Associate Professor Joergen Ahring

A16 - Badham Building
The University of Sydney

Selected grants

2017

  • Ion Channel Drug Discovery Consortium; Collins M, MacDonald C, Kassiou M, Ahring J, Fuller S, Vandenberg R, Balle T, Ryan R, Imlach W; DVC Research/Sydney Research Excellence Initiative 2020 (SREI).
  • The awakening:GABA-A receptors as targets for improving motor function; Collins M, Clarkson A, Ahring J, Balle T; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • delta-containing GABA-A receptors as targets for neuroprotection; Collins M, Clarkson A, Balle T, Nicolazzo J, Hanrahan J, Ahring J, Vaughan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Mapping of a new allosteric binding site in nicotinic receptors; Balle T, Ahring J; IMK Almene Fond/Research Support.

Selected publications

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Journals

  • Absalom, N., Ahring, J., Liao, V., Balle, T., Jiang, T., Anderson, L., Arnold, J., McGregor, I., Bowen, M., Chebib, M. (2019). Functional genomics of epilepsy-associated mutations in the GABAa receptor subunits reveal that one mutation impairs function and two are catastrophic. Journal of Biological Chemistry. [More Information]
  • Indurthi Venkata, D., Qudah, T., Liao, V., Ahring, J., Lewis, T., Balle, T., Collins, M., Absalom, N. (2019). Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry. Pharmacological Research, 139, 215-227. [More Information]
  • Ahring, J., Liao, V., Balle, T. (2018). Concatenated nicotinic acetylcholine receptors: A gift or a curse? Journal of General Physiology, 150(3), 453-473. [More Information]
  • Kowal, N., Ahring, J., Liao, V., Indurti, D., Harvey, B., O'Connor, S., Collins, M., Olafsdottir, E., Balle, T. (2018). Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors. British Journal of Pharmacology, 175(14), 2911-2925. [More Information]
  • Soderhielm, P., Balle, T., Bak-Nyhus, S., Zhang, M., Hansen, K., Ahring, J., Jensen, A. (2018). Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochemical Pharmacology, 158, 339-358. [More Information]
  • Ahring, J., Bang, L., Jensen, M., Strobaek, D., Hartiadi, L., Collins, M., Absalom, N. (2016). A pharmacological assessment of agonists and modulators at (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) GABAA receptors: The challenge in comparing apples with oranges. Pharmacological Research, 111, 563-576. [More Information]
  • Lee, H., Absalom, N., Hanrahan, J., van Nieuwenhuijzen, P., Ahring, J., Chebib, M. (2016). A pharmacological characterization of GABA, THIP and DS2 at binary alpha4Beta3 and Beta3delta receptors: GABA activates Beta3delta receptors via the Beta3(+)delta(-) interface. Brain Research, 1644, 222-230. [More Information]
  • Gasiorek, A., Trattnig, S., Ahring, P., Kristiansen, U., Frolund, B., Frederiksen, K., Jensen, A. (2016). Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors. Biochemical Pharmacology, 110-111, 92-108. [More Information]
  • Hartiadi, L., Ahring, J., Chebib, M., Absalom, N. (2016). High and low GABA sensitivity alpha4beta2delta GABAA receptors are expressed in Xenopus laevis oocytes with divergent stoichiometries. Biochemical Pharmacology, 103, 98-108. [More Information]
  • Indurthi Venkata, D., Lewis, T., Ahring, J., Balle, T., Collins, M., Absalom, N. (2016). Ligand binding at the (alpha)4-(alpha)4 agonist-binding site of the (alpha)4(beta)2 nAChR triggers receptor activation through a pre-activated conformational state. PloS One, 11(8), 1-20. [More Information]
  • Munro, G., Christensen, J., Erichsen, H., Dyhring, T., Demnitz, J., Dam, E., Ahring, J. (2016). NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neuroscience and Therapeutics, 22(2), 135-145. [More Information]
  • Che Has, A., Absalom, N., van Nieuwenhuijzen, P., Clarkson, A., Ahring, J., Collins, M. (2016). Zolpidem is a potent stoichiometry-selective modulator of (alpha)1(beta)3 GABAA receptors: evidence of a novel benzodiazepine site in the (alpha)1-(alpha)1 interface. Scientific Reports, 6, 1-12. [More Information]
  • Shahsavar, A., Ahring, J., Olsen, J., Krintel, C., Kastrup, J., Balle, T., Gajhede, M. (2015). Acetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. Molecular Pharmacology, 88(4), 697-707. [More Information]
  • Ahring, J., Olsen, J., Nielsen, E., Peters, D., Pedersen, M., Rohde, L., Kastrup, J., Shahsavar, A., Indurthi Venkata, D., Chebib, M., Balle, T., et al (2015). Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface. Neuropharmacology, 92, 135-145. [More Information]
