Associate Professor Thomas Grewal

Diplom (Honours), PhD, PD (Habilitation)
Associate Professor, Pharmaceutical Chemistry
Research Theme Leader, Cardiovascular and Diabetes

Member of China Studies Centre

Member of The University of Sydney Nano Institute

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 8496

Biographical details

After completing his PhD on gene regulation in Germany in 1993, Associate Professor Thomas Grewal studied lipoprotein receptors during postdoctoral fellowships at the Heart Research Institute (HRI, Sydney) and the Clinical Research Institute (Montreal, Canada). From 1997-2003, Thomas Grewal led a research group at the University Hospital Eppendorf (Hamburg, Germany) and later (2003-2007) at the Centre for Immunology (CFI, St Vincent’s Hospital, Sydney). Thomas Grewal joined the School of Pharmacy in October 2007. His research examines the link between membrane transport and cell signalling, which regulates spatiotemporal signalling in health and disease. Utilising a multi-disciplinal approach involving biochemistry, molecular cell biology, and state-of-the-art microscopy, he has developed an expertise in scaffolding proteins and cellular cholesterol transport, which coordinates the localisation/activity of signaling complexes and receptors.

Overall he has published 95 manuscripts (excluding conference papers) with >3000 cites including articles in leading journals (Cell Reports, Oncogene,Br J Pharmacol, J Cell Sci,J Biol Chem, BBA, mBio,Traffic, Mol Biol Cell, Arterio Thromb Vasc Biol). He received invitations to present at national/international meetings and seminars, reviews manuscripts and research grants for journals and national/international granting bodies. 3 recent guest-editorials were in Cell Adh & Migr, Biol Chem, Int J Mol Sci.

Collaborations with leading national/international scientists include C Enrich (Barcelona, Spain), J Heeren (Hamburg, Germany), U. Rescher (Munester, Germany) Andrew Hoy (Charles Perkins Centre), P Timpson (Garvan), KA Rye, K Gaus (UNSW). Since being in Australia, he received funding from NHMRC, NHF and Cure Cancer Australia.

Research interests

  • Role of Annexin A6 and LDL-cholesterol export from late endosomes in health and disease
  • LDL-cholesterol and cancer cell growth, migration and invasion
  • Cholesterol and formation of membrane contact sites
  • Lipid accumulation, obesity and anti-cancer drug performance
  • Annexins in endo- and exocytosis
  • EGFR/Ras signalling

Teaching and supervision

Associate Professor Thomas Grewal is currently supervising three PhD, 2 visiting MD students and is Associate Supervisor of two PhD students. Overall he has supervised 17 MD, 12 Honours, 4 PhD, 4 postdoctoral scientists and co-supervised 16 PhD and 4 honours students. He gives lectures and tutorials focusing on drugs targeting signalling molecules and lipids in cardiovascular disease, cancer and other diseases. He coordinates lectures/tutorial for fourth year Pharmacy students (BPharm), and as postgraduate coordinator (2010-2011), was involved in student consultation, development of under-/postgraduate student programs and student assessments.

Current research students

Project title Research student
Role of annexin A6 in hepatocyte and prostate cancer cell migration Yasmin ELMAGHRABI
Chemical profile and anti-cancer activity of Dendrobium kingianum, a native Australian orchid Surya TRAPIKA
Role of LDL cholesterol, SRC and annexin A6 for integrin dependent cancer cell migration Mohamed WAHBA

Current projects

Anti-cancer drug efficay in obesity

Role of LDL-induced mTOR signaling in prostate cancer

Role of LDL-cholesterol, NPC1 and annexin A6 in focal adhesion assembly and migration of cancer cells

Membrane contact sites – novel targets to reduce cholesteryl ester accumulation in metastatic prostate cancer

Role of LDL-cholesterol, NPC1 and annexin A6 in pancreatic cancer cell aggressiveness

Associations

Collaborations

International ( C. Enrich, Barcelona, Spain; J Heeren, V Gerke, U Rescher, Germany; SE Moss, S Humphries, UK; K Monastyrkaya, Switzerland; E Ikonen, Finland).

National (RZ Murray, F Simpson, Brisbane; RJ Daly, Melbourne; J Neuzil, Griffith),

Sydney (K Gaus, KA Rye, N Turner, UNSW; A Swarbrick, D Gallego-Ortega; C Pfeffer, Garvan; J Byrne, Westmead)

On campus (A Hoy, L Munoz) and In-house (D Hibbs, P Groundwater, F Zhou, K Chan, T Chen),

Awards and honours

1993-1996 Post-doctoral fellowship (German Research Council, DFG)

1997 Post-doctoral Quebec Fellowship of Excellence (Canada)

2003 Habilitation (PD) in biochemistry, highest post-doctoral degree in Germany

2008 Faculty’s Elizabeth Wunsch Scholarship to attract PhD scholar

In the media

Reverter M, Rentero C, Garcia-Melero A, Hoque M, Vilà de Muga S, Álvarez-Guaita A, Conway J, Wood P, Cairns R, Lykopoulou L, Grinberg D, Vilageliu L, Bosch M, Heeren J, Blasi J, Timpson P, Pol A, Tebar F, Murray RZ,Grewal T, Enrich C. Cholesterol regulates Syntaxin 6 trafficking at the TGN-endosomal boundaries.Cell Reports7 (2014), 883-97.Co-corresponding author(IF 8.03, 50 citations).

