Dr Thomas Balle

MSc Eng, PhD
Senior Lecturer, Pharmaceutical Sciences

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 (0)2 9036 7035

Biographical details

Dr Thomas Balle was previously employed as an Associate Professor at the University of Copenhagen, Denmark where he was a project leader of the Cys-loop receptor project which takes a structural approach to ligand gated ion channel drug discovery. His most recent work includes establishing a pipeline for crystallisation and structure determination of acetylcholine binding proteins as structural surrogates for nicotinic acetylcholine a4b2 receptors and establishment of a computational chemistry platform being used in collaboration with academic and biotech collaborators in discovery projects identifying novel modulators of ligand gated ion channels.

Thomas originally trained as medicinal chemist and did his PhD in an industrial setting at the Danish pharmaceutical company H. Lundbeck A/S. Here Thomas was involved in design and synthesis of CNS drugs and in particular in identification and development of biomarkers for noninvasive brain imaging using positron emission tomography.

Research interests

  • Computational and medicinal chemistry applied to ligand gated ion channels
  • Structure and function of ligand gated ion channels
  • Structure, ligand and fragment based drug design
  • Development of radioligands for noninvasive brain imaging by positron emission tomography

Keywords

Drug design; Mental health

Selected grants

2014

  • IEF: Thomas Balle - Pharmacy- travel to Copenhagen to meet new linkage partner; Balle T; DVC Research/Industry Engagement Funds.
  • New positive allosteric modulators of nicotinic acetylcholine receptors for treatment of cognitive impairment in ADHD; Balle T, Collins M, McLeod M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stereotaxic frame; Arnold J, Christie M, Collins M, Sawatari A, Leamey C, Stone J, van Nieuwenhuijzen P, Chan-Ling T, Balle T; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Mapping of a new allosteric binding site in nicotinic receptors; Balle T, Ahring J; IMK Almene Fond/Research Support.