  • Garcia de Lucas, A., Ahring, J., Larsen, J., Rivera-Arconada, I., Lopez-Garcia, J., Mirza, N., Munro, G. (2015). GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085. Biochemical Pharmacology, 93(3), 370-379. [More Information]
  • Rasmussen, A., Strobaek, D., Dyhring, T., Jensen, M., Peters, D., Grunnet, M., Timmermann, D., Ahring, P. (2014). Biophysical and pharmacological characterization of alpha6-containing nicotinic acetylcholine receptors expressed in HEK293 cells. Brain Research, 1542, 1-11. [More Information]
  • Rasmussen, A., Strøbæk, D., Dyhring, T., Jensen, M., Peters, D., Grunnet, M., Timmermann, D., Ahring, J. (2014). Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells. Brain Research, 1542, 1-11. [More Information]
  • Olsen, J., Balle, T., Gajhede, M., Ahring, J., Kastrup, J. (2014). Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors. PloS One, 9(3), 1-8. [More Information]
  • Olsen, J., Ahring, J., Kastrup, J., Gajhede, M., Balle, T. (2014). Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine Receptors. Journal of Biological Chemistry, 289(36), 24911-24921. [More Information]
  • Dalby-Brown, W., Jessen, C., Hougaard, C., Jensen, M., Jacobsen, T., Sandager-Nielson, K., Erichsen, H., Grunnet, M., Ahring, P., et al (2013). Characterization of a novel high-potency positive modulator of Kv7 channels. European Journal of Pharmacology, 709, 52-63. [More Information]
  • Harpsøe, K., Hald, H., Timmermann, D., Jensen, M., Dyhring, T., Nielsen, E., Peters, D., Balle, T., Gajhede, M., Kastrup, J., et al (2013). Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288(4), 2559-2570. [More Information]
  • Ussing, C., Hansen, C., Petersen, J., Jensen, A., Rohde, L., Ahring, P., Nielsen, E., Kastrup, J., Gajhede, M., Frølund, B., Balle, T. (2013). Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists. Journal of Medicinal Chemistry, 56(3), 940-951. [More Information]
  • Olsen, J., Kastrup, J., Peters, D., Gajhede, M., Balle, T., Ahring, J. (2013). Two Distinct Allosteric Binding Sites at a4B2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors. Journal of Biological Chemistry, 288(50), 35997-36006. [More Information]
  • Grupe, M., Jensen, A., Ahring, P., Christensen, J., Grunnet, M. (2013). Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (alpha4)3(beta2)2 nicotinic ACh receptors. British Journal of Pharmacology, 168(8), 2000-2010. [More Information]
  • Trattnig, S., Harpsøe, K., Thygesen, S., Rahr, L., Ahring, P., Balle, T., Jensen, A. (2012). Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: Inhibition and potentiation of cys-loop receptor signaling through a conserved transmembrane intersubunit site. Journal of Biological Chemistry, 287(30), 25241-25254. [More Information]
  • Rohde, L., Ahring, P., Jensen, M., Nielsen, E., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Kastrup, J., et al (2012). Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine (alpha)4(beta)2 Receptors:Unique role of halogen bonding revealed. Journal of Biological Chemistry, 287(6), 4248-4259. [More Information]
  • Venskutonyte, R., Frydenvang, K., Hald, H., Ceravalls de Rabassa, A., Gajhede, M., Ahring, P., Kastrup, J. (2012). Kainate induces various domain closures in AMPA and kainate receptors. Neurochemistry International, 61(4), 536-545. [More Information]
  • Harpsøe, K., Ahring, P., Jensen, M., Christensen, J., Peters, D., Balle, T. (2011). Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors. Journal of Neuroscience, 31(30), 10759-10766. [More Information]
  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsøe, K., Liljefors, T., Balle, T. (2009). Complementary Three-Dimensional Quantitative Structure-Activity Relationship Modeling of Binding Affinity and Functional Potency: A Study on alpha4beta2 Nicotinic Ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]
  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsae, K., Liljefors, T., Balle, T. (2009). Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]
  • Audouze, K., Nielsen, E., Olsen, G., Ahring, P., Jørgensen, T., Peters, D., Liljefors, T., Balle, T. (2006). New Ligands with Affinity for the alpha4beta2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling. Journal of Medicinal Chemistry, 49, 3159-3171. [More Information]