The Cell Reports study generated great media interest on national/local TV/radio networks (Channel 7, 10, ABC), press (SMH, Daily telegraph) and overseas.

Selected Publications

2018

Heitzig N, Grill D, Kühnl A, Schloer S, Galla HJ, Grewal T, Gerke V, Rescher U. Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. Biochim Biophys Acta – Mol Cell Biol Lipids 1863 (2018) 349-358. (IF 4.65)

Rentero C, Blanco-Muñoz P, Meneses-Salas E, Grewal T, Enrich C. Annexins – coordinators of cholesterol homeostasis in endocytic pathways.Int J Mol Sci 12 (2018) 19.(IF. 3.24)

Kühnl A, Musiol A, Heitzig N, Ehrhardt C, Grewal T, Gerke V, LudwigS, Rescher U. Late endosomal/lysosomal cholesterol accumulation is a host cell-protective mechanism inhibiting endosomal release of Influenza A virus. mBIO 2018 Jul 24;9(4). pii: e01345-18. doi: 10.1128/mBio.01345-18. (IF 6.68).

Cairns R, Fischer AW, Blanco-Munoz P, Alvarez-Guaita A, Meneses-Salas E, Egert A,Buechler C, Hoy AJ, Heeren J, Enrich C, Rentero C, Grewal T. Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet.Corresponding author. AcceptedPLOS ONE, 14/07/2018, in press (IF 2.7)

Balaban S,Lee LS,Varney B, Aishah A, Gao Q, Shearer RF,Saunders DN, Grewal T, Hoy AJ. Heterogeneity of fatty acid metabolism in breast cancer cells underlying differential sensitivity to palmitate-induced apoptosis.AcceptedMol Oncol, 06/08/2018, in press (IF 5.3).

2017

Krautbauer S, Meier EM, EisingerK, Pohl R, Rein-Fischboeck L, Rentero C, Enrich C, Grewal T, Buechler C,Neumeier M. Annexin A6 regulates adipocyte lipid storage and adiponectin release. Mol Cell Endocrinol (2017) 439, 419-430. (IF 3.56)

Enrich C, Rentero C, Grewal T. Annexin A6 in the liver: from the endocytic compartment to cellular physiology. Biochim Biophys Acta – Mol Cell Res1864 (2017) 933-946.(IF 4.65)

Grewal T, Hoque M, Conway JRW, Reverter M, Wahba M, Beevi SS, Timpson P, Enrich C, Rentero C. Annexin A6 – a multifunctional scaffold in cell motility. Corresponding author. Special issue ‘Annexins in migration and adhesion’ (T Grewal guest editor) in Cell Adh and Migr 11 (2017), 288-304.(IF 3.56)

Balaban S, Shearer RF, Lee LS, van Geldermalsen M,Schreuder M, Shtein H, Cairns R, Thomas KC, Fazakerley DJ, Grewal T, Holst J, Saunders DN, Hoy AJ. Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab (2017) Jan 13;5:1. doi: 10.1186/s40170-016-0163-7. eCollection 2017.

Fairoozy RH, Cooper J, White J, Giambartolomei C, Folkersen L, Wannamethee SG, Jefferis BJ, Whincup P, Ben-Shlomo Y, Kumari M, Kivimaki M, Wong A, Hardy R, Kuh D, Gaunt TR, Casas JP, McLachlan S, Price JF, Hingorani A, Franco-Cereceda A, Grewal T, Kalea, AZ, Humphries SE. Identifying Low Density Lipoprotein Cholesterol Associated Variants in theAnnexin A2 (ANXA2) Gene. Atherosclerosis261 (2017) 60-68.(IF 4.4)

Cairns R, Alvarez-Guaita A, Martínez-Saludes I, Wason SJ, Hanh J, NagarajanSR, Hosseini-Beheshti E, Monastyrskaya K, Hoy AJ, Buechler C, Enrich C, Rentero C, Grewal T. Role of hepatic Annexin A6 in fatty acid -induced lipid droplet formation. Corresponding author. Exp Cell Res 358 (2017) 397-410.(IF 3.3)

2016

García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JRW, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, Tebar F, Murray RZ, Timpson P, Enrich C, Grewal T, Rentero C. Annexin A6 and late endosomal cholesterol modulate integrin recycling and cell migration. Co-corresponding author. J Biol Chem 291(2016), 1320-35. (IF 4.01)

