collins, J., Aldrich-Wright, J. (2007). The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators. Journal of Inorganic Biochemistry, 101(7), 1049-1058. [More Information]
  • Kemp, S., Wheate, N., Stootman, F., Aldrich-Wright, J. (2007). The host-guest chemistry of proflavine with cucurbit[6,7,8]urils. Supramolecular Chemistry, 19(7), 475-484. [More Information]
  • Brodie, C., Turner, P., Wheate, N., Riches, J. (2006). (4,7-Dimethyl-1,10-phenanthroline (ethylenediamine) platinum(II) dichloride tris(deuterium oxide) solvate. Acta Crystallographica. Section E: Structure Reports Online, E62, m3137-m3139.
  • Wheate, N., Buck, D., Day, A., Collins, J. (2006). Cucurbit[n]uril binding of platinum anticancer complexes. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (3), 451-458. [More Information]
  • Wheate, N. (2006). Cucurbit[n]uril: A New Molecule in Host–Guest Chemistry. Australian Journal of Chemistry: an international journal for chemical science, 59(5), 354-354. [More Information]
  • Jaramillo, D., Wheate, N., Ralph, S., Howard, W., Tor, Y., Aldrich-Wright, J. (2006). Polyamide platinum anticancer complexes designed to target specific DNA sequences. Inorganic Chemistry, 46(15), 6004-6013. [More Information]
  • Fenton, R., Jaramillo, D., Buck, D., Collins, J., Stootman, F., Wheate, N., Riches, J. (2006). Synthesis, characterisation and biological activity of chiral platinum(II) complexes. European Journal of Inorganic Chemistry, (4), 839-849. [More Information]
  • Wheate, N., Collins, J. (2005). Multi-nuclear Platinum drugs: A new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]
  • Wheate, N. (2005). Platinum-based chemotherapy: are we any closer to cure for cancer? Chemistry in Australia, 72(7), 11-14.

Conferences

  • Oun, R., Plumb, J., Rowan, E., Wheate, N. (2013). Encapsulation of cisplatin by cucurbit[7]uril decreases the neurotoxic and cardiotoxic side effects of cisplatin. 49th Congress of EUROTOX, Switzerland: Elsevier Ireland Ltd.
  • Plumb, J., Gomez-Roman, N., Venugopal, B., Wheate, N. (2009). Drug delivery as a means of enhancing the activity of platinum compounds. 100th Annual Meeting of the American Association for Cancer Research, USA: N/A.
  • Kirkpatrick, G., Sutcliffe, O., Flint, D., Wheate, N. (2009). PAMAM dendrimers as delivery vehicles for platinum anticancer drugs. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Wright, E., Aldrich-Wright, J., Wheate, N., Dawes, I., Higgins, V. (2007). Molecular mechanisms involved in the Saccharomyces cerevisiae response to the novel anticancer platinum compound 56MESS. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.
  • Aldrich-Wright, J., Wheate, N., Taleb, R. (2007). Novel Platinum(II)- based anticancer drugs: metallointercalators and DNA sequence specific agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.
  • van Holst, M., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Platinum metallointercalators in solid phase synthesis. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.
  • Krause-Heuer, A., Wheate, N., Aldrich-Wright, J. (2007). Use of molecular hosts in the drug delivery of platinum(II)-based DNA intercalating agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.

Patents

  • Brown, S., Craig, G., Graham, D., Wheate, N. (2010). University of Strathclyde. Patent No. WO 2010/139942. United Kingdom.
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2009). UK Intellectual Property Office. United Kingdom.
  • Wheate, N., Day, A., Blanch, R., Collins, J. (2005). Newsouth Innovations Pty Ltd. Patent No. WO 2005/068469.

2014

  • Oun, R., Plumb, J., Wheate, N. (2014). A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol. Journal of Inorganic Biochemistry, 134C, 100-105. [More Information]
  • Apps, M., Johnson, B., Sutcliffe, O., Brown, S., Wheate, N. (2014). Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents. Journal of Visualized Experiments, 87(87), 1-7. [More Information]
  • Rhodes, S., Booth, J., Campbell, L., Blythe, R., Wheate, N., Delibegovic, M. (2014). Evidence for a Role of Executive Functions in Learning Biology. Infant and Child Development (Online), 23(1), 67-83. [More Information]
  • Seif, M., Impelido, M., Apps, M., Wheate, N. (2014). Topical Cream-Based Dosage Forms of the Macrocyclic Drug Delivery Vehicle Cucurbit[6]uril. PLoS One, 9(1), e85361. [More Information]

2013

  • McGinely, N., Plumb, J., Wheate, N. (2013). DNA-based aptamer fails as a simultaneous cancer targeting agent and drug delivery vehicle for a phenanthroline-based platinum(II) complex. Journal of Inorganic Biochemistry, 128, 124-130. [More Information]
  • Oun, R., Plumb, J., Rowan, E., Wheate, N. (2013). Encapsulation of cisplatin by cucurbit[7]uril decreases the neurotoxic and cardiotoxic side effects of cisplatin. 49th Congress of EUROTOX, Switzerland: Elsevier Ireland Ltd.
  • Oun, R., Wheate, N. (2013). Platinum Anticancer Drugs. In Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov (Eds.), Encyclopedia of Metalloproteins, (pp. 1710-1714). United States: Springer Science+Business Media.

