Dr Nial Wheate

PhD FRACI CChem FHEA
Senior Lecturer, Pharmaceutical Chemistry

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9036 7647
Fax +61 2 9351 4391

Biographical details

Dr Wheate completed a Bachelor of Science degree from the University of New South Wales while at the Australian Defence Force Academy. He then completed a PhD under Prof. J. Grant Collins. Since then he has worked in the School of Biomedical and Health Sciences (now the School of Science and Health) at the University of Western Sydney (Australia) and the Strathclyde Institute of Pharmacy and Biomedical Science,at the University of Strathclyde in Scotland, before he took up his current position in the Faculty of Pharmacy at the University of Sydney (Australia). Recently, he was the head of cancer research within the Faculty.

Research interests

Dr Wheate's research interests are primarily into pharmaceutically related fields: platinum-based cancer drugs, and drug delivery and formulation.

Platinum drugs for the treatment of cancer

Cisplatin was the first platinum drug approved for human use, and since its discovery, platinum-based drugs are listed in more than 50% of all chemotherapy regimens. In his work, Dr Wheate examines the DNA binding of platinum drugs, as well the design and synthesis of new drugs. Recently, he has been exploring new drug designs that incorporate the structural features of picoplatin and triplatininto a single drug.

Drug delivery for cancer

Many cancer drugs can be improved by better targeting them to solid cancers. To this effect, Dr Wheate has examined a range of delivery scaffolds for platinum drugs including: dendrimers, gold and iron oxide nanoparticles, aptamers and macrocycles, including cyclodextrins and calixarenes.

Cucurbiturils

One particular drug delivery scaffold of interest to Dr Wheate is the family of macrocycles called cucurbiturils. Dr Wheate was the first to show their application as delivery vehicles and has since shown how they can be used to improve drug solubility, drug stability in the solid and solution states, overcome drug resistance, their safety and their use in biodiagnostics. He is also the leading expert in the pharmaceutical formulation of cucurbiturils having designed oral tablet, eye and topical cream dosage forms.

ORCID ID

0000-0002-0505-1363

ESI highly cited papers

The status of platinum anticancer drugs in the clinic and in clinical trials, 324 cites since 2010

Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin, 221 cites since 2010

Total Citations(Web of Science)

2103

h-index(Web of Science)

24

Teaching and supervision

1st year BPharm coordinator

Coordintor: PHAR1822 - Physical Pharmaceutics and Formulation A

Coordinator: PHAR3826 - Musculoskeletal, Dermatological and Senses

2015 Summer Scholarship Project

Associations

Awards and honours

Australian Defence Medal (awarded 2007)

In the media

Dr Wheate appears regularly in the print media, on the radio and television. He is also a regular journalist and a member of the community council for the online news analysis websiteThe Conversation. Some selected media appearances and articles are given below:

Television

Patients call for medical marijuana legalisation to be brought forward, The 7.30 report, May 2015

Pharmacy services in the bush, The 7.30 report NT edition, June 2013

Radio

Powdered alcohol, what's the fuss?, The Daily, Radio 2SER, March 2015

Powdered alcohol a dangerous solution to inconvience, Panacea program, Radio 2SER, May 2014

Print and online media

How marriage helps cancer patients, The New Zealand Herald, May 2015

Happy 50th anniversary to cisplatin, the drugs that changed cancer treatment, The Conversation, March 2015

Listen up guys, you should get the HPV vaccine too, The Washington Post, September 2014