Chan T, Cheung F, Lu X, Zhu L, Grewal T, Murray M, Zhou F.Casein kinase 2 is a novel regulator of the human organic anion transporting polypeptide 1A2 (OATP1A2). Mol Pharmaceutics 13 (2016), 144-54. (IF 4.55)

Cornely R, Pollock AH, Rentero C, Norris SE, Alvarez-Guaita A, Grewal T, Mitchell T, Enrich C, Moss SE, Parton RG, Rossy J, Gaus K. Annexin A6 regulates interleukin-2-mediated Tcell proliferation. Immunol Cell Biol 94 (2016), 543-53. (IF 3.79)

Tran J, Magenau A, RodriguezM, RenteroC, RoyoT, EnrichC, ThomasSR, GrewalT, Gaus K. Activation of endothelial nitric oxide (eNOS) occurs through different membrane domains in endothelial cells. PLoS One11 (2016): e0151556. (IF 2.79)

Grewal T, Wason SJ, Enrich C, Rentero C. Annexins – insights from knockout-mice.Corresponding author. In Highlight issue ‘Annexins in Health and Disease’ (Co-guest editors U. Rescher and T. Grewal). Biol Chem (2016) 397, 1031-53.(IF 3.02, 14 citations)

80.Meier EM, Rein-FischboeckL, PohlR, WanningerJ, HoyAJ, GrewalT, EisingerK, KrautbauerS, LiebischG, WeissTS, BuechlerC. AnxA6 is downregulated in human hepatocellular carcinoma. Mol Cell Biochem418 (2016), 81-90.(IF 2.56, 9 citations)

Keywords

Pharmaceutical Sciences; Cancer; Cardiovascular diseases; Pharmaceutical; Cell biology

Clinical Specialty

Oncology

International links

Finland

(Elina Ikonen: Faculty of Medicine, Dept. of Anatomy and HiLIFE, Univ. of Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.) cellular cholesterol homeostasis

Germany

(Christa Buechler: Department of Internal Medicine I, Regensburg University Hospital, Regensburg, Germany.) Annexins, adipose tissue and lipid metabolism in vivo

Germany

(Joerg Heeren: Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany) lipid metabolism in mouse models.

Germany

(Ursula Rescher: Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Muenster, Germany) annexins and cholesterol/membrane transport

Spain

(Carlos Enrich: Departament de Biomedicina, Unitat de Biologia Cel·lular, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona. 08036-Barcelona. Spain) >45 joint publications over the last 18 years Annexins, membrane transport, endo-/exocytosis, lipid raft formation, EGFR/Ras signalling

Switzerland

(Katia Monastyrskaya: Urology Research Laboratory, Department Clinical Research, University of Bern, 3010 Bern, Switzerland) annexins and membrane transport

Selected grants

2017

  • Ultra-high-performance microbalance, XPR2; Varamini P, Duong H, Grewal T, Kayser V, Gelissen I, Chrzanowski W, Boddy A; University of Sydney, Faculty of Pharmacy/Equipment Grant.
  • LDL-cholesterol, a novel player in cell mobility; Grewal T; DVC Research/Bridging Support Grant.

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho P, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • Cardiovascular benefits of PCSK9 inhibition; Grewal T, Barter P; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Fluorescence microscopy with optical tweezers: imaging cellular responses; Weninger W, Gunning P, Grau G, King N, Grewal T, Soon L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Annexin A6 - a scaffold to switch off EGF receptor; Grewal T; DVC Research/Bridging Support Grant.

2010

  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Super-resolution fluorescence microscopy; Gaus K, Gandevia S, King N, Allen D, Vadas M, Ammit A, Grewal T, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2008

  • Regulation of EGF receptor signaling; Grewal T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ras signalling and cholesterol efflux from late endosomes; Grewal T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ras signalling and cholesterol efflux from late endosomes; Grewal T; National Heart Foundation of Australia/Grants-in-Aid.

Selected publications

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Book Chapters

  • Tebar, F., Gelabert-Baldrich, M., Hoque, M., Cairns, R., Rentero, C., Pol, A., Grewal, T., Enrich, C. (2014). Annexins and Endosomal Signaling. In John N Abelson, Melvin I. Simon, Anna Marie Pyle, Gregory L. Verdine (Eds.), Methods in Enzymology, (pp. 55-74). San Diego: Academic Press. [More Information]
  • Cornely, R., Grewal, T., Gaus, K. (2012). The actin cytoskeleton and membrane organisation in T lymphocytes. In Maria Kavallaris (Eds.), Cytoskeleton and Human Disease, (pp. 103-121). New York: Humana Press. [More Information]
  • Grewal, T., Enrich, C., Jaeckle, S. (2003). Role of annexin VI in receptor-mediated endocytosis, membrane trafficking and signal transduction. In Joanna Bandorowicz-Pikula (Eds.), Annexins: Biological Importance and Annexin-Related Pathologies, (pp. 157-164). United States: Landes Biosciences.

