Dr Tony Zhou

BEng (Shenyang); MSc (Singapore); PhD (Monash)
NHMRC Early Career Fellow

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 93513020

Biographical details

Dr Qi (Tony) Zhou graduated from Shenyang Pharmaceutical University (BEng in Pharmaceutics), National University of Singapore (MSc in Pharmacy), and Monash University (PhD in Pharmacy). He has previously worked as a scientist at Shenzhen Neptunus Pharmaceuticals, China (2001-2003) and as a post-doctoral research fellow at Monash University (2011-2012).

Research interests

  • Novel particle engineering to generate or modify inhalable drug powders
  • Inhaled dry powder formulation of antibiotics for respiratory infections
  • Nano-technology for inhalation therapy
  • Inhaler device design

Awards and honours

  • Australian Endeavor Fellowship, Australian Government (2014)
  • NHMRC Early Career Fellowship (2013)
  • Outstanding Graduate Student Research Award in Pharmaceutical Technologies, American Association of Pharmaceutical Scientists (2012)
  • Postgraduate Publications Award, Monash University (2011)
  • Excipients Graduate Student Award, The International Pharmaceutical Excipients Council of the Americas Foundation (2010)

Keywords

Pulmonary drug delivery; Nanotechnology; Inhaled antibiotics; Inhaler device design; Aerosol technology

Selected grants

2014

  • Novel inhalation formulation of colistin and combination therapy against Gram-negative 'superbugs'; Chan H, Zhou Q, Li J, Fouras A; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Inhaled antibiotic aerosols for respiratory infection treatment; Zhou Q; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Journals

  • Chan, J., Wong, J., Zhou, Q., Leung, S., Chan, H. (2014). Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech, 15(4), 882-897. [More Information]
  • Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, H. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information]
  • Zhou, Q., Gegenbach, T., Denman, J., Yu, H., Li, J., Chan, H. (2014). Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection. The AAPS Journal, 16(1), 37-47. [More Information]
  • Zhou, Q., Morton, D., Yu, H., Jacob, J., Wang, J., Li, J., Chan, H. (2013). Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. Journal of Pharmaceutical Sciences, 102(10), 3736-3747. [More Information]
  • Zhou, Q., Tong, Z., Tang, P., Citterio, M., Yang, R., Chan, H. (2013). Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler - A Case Study on Aerolizer® Foradile®. The AAPS Journal, 15(2), 511-522. [More Information]
  • Zhou, Q., Qu, L., Gegenbach, T., Larson, I., Stewart, P., Morton, D. (2013). Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. AAPS PharmSciTech, 14(1), 38-44. [More Information]
  • Zhou, Q., Morton, D. (2012). Drug-lactose binding aspects in adhesive mixtures: controlling performance in dry powder inhaler formulations by altering lactose carrier surfaces. Advanced Drug Delivery Reviews, 64(3), 275-284. [More Information]
  • Rajkhowa, R., Zhou, Q., Tsuzuki, T., Morton, D., Wang, X. (2012). Ultrafine wool powders and their bulk properties. Powder Technology, 224, 183-188. [More Information]
  • Zhou, Q., Denman, J., Gegenbach, T., Das, S., Qu, L., Zhang, H., Larson, I., Stewart, P., Morton, D. (2011). Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach. Journal of Pharmaceutical Sciences, 100(8), 3421-3430. [More Information]
  • Zhou, Q., Qu, L., Larson, I., Stewart, P., Morton, D. (2011). Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: a model cohesive pharmaceutical powder. Powder Technology, 207(1-3), 414-421. [More Information]
  • Zhou, Q., Qu, L., Gegenbach, T., Denman, J., Larson, I., Stewart, P., Morton, D. (2011). Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. International Journal of Pharmaceutics, 413(1), 36-43. [More Information]
  • Das, S., Zhou, Q., Morton, D., Larson, I., Stewart, P. (2011). Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. European Journal of Pharmaceutical Sciences, 43(4), 325-333. [More Information]
  • Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Effect of host particle size on the modification of powder flow behaviours of lactose monohydrate following dry coating. Dairy Science and Technology, 90, 237-251. [More Information]
  • Zhou, Q., Qu, L., Larson, I., Stewart, P., Morton, D. (2010). Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach. International Journal of Pharmaceutics, 394(1), 50-59. [More Information]
  • Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. Journal of Pharmaceutical Sciences, 99(2), 969-981. [More Information]
  • Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders. European Journal of Pharmaceutical Sciences, 40(5), 412-421. [More Information]
  • Zhu, K., Tan, R., Ng, W., Shen, S., Zhou, Q., Heng, P. (2008). Analysis of the influence of relative humidity on the moisture sorption of particles and the aerosolization process in a dry powder inhaler. Journal of Aerosol Science, 39, 510-524. [More Information]
  • Chan, L., Zhou, Q., Heng, P. (2007). Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers. Journal of Drug Delivery Science and Technology, 17(3), 217-222.
  • Karande, A., Zhou, Q., Chan, L., Heng, P., Liew, C. (2007). Scanning Probe Microscopy for Surface Roughness Characterization of Lactose Carriers Used in Dry Powder Inhalation Therapy. Journal of Scanning Probe Microscopy, 2(1), 5-9. [More Information]