Selected publications

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Journals

  • Petersen, J., Bergmann, R., Krogsgarrd-Larsen, P., Balle, T., Frolund, B. (2014). Probing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres. Neurochemical Research, 39(6), 1005-1015. [More Information]
  • Bergmann, R., Kongsbak, K., Sørensen, P., Sander, T., Balle, T. (2013). A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites. PLoS One, 8(1), 1-13. [More Information]
  • Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Collins, M. (2013). Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. Journal of Biological Chemistry, 288(37), 26521-26532. [More Information]
  • Crestey, F., Jensen, A., Borch, M., Andreasen, J., Andersen, J., Balle, T., Kristensen, J. (2013). Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists. Journal of Medicinal Chemistry, 56(23), 9673-9682. [More Information]
  • Jorgensen, M., Jorgensen, P., Christoffersen, C., Jensen, K., Balle, T., Bang-Andersen, B. (2013). Discovery of novel a1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands. Bioorganic and Medicinal Chemistry, 21(1), 196-204. [More Information]
  • Krall, J., Jensen, C., Sorensen, T., Nielsen, B., Jensen, A., Sander, T., Balle, T., Frolund, B. (2013). Exploring the Orthosteric Binding Site of the y-Aminobutyric Acid Type A Receptor Using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-Imidazolyl Substituted: Design, Synthesis, and Pharmacological Evaluation. Journal of Medicinal Chemistry, 56(16), 6536-6540. [More Information]
  • Harpsøe, K., Hald, H., Timmermann, D., Jensen, M., Dyhring, T., Nielsen, E., Peters, D., Balle, T., Gajhede, M., Kastrup, J., et al (2013). Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. The Journal of Biological Chemistry, 288(4), 2559-2570. [More Information]
  • Eildal, J., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, K., Jemth, P. (2013). Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations. Journal of the American Chemical Society, 135(35), 12998-13007. [More Information]
  • Risgaard, R., Ettrup, A., Balle, T., Dyssegaard, A., Hansen, H., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., et al (2013). Radiolabelling and PET brain imaging of the (alpha)-adrenoceptor antagonist Lu AE43936. Nuclear Medicine and Biology, 40(1), 135-140. [More Information]
  • Airaksinen, A., Finnema, S., Balle, T., Varnas, K., Bang-Andersen, B., Gulyas, B., Farde, L., Halldin, C. (2013). Radiosynthesis and evaluation of a new a1-adrenoceptor antagonists as PET radioligands for brain imaging. Nuclear Medicine and Biology, 40(6), 747-754. [More Information]
  • Petersen, J., Bergmann, R., Moller, H., Jogensen, C., Nielsen, B., Kehler, J., Frydenvang, K., Kristensen, J., Balle, T., Jensen, A., et al (2013). Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as I?-aminobutyric acid(a) receptor agonists. Journal of Medicinal Chemistry, 56(3), 993-1006. [More Information]
  • Ussing, C., Hansen, C., Petersen, J., Jensen, A., Rohde, L., Ahring, P., Nielsen, E., Kastrup, J., Gajhede, M., Frølund, B., Balle, T. (2013). Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists. Journal of Medicinal Chemistry, 56(3), 940-951. [More Information]
  • Olsen, J., Kastrup, J., Peters, D., Gajhede, M., Balle, T., Ahring, J. (2013). Two Distinct Allosteric Binding Sites at a4B2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors. Journal of Biological Chemistry, 288(50), 35997-36006. [More Information]
  • Tosco, P., Balle, T. (2012). A 3D-QSAR-Driven Approach to Binding Mode and Affinity Prediction. Journal of Chemical Information and Modeling, 52(2), 302-307. [More Information]
  • Ambrus, J., Halliday, J., Kanizaj, N., Absalom, N., Harpsøe, K., Balle, T., Collins, M., McLeod, M. (2012). Covalent attachment of antagonists to the (alpha)7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chemical Communications, 48(53), 6699-6701. [More Information]
  • Shahsavar, A., Kastrup, J., Nielsen, E., Kristensen, J., Gajhede, M., Balle, T. (2012). Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHIE suggests a unique mode of antagonism. PLoS One, 7(8), e40757. [More Information]
  • Trattnig, S., Harpsøe, K., Thygesen, S., Rahr, L., Ahring, P., Balle, T., Jensen, A. (2012). Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors. Journal of Biological Chemistry, 287(30), 25241-25254. [More Information]
  • Rohde, L., Ahring, P., Jensen, M., Nielsen, E., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Balle, T., et al (2012). Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine 42 Receptors. Journal of Biological Chemistry, 287(6), 4248-4259. [More Information]
  • Isberg, V., Balle, T., Sander, T., Jørgensen, F., Gloriam, D. (2011). G protein-and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations. Journal of Chemical Information and Modeling, 51(2), 315-325. [More Information]
  • Sander, T., Frølund, B., Bruun, A., Ivanov, I., McCammon, J., Balle, T. (2011). New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data. Proteins: Structure, Function, and Bioinformatics, 79, 1458-1477. [More Information]