Journals

  • Cairns, R., Fischer, A., Blanco-Munoz, P., Alvarez-Guaita, A., Meneses-Salas, E., Egert, A., Buechler, C., Hoy, A., Heeren, J., Enrich, C., Grewal, T., et al (2018). Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. PloS One, 13(8), 1-26. [More Information]
  • Rentero, C., Blanco-Munoz, P., Meneses-Salas, E., Grewal, T., Enrich, C. (2018). Annexins�coordinators of cholesterol homeostasis in endocytic pathways. International Journal of Molecular Sciences, 19(5). [More Information]
  • Hietzig, N., Kuhnl, A., Grill, D., Ludewig, K., Schloer, S., Galla, H., Grewal, T., Gerke, V., Rescher, U. (2018). Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (4), 349-358. [More Information]
  • Tebar, F., Enrich, C., Rentero, C., Grewal, T. (2018). GTPases Rac1 and Ras Signaling from Endosomes. Progress in Molecular and Subcellular Biology, 57, 65-105. [More Information]
  • Balaban, S., Lee, L., Varney, B., Aishah, A., Gao, Q., Shearer, R., Saunders, D., Grewal, T., Hoy, A. (2018). Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. Molecular Oncology, 12(9), 1623-1638. [More Information]
  • Kuhnl, A., Musiol, A., Heitzig, N., Johnson, D., Ehrhardt, C., Grewal, T., Gerke, V., Ludwig, S., Rescher, U. (2018). Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. mBio, 9(4), 1-16. [More Information]
  • Balaban, S., Shearer, R., Lee, L., van Geldermalsen, M., Schreuder, M., Shtein, H., Cairns, R., Cooke, K., Fazakerley, D., Grewal, T., Holst, J., Hoy, A., et al (2017). Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer and Metabolism, 5(1). [More Information]
  • Enrich, C., Rentero, C., Grewal, T. (2017). Annexin A6 in the liver: From the endocytic compartment to cellular physiology. Biochimica et Biophysica Acta, 1864 (6), 933-946. [More Information]
  • Krautbauer, S., Haberl, E., Eisinger, K., Pohl, R., Rein-Fischboeck, L., Rentero, C., Alvarez-Guaita, A., Enrich, C., Grewal, T., Buechler, C., et al (2017). Annexin A6 regulates adipocyte lipid storage and adiponectin release. Molecular And Cellular Endocrinology, 439, 419-430. [More Information]
  • Grewal, T., Hoque, M., Conway, J., Reverter, M., Wahba, M., Beevi, S., Timpson, P., Enrich, C., Rentero, C. (2017). Annexin A6�A multifunctional scaffold in cell motility. Cell Adhesion and Migration, 11(3), 288-304. [More Information]
  • Grewal, T. (2017). Annexins in cell migration and adhesion. Cell Adhesion and Migration, 11(3), 245-246. [More Information]
  • Enrich, C., Rentero, C., Meneses-Salas, E., Tebar, F., Grewal, T. (2017). Annexins: Ca(2+) Effectors Determining Membrane Trafficking in the Late Endocytic Compartment. Advances in Experimental Medicine and Biology, 981, 351-385. [More Information]
  • Fairoozy, R., White, J., Cooper, J., Folkersen, L., Giambartolomei, C., Kalea, A., Grewal, T., Humphries, S. (2017). Identifying LDL-C associated variants in the Annexin a2 (ANXA2) gene. Atherosclerosis, 263, e20. [More Information]
  • Fairoozy, R., Cooper, J., White, J., Giambartolomei, C., Folkersen, L., Wannamethee, S., Jefferis, B., Whincup, P., Ben-Shlomo, Y., Kumari, M., Grewal, T., et al (2017). Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene. Atherosclerosis, 261, 60-68. [More Information]
  • Cairns, R., Alvarez-Guaita, A., Mart�nez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]
  • Tran, J., Magenau, A., Rodriguez, M., Rentero, C., Royo, T., Enrich, C., Thomas, S., Grewal, T., Gaus, K. (2016). Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. PloS One, 11(3), 1-20. [More Information]
  • Garcia-Melero, A., Reverter, M., Hoque, M., Meneses-Salas, E., Koese, M., Conway, J., Johnsen, C., Alvarez-Guaita, A., Morales-Paytuvi, F., Elmaghrabi, Y., Grewal, T., et al (2016). Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration. Journal of Biological Chemistry, 291(3), 1320-1335. [More Information]
  • Meier, E., Rein-Fischboeck, L., Pohl, R., Wanninger, J., Hoy, A., Grewal, T., Eisinger, K., Krautbauer, S., Liebisch, G., Weiss, T., et al (2016). Annexin A6 protein is downregulated in human hepatocellular carcinoma. Molecular and Cellular Biochemistry, 418(1-2), 81-90. [More Information]
  • Cornely, R., Pollock, A., Rentero, C., Norris, S., Alvarez-Guaita, A., Grewal, T., Mitchell, T., Enrich, C., Moss, S., Parton, R., et al (2016). Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunology and Cell Biology, 94(6), 543-553. [More Information]
  • Grewal, T., Wason, S., Enrich, C., Rentero, C. (2016). Annexins-insights from knockout mice. Biological Chemistry, 397(10), 1031-1053. [More Information]
  • Chan, T., Cheung, F., Zheng, J., Lu, X., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2016). Casein Kinase 2 Is a Novel Regulator of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Trafficking. Molecular Pharmaceutics, 13(1), 144-154. [More Information]
  • Rescher, U., Grewal, T. (2016). Highlight: Annexins in health and disease. Biological Chemistry, 397(10), 947-948. [More Information]
  • Munoz, L., Yeung, Y., Grewal, T. (2016). Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells. Cancer Biology and Therapy, 17(4), 355-363. [More Information]
  • Lasrich, D., Bartelt, A., Grewal, T., Heeren, J. (2015). Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes. Experimental Cell Research, 337(1), 94-102. [More Information]
  • Alvarez-Guaita, A., Vila de Muga, S., Owen, D., Williamson, D., Magenau, A., Garcia-Melero, A., Reverter, M., Hoque, M., Cairns, R., Cornely, R., Grewal, T., et al (2015). Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. British Journal of Pharmacology, 172(7), 1677-1690. [More Information]
  • Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information]
  • Chan, T., Zheng, J., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2015). Putative Transmembrane Domain 6 of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Influences Transporter Substrate Binding, Protein Trafficking, and Quality Control. Molecular Pharmaceutics, 12(1), 111-119. [More Information]
  • Enrich, C., Rentero, C., Hierro, A., Grewal, T. (2015). Role of cholesterol in SNARE-mediated trafficking on intracellular membranes. Journal of Cell Science, 128(6), 1071-1081. [More Information]
  • Hoque, M., Rentero, C., Conway, J., Murray, R., Timpson, P., Enrich, C., Grewal, T. (2015). The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking. Cell adhesion & migration, 9(5), 384-391. [More Information]
  • Gurgis, F., Yeung, Y., Tang, M., Heng, B., Buckland, M., Ammit, A., Haapasalo, J., Haapasalo, H., Guillemin, G., Grewal, T., Munoz, L. (2015). The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells. Oncogene, 34(22), 2934-2942. [More Information]
  • Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information]
  • Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information]
  • Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information]
  • Musiol, A., Gran, S., Ehrhardt, C., Ludwig, S., Grewal, T., Gerke, V., Rescher, U. (2013). Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation. MBIO, 4(6), 1-11. [More Information]
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
  • Poeter, M., Radke, S., Koese, M., Hessner, F., Hegemann, A., Musiol, A., Gerke, V., Grewal, T., Rescher, U. (2013). Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling. Biochimica et Biophysica Acta, 1833 (7), 1700-1711. [More Information]
  • Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]
  • Yeung, Y., McDonald, K., Grewal, T., Munoz, L. (2013). Interleukins in glioblastoma pathophysiology: implications for therapy. British Journal of Pharmacology, 168(3), 591-606. [More Information]
  • Jiang, L., Salao, K., Li, H., Rybicka, J., Yates, R., Luo, X., Shi, X., Kuffner, T., Tsai, V., Husaini, Y., Grewal, T. (2012). Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification. Journal of Cell Science, 125(Pt22), 5479-5488. [More Information]
  • Laatsch, A., Panteli, M., Sornsakrin, M., Hoffzimmer, B., Grewal, T., Heeren, J. (2012). Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. PloS One, 7(1), 1-10. [More Information]
  • Kim, M., Kung, S., Grewal, T., Roufogalis, B. (2012). Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD). Current Pharmaceutical Biotechnology, 13(2), 278-291. [More Information]
  • Roufogalis, B., Grewal, T. (2012). New Methodology and Approaches to Intracellular Lipid Transport in Atherosclerosis and Cardiovascular Disease. Current Pharmaceutical Biotechnology, 13(2), 276-277. [More Information]
  • Yeung, Y., Bryce, N., Adams, S., Braidy, N., Konayagi, M., McDonald, K., Teo, C., Guillemin, G., Grewal, T., Munoz, L. (2012). p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells. Journal of Neuro-Oncology, 109(1), 35-44. [More Information]
  • Mulay, V., Wood, P., Rentero, C., Enrich, C., Grewal, T. (2012). Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport. Current Pharmaceutical Biotechnology, 13(2), 352-364. [More Information]
  • Cornely, R., Rentero, C., Enrich, C., Grewal, T., Gaus, K. (2011). Annexin A6 is an Organizer of Membrane Microdomains to Regulate Receptor Localization and Signalling. IUBMB Life, 63(11), 1009-1017. [More Information]
  • Enrich, C., Rentero, C., de Muga, S., Reverter, M., Mulay, V., Wood, P., Koese, M., Grewal, T. (2011). Annexin A6-Linking Ca2+ signaling with cholesterol transport. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1813, 935-947. [More Information]
  • Le Lay, S., Rodriguez, M., Jessup, W., Rentero, C., Li, Q., Cartland, S., Grewal, T., Gaus, K. (2011). Caveolin-1-Mediated Apolipoprotein A-I Membrane Binding Sites Are Not Required for Cholesterol Efflux. PloS One, 6(8), e23353-1-e23353-11. [More Information]
  • Reverter, M., Rentero, C., Vila de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Grewal, T., et al (2011). Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function. Molecular Biology of the Cell, 22(21), 4108-4123. [More Information]
  • Grewal, T., Koese, M., Tebar, F., Enrich, C. (2011). Differential Regulation of RasGAPs in Cancer. Genes and Cancer, 2(3), 288-297. [More Information]
  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, T., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699. [More Information]
  • Wood, P., Mulay, V., Darabi, M., Chan, K., Heeren, J., Pol, A., Lambert, G., Rye, K., Enrich, C., Grewal, T. (2011). RAS/Mitogen-activated Protein Kinase (MAPK) Signalling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI. Journal of Biological Chemistry, 286(26), 23077-23092. [More Information]
  • Grewal, T., Koese, M., Rentero, C., Enrich, C. (2010). Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis. The International Journal of Biochemistry and Cell Biology, 42, 580-584. [More Information]
  • Vila de Muga, S., Timpson, P., Cubells, L., Evans, R., Hayes, T., Rentero, C., Hegemann, A., Reverter, M., Leschner, J., Pol, A., Grewal, T., et al (2009). Annexin A6 inhibits Ras signalling in breast cancer cells. Oncogene, 28(3), 363-377. [More Information]
