Professor Paul Groundwater

BSc (Chemistry), PhD (Organic Chemistry), CSci, CChem, FRSC
Associate Dean (Learning & Teaching)
Professor of Medicinal Chemistry

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9114 1232
Fax +61 2 9351 4391

Biographical details

Professor Paul Groundwater is Professor of Medicinal Chemistry in the Faculty of Pharmacy. Paul's research interests include the design and synthesis of novel agents for the treatment of cancer and psoriasis; the identification of the active principle of medicinal plants; and new methods for the detection of bacteria.

Professor Groundwaterhas a BSc and Doctorate in Chemistry from the University of Edinburgh. In 1987-88, he was a postdoctoral fellow at the Australian National University, Canberra and then returned to the UK to join the Cancer Research Campaign Experimental Chemotherapy Research Group, Aston University, UK.

In 1989 Paul was appointed as a lecturer in the Department of Chemistry, Cardiff University. In 1996 he was appointed to a Readership in Organic Chemistry in the Institute of Pharmacy and Chemistry at the University of Sunderland and was promoted to Professor, in the Sunderland Pharmacy School, in 2001. Paul was the Centre Director of chemiSPEC, a business providing spectroscopic services to industry.

He has published more than 70 papers and three books. He is a Guest Professor in the School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China and an Honorary Professor in the School of Medicine, Pharmacy and Health, University of Durham, UK.

Research interests

  • The design, synthesis and testing of novel agents for the treatment of cancer and psoriasis.
  • New chromogenic methods for the detection of bacteria.
  • The identification of the active principle of medicinal plants.

Keywords

Pharmaceutical Sciences; Cancer; Cardiovascular diseases

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho P, Dong Q, Bao S, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons J, Jansson J, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, dos Remedios C, Ju Y, Kovacevic Z, Lyons J, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao S, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson J, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel Fluorogenic Probes for the Selective Detection of Pathogenic Bacteria; Groundwater P, Hibbs D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons J, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson J, dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao S, Byrne S, Zhou F, Buckland M, Grewal (, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho P, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • HPLC-MS for high throughput drug and protein analysis; Payne R, Kassiou M, Cordwell S, Hibbs D, Groundwater P, Shepherd N; DVC Research/Equipment Grant.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao S, Bishop G, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson J, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Journals