  • Tosco, P., Balle, T., Shiri, F. (2011). Open3DALIGN: an open-source software aimed at unsupervised ligand alignment. Journal of Computer - Aided Molecular Design, 25(8), 777-783. [More Information]
  • Tosco, P., Balle, T. (2011). Open3DQSAR: a new open-source software aimed at high-throughput chemometric analysis of molecular interaction fields. Journal of Molecular Modeling, 17, 201-208. [More Information]
  • Tosco, P., Balle, T., Shiri, F. (2011). SDF2XYZ2SDF: how to exploit TINKER power in cheminformatics projects. Journal of Molecular Modeling, 17(11), 3021-3023. [More Information]
  • Harpsøe, K., Ahring, P., Christensen, J., Jensen, M., Peters, D., Balle, T. (2011). Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors. The Journal of Neuroscience, 31(30), 10759-10766. [More Information]
  • Sander, T., Bruun, A., Balle, T. (2010). Docking to flexible nicotinic acetylcholine receptors: A validation study using the acetylcholine binding protein. Journal of Molecular Graphics and Modelling, 29(3), 415-424. [More Information]
  • Kristensen, J., Püschl, A., Jensen, M., Risgaard, R., Christoffersen, C., Bang-Andersen, B., Balle, T. (2010). Exploring the Neuroleptic Substituent in Octoclothepin: Potential Ligands for Positron Emission Tomography with Subnanomolar Affinity for alpha1-Adrenoceptors. Journal of Medicinal Chemistry, 53(19), 7021-7034. [More Information]
  • Jensen, A., Bergmann, M., Sander, T., Balle, T. (2010). Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors. Journal of Biological Chemistry, 285, 10141-10153. [More Information]
  • Moller, H., Sander, T., Kristensen, J., Nielsen, B., Krall, J., Bergmann, M., Christiansen, B., Balle, T., Jensen, A., Frølund, B. (2010). Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. Journal of Medicinal Chemistry, 53(8), 3417-3421. [More Information]
  • Hansen, C., Jensen, A., Balle, T., Bitsch-Jensen, K., Hassan, M., Liljefors, T., Frølund, B. (2009). Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists—Structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC). Bioorganic & Medicinal Chemistry Letters, 19(1), 87-91. [More Information]
  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsøe, K., Liljefors, T., Balle, T. (2009). Complementary Three-Dimensional Quantitative Structure-Activity Relationship Modeling of Binding Affinity and Functional Potency: A Study on alpha4beta2 Nicotinic Ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]
  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsae, K., Liljefors, T., Balle, T. (2009). Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]
  • Armishaw, C., Jensen, A., Balle, T., Clark, R., Harpsae, K., Skonberg, C., Liljefors, T., Stramgaard, K. (2009). Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. The Journal of Biological Chemistry, 284(14), 9498-9512. [More Information]
  • Armishaw, C., Jensen, A., Balle, T., Clark, R., Harpsøe, K., Skonberg, C., Liljefors, T., Stromgaard, K. (2009). Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. Journal of Biological Chemistry, 284, 9498-9512.
  • Hansen, C., Jensen, A., Christensen, J., Balle, T., Liljefors, T., Frølund, B. (2008). Novel Acetylcholine and Carbamoylcholine Analogues: Development of a Functionally Selective alpha4beta2 Nicotinic Acetylcholine Receptor Agonist. Journal of Medicinal Chemistry, 51(23), 7380-7395. [More Information]
  • Harpsøe, K., Liljefors, T., Balle, T. (2008). Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis. Journal of Molecular Graphics and Modelling, 26(5), 874-883. [More Information]
  • Sander, T., Liljefors, T., Balle, T. (2008). Prediction of the receptor conformation for iGluR2 agonist binding: QM/MM docking to an extensive conformational ensemble generated using normal mode analysis. Journal of Molecular Graphics and Modelling, 26(8), 1259-1268. [More Information]
  • Audouze, K., Nielsen, E., Olsen, G., Ahring, P., Jørgensen, T., Peters, D., Liljefors, T., Balle, T. (2006). New Ligands with Affinity for the alpha4beta2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling. Journal of Medicinal Chemistry, 49, 3159-3171. [More Information]
  • Balle, T., Begtrup, M., Jaroszewski, J., Liljefors, T., Norrby, P. (2006). Regioselectivity in lithiation of 1-methylpyrazole: experimental, density functional theory and multinuclear NMR study. Organic and Biomolecular Chemistry, 4, 1261-1267. [More Information]
  • Balle, T., Halldin, C., Andersen, L., Alifrangis, L., Badolo, L., Jensen, K., Chou, Y., Andersen, K., Perregaard, J., Farde, L. (2004). New Alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey. Nuclear Medicine and Biology, 31, 327-336.
  • Balle, T., Andersen, K., Søby, K., Liljefors, T. (2003). Alpha(1) adrenoceptor subtype selectivity. 3D-QSAR models for a new class of alpha(1) adrenoceptor antagonists derived from the novel antipsychotic sertindole. Journal of Molecular Graphics and Modelling, 21, 523-534.
  • Balle, T., Perregaard, J., Ramirez, M., Larsen, A., Søby, K., Liljefors, T., Andersen, K. (2003). Synthesis and Structure-Affinity Relationship Investigations of 5-Heteroaryl-Substituted Analogues of the Antipsychotic Sertindole. A New Class of Highly Selective Alpha(1) Adrenoceptor Antagonists. Journal of Medicinal Chemistry, 46, 265-283.