  • Stogbauer, F., Weigert, J., Neumeier, M., Wanninger, J., Sporrer, D., Weber, M., Schaffler, A., Enrich, C., Wood, P., Grewal, T., et al (2009). Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro. Experimental and Molecular Medicine, 41(7), 501-507. [More Information]
  • Grewal, T., Enrich, C. (2009). Annexins - Modulators of EGF receptor signalling and trafficking. Cellular Signalling, 21(6), 847-858. [More Information]
  • Moreto´, J., Vidal-Quadras, M., Pol, A., Santos, E., Grewal, T., Enrich, C., Tebar, F. (2009). Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling. Cellular Signalling, 21, 1827-1836. [More Information]
  • Ingelmo-Torres, M., Gonzales-Moreno, E., Kassan, A., Hanzal-Bayer, M., Tebar, F., Herms, A., Grewal, T., Hancock, J., Enrich, C., Bosch, M., et al (2009). Hydrophobic and Basic Domains Target Proteins to Lipid Droplets. Traffic, 10(12), 1785-1801. [More Information]
  • Laatsch, A., Merkel, M., Talmud, P., Grewal, T., Beisiegel, U., Heeren, J. (2009). Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Atherosclerosis, 204, 105-111. [More Information]
  • Monastyrskaya, K., Babiychuk, E., Hostettler, A., Wood, P., Grewal, T., Draeger, A. (2009). Plasma Membrane-associated Annexin A6 Reduces Ca2+ Entry by Stabilizing the Cortical Actin Cytoskeleton. Journal of Biological Chemistry, 284(25), 17227-17242. [More Information]
  • Ingelmo-Torres, M., Gaus, K., Herms, A., Gonzales-Moreno, E., Kassan, A., Bosch, M., Grewal, T., Tebar, F., Enrich, C., Pol, A. (2009). Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane. Biochemical Journal, 420(3), 373-381. [More Information]
  • Cubells, L., de Muga, S., Tebar, F., Bonventre, J., Balsinde, J., Pol, A., Grewal, T., Enrich, C. (2008). Annexin A6-induced inhibition of cytoplasmic phospholipase A(2) is linked to Caveolin-1 export from the Golgi. Journal of Biological Chemistry, 283(15), 10174-10183. [More Information]
  • Rentero, C., Zech, T., Quinn, C., Engelhardt, K., Williamson, D., Grewal, T., Jessup, W., Harder, T., Gaus, K. (2008). Functional Implications of Plasma Membrane Condensation for T Cell Activation. PloS One, 3(5), e2262-1-e2262-14. [More Information]
  • Llado, A., Timpson, P., de Muga, S., Moreto´, J., Pol, A., Grewal, T., Daly, R., Enrich, C., Tebar, F. (2008). Protein kinase Cδ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Molecular Biology of the Cell, 19(1), 17-29. [More Information]
  • Cubells, L., de Muga, S., Tebar, F., Wood, P., Evans, R., Ingelmo-Torres, M., Calvo, M., Gaus, K., Pol, A., Grewal, T., et al (2007). Annexin a6-Induced alterations in cholesterol transport and caveolin export from the Golgi complex. Traffic, 8(11), 1568-1589. [More Information]
  • Grewal, T., Hegemann, A., Vila de Muga, S., Enrich, C. (2007). Annexins Regulate EGFR Signaling and Trafficking. Calcium Binding Proteins, 2(1), 11-20.
  • Heeren, J., Beisiegel, U., Grewal, T. (2006). Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 442-448. [More Information]
  • Turro, S., Ingelmo-Torres, M., Estanyol, J., Tebar, F., Fernandez, M., Albor, C., Gaus, K., Grewal, T., Enrich, C., Pol, A. (2006). Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane-Associated Protein That Resides on Hepatic Lipid Droplets. Traffic, 7, 1254-1269. [More Information]
  • Rentero, C., Evans, R., Wood, P., Tebar, F., Vila de Muga, S., Cubells, L., de Diego, I., Hayes, T., Hughes, W., Pol, A., Rye, K., Grewal, T., et al (2006). Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells. Cellular Signalling, 18(7), 1006-1016. [More Information]
  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2006). Involvement of Targeting and Scaffolding Proteins in the Regulation of the EGFR/Ras/MAPK Pathway in Oncogenesis. Current Signal Transduction Therapy, 1(2), 147-167.
  • Grewal, T., Enrich, C. (2006). Molecular mechanisms involved in Ras inactivation: the annexin A6-p120GAP complex. BioEssays, 28(12), 1211-1220. [More Information]
  • Grewal, T., Evans, R., Rentero, C., Tebar, F., Cubells, L., de Diego, I., Kirchhoff, M., Hughes, W., Heeren, J., Rye, K., et al (2005). Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. Oncogene, 24, 5809-5820. [More Information]
  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2004). Annexin A6 and its Role in Ras Signaling. Annexins, 1(1), 62-67.
  • Laatsch, A., Ragozin, S., Grewal, T., Beisiegel, U., Heeren, J. (2004). Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). European Journal of Cell Biology, 83, 113-120. [More Information]
  • Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K., Beisiegel, U. (2004). Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation. Journal of Biological Chemistry, 279(53), 55483-55492. [More Information]
  • Grewal, T., de Diego, I., Kirchhoff, M., Tebar, F., Heeren, J., Rinninger, F., Enrich, C. (2003). High Density Lipoprotein induced Signaling of the MAPK Pathway Involves Scavenger Receptor Type BI-mediated Activation of Ras. Journal of Biological Chemistry, 278(19), 16478-16481. [More Information]
  • Heeren, J., Grewal, T., Laatsch, A., Rottke, D., Rinninger, F., Enrich, C., Beisiegel, U. (2003). Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization. Journal of Biological Chemistry, 278(16), 14370-14378. [More Information]
  • de Diego, I., Schwartz, F., Siegfried, H., Dauterstedt, P., Heeren, J., Beisiegel, U., Enrich, C., Grewal, T. (2002). Cholesterol Modulates the Membrane Binding and Intracellular Distribution of Annexin 6. Journal of Biological Chemistry, 35, 32187-32194.