  • Bedernjak, A., Groundwater, P., Gray, M., James, A., Orenga, S., Perry, J., Anderson, R. (2013). Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria. Tetrahedron, 69(39), 8456-8462. [More Information]
  • Matin, A., Doddareddy, M., Gavande, N., Nammi, S., Groundwater, P., Roubin, R., Hibbs, D. (2013). The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists. Bioorganic and Medicinal Chemistry, 21(3), 766-778. [More Information]
  • Alqahtani, A., Hamid, K., Kam, A., Wong, K., Abdelhak, Z., Razmovski-Naumovski, V., Chan, K., Li, K., Groundwater, P., Li, G. (2013). The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications. Current Medicinal Chemistry, 20(7), 908-931. [More Information]
  • George, S., Anderson, R., Hambleton, P., Groundwater, P. (2012). A Simple RP-HPLC Method for the Determination of the Anti-Psoriatic Drug Dithranol and its Application in an In Vitro Cell Uptake Study. Current Pharmaceutical Analysis, 8(1), 75-82. [More Information]
  • Petch, D., Anderson, R., Cunningham, A., George, S., Hibbs, D., Liu, R., Mackay, S., Paul, A., Small, D., Groundwater, P. (2012). Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis. Bioorganic & Medicinal Chemistry Letters, 20(19), 5901-5914. [More Information]
  • Zhao, Y., Hibbs, D., Groundwater, P., Wassef, A. (2012). Diethyl 4-(4-acetamidophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. Acta Crystallographica. Section E: Structure Reports Online, 68(8), 1-8. [More Information]
  • Nguyen, T., Howard, S., Hanrahan, J., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and Theoretical Charge Density Distribution in a Host-Guest System: Synthetic Terephthaloyl Receptor Complexed to Adipic Acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116, 5618-5628. [More Information]
  • Nguyen, T., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and theoretical charge density studies of 8-hydroxyquinoline cocrystallized with salicylic acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116(13), 3420-3427. [More Information]
  • Kottakota, S., Evangelopoulos, D., Alnimr, A., Bhakta, S., McHugh, T., Gray, M., Groundwater, P., Marrs, E., Perry, J., Spilling, C., et al (2012). Synthesis and biological evaluation of purpurealidin E-derived marine sponge metabolites: aplysamine-2, aplyzanzine A, and suberedamines A and B. Journal of Natural Products, 75(6), 1090-1101. [More Information]
  • Varadi, L., Gray, M., Groundwater, P., Hall, A., James, A., Orenga, S., Perry, J., Anderson, R. (2012). Synthesis and evaluation of fluorogenic 2-amino-1,8-naphthyridine derivatives for the detection of bacteria. Organic and Biomolecular Chemistry, 10(13), 2578-2589. [More Information]
  • Kottakota, S., Benton, M., Evangelopoulos, D., Guzman, J., Bhakta, S., McHugh, T., Gray, M., Groundwater, P., Marrs, E., Perry, J., et al (2012). Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines. Organic Letters, 14(24), 6310-6313. [More Information]
  • Zhao, Y., Groundwater, P., Hibbs, D., Nguyen, P., Narlawar, R. (2011). (1E,4Z,6E)-5-Hydroxy-1,7-bis(2-meth-oxyphenyl)-1,4,6-heptatrien-3-one. Acta Crystallographica. Section E: Structure Reports Online, E67(8), o1885. [More Information]
  • George, S., Anderson, R., Cunningham, A., Donaldson, M., Groundwater, P. (2011). Evaluation of a range of anti-proliferative assays for the preclinical screening of anti-psoriatic drugs: a comparison of colorimetric and fluorimetric assays with the thymidine incorporation assay. ASSAY and Drug Development Technologies, 8(3), 389-400. [More Information]
  • Rowe, A., Narlawar, R., Groundwater, P., Ramzan, I. (2011). Kavalactone Pharmacophores for Major Cellular Drug Targets. Mini - Reviews in Medicinal Chemistry, 11(1), 79-83. [More Information]
  • Yan, Z., Liu, J., Lu, D., Groundwater, P., He, C., Li, P. (2010). A new 3,4-seco-lupane-type triterpenoid from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Natural Product Research, 24(16), 1523-1527. [More Information]
  • Ning, F., Anderson, R., Hibbs, D., Groundwater, P. (2010). A new, one-step synthesis of 1-heteroaryl-2-alkylaminoethanols. Tetrahedron Letters, 51, 843-845.
  • Marth, G., Anderson, R., Thompson, B., Ashton, M., Groundwater, P. (2010). Chemo- and Regioselectivity in the Reactions of Polyfunctional Pyrroles. Tetrahedron, 66(32), 6113-6120. [More Information]
  • Williamson, S., Todd, A., Anderson, R., Groundwater, P. (2010). Current advances and research in the treatment of pancreatic cancer. The Pharmaceutical Journal, 284, 137-138.
  • Todd, A., Anderson, R., Groundwater, P., George, S. (2010). Current and potential new therapies for the treatment of psoriasis. The Pharmaceutical Journal, 284, 560-561.
  • George, S., Anderson, R., Cunningham, A., Donaldson, M., Groundwater, P. (2010). Evaluation of a Range of Anti-Proliferative Assays for the Preclinical Screening of Anti-Psoriatic Drugs: A Comparison of Colorimetric and Fluorimetric Assays with the Thymidine Incorporation Assay. ASSAY and Drug Development Technologies, 8(3), 384-395. [More Information]
  • Todd, A., Anderson, R., Pickles, G., Groundwater, P. (2010). Targeting the thioredoxin system in the treatment of certain cancers. The Pharmaceutical Journal, 284, 243-244.
  • Nyerges, M., Bendell, D., Arany, A., Hibbs, D., Coles, S., Hursthouse, M., Groundwater, P., Meth-Cohn, O. (2005). Silver acetate-catalysed asymmetric 1,3-dipolar cycloadditions of imines and chiral acrylamides. Tetrahedron, 61(15), 3745-3753.
  • Nyerges, M., Bendell, D., Arany, A., Hibbs, D., Coles, S., Hursthouse, M., Groundwater, P., Meth-Cohn, O. (2003). Silver acetate catalysed asymmetric 1,3-dipolar cycloadditions of imines and chiral acrylamides. Synlett, 7, 947-950.

2013

  • Bedernjak, A., Groundwater, P., Gray, M., James, A., Orenga, S., Perry, J., Anderson, R. (2013). Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria. Tetrahedron, 69(39), 8456-8462. [More Information]
  • Matin, A., Doddareddy, M., Gavande, N., Nammi, S., Groundwater, P., Roubin, R., Hibbs, D. (2013). The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists. Bioorganic and Medicinal Chemistry, 21(3), 766-778. [More Information]
  • Alqahtani, A., Hamid, K., Kam, A., Wong, K., Abdelhak, Z., Razmovski-Naumovski, V., Chan, K., Li, K., Groundwater, P., Li, G. (2013). The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications. Current Medicinal Chemistry, 20(7), 908-931. [More Information]