2014

  • Petersen, J., Bergmann, R., Krogsgarrd-Larsen, P., Balle, T., Frolund, B. (2014). Probing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres. Neurochemical Research, 39(6), 1005-1015. [More Information]

2013

  • Bergmann, R., Kongsbak, K., Sørensen, P., Sander, T., Balle, T. (2013). A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites. PLoS One, 8(1), 1-13. [More Information]
  • Absalom, N., Quek, G., Lewis, T., Qudah, T., von Arenstorff, I., Ambrus, J., Harpsøe, K., Karim, N., Balle, T., McLeod, M., Collins, M. (2013). Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the apha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. Journal of Biological Chemistry, 288(37), 26521-26532. [More Information]
  • Crestey, F., Jensen, A., Borch, M., Andreasen, J., Andersen, J., Balle, T., Kristensen, J. (2013). Design, Synthesis, and Biological Evaluation of Erythrina Alkaloid Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists. Journal of Medicinal Chemistry, 56(23), 9673-9682. [More Information]
  • Jorgensen, M., Jorgensen, P., Christoffersen, C., Jensen, K., Balle, T., Bang-Andersen, B. (2013). Discovery of novel a1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands. Bioorganic and Medicinal Chemistry, 21(1), 196-204. [More Information]
  • Krall, J., Jensen, C., Sorensen, T., Nielsen, B., Jensen, A., Sander, T., Balle, T., Frolund, B. (2013). Exploring the Orthosteric Binding Site of the y-Aminobutyric Acid Type A Receptor Using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-Imidazolyl Substituted: Design, Synthesis, and Pharmacological Evaluation. Journal of Medicinal Chemistry, 56(16), 6536-6540. [More Information]
  • Harpsøe, K., Hald, H., Timmermann, D., Jensen, M., Dyhring, T., Nielsen, E., Peters, D., Balle, T., Gajhede, M., Kastrup, J., et al (2013). Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. The Journal of Biological Chemistry, 288(4), 2559-2570. [More Information]
  • Eildal, J., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, K., Jemth, P. (2013). Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations. Journal of the American Chemical Society, 135(35), 12998-13007. [More Information]
  • Risgaard, R., Ettrup, A., Balle, T., Dyssegaard, A., Hansen, H., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., et al (2013). Radiolabelling and PET brain imaging of the (alpha)-adrenoceptor antagonist Lu AE43936. Nuclear Medicine and Biology, 40(1), 135-140. [More Information]
  • Airaksinen, A., Finnema, S., Balle, T., Varnas, K., Bang-Andersen, B., Gulyas, B., Farde, L., Halldin, C. (2013). Radiosynthesis and evaluation of a new a1-adrenoceptor antagonists as PET radioligands for brain imaging. Nuclear Medicine and Biology, 40(6), 747-754. [More Information]
  • Petersen, J., Bergmann, R., Moller, H., Jogensen, C., Nielsen, B., Kehler, J., Frydenvang, K., Kristensen, J., Balle, T., Jensen, A., et al (2013). Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as I?-aminobutyric acid(a) receptor agonists. Journal of Medicinal Chemistry, 56(3), 993-1006. [More Information]
  • Ussing, C., Hansen, C., Petersen, J., Jensen, A., Rohde, L., Ahring, P., Nielsen, E., Kastrup, J., Gajhede, M., Frølund, B., Balle, T. (2013). Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists. Journal of Medicinal Chemistry, 56(3), 940-951. [More Information]
  • Olsen, J., Kastrup, J., Peters, D., Gajhede, M., Balle, T., Ahring, J. (2013). Two Distinct Allosteric Binding Sites at a4B2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors. Journal of Biological Chemistry, 288(50), 35997-36006. [More Information]