Eat well: The risks of red meat, SBS, June 2014

Why do medicines have such ridiculous names?, Life Hacker, June 2013

Magnetic medicine, Australasian Science Magazine, November 2012

Keywords

Cancer; Drug delivery; Drug design; Pharmaceutics

PhD and master's project opportunities

Selected grants

2013

  • Thermogravimetric Analyser (TGA); Kepert C, D'Alessandro D, Perrier S, Hawkett B, Hibbs D, Wheate N, Harris A, Minett A, Ling C, Kennedy B; DVC Research/Equipment Grant.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Oun, R., Wheate, N. (2013). Platinum Anticancer Drugs. In Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov (Eds.), Encyclopedia of Metalloproteins, (pp. 1710-1714). United States: Springer Science+Business Media.
  • Hicks, M., Orkey, N., Pisani, M., Collins, J., Wheate, N., Aldrich-Wright, J. (2012). Using Spectroscopic Techniques to Examine Drug-DNA Interactions. In Meni Wanunu, Yitzhak Tor (Eds.), Methods for Studying Nucleic Acid/Drug Interactions, (pp. 3-42). United States: CRC Press.

Journals

  • Apps, M., Choi, E., Wheate, N. (2015). The state-of-play and future of platin drugs. Endocrine-Related Cancer, 22(4), R219-233. [More Information]
  • Oun, R., Plumb, J., Wheate, N. (2014). A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol. Journal of Inorganic Biochemistry, 134, 100-105. [More Information]
  • Apps, M., Johnson, B., Sutcliffe, O., Brown, S., Wheate, N. (2014). Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents. Journal of Visualized Experiments, 87(87), 1-7. [More Information]
  • Apps, M., Ammit, A., Gu, A., Wheate, N. (2014). Analysis of montmorillonite clay as a vehicle in platinum anticancer drug delivery. Inorganica Chimica Acta, 421, 513-518. [More Information]
  • Chu, J., Apps, M., Wheate, N. (2014). Chemical factors affecting cucurbit[n]uril formulation into ocular dosage forms: excipient binding, solubility, corneal permeability and antibiotic encapsulation. Supramolecular Chemistry, 26(9), 648-656. [More Information]
  • Rhodes, S., Booth, J., Campbell, L., Blythe, R., Wheate, N., Delibegovic, M. (2014). Evidence for a Role of Executive Functions in Learning Biology. Infant and Child Development (Online), 23(1), 67-83. [More Information]
  • Oun, R., Floriano, R., Isaacs, L., Rowan, E., Wheate, N. (2014). The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles. Toxicology Research, 3(6), 447-455. [More Information]
  • Seif, M., Impelido, M., Apps, M., Wheate, N. (2014). Topical Cream-Based Dosage Forms of the Macrocyclic Drug Delivery Vehicle Cucurbit[6]uril. PloS One, 9(1), 1-8. [More Information]
  • McGinely, N., Plumb, J., Wheate, N. (2013). DNA-based aptamer fails as a simultaneous cancer targeting agent and drug delivery vehicle for a phenanthroline-based platinum(II) complex. Journal of Inorganic Biochemistry, 128, 124-130. [More Information]
  • Wagstaff, A., Brown, S., Holden, M., Craig, G., Plumb, J., Brown, R., Schreiter, N., Chrzanowski, W., Wheate, N. (2012). Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields. Inorganica Chimica Acta, 393, 328-333. [More Information]
  • Craig, G., Brown, S., Lamprou, D., Graham, D., Wheate, N. (2012). Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval? Inorganic Chemistry, 51(6), 3490-3497. [More Information]
  • Brown, S., Trotter, K., Sutcliffe, O., Plumb, J., Waddell, B., Briggs, N., Wheate, N. (2012). Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 41(37), 11330-11339. [More Information]
  • Plumb, J., Venugopal, B., Oun, R., Gomez-Roman, N., Kawazoe, Y., Venkataramanan, N., Wheate, N. (2012). Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect. Metallomics, 4(6), 561-567. [More Information]
  • Brown, S., Plumb, J., Johnston, B., Wheate, N. (2012). Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene. Inorganica Chimica Acta, 393, 182-186. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Wheate, N. (2012). Nanoparticles: the future for platinum drugs or a research red herring? Nanomedicine, 7(9), 1285-1287. [More Information]
  • Alniss, H., Anthony, N., Khalaf, A., Mackay, S., Suckling, C., Waigh, R., Wheate, N., Parkinson, J. (2012). Rationalising sequence selection by ligand assemblies in the DNA minor groove; The case for thiazotropsin A. Chemical Science, 3, 711-722. [More Information]
  • Walker, S., Oun, R., McInnes, F., Wheate, N. (2011). The Potential of Cucurbit[n]urils in Drug Delivery. Israel Journal Of Chemistry, 51(5-6), 616-624. [More Information]
  • Brown, S., Nativo, P., Smith, J., Stirling, D., Edwards, P., Venugopal, B., Flint, D., Plumb, J., Graham, D., Wheate, N. (2010). Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. Journal of the American Chemical Society, 132(13), 4678-4684. [More Information]