2018

  • Cairns, R., Fischer, A., Blanco-Munoz, P., Alvarez-Guaita, A., Meneses-Salas, E., Egert, A., Buechler, C., Hoy, A., Heeren, J., Enrich, C., Grewal, T., et al (2018). Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. PloS One, 13(8), 1-26. [More Information]
  • Rentero, C., Blanco-Munoz, P., Meneses-Salas, E., Grewal, T., Enrich, C. (2018). Annexins�coordinators of cholesterol homeostasis in endocytic pathways. International Journal of Molecular Sciences, 19(5). [More Information]
  • Hietzig, N., Kuhnl, A., Grill, D., Ludewig, K., Schloer, S., Galla, H., Grewal, T., Gerke, V., Rescher, U. (2018). Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (4), 349-358. [More Information]
  • Tebar, F., Enrich, C., Rentero, C., Grewal, T. (2018). GTPases Rac1 and Ras Signaling from Endosomes. Progress in Molecular and Subcellular Biology, 57, 65-105. [More Information]
  • Balaban, S., Lee, L., Varney, B., Aishah, A., Gao, Q., Shearer, R., Saunders, D., Grewal, T., Hoy, A. (2018). Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. Molecular Oncology, 12(9), 1623-1638. [More Information]
  • Kuhnl, A., Musiol, A., Heitzig, N., Johnson, D., Ehrhardt, C., Grewal, T., Gerke, V., Ludwig, S., Rescher, U. (2018). Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. mBio, 9(4), 1-16. [More Information]