Conferences

  • Zhou, Q., Tong, Z., Tang, P., Yang, R., Chan, H. (2013). CFD analysis of the aerosolization of carrier-based dry powder inhaler formulations. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]
  • Zhou, Q., Li, Q., Stewart, P., Morton, D. (2011). Nano-scale surface engineering via mechanical dry coating for improving flow, fluidization and aerosolization of fine cohesive powders. Particulate Processes in the Pharmaceutical Industry III, Goldcoast, Australia.
  • Zhou, Q., Qu, L., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Effect of surface modification via mechanical dry coating on the aerosolization of a range of milled drug powders. LACTOSE as a Carrier for Inhalation Products.
  • Zhou, Q., Qu, L., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Effect of surface modification via mechanical dry coating on the flowability and fluidization of a range of milled lactose powders. LACTOSE as a Carrier for Inhalation Products.
  • Zhou, Q., Morton, D., Qu, L., Armstrong, B., Stewart, P., Larson, I. (2010). Improving the flow and dispersion properties of several micronized drug powders using an innovative dry coating approach. World Congress of Particle Technology 6, Nuremburg, Germany.
  • Zhou, Q., Li, Q., Denman, J., Gengenbach, T., Stewart, P., Morton, D. (2010). Investigating the effect of nano-scale surface coating on the aerosolization of micronized drug powders. Drug Delivery to Lungs 21 (DDL).
  • Morton, D., Freeman, G., Zhou, Q., Stewart, P., Armstrong, B., Freeman, T., Larson, I. (2010). The influence of dry powder coating methods, including mechanofusion, on the flow properties of inhalable grades of lactose monohydrate. World Congress of Particle Technology 6, Nuremburg, Germany.
  • Das, S., Morton, D., Zhou, Q., Stewart, P. (2010). Understanding the surface energy changes of mechanofused pharmaceutical powders. World Congress of Particle Technology 6, Nuremburg, Germany.
  • Zhou, Q., Li, Q., Denman, J., Gengenbach, T., Stewart, P., Morton, D. (2010). Understanding the influence of surface modification via mechanical dry coating on the flowability of a cohesive fine lactose powder. Drug Delivery to Lungs 21 (DDL).
  • Morton, D., Stewart, P., Zhou, Q. (2009). Improving Aerosol Performance of Model Drugs via Mechanical Surface Modification. Drug Delivery to Lungs 20 (DDL), Edinburgh, UK.
  • Armstrong, B., Zhou, Q., Stewart, P., Morton, D. (2009). Improving Flow Properties of Fine Particles by Mechanical Surface Modification. The 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS), Brisbane, Australia.
  • Zhou, Q., Armstrong, B., Stewart, P., Morton, D. (2009). Improving Flowability, Fluidization and Dispersion Behaviours of Fine Lactose Powders by Mechanical Surface Modification. Drug Delivery to Lungs 20 (DDL), Edinburgh, UK.
  • Morton, D., Zhou, Q., Armstrong, B., Larson, I., Stewart, P. (2009). Surface engineering to improve the flowability and fluidization of a cohesive powder. CHEMECA 2009, Australia: Engineers Australia.
  • Morton, D., Stewart, P., Zhou, Q. (2008). Investigating the Flow Modification of Fine Lactose Carrier Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Zhou, Q., Armstrong, B., Morton, D., Stewart, P. (2008). Investigation of Fundamental Powder Flow Properties of Fine Lactose Particles Following Mechanical Surface Modification. Drug Delivery to Lungs 19 (DDL), Edinburgh, UK.