  • Wheate, N., Vora, V., Anthony, N., McInnes, F. (2010). Host-guest complexes of the antituberculosis drugs pyrazinamide and isoniazid with cucurbit[7]uril. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 68, 359-367. [More Information]
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2010). Synthesis, Processing and Solid State Excipient Interactions of Cucurbit[6]uril and Its Formulation into Tablets for Oral Drug Delivery. Molecular Pharmaceutics, 7(6), 2166-2172. [More Information]
  • Wheate, N., Walker, S., Craig, G., Oun, R. (2010). The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(35), 8113-8127. [More Information]
  • Kennedy, A., Florence, A., McInnes, F., Wheate, N. (2009). A chemical preformulation study of a host-guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (37), 7695-7700. [More Information]
  • Pisani, M., Wheate, N., Keene, F., Aldrich-Wright, J., Collins, J. (2009). Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs. Journal of Inorganic Biochemistry, 103(3), 373-380. [More Information]
  • Grant, M., Wheate, N., Aldrich-Wright, J. (2009). Diffusion coefficient of cucurbit[n]urils (n = 6 or 7) at various concentrations, temperatures, and pH. Journal of Chemical and Engineering Data, 54(2), 323-326. [More Information]
  • Krause-Heuer, A., Wheate, N., Price, W., Aldrich-Wright, J. (2009). Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators. Chemical Communications, 2009 (10), 1210-1212. [More Information]
  • Wheate, N., Abbott, G., Tate, R., Celements, C., Edrada-Ebel, R., Johnston, B. (2009). Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2μ-dpzm]2+ and its implications for anticancer drug delivery. Journal of Inorganic Biochemistry, 103(3), 448-454. [More Information]
  • Krause-Heuer, A., Grunert, R., Kuhne, S., Buczkowska, M., Wheate, N., le Pevelen, D., Boag, L., Fisher, D., Kasparkova, J., Malina, J., et al (2009). Studies of the Mechanism of Action of Platinum(II) Complexes with Potent Cytotoxicity in Human Cancer Cells. Journal of Medicinal Chemistry, 52(17), 5474-5484. [More Information]
  • Wheate, N., Brodie, C., Collins, J., Kemp, S., Aldrich-Wright, J. (2007). DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis. Mini - Reviews in Medicinal Chemistry, 7(6), 627-648. [More Information]
  • Kemp, S., Wheate, N., Collins, J., Ralph, S., Day, A., Higgins, V., Aldrich-Wright, J., Wang, S. (2007). Encapsulation of platinum(II)-based DNA intercalators within cucurbit[6,7,8]urils. Journal of Biological Inorganic Chemistry, 12(7), 969-979. [More Information]
  • Wheate, N., Taleb, R., Krause-Heuer, A., Cook, R., Wang, S., Higgins, V., Aldrich-Wright, J. (2007). Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2007 (43), 5055-5064. [More Information]
  • Yousouf, S., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester. Polyhedron, 26, 318-328. [More Information]
  • Taleb, R., Jaramillo, D., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes. Chemistry: A European Journal, 13, 3177-3186. [More Information]
  • Kemp, S., Wheate, N., Buck, D., Nikac, M., Collins, J., Aldrich-Wright, J. (2007). The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators. Journal of Inorganic Biochemistry, 101(7), 1049-1058. [More Information]
  • Kemp, S., Wheate, N., Stootman, F., Aldrich-Wright, J. (2007). The host-guest chemistry of proflavine with cucurbit[6,7,8]urils. Supramolecular Chemistry, 19(7), 475-484. [More Information]
  • Brodie, C., Turner, P., Wheate, N., Riches, J. (2006). (4,7-Dimethyl-1,10-phenanthroline (ethylenediamine) platinum(II) dichloride tris(deuterium oxide) solvate. Acta Crystallographica. Section E: Structure Reports Online, E62, m3137-m3139.
  • Wheate, N., Buck, D., Day, A., Collins, J. (2006). Cucurbit[n]uril binding of platinum anticancer complexes. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (3), 451-458. [More Information]
  • Wheate, N. (2006). Cucurbit[n]uril: A New Molecule in Host–Guest Chemistry. Australian Journal of Chemistry: an international journal for chemical science, 59(5), 354-354. [More Information]
  • Jaramillo, D., Wheate, N., Ralph, S., Howard, W., Tor, Y., Aldrich-Wright, J. (2006). Polyamide platinum anticancer complexes designed to target specific DNA sequences. Inorganic Chemistry, 46(15), 6004-6013. [More Information]
  • Fenton, R., Jaramillo, D., Buck, D., Collins, J., Stootman, F., Wheate, N., Riches, J. (2006). Synthesis, characterisation and biological activity of chiral platinum(II) complexes. European Journal of Inorganic Chemistry, (4), 839-849. [More Information]
  • Wheate, N., Collins, J. (2005). Multi-nuclear Platinum drugs: A new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]
  • Wheate, N., Collins, J. (2005). Multi-nuclear platinum drugs: a new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]
  • Wheate, N. (2005). Platinum-based chemotherapy: are we any closer to cure for cancer? Chemistry in Australia, 72(7), 11-14.