2012

  • Wagstaff, A., Brown, S., Holden, M., Craig, G., Plumb, J., Brown, R., Schreiter, N., Chrzanowski, W., Wheate, N. (2012). Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields. Inorganica Chimica Acta, 393, 328-333. [More Information]
  • Craig, G., Brown, S., Lamprou, D., Graham, D., Wheate, N. (2012). Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval? Inorganic Chemistry, 51(6), 3490-3497. [More Information]
  • Brown, S., Trotter, K., Sutcliffe, O., Plumb, J., Waddell, B., Briggs, N., Wheate, N. (2012). Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 41(37), 11330-11339. [More Information]
  • Plumb, J., Venugopal, B., Oun, R., Gomez-Roman, N., Kawazoe, Y., Venkataramanan, N., Wheate, N. (2012). Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect. Metallomics, 4(6), 561-567. [More Information]
  • Brown, S., Plumb, J., Johnston, B., Wheate, N. (2012). Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene. Inorganica Chimica Acta, 393, 182-186. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Wheate, N. (2012). Nanoparticles: the future for platinum drugs or a research red herring? Nanomedicine, 7(9), 1285-1287. [More Information]
  • Alniss, H., Anthony, N., Khalaf, A., Mackay, S., Suckling, C., Waigh, R., Wheate, N., Parkinson, J. (2012). Rationalising sequence selection by ligand assemblies in the DNA minor groove; The case for thiazotropsin A. Chemical Science, 3, 711-722. [More Information]
  • Walker, S., Oun, R., McInnes, F., Wheate, N. (2012). The Potential of Cucurbit[n]urils in Drug Delivery. Israel Journal Of Chemistry, 51(5-6), 616-624. [More Information]
  • Hicks, M., Orkey, N., Pisani, M., Collins, J., Wheate, N., Aldrich-Wright, J. (2012). Using Spectroscopic Techniques to Examine Drug-DNA Interactions. In Meni Wanunu and Yitzhak Tor (Eds.), Methods for Studying Nucleic Acid/Drug Interactions, (pp. 3-42). United States: CRC Press.

2011

  • Wheate, N., Collins, J. (2011). Multi-nuclear platinum drugs: a new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]

2010

  • Brown, S., Nativo, P., Smith, J., Stirling, D., Edwards, P., Venugopal, B., Flint, D., Plumb, J., Graham, D., Wheate, N. (2010). Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. Journal of the American Chemical Society, 132(13), 4678-4684. [More Information]
  • Wheate, N., Vora, V., Anthony, N., McInnes, F. (2010). Host-guest complexes of the antituberculosis drugs pyrazinamide and isoniazid with cucurbit[7]uril. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 68, 359-367. [More Information]
  • Wheate, N., Patel, N., Sutcliffe, O. (2010). Microwave synthesis of cucurbit[n]urils. Future Medicinal Chemistry, 2(2), 231-236. [More Information]
  • Brown, S., Craig, G., Graham, D., Wheate, N. (2010). University of Strathclyde. Patent No. WO 2010/139942. United Kingdom.
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2010). Synthesis, Processing and Solid State Excipient Interactions of Cucurbit[6]uril and Its Formulation into Tablets for Oral Drug Delivery. Molecular Pharmaceutics, 7(6), 2166-2172. [More Information]
  • Wheate, N., Walker, S., Craig, G., Oun, R. (2010). The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(35), 8113-8127. [More Information]

2009

  • Kennedy, A., Florence, A., McInnes, F., Wheate, N. (2009). A chemical preformulation study of a host–guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (37), 7695-7700. [More Information]
  • Pisani, M., Wheate, N., Keene, F., Aldrich-Wright, J., Collins, J. (2009). Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs. Journal of Inorganic Biochemistry, 103(3), 373-380. [More Information]
  • Grant, M., Wheate, N., Aldrich-Wright, J. (2009). Diffusion coefficient of cucurbit[n]urils (n = 6 or 7) at various concentrations, temperatures, and pH. Journal of Chemical and Engineering Data, 54(2), 323-326. [More Information]
  • Krause-Heuer, A., Wheate, N., Price, W., Aldrich-Wright, J. (2009). Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators. Chemical Communications, 2009 (10), 1210-1212. [More Information]
  • Plumb, J., Gomez-Roman, N., Venugopal, B., Wheate, N. (2009). Drug delivery as a means of enhancing the activity of platinum compounds. 100th Annual Meeting of the American Association for Cancer Research, USA: N/A.
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2009). UK Intellectual Property Office. United Kingdom.
  • Kirkpatrick, G., Sutcliffe, O., Flint, D., Wheate, N. (2009). PAMAM dendrimers as delivery vehicles for platinum anticancer drugs. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Wheate, N., Abbott, G., Tate, R., Celements, C., Edrada-Ebel, R., Johnston, B. (2009). Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2μ-dpzm]2+ and its implications for anticancer drug delivery. Journal of Inorganic Biochemistry, 103(3), 448-454. [More Information]
  • Krause-Heuer, A., Grunert, R., Kuhne, S., Buczkowska, M., Wheate, N., le Pevelen, D., Boag, L., Fisher, D., Kasparkova, J., Malina, J., et al (2009). Studies of the Mechanism of Action of Platinum(II) Complexes with Potent Cytotoxicity in Human Cancer Cells. Journal of Medicinal Chemistry, 52(17), 5474-5484. [More Information]