2014

  • Chan, J., Wong, J., Zhou, Q., Leung, S., Chan, H. (2014). Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech, 15(4), 882-897. [More Information]
  • Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, H. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information]
  • Zhou, Q., Gegenbach, T., Denman, J., Yu, H., Li, J., Chan, H. (2014). Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection. The AAPS Journal, 16(1), 37-47. [More Information]

2013

  • Zhou, Q., Tong, Z., Tang, P., Yang, R., Chan, H. (2013). CFD analysis of the aerosolization of carrier-based dry powder inhaler formulations. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics (AIP). [More Information]
  • Zhou, Q., Morton, D., Yu, H., Jacob, J., Wang, J., Li, J., Chan, H. (2013). Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. Journal of Pharmaceutical Sciences, 102(10), 3736-3747. [More Information]
  • Zhou, Q., Tong, Z., Tang, P., Citterio, M., Yang, R., Chan, H. (2013). Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler - A Case Study on Aerolizer® Foradile®. The AAPS Journal, 15(2), 511-522. [More Information]
  • Zhou, Q., Qu, L., Gegenbach, T., Larson, I., Stewart, P., Morton, D. (2013). Effect of surface coating with magnesium stearate via mechanical dry powder coating approach on the aerosol performance of micronized drug powders from dry powder inhalers. AAPS PharmSciTech, 14(1), 38-44. [More Information]

2012

  • Zhou, Q., Morton, D. (2012). Drug-lactose binding aspects in adhesive mixtures: controlling performance in dry powder inhaler formulations by altering lactose carrier surfaces. Advanced Drug Delivery Reviews, 64(3), 275-284. [More Information]
  • Rajkhowa, R., Zhou, Q., Tsuzuki, T., Morton, D., Wang, X. (2012). Ultrafine wool powders and their bulk properties. Powder Technology, 224, 183-188. [More Information]

2011

  • Zhou, Q., Denman, J., Gegenbach, T., Das, S., Qu, L., Zhang, H., Larson, I., Stewart, P., Morton, D. (2011). Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach. Journal of Pharmaceutical Sciences, 100(8), 3421-3430. [More Information]
  • Zhou, Q., Qu, L., Larson, I., Stewart, P., Morton, D. (2011). Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: a model cohesive pharmaceutical powder. Powder Technology, 207(1-3), 414-421. [More Information]
  • Zhou, Q., Qu, L., Gegenbach, T., Denman, J., Larson, I., Stewart, P., Morton, D. (2011). Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. International Journal of Pharmaceutics, 413(1), 36-43. [More Information]
  • Zhou, Q., Li, Q., Stewart, P., Morton, D. (2011). Nano-scale surface engineering via mechanical dry coating for improving flow, fluidization and aerosolization of fine cohesive powders. Particulate Processes in the Pharmaceutical Industry III, Goldcoast, Australia.
  • Das, S., Zhou, Q., Morton, D., Larson, I., Stewart, P. (2011). Use of surface energy distributions by inverse gas chromatography to understand mechanofusion processing and functionality of lactose coated with magnesium stearate. European Journal of Pharmaceutical Sciences, 43(4), 325-333. [More Information]