Conferences

  • Oun, R., Plumb, J., Rowan, E., Wheate, N. (2013). Encapsulation of cisplatin by cucurbit[7]uril decreases the neurotoxic and cardiotoxic side effects of cisplatin. 49th Congress of EUROTOX, Switzerland: Elsevier Ireland Ltd. [More Information]
  • Plumb, J., Gomez-Roman, N., Venugopal, B., Wheate, N. (2009). Drug delivery as a means of enhancing the activity of platinum compounds. 100th Annual Meeting of the American Association for Cancer Research, USA: N/A.
  • Kirkpatrick, G., Sutcliffe, O., Flint, D., Wheate, N. (2009). PAMAM dendrimers as delivery vehicles for platinum anticancer drugs. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Wright, E., Aldrich-Wright, J., Wheate, N., Dawes, I., Higgins, V. (2007). Molecular mechanisms involved in the Saccharomyces cerevisiae response to the novel anticancer platinum compound 56MESS. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.
  • Aldrich-Wright, J., Wheate, N., Taleb, R. (2007). Novel Platinum(II)- based anticancer drugs: metallointercalators and DNA sequence specific agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.
  • van Holst, M., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Platinum metallointercalators in solid phase synthesis. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.
  • Krause-Heuer, A., Wheate, N., Aldrich-Wright, J. (2007). Use of molecular hosts in the drug delivery of platinum(II)-based DNA intercalating agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.

Patents

  • Brown, S., Craig, G., Graham, D., Wheate, N. (2010). University of Strathclyde. Patent No. WO 2010/139942. United Kingdom.
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2009). UK Intellectual Property Office. United Kingdom.
  • Wheate, N., Day, A., Blanch, R., Collins, J. (2005). Newsouth Innovations Pty Ltd. Patent No. WO 2005/068469.