2008

  • Krause-Heuer, A., Wheate, N., Tilby, M., Pearson, D., Ottley, C., Aldrich-Wright, J. (2008). Substituted -Cyclodextrin and Calix[4]arene As Encapsulatory Vehicles for Platinum(II)-Based DNA Intercalators. Inorganic Chemistry, 47, 6880-6888.

2007

  • Wheate, N., Brodie, C., Collins, J., Kemp, S., Aldrich-Wright, J. (2007). DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis. Mini - Reviews in Medicinal Chemistry, 7(6), 627-648. [More Information]
  • Kemp, S., Wheate, N., Collins, J., Ralph, S., Day, A., Higgins, V., Aldrich-Wright, J., Wang, S. (2007). Encapsulation of platinum(II)-based DNA intercalators within cucurbit[6,7,8]urils. Journal of Biological Inorganic Chemistry, 12(7), 969-979. [More Information]
  • Wright, E., Aldrich-Wright, J., Wheate, N., Dawes, I., Higgins, V. (2007). Molecular mechanisms involved in the Saccharomyces cerevisiae response to the novel anticancer platinum compound 56MESS. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.
  • Aldrich-Wright, J., Wheate, N., Taleb, R. (2007). Novel Platinum(II)- based anticancer drugs: metallointercalators and DNA sequence specific agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.
  • Wheate, N., Taleb, R., Krause-Heuer, A., Cook, R., Wang, S., Higgins, V., Aldrich-Wright, J. (2007). Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2007 (43), 5055-5064. [More Information]
  • van Holst, M., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Platinum metallointercalators in solid phase synthesis. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.
  • Yousouf, S., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester. Polyhedron, 26, 318-328. [More Information]
  • Taleb, R., Jaramillo, D., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes. Chemistry: A European Journal, 13, 3177-3186. [More Information]
  • Kemp, S., Wheate, N., Buck, D., Nikac, M., Collins, J., Aldrich-Wright, J. (2007). The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators. Journal of Inorganic Biochemistry, 101(7), 1049-1058. [More Information]
  • Kemp, S., Wheate, N., Stootman, F., Aldrich-Wright, J. (2007). The host-guest chemistry of proflavine with cucurbit[6,7,8]urils. Supramolecular Chemistry, 19(7), 475-484. [More Information]
  • Krause-Heuer, A., Wheate, N., Aldrich-Wright, J. (2007). Use of molecular hosts in the drug delivery of platinum(II)-based DNA intercalating agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science + Business Media.

2006

  • Brodie, C., Turner, P., Wheate, N., Riches, J. (2006). (4,7-Dimethyl-1,10-phenanthroline (ethylenediamine) platinum(II) dichloride tris(deuterium oxide) solvate. Acta Crystallographica. Section E: Structure Reports Online, E62, m3137-m3139.
  • Wheate, N., Buck, D., Day, A., Collins, J. (2006). Cucurbit[n]uril binding of platinum anticancer complexes. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (3), 451-458. [More Information]
  • Wheate, N. (2006). Cucurbit[n]uril: A New Molecule in Host–Guest Chemistry. Australian Journal of Chemistry: an international journal for chemical science, 59(5), 354-354. [More Information]
  • Jaramillo, D., Wheate, N., Ralph, S., Howard, W., Tor, Y., Aldrich-Wright, J. (2006). Polyamide platinum anticancer complexes designed to target specific DNA sequences. Inorganic Chemistry, 46(15), 6004-6013. [More Information]
  • Fenton, R., Jaramillo, D., Buck, D., Collins, J., Stootman, F., Wheate, N., Riches, J. (2006). Synthesis, characterisation and biological activity of chiral platinum(II) complexes. European Journal of Inorganic Chemistry, (4), 839-849. [More Information]

2005

  • Wheate, N., Day, A., Blanch, R., Collins, J. (2005). Newsouth Innovations Pty Ltd. Patent No. WO 2005/068469.
  • Wheate, N., Collins, J. (2005). Multi-nuclear Platinum drugs: A new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]
  • Wheate, N. (2005). Platinum-based chemotherapy: are we any closer to cure for cancer? Chemistry in Australia, 72(7), 11-14.

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