2010

  • Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Effect of host particle size on the modification of powder flow behaviours of lactose monohydrate following dry coating. Dairy Science and Technology, 90, 237-251. [More Information]
  • Zhou, Q., Qu, L., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Effect of surface modification via mechanical dry coating on the aerosolization of a range of milled drug powders. LACTOSE as a Carrier for Inhalation Products.
  • Zhou, Q., Qu, L., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Effect of surface modification via mechanical dry coating on the flowability and fluidization of a range of milled lactose powders. LACTOSE as a Carrier for Inhalation Products.
  • Zhou, Q., Qu, L., Larson, I., Stewart, P., Morton, D. (2010). Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach. International Journal of Pharmaceutics, 394(1), 50-59. [More Information]
  • Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating. Journal of Pharmaceutical Sciences, 99(2), 969-981. [More Information]
  • Zhou, Q., Morton, D., Qu, L., Armstrong, B., Stewart, P., Larson, I. (2010). Improving the flow and dispersion properties of several micronized drug powders using an innovative dry coating approach. World Congress of Particle Technology 6, Nuremburg, Germany.
  • Zhou, Q., Li, Q., Denman, J., Gengenbach, T., Stewart, P., Morton, D. (2010). Investigating the effect of nano-scale surface coating on the aerosolization of micronized drug powders. Drug Delivery to Lungs 21 (DDL).
  • Morton, D., Freeman, G., Zhou, Q., Stewart, P., Armstrong, B., Freeman, T., Larson, I. (2010). The influence of dry powder coating methods, including mechanofusion, on the flow properties of inhalable grades of lactose monohydrate. World Congress of Particle Technology 6, Nuremburg, Germany.
  • Das, S., Morton, D., Zhou, Q., Stewart, P. (2010). Understanding the surface energy changes of mechanofused pharmaceutical powders. World Congress of Particle Technology 6, Nuremburg, Germany.
  • Zhou, Q., Armstrong, B., Larson, I., Stewart, P., Morton, D. (2010). Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders. European Journal of Pharmaceutical Sciences, 40(5), 412-421. [More Information]
  • Zhou, Q., Li, Q., Denman, J., Gengenbach, T., Stewart, P., Morton, D. (2010). Understanding the influence of surface modification via mechanical dry coating on the flowability of a cohesive fine lactose powder. Drug Delivery to Lungs 21 (DDL).

2009

  • Morton, D., Stewart, P., Zhou, Q. (2009). Improving Aerosol Performance of Model Drugs via Mechanical Surface Modification. Drug Delivery to Lungs 20 (DDL), Edinburgh, UK.
  • Armstrong, B., Zhou, Q., Stewart, P., Morton, D. (2009). Improving Flow Properties of Fine Particles by Mechanical Surface Modification. The 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS), Brisbane, Australia.
  • Zhou, Q., Armstrong, B., Stewart, P., Morton, D. (2009). Improving Flowability, Fluidization and Dispersion Behaviours of Fine Lactose Powders by Mechanical Surface Modification. Drug Delivery to Lungs 20 (DDL), Edinburgh, UK.
  • Morton, D., Zhou, Q., Armstrong, B., Larson, I., Stewart, P. (2009). Surface engineering to improve the flowability and fluidization of a cohesive powder. CHEMECA 2009, Australia: Engineers Australia.

2008

  • Zhu, K., Tan, R., Ng, W., Shen, S., Zhou, Q., Heng, P. (2008). Analysis of the influence of relative humidity on the moisture sorption of particles and the aerosolization process in a dry powder inhaler. Journal of Aerosol Science, 39, 510-524. [More Information]
  • Morton, D., Stewart, P., Zhou, Q. (2008). Investigating the Flow Modification of Fine Lactose Carrier Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Zhou, Q., Armstrong, B., Morton, D., Stewart, P. (2008). Investigation of Fundamental Powder Flow Properties of Fine Lactose Particles Following Mechanical Surface Modification. Drug Delivery to Lungs 19 (DDL), Edinburgh, UK.

2007

  • Chan, L., Zhou, Q., Heng, P. (2007). Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers. Journal of Drug Delivery Science and Technology, 17(3), 217-222.
  • Karande, A., Zhou, Q., Chan, L., Heng, P., Liew, C. (2007). Scanning Probe Microscopy for Surface Roughness Characterization of Lactose Carriers Used in Dry Powder Inhalation Therapy. Journal of Scanning Probe Microscopy, 2(1), 5-9. [More Information]

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