2015

  • Apps, M., Choi, E., Wheate, N. (2015). The state-of-play and future of platin drugs. Endocrine-Related Cancer, 22(4), R219-233. [More Information]

2014

  • Oun, R., Plumb, J., Wheate, N. (2014). A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol. Journal of Inorganic Biochemistry, 134, 100-105. [More Information]
  • Apps, M., Johnson, B., Sutcliffe, O., Brown, S., Wheate, N. (2014). Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents. Journal of Visualized Experiments, 87(87), 1-7. [More Information]
  • Apps, M., Ammit, A., Gu, A., Wheate, N. (2014). Analysis of montmorillonite clay as a vehicle in platinum anticancer drug delivery. Inorganica Chimica Acta, 421, 513-518. [More Information]
  • Chu, J., Apps, M., Wheate, N. (2014). Chemical factors affecting cucurbit[n]uril formulation into ocular dosage forms: excipient binding, solubility, corneal permeability and antibiotic encapsulation. Supramolecular Chemistry, 26(9), 648-656. [More Information]
  • Rhodes, S., Booth, J., Campbell, L., Blythe, R., Wheate, N., Delibegovic, M. (2014). Evidence for a Role of Executive Functions in Learning Biology. Infant and Child Development (Online), 23(1), 67-83. [More Information]
  • Oun, R., Floriano, R., Isaacs, L., Rowan, E., Wheate, N. (2014). The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles. Toxicology Research, 3(6), 447-455. [More Information]
  • Seif, M., Impelido, M., Apps, M., Wheate, N. (2014). Topical Cream-Based Dosage Forms of the Macrocyclic Drug Delivery Vehicle Cucurbit[6]uril. PloS One, 9(1), 1-8. [More Information]

2013

  • McGinely, N., Plumb, J., Wheate, N. (2013). DNA-based aptamer fails as a simultaneous cancer targeting agent and drug delivery vehicle for a phenanthroline-based platinum(II) complex. Journal of Inorganic Biochemistry, 128, 124-130. [More Information]
  • Oun, R., Plumb, J., Rowan, E., Wheate, N. (2013). Encapsulation of cisplatin by cucurbit[7]uril decreases the neurotoxic and cardiotoxic side effects of cisplatin. 49th Congress of EUROTOX, Switzerland: Elsevier Ireland Ltd. [More Information]
  • Oun, R., Wheate, N. (2013). Platinum Anticancer Drugs. In Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov (Eds.), Encyclopedia of Metalloproteins, (pp. 1710-1714). United States: Springer Science+Business Media.

2012

  • Wagstaff, A., Brown, S., Holden, M., Craig, G., Plumb, J., Brown, R., Schreiter, N., Chrzanowski, W., Wheate, N. (2012). Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields. Inorganica Chimica Acta, 393, 328-333. [More Information]
  • Craig, G., Brown, S., Lamprou, D., Graham, D., Wheate, N. (2012). Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval? Inorganic Chemistry, 51(6), 3490-3497. [More Information]
  • Brown, S., Trotter, K., Sutcliffe, O., Plumb, J., Waddell, B., Briggs, N., Wheate, N. (2012). Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 41(37), 11330-11339. [More Information]
  • Plumb, J., Venugopal, B., Oun, R., Gomez-Roman, N., Kawazoe, Y., Venkataramanan, N., Wheate, N. (2012). Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect. Metallomics, 4(6), 561-567. [More Information]
  • Brown, S., Plumb, J., Johnston, B., Wheate, N. (2012). Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene. Inorganica Chimica Acta, 393, 182-186. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Wheate, N. (2012). Nanoparticles: the future for platinum drugs or a research red herring? Nanomedicine, 7(9), 1285-1287. [More Information]
  • Alniss, H., Anthony, N., Khalaf, A., Mackay, S., Suckling, C., Waigh, R., Wheate, N., Parkinson, J. (2012). Rationalising sequence selection by ligand assemblies in the DNA minor groove; The case for thiazotropsin A. Chemical Science, 3, 711-722. [More Information]
  • Hicks, M., Orkey, N., Pisani, M., Collins, J., Wheate, N., Aldrich-Wright, J. (2012). Using Spectroscopic Techniques to Examine Drug-DNA Interactions. In Meni Wanunu, Yitzhak Tor (Eds.), Methods for Studying Nucleic Acid/Drug Interactions, (pp. 3-42). United States: CRC Press.

2011

  • Walker, S., Oun, R., McInnes, F., Wheate, N. (2011). The Potential of Cucurbit[n]urils in Drug Delivery. Israel Journal Of Chemistry, 51(5-6), 616-624. [More Information]

2010

  • Brown, S., Nativo, P., Smith, J., Stirling, D., Edwards, P., Venugopal, B., Flint, D., Plumb, J., Graham, D., Wheate, N. (2010). Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. Journal of the American Chemical Society, 132(13), 4678-4684. [More Information]
  • Wheate, N., Vora, V., Anthony, N., McInnes, F. (2010). Host-guest complexes of the antituberculosis drugs pyrazinamide and isoniazid with cucurbit[7]uril. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 68, 359-367. [More Information]
  • Brown, S., Craig, G., Graham, D., Wheate, N. (2010). University of Strathclyde. Patent No. WO 2010/139942. United Kingdom.
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2010). Synthesis, Processing and Solid State Excipient Interactions of Cucurbit[6]uril and Its Formulation into Tablets for Oral Drug Delivery. Molecular Pharmaceutics, 7(6), 2166-2172. [More Information]
  • Wheate, N., Walker, S., Craig, G., Oun, R. (2010). The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(35), 8113-8127. [More Information]

2009

  • Kennedy, A., Florence, A., McInnes, F., Wheate, N. (2009). A chemical preformulation study of a host-guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (37), 7695-7700. [More Information]
  • Pisani, M., Wheate, N., Keene, F., Aldrich-Wright, J., Collins, J. (2009). Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs. Journal of Inorganic Biochemistry, 103(3), 373-380. [More Information]
  • Grant, M., Wheate, N., Aldrich-Wright, J. (2009). Diffusion coefficient of cucurbit[n]urils (n = 6 or 7) at various concentrations, temperatures, and pH. Journal of Chemical and Engineering Data, 54(2), 323-326. [More Information]
  • Krause-Heuer, A., Wheate, N., Price, W., Aldrich-Wright, J. (2009). Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators. Chemical Communications, 2009 (10), 1210-1212. [More Information]
  • Plumb, J., Gomez-Roman, N., Venugopal, B., Wheate, N. (2009). Drug delivery as a means of enhancing the activity of platinum compounds. 100th Annual Meeting of the American Association for Cancer Research, USA: N/A.
  • Walker, S., Kaur, R., McInnes, F., Wheate, N. (2009). UK Intellectual Property Office. United Kingdom.
  • Kirkpatrick, G., Sutcliffe, O., Flint, D., Wheate, N. (2009). PAMAM dendrimers as delivery vehicles for platinum anticancer drugs. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Wheate, N., Abbott, G., Tate, R., Celements, C., Edrada-Ebel, R., Johnston, B. (2009). Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH3)2}2μ-dpzm]2+ and its implications for anticancer drug delivery. Journal of Inorganic Biochemistry, 103(3), 448-454. [More Information]
  • Krause-Heuer, A., Grunert, R., Kuhne, S., Buczkowska, M., Wheate, N., le Pevelen, D., Boag, L., Fisher, D., Kasparkova, J., Malina, J., et al (2009). Studies of the Mechanism of Action of Platinum(II) Complexes with Potent Cytotoxicity in Human Cancer Cells. Journal of Medicinal Chemistry, 52(17), 5474-5484. [More Information]

2007

  • Wheate, N., Brodie, C., Collins, J., Kemp, S., Aldrich-Wright, J. (2007). DNA intercalators in cancer therapy: Organic and inorganic drugs and their spectroscopic tools of analysis. Mini - Reviews in Medicinal Chemistry, 7(6), 627-648. [More Information]
  • Kemp, S., Wheate, N., Collins, J., Ralph, S., Day, A., Higgins, V., Aldrich-Wright, J., Wang, S. (2007). Encapsulation of platinum(II)-based DNA intercalators within cucurbit[6,7,8]urils. Journal of Biological Inorganic Chemistry, 12(7), 969-979. [More Information]
  • Wright, E., Aldrich-Wright, J., Wheate, N., Dawes, I., Higgins, V. (2007). Molecular mechanisms involved in the Saccharomyces cerevisiae response to the novel anticancer platinum compound 56MESS. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.
  • Aldrich-Wright, J., Wheate, N., Taleb, R. (2007). Novel Platinum(II)- based anticancer drugs: metallointercalators and DNA sequence specific agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.
  • Wheate, N., Taleb, R., Krause-Heuer, A., Cook, R., Wang, S., Higgins, V., Aldrich-Wright, J. (2007). Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2007 (43), 5055-5064. [More Information]
  • van Holst, M., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Platinum metallointercalators in solid phase synthesis. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.
  • Yousouf, S., Brodie, C., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by l-cysteine methyl ester. Polyhedron, 26, 318-328. [More Information]
  • Taleb, R., Jaramillo, D., Wheate, N., Aldrich-Wright, J. (2007). Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes. Chemistry: A European Journal, 13, 3177-3186. [More Information]
  • Kemp, S., Wheate, N., Buck, D., Nikac, M., Collins, J., Aldrich-Wright, J. (2007). The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators. Journal of Inorganic Biochemistry, 101(7), 1049-1058. [More Information]
  • Kemp, S., Wheate, N., Stootman, F., Aldrich-Wright, J. (2007). The host-guest chemistry of proflavine with cucurbit[6,7,8]urils. Supramolecular Chemistry, 19(7), 475-484. [More Information]
  • Krause-Heuer, A., Wheate, N., Aldrich-Wright, J. (2007). Use of molecular hosts in the drug delivery of platinum(II)-based DNA intercalating agents. 13th International Conference on Biological Inorganic Chemistry, Berlin: Springer Science+Business Media.

2006

  • Brodie, C., Turner, P., Wheate, N., Riches, J. (2006). (4,7-Dimethyl-1,10-phenanthroline (ethylenediamine) platinum(II) dichloride tris(deuterium oxide) solvate. Acta Crystallographica. Section E: Structure Reports Online, E62, m3137-m3139.
  • Wheate, N., Buck, D., Day, A., Collins, J. (2006). Cucurbit[n]uril binding of platinum anticancer complexes. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (3), 451-458. [More Information]
  • Wheate, N. (2006). Cucurbit[n]uril: A New Molecule in Host–Guest Chemistry. Australian Journal of Chemistry: an international journal for chemical science, 59(5), 354-354. [More Information]
  • Jaramillo, D., Wheate, N., Ralph, S., Howard, W., Tor, Y., Aldrich-Wright, J. (2006). Polyamide platinum anticancer complexes designed to target specific DNA sequences. Inorganic Chemistry, 46(15), 6004-6013. [More Information]
  • Fenton, R., Jaramillo, D., Buck, D., Collins, J., Stootman, F., Wheate, N., Riches, J. (2006). Synthesis, characterisation and biological activity of chiral platinum(II) complexes. European Journal of Inorganic Chemistry, (4), 839-849. [More Information]

2005

  • Wheate, N., Day, A., Blanch, R., Collins, J. (2005). Newsouth Innovations Pty Ltd. Patent No. WO 2005/068469.
  • Wheate, N., Collins, J. (2005). Multi-nuclear Platinum drugs: A new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]
  • Wheate, N., Collins, J. (2005). Multi-nuclear platinum drugs: a new paradigm in chemotherapy. Current Medicinal Chemistry, 5(3), 267-279. [More Information]
  • Wheate, N. (2005). Platinum-based chemotherapy: are we any closer to cure for cancer? Chemistry in Australia, 72(7), 11-14.

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