2012

  • George, S., Anderson, R., Hambleton, P., Groundwater, P. (2012). A Simple RP-HPLC Method for the Determination of the Anti-Psoriatic Drug Dithranol and its Application in an In Vitro Cell Uptake Study. Current Pharmaceutical Analysis, 8(1), 75-82. [More Information]
  • Petch, D., Anderson, R., Cunningham, A., George, S., Hibbs, D., Liu, R., Mackay, S., Paul, A., Small, D., Groundwater, P. (2012). Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis. Bioorganic & Medicinal Chemistry Letters, 20(19), 5901-5914. [More Information]
  • Zhao, Y., Hibbs, D., Groundwater, P., Wassef, A. (2012). Diethyl 4-(4-acetamidophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. Acta Crystallographica. Section E: Structure Reports Online, 68(8), 1-8. [More Information]
  • Nguyen, T., Howard, S., Hanrahan, J., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and Theoretical Charge Density Distribution in a Host-Guest System: Synthetic Terephthaloyl Receptor Complexed to Adipic Acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116, 5618-5628. [More Information]
  • Nguyen, T., Groundwater, P., Platts, J., Hibbs, D. (2012). Experimental and theoretical charge density studies of 8-hydroxyquinoline cocrystallized with salicylic acid. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 116(13), 3420-3427. [More Information]
  • Kottakota, S., Evangelopoulos, D., Alnimr, A., Bhakta, S., McHugh, T., Gray, M., Groundwater, P., Marrs, E., Perry, J., Spilling, C., et al (2012). Synthesis and biological evaluation of purpurealidin E-derived marine sponge metabolites: aplysamine-2, aplyzanzine A, and suberedamines A and B. Journal of Natural Products, 75(6), 1090-1101. [More Information]
  • Varadi, L., Gray, M., Groundwater, P., Hall, A., James, A., Orenga, S., Perry, J., Anderson, R. (2012). Synthesis and evaluation of fluorogenic 2-amino-1,8-naphthyridine derivatives for the detection of bacteria. Organic and Biomolecular Chemistry, 10(13), 2578-2589. [More Information]
  • Kottakota, S., Benton, M., Evangelopoulos, D., Guzman, J., Bhakta, S., McHugh, T., Gray, M., Groundwater, P., Marrs, E., Perry, J., et al (2012). Versatile Routes to Marine Sponge Metabolites through Benzylidene Rhodanines. Organic Letters, 14(24), 6310-6313. [More Information]

2011

  • Zhao, Y., Groundwater, P., Hibbs, D., Nguyen, P., Narlawar, R. (2011). (1E,4Z,6E)-5-Hydroxy-1,7-bis(2-meth-oxyphenyl)-1,4,6-heptatrien-3-one. Acta Crystallographica. Section E: Structure Reports Online, E67(8), o1885. [More Information]
  • George, S., Anderson, R., Cunningham, A., Donaldson, M., Groundwater, P. (2011). Evaluation of a range of anti-proliferative assays for the preclinical screening of anti-psoriatic drugs: a comparison of colorimetric and fluorimetric assays with the thymidine incorporation assay. ASSAY and Drug Development Technologies, 8(3), 389-400. [More Information]
  • Rowe, A., Narlawar, R., Groundwater, P., Ramzan, I. (2011). Kavalactone Pharmacophores for Major Cellular Drug Targets. Mini - Reviews in Medicinal Chemistry, 11(1), 79-83. [More Information]

2010

  • Yan, Z., Liu, J., Lu, D., Groundwater, P., He, C., Li, P. (2010). A new 3,4-seco-lupane-type triterpenoid from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Natural Product Research, 24(16), 1523-1527. [More Information]
  • Ning, F., Anderson, R., Hibbs, D., Groundwater, P. (2010). A new, one-step synthesis of 1-heteroaryl-2-alkylaminoethanols. Tetrahedron Letters, 51, 843-845.
  • Marth, G., Anderson, R., Thompson, B., Ashton, M., Groundwater, P. (2010). Chemo- and Regioselectivity in the Reactions of Polyfunctional Pyrroles. Tetrahedron, 66(32), 6113-6120. [More Information]
  • Williamson, S., Todd, A., Anderson, R., Groundwater, P. (2010). Current advances and research in the treatment of pancreatic cancer. The Pharmaceutical Journal, 284, 137-138.
  • Todd, A., Anderson, R., Groundwater, P., George, S. (2010). Current and potential new therapies for the treatment of psoriasis. The Pharmaceutical Journal, 284, 560-561.
  • George, S., Anderson, R., Cunningham, A., Donaldson, M., Groundwater, P. (2010). Evaluation of a Range of Anti-Proliferative Assays for the Preclinical Screening of Anti-Psoriatic Drugs: A Comparison of Colorimetric and Fluorimetric Assays with the Thymidine Incorporation Assay. ASSAY and Drug Development Technologies, 8(3), 384-395. [More Information]
  • Todd, A., Anderson, R., Pickles, G., Groundwater, P. (2010). Targeting the thioredoxin system in the treatment of certain cancers. The Pharmaceutical Journal, 284, 243-244.

2005

  • Nyerges, M., Bendell, D., Arany, A., Hibbs, D., Coles, S., Hursthouse, M., Groundwater, P., Meth-Cohn, O. (2005). Silver acetate-catalysed asymmetric 1,3-dipolar cycloadditions of imines and chiral acrylamides. Tetrahedron, 61(15), 3745-3753.

2003

  • Nyerges, M., Bendell, D., Arany, A., Hibbs, D., Coles, S., Hursthouse, M., Groundwater, P., Meth-Cohn, O. (2003). Silver acetate catalysed asymmetric 1,3-dipolar cycloadditions of imines and chiral acrylamides. Synlett, 7, 947-950.

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