2012

  • Tosco, P., Balle, T. (2012). A 3D-QSAR-Driven Approach to Binding Mode and Affinity Prediction. Journal of Chemical Information and Modeling, 52(2), 302-307. [More Information]
  • Ambrus, J., Halliday, J., Kanizaj, N., Absalom, N., Harpsøe, K., Balle, T., Collins, M., McLeod, M. (2012). Covalent attachment of antagonists to the (alpha)7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chemical Communications, 48(53), 6699-6701. [More Information]
  • Shahsavar, A., Kastrup, J., Nielsen, E., Kristensen, J., Gajhede, M., Balle, T. (2012). Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHIE suggests a unique mode of antagonism. PLoS One, 7(8), e40757. [More Information]
  • Trattnig, S., Harpsøe, K., Thygesen, S., Rahr, L., Ahring, P., Balle, T., Jensen, A. (2012). Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors. Journal of Biological Chemistry, 287(30), 25241-25254. [More Information]
  • Rohde, L., Ahring, P., Jensen, M., Nielsen, E., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Balle, T., et al (2012). Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine 42 Receptors. Journal of Biological Chemistry, 287(6), 4248-4259. [More Information]

2011

  • Isberg, V., Balle, T., Sander, T., Jørgensen, F., Gloriam, D. (2011). G protein-and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations. Journal of Chemical Information and Modeling, 51(2), 315-325. [More Information]
  • Sander, T., Frølund, B., Bruun, A., Ivanov, I., McCammon, J., Balle, T. (2011). New insights into the GABAA receptor structure and orthosteric ligand binding: Receptor modeling guided by experimental data. Proteins: Structure, Function, and Bioinformatics, 79, 1458-1477. [More Information]
  • Tosco, P., Balle, T., Shiri, F. (2011). Open3DALIGN: an open-source software aimed at unsupervised ligand alignment. Journal of Computer - Aided Molecular Design, 25(8), 777-783. [More Information]
  • Tosco, P., Balle, T. (2011). Open3DQSAR: a new open-source software aimed at high-throughput chemometric analysis of molecular interaction fields. Journal of Molecular Modeling, 17, 201-208. [More Information]
  • Tosco, P., Balle, T., Shiri, F. (2011). SDF2XYZ2SDF: how to exploit TINKER power in cheminformatics projects. Journal of Molecular Modeling, 17(11), 3021-3023. [More Information]
  • Harpsøe, K., Ahring, P., Christensen, J., Jensen, M., Peters, D., Balle, T. (2011). Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors. The Journal of Neuroscience, 31(30), 10759-10766. [More Information]

2010

  • Sander, T., Bruun, A., Balle, T. (2010). Docking to flexible nicotinic acetylcholine receptors: A validation study using the acetylcholine binding protein. Journal of Molecular Graphics and Modelling, 29(3), 415-424. [More Information]
  • Kristensen, J., Püschl, A., Jensen, M., Risgaard, R., Christoffersen, C., Bang-Andersen, B., Balle, T. (2010). Exploring the Neuroleptic Substituent in Octoclothepin: Potential Ligands for Positron Emission Tomography with Subnanomolar Affinity for alpha1-Adrenoceptors. Journal of Medicinal Chemistry, 53(19), 7021-7034. [More Information]
  • Jensen, A., Bergmann, M., Sander, T., Balle, T. (2010). Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors. Journal of Biological Chemistry, 285, 10141-10153. [More Information]
  • Moller, H., Sander, T., Kristensen, J., Nielsen, B., Krall, J., Bergmann, M., Christiansen, B., Balle, T., Jensen, A., Frølund, B. (2010). Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships. Journal of Medicinal Chemistry, 53(8), 3417-3421. [More Information]