2017

  • Balaban, S., Shearer, R., Lee, L., van Geldermalsen, M., Schreuder, M., Shtein, H., Cairns, R., Cooke, K., Fazakerley, D., Grewal, T., Holst, J., Hoy, A., et al (2017). Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer and Metabolism, 5(1). [More Information]
  • Enrich, C., Rentero, C., Grewal, T. (2017). Annexin A6 in the liver: From the endocytic compartment to cellular physiology. Biochimica et Biophysica Acta, 1864 (6), 933-946. [More Information]
  • Krautbauer, S., Haberl, E., Eisinger, K., Pohl, R., Rein-Fischboeck, L., Rentero, C., Alvarez-Guaita, A., Enrich, C., Grewal, T., Buechler, C., et al (2017). Annexin A6 regulates adipocyte lipid storage and adiponectin release. Molecular And Cellular Endocrinology, 439, 419-430. [More Information]
  • Grewal, T., Hoque, M., Conway, J., Reverter, M., Wahba, M., Beevi, S., Timpson, P., Enrich, C., Rentero, C. (2017). Annexin A6�A multifunctional scaffold in cell motility. Cell Adhesion and Migration, 11(3), 288-304. [More Information]
  • Grewal, T. (2017). Annexins in cell migration and adhesion. Cell Adhesion and Migration, 11(3), 245-246. [More Information]
  • Enrich, C., Rentero, C., Meneses-Salas, E., Tebar, F., Grewal, T. (2017). Annexins: Ca(2+) Effectors Determining Membrane Trafficking in the Late Endocytic Compartment. Advances in Experimental Medicine and Biology, 981, 351-385. [More Information]
  • Fairoozy, R., White, J., Cooper, J., Folkersen, L., Giambartolomei, C., Kalea, A., Grewal, T., Humphries, S. (2017). Identifying LDL-C associated variants in the Annexin a2 (ANXA2) gene. Atherosclerosis, 263, e20. [More Information]
  • Fairoozy, R., Cooper, J., White, J., Giambartolomei, C., Folkersen, L., Wannamethee, S., Jefferis, B., Whincup, P., Ben-Shlomo, Y., Kumari, M., Grewal, T., et al (2017). Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene. Atherosclerosis, 261, 60-68. [More Information]
  • Cairns, R., Alvarez-Guaita, A., Mart�nez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]

2016

  • Tran, J., Magenau, A., Rodriguez, M., Rentero, C., Royo, T., Enrich, C., Thomas, S., Grewal, T., Gaus, K. (2016). Activation of Endothelial Nitric Oxide (eNOS) Occurs through Different Membrane Domains in Endothelial Cells. PloS One, 11(3), 1-20. [More Information]
  • Garcia-Melero, A., Reverter, M., Hoque, M., Meneses-Salas, E., Koese, M., Conway, J., Johnsen, C., Alvarez-Guaita, A., Morales-Paytuvi, F., Elmaghrabi, Y., Grewal, T., et al (2016). Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration. Journal of Biological Chemistry, 291(3), 1320-1335. [More Information]
  • Meier, E., Rein-Fischboeck, L., Pohl, R., Wanninger, J., Hoy, A., Grewal, T., Eisinger, K., Krautbauer, S., Liebisch, G., Weiss, T., et al (2016). Annexin A6 protein is downregulated in human hepatocellular carcinoma. Molecular and Cellular Biochemistry, 418(1-2), 81-90. [More Information]
  • Cornely, R., Pollock, A., Rentero, C., Norris, S., Alvarez-Guaita, A., Grewal, T., Mitchell, T., Enrich, C., Moss, S., Parton, R., et al (2016). Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunology and Cell Biology, 94(6), 543-553. [More Information]
  • Grewal, T., Wason, S., Enrich, C., Rentero, C. (2016). Annexins-insights from knockout mice. Biological Chemistry, 397(10), 1031-1053. [More Information]
  • Chan, T., Cheung, F., Zheng, J., Lu, X., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2016). Casein Kinase 2 Is a Novel Regulator of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Trafficking. Molecular Pharmaceutics, 13(1), 144-154. [More Information]
  • Rescher, U., Grewal, T. (2016). Highlight: Annexins in health and disease. Biological Chemistry, 397(10), 947-948. [More Information]
  • Munoz, L., Yeung, Y., Grewal, T. (2016). Oncogenic Ras modulates p38 MAPK-mediated inflammatory cytokine production in glioblastoma cells. Cancer Biology and Therapy, 17(4), 355-363. [More Information]

2015

  • Lasrich, D., Bartelt, A., Grewal, T., Heeren, J. (2015). Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes. Experimental Cell Research, 337(