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Dr Patricia Tang

Level A Research Only Academic

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 2516
Fax +61 2 9351 4391

Biographical details

Dr Patricia Tang has a PhD degree from Chemical Engineering, the University of Sydney, and a bachelor’s degree from Chemical Engineering, the University of New South Wales. She completed her PhD (title: The Relationship between Flow Fractal Dimension and Sedimentation Rate in Water Pollution Control) under the supervision of Professor Judy Raper. She commenced working full-time as a postdoctoral fellow in Aerosol Drug Delivery Group, led by Professor Hak-Kim Chan, straight after she completed her PhD in 2002.

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Research interests

Dr Tang has extensive skills in characterisation of particles, including: dispersibility of drug powders using various impaction methods; determination of surface and mass fractal dimensions using light diffraction; particle sizing (using light diffraction, time-of-flight instrument); x-ray diffraction; scanning and transmission electron microscope imaging techniques; and focused ion-beam imaging to see internal structure of particles. She has been involved in various collaboration projects with:

  • Intensive Care Units, Royal Prince Alfred Hospital (Sydney) to develop an in-line device for administering dry powder mannitol to ventilated patients for the clearance of mucus from lungs.
  • Prince Charles Hospital (Brisbane) to characterise antibiotic droplets’ particle size distribution and mass output when the drug is nebulised in line with a ventilator.
  • Center for Neuro-Medicine, Korea Institute of Science and Technology, to synthesise liposome and characterisation of the droplet’s size when administered using a micro-sprayer. School of Health Science,
  • The University of Wollongong to prepare a stable form of beta-glucan extracted from shiitake mushroom for the prevention of colon cancer.

She has been successful in producing inhalable and stable drug compounds by ultrasonic precipitation, confined liquid impinging jet crystallisation, vortex mixer precipitation, high gravity reaction, spray drying and freeze drying.

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Selected publications

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Book Chapters

  • Coates, M., Tang, P., Chan, H., Fletcher, D., Raper, J. (2009). Characterization of pharmaceutical aerosols and dry powder inhalers for pulmonary drug delivery. In Sigmund W, El-Shall H, Shah D, Moudgil B (Eds.), Particulate Systems in Nano and Biotechnologies, (pp. 193-222). Boca Raton, USA: CRC Press.
  • Tang, P., Chan, H., Raper, J. (2004). Fractal Geometry In Pharmaceutical And Biological Applications - A Review. In James Swarbrick (Eds.), Encyclopaedia of Pharmaceutical Technology, (pp. 1779-1806). New York (on-line): Informa Healthcare.

Journals

  • Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807.
  • Handayani, D., Meyer, B., Chen, J., Tang, P., Kwok, P., Chan, H., Huang, X. (2012). The comparison of the effect of oat and Shiitake mushroom powder to prevent body weight gain in rats fed high fat diet. Food and Nutrition Sciences, 3(7), 1009-1019.
  • Syed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. Journal of Supercritical Fluids, 71, 92-101.
  • Tang, P., Chan, H., Rajbhandari, D., Phipps, P. (2011). Method to Introduce Mannitol Powder to Intubated Patients to Improve Sputum Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24(1), 1-9.
  • Syed Muhammad, S., Langrish, T., Tang, P., Adi, H., Chan, H., Kazarian, S., Dehghani, F. (2010). A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388(1-2), 114-122.
  • Tang, P., Chan, H., Chiou, H., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud’homme, R., Raper, J. (2009). Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets. International Journal of Pharmaceutics, 367, 51-57.
  • Tang, P., Chan, H., Raper, J. (2009). Validation of computation method to predict aerodynamic diameter of particles with rough surface. Powder Technology, 192(1), 74-84.
  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18.
  • Tang, P., Fletcher, D., Chan, H., Raper, J. (2008). Simple and cost-effective powder disperser for aerosol particle size measurement. Powder Technology, 187(1), 27-36.
  • Heng, D., Tang, P., Cairney, J., Chan, H., Cutler, D., Salama, R., Yun, J. (2007). Focused-ion-beam Milling: A Novel Approach to Probing the Interior of Particles Used for Inhalation Aerosols. Pharmaceutical Research, 24(9), 1608-1617.
  • Abbas, A., Srour, M., Tang, P., Chiou, H., Chan, H., Romagnoli, J. (2007). Sonocrystallization of sodium chloride particles for inhalation. Chemical Engineering Science, 62(9), 2445-2453.
  • Tang, P., Chan, H., Tam, E., de Gruyter, N., Chan, J. (2006). Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research, 45(12), 4188-4192.
  • Chew, N., Tang, P., Chan, H., Raper, J. (2005). How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical Research, 22(1), 148-152.
  • Tang, P., Chan, H., Raper, J. (2004). Prediction Of Aerodynamic Diameter Of Particles With Rough Surfaces. Powder Technology, 147(1-3), 64-78.
  • Tang, P., Chew, N., Chan, H., Raper, J. (2003). Limitation of Determination of Surface Fractal Dimension Using N2 Adsorption Isotherms and Modified Frenkel-Halsey-Hill Theory. Langmuir, 19(7), 2632-2638.
  • Tang, P., Raper, J. (2002). Modelling the settling behaviour of fractal aggregates - a review. Powder Technology, 123(2-3), 114-125.
  • Nobbs, D., Tang, P., Raper, J. (2002). The design, construction and commissioning of a low-cost optical particle size analyser specifically for measurement of settling velocities and size of flocs. Measurement Science and Technology, 13(3), 297-302.