2009

  • Hansen, C., Jensen, A., Balle, T., Bitsch-Jensen, K., Hassan, M., Liljefors, T., Frølund, B. (2009). Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists—Structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC). Bioorganic & Medicinal Chemistry Letters, 19(1), 87-91. [More Information]
  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsøe, K., Liljefors, T., Balle, T. (2009). Complementary Three-Dimensional Quantitative Structure-Activity Relationship Modeling of Binding Affinity and Functional Potency: A Study on alpha4beta2 Nicotinic Ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]
  • Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsae, K., Liljefors, T., Balle, T. (2009). Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]
  • Armishaw, C., Jensen, A., Balle, T., Clark, R., Harpsae, K., Skonberg, C., Liljefors, T., Stramgaard, K. (2009). Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. The Journal of Biological Chemistry, 284(14), 9498-9512. [More Information]
  • Armishaw, C., Jensen, A., Balle, T., Clark, R., Harpsøe, K., Skonberg, C., Liljefors, T., Stromgaard, K. (2009). Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives. Journal of Biological Chemistry, 284, 9498-9512.

2008

  • Hansen, C., Jensen, A., Christensen, J., Balle, T., Liljefors, T., Frølund, B. (2008). Novel Acetylcholine and Carbamoylcholine Analogues: Development of a Functionally Selective alpha4beta2 Nicotinic Acetylcholine Receptor Agonist. Journal of Medicinal Chemistry, 51(23), 7380-7395. [More Information]
  • Harpsøe, K., Liljefors, T., Balle, T. (2008). Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis. Journal of Molecular Graphics and Modelling, 26(5), 874-883. [More Information]
  • Sander, T., Liljefors, T., Balle, T. (2008). Prediction of the receptor conformation for iGluR2 agonist binding: QM/MM docking to an extensive conformational ensemble generated using normal mode analysis. Journal of Molecular Graphics and Modelling, 26(8), 1259-1268. [More Information]

2006

  • Audouze, K., Nielsen, E., Olsen, G., Ahring, P., Jørgensen, T., Peters, D., Liljefors, T., Balle, T. (2006). New Ligands with Affinity for the alpha4beta2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling. Journal of Medicinal Chemistry, 49, 3159-3171. [More Information]
  • Balle, T., Begtrup, M., Jaroszewski, J., Liljefors, T., Norrby, P. (2006). Regioselectivity in lithiation of 1-methylpyrazole: experimental, density functional theory and multinuclear NMR study. Organic and Biomolecular Chemistry, 4, 1261-1267. [More Information]

2004

  • Balle, T., Halldin, C., Andersen, L., Alifrangis, L., Badolo, L., Jensen, K., Chou, Y., Andersen, K., Perregaard, J., Farde, L. (2004). New Alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey. Nuclear Medicine and Biology, 31, 327-336.

2003

  • Balle, T., Andersen, K., Søby, K., Liljefors, T. (2003). Alpha(1) adrenoceptor subtype selectivity. 3D-QSAR models for a new class of alpha(1) adrenoceptor antagonists derived from the novel antipsychotic sertindole. Journal of Molecular Graphics and Modelling, 21, 523-534.
  • Balle, T., Perregaard, J., Ramirez, M., Larsen, A., Søby, K., Liljefors, T., Andersen, K. (2003). Synthesis and Structure-Affinity Relationship Investigations of 5-Heteroaryl-Substituted Analogues of the Antipsychotic Sertindole. A New Class of Highly Selective Alpha(1) Adrenoceptor Antagonists. Journal of Medicinal Chemistry, 46, 265-283.

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