2019

  • Absalom, N., Ahring, J., Liao, V., Balle, T., Jiang, T., Anderson, L., Arnold, J., McGregor, I., Bowen, M., Chebib, M. (2019). Functional genomics of epilepsy-associated mutations in the GABAa receptor subunits reveal that one mutation impairs function and two are catastrophic. Journal of Biological Chemistry. [More Information]
  • Indurthi Venkata, D., Qudah, T., Liao, V., Ahring, J., Lewis, T., Balle, T., Collins, M., Absalom, N. (2019). Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry. Pharmacological Research, 139, 215-227. [More Information]

2018

  • Ahring, J., Liao, V., Balle, T. (2018). Concatenated nicotinic acetylcholine receptors: A gift or a curse? Journal of General Physiology, 150(3), 453-473. [More Information]
  • Kowal, N., Ahring, J., Liao, V., Indurti, D., Harvey, B., O'Connor, S., Collins, M., Olafsdottir, E., Balle, T. (2018). Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors. British Journal of Pharmacology, 175(14), 2911-2925. [More Information]
  • Soderhielm, P., Balle, T., Bak-Nyhus, S., Zhang, M., Hansen, K., Ahring, J., Jensen, A. (2018). Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochemical Pharmacology, 158, 339-358. [More Information]

2016

  • Ahring, J., Bang, L., Jensen, M., Strobaek, D., Hartiadi, L., Collins, M., Absalom, N. (2016). A pharmacological assessment of agonists and modulators at (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) GABAA receptors: The challenge in comparing apples with oranges. Pharmacological Research, 111, 563-576. [More Information]
  • Lee, H., Absalom, N., Hanrahan, J., van Nieuwenhuijzen, P., Ahring, J., Chebib, M. (2016). A pharmacological characterization of GABA, THIP and DS2 at binary alpha4Beta3 and Beta3delta receptors: GABA activates Beta3delta receptors via the Beta3(+)delta(-) interface. Brain Research, 1644, 222-230. [More Information]
  • Gasiorek, A., Trattnig, S., Ahring, P., Kristiansen, U., Frolund, B., Frederiksen, K., Jensen, A. (2016). Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors. Biochemical Pharmacology, 110-111, 92-108. [More Information]
  • Hartiadi, L., Ahring, J., Chebib, M., Absalom, N. (2016). High and low GABA sensitivity alpha4beta2delta GABAA receptors are expressed in Xenopus laevis oocytes with divergent stoichiometries. Biochemical Pharmacology, 103, 98-108. [More Information]
  • Indurthi Venkata, D., Lewis, T., Ahring, J., Balle, T., Collins, M., Absalom, N. (2016). Ligand binding at the (alpha)4-(alpha)4 agonist-binding site of the (alpha)4(beta)2 nAChR triggers receptor activation through a pre-activated conformational state. PloS One, 11(8), 1-20. [More Information]
  • Munro, G., Christensen, J., Erichsen, H., Dyhring, T., Demnitz, J., Dam, E., Ahring, J. (2016). NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neuroscience and Therapeutics, 22(2), 135-145. [More Information]
  • Che Has, A., Absalom, N., van Nieuwenhuijzen, P., Clarkson, A., Ahring, J., Collins, M. (2016). Zolpidem is a potent stoichiometry-selective modulator of (alpha)1(beta)3 GABAA receptors: evidence of a novel benzodiazepine site in the (alpha)1-(alpha)1 interface. Scientific Reports, 6, 1-12. [More Information]

2015

  • Shahsavar, A., Ahring, J., Olsen, J., Krintel, C., Kastrup, J., Balle, T., Gajhede, M. (2015). Acetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. Molecular Pharmacology, 88(4), 697-707. [More Information]
  • Ahring, J., Olsen, J., Nielsen, E., Peters, D., Pedersen, M., Rohde, L., Kastrup, J., Shahsavar, A., Indurthi Venkata, D., Chebib, M., Balle, T., et al (2015). Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface. Neuropharmacology, 92, 135-145. [More Information]
  • Garcia de Lucas, A., Ahring, J., Larsen, J., Rivera-Arconada, I., Lopez-Garcia, J., Mirza, N., Munro, G. (2015). GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085. Biochemical Pharmacology, 93(3), 370-379. [More Information]

2014

  • Rasmussen, A., Strobaek, D., Dyhring, T., Jensen, M., Peters, D., Grunnet, M., Timmermann, D., Ahring, P. (2014). Biophysical and pharmacological characterization of alpha6-containing nicotinic acetylcholine receptors expressed in HEK293 cells. Brain Research, 1542, 1-11. [More Information]
  • Rasmussen, A., Strøbæk, D., Dyhring, T., Jensen, M., Peters, D., Grunnet, M., Timmermann, D., Ahring, J. (2014). Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells. Brain Research, 1542, 1-11. [More Information]
  • Olsen, J., Balle, T., Gajhede, M., Ahring, J., Kastrup, J. (2014). Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors. PloS One, 9(3), 1-8. [More Information]
  • Olsen, J., Ahring, J., Kastrup, J., Gajhede, M., Balle, T. (2014). Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine Receptors. Journal of Biological Chemistry, 289(36), 24911-24921. [More Information]

2013

  • Dalby-Brown, W., Jessen, C., Hougaard, C., Jensen, M., Jacobsen, T., Sandager-Nielson, K., Erichsen, H., Grunnet, M., Ahring, P., et al (2013). Characterization of a novel high-potency positive modulator of Kv7 channels. European Journal of Pharmacology, 709, 52-63. [More Information]
  • Harpsøe, K., Hald, H., Timmermann, D., Jensen, M., Dyhring, T., Nielsen, E., Peters, D., Balle, T., Gajhede, M., Kastrup, J., et al (2013). Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288(4), 2559-2570. [More Information]
  • Ussing, C., Hansen, C., Petersen, J., Jensen, A., Rohde, L., Ahring, P., Nielsen, E., Kastrup, J., Gajhede, M., Frølund, B., Balle, T. (2013). Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists. Journal of Medicinal Chemistry, 56(3), 940-951. [More Information]
  • Olsen, J., Kastrup, J., Peters, D., Gajhede, M., Balle, T., Ahring, J. (2013). Two Distinct Allosteric Binding Sites at a4B2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors. Journal of Biological Chemistry, 288(50), 35997-36006. [More Information]
  • Grupe, M., Jensen, A., Ahring, P., Christensen, J., Grunnet, M. (2013). Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (alpha4)3(beta2)2 nicotinic ACh receptors. British Journal of Pharmacology, 168(8), 2000-2010. [More Information]

2012

  • Trattnig, S., Harpsøe, K., Thygesen, S., Rahr, L., Ahring, P., Balle, T., Jensen, A. (2012). Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: Inhibition and potentiation of cys-loop receptor signaling through a conserved transmembrane intersubunit site. Journal of Biological Chemistry, 287(30), 25241-25254. [More Information]
  • Rohde, L., Ahring, P., Jensen, M., Nielsen, E., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Kastrup, J., et al (2012). Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine (alpha)4(beta)2 Receptors:Unique role of halogen bonding revealed. Journal of Biological Chemistry, 287(6), 4248-4259. [More Information]
  • Venskutonyte, R., Frydenvang, K., Hald, H., Ceravalls de Rabassa, A., Gajhede, M., Ahring, P., Kastrup, J. (2012). Kainate induces various domain closures in AMPA and kainate receptors. Neurochemistry International, 61(4), 536-545. [More Information]

2011

  • Harpsøe, K., Ahring, P., Jensen, M., Christensen, J., Peters, D., Balle, T. (2011). Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors. Journal of Neuroscience, 31(30), 10759-10766. [More Information]

2009

  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsøe, K., Liljefors, T., Balle, T. (2009). Complementary Three-Dimensional Quantitative Structure-Activity Relationship Modeling of Binding Affinity and Functional Potency: A Study on alpha4beta2 Nicotinic Ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]
  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsae, K., Liljefors, T., Balle, T. (2009). Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]

2006

  • Audouze, K., Nielsen, E., Olsen, G., Ahring, P., Jørgensen, T., Peters, D., Liljefors, T., Balle, T. (2006). New Ligands with Affinity for the alpha4beta2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling. Journal of Medicinal Chemistry, 49, 3159-3171. [More Information]

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