Conferences

  • Tang, P., Chan, H., Raper, J. (2009). Prediction of Aerodynamic Diameter of Particles with Corrugated Surface. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Tang, P., Chan, H., Raper, J. (2006). Validation of Computation Method to Predict Aerodynamic Diameter of Particles with Rough Surface. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Tang, P., Greenwood, J., Raper, J. (2002). A model to predict fractal diension from sedimentation. World Congress Particle Technology 4, : British Medical Journal Publishing Group.
  • Tang, P., Greenwood, J., Raper, J. (2002). A Model to predict Fractal Dimension from Sedimentation. World Congress on Particle Technology 4, Sydney, Australia: WCPT4/IEAust.
  • Tang, P., Chan, H., Schneider, C. (2002). Impact of timing valve on the invitro particle size distribution of the Bricanyl Turhuhaler�. Pharmaceutical Science beyond the Genome: Harnessing the Potential, : British Medical Journal Publishing Group.
  • Raper, J., Tang, P., Greenwood, J. (2001). Flocculation of calcium phosphate in sucrose solutions. 6th World Congress of Chemical Engineering. UNSW Australian Defence Force Academy.

2012

  • Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807.
  • Handayani, D., Meyer, B., Chen, J., Tang, P., Kwok, P., Chan, H., Huang, X. (2012). The comparison of the effect of oat and Shiitake mushroom powder to prevent body weight gain in rats fed high fat diet. Food and Nutrition Sciences, 3(7), 1009-1019.
  • Syed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. Journal of Supercritical Fluids, 71, 92-101.

2011

  • Tang, P., Chan, H., Rajbhandari, D., Phipps, P. (2011). Method to Introduce Mannitol Powder to Intubated Patients to Improve Sputum Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24(1), 1-9.

2010

  • Syed Muhammad, S., Langrish, T., Tang, P., Adi, H., Chan, H., Kazarian, S., Dehghani, F. (2010). A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388(1-2), 114-122.

2009

  • Tang, P., Chan, H., Chiou, H., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud’homme, R., Raper, J. (2009). Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets. International Journal of Pharmaceutics, 367, 51-57.
  • Coates, M., Tang, P., Chan, H., Fletcher, D., Raper, J. (2009). Characterization of pharmaceutical aerosols and dry powder inhalers for pulmonary drug delivery. In Sigmund W, El-Shall H, Shah D, Moudgil B (Eds.), Particulate Systems in Nano and Biotechnologies, (pp. 193-222). Boca Raton, USA: CRC Press.
  • Tang, P., Chan, H., Raper, J. (2009). Prediction of Aerodynamic Diameter of Particles with Corrugated Surface. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Tang, P., Chan, H., Raper, J. (2009). Validation of computation method to predict aerodynamic diameter of particles with rough surface. Powder Technology, 192(1), 74-84.

2008

  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18.
  • Tang, P., Fletcher, D., Chan, H., Raper, J. (2008). Simple and cost-effective powder disperser for aerosol particle size measurement. Powder Technology, 187(1), 27-36.

2007

  • Heng, D., Tang, P., Cairney, J., Chan, H., Cutler, D., Salama, R., Yun, J. (2007). Focused-ion-beam Milling: A Novel Approach to Probing the Interior of Particles Used for Inhalation Aerosols. Pharmaceutical Research, 24(9), 1608-1617.
  • Abbas, A., Srour, M., Tang, P., Chiou, H., Chan, H., Romagnoli, J. (2007). Sonocrystallization of sodium chloride particles for inhalation. Chemical Engineering Science, 62(9), 2445-2453.

2006

  • Tang, P., Chan, H., Tam, E., de Gruyter, N., Chan, J. (2006). Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research, 45(12), 4188-4192.
  • Tang, P., Chan, H., Raper, J. (2006). Validation of Computation Method to Predict Aerodynamic Diameter of Particles with Rough Surface. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.

2005

  • Chew, N., Tang, P., Chan, H., Raper, J. (2005). How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical Research, 22(1), 148-152.

2004

  • Tang, P., Chan, H., Raper, J. (2004). Fractal Geometry In Pharmaceutical And Biological Applications - A Review. In James Swarbrick (Eds.), Encyclopaedia of Pharmaceutical Technology, (pp. 1779-1806). New York (on-line): Informa Healthcare.
  • Tang, P., Chan, H., Raper, J. (2004). Prediction Of Aerodynamic Diameter Of Particles With Rough Surfaces. Powder Technology, 147(1-3), 64-78.

2003

  • Tang, P., Chew, N., Chan, H., Raper, J. (2003). Limitation of Determination of Surface Fractal Dimension Using N2 Adsorption Isotherms and Modified Frenkel-Halsey-Hill Theory. Langmuir, 19(7), 2632-2638.

2002

  • Tang, P., Greenwood, J., Raper, J. (2002). A model to predict fractal diension from sedimentation. World Congress Particle Technology 4, : British Medical Journal Publishing Group.
  • Tang, P., Greenwood, J., Raper, J. (2002). A Model to predict Fractal Dimension from Sedimentation. World Congress on Particle Technology 4, Sydney, Australia: WCPT4/IEAust.
  • Tang, P., Chan, H., Schneider, C. (2002). Impact of timing valve on the invitro particle size distribution of the Bricanyl Turhuhaler�. Pharmaceutical Science beyond the Genome: Harnessing the Potential, : British Medical Journal Publishing Group.
  • Tang, P., Raper, J. (2002). Modelling the settling behaviour of fractal aggregates - a review. Powder Technology, 123(2-3), 114-125.
  • Nobbs, D., Tang, P., Raper, J. (2002). The design, construction and commissioning of a low-cost optical particle size analyser specifically for measurement of settling velocities and size of flocs. Measurement Science and Technology, 13(3), 297-302.

2001

  • Raper, J., Tang, P., Greenwood, J. (2001). Flocculation of calcium phosphate in sucrose solutions. 6th World Congress of Chemical Engineering. UNSW Australian Defence Force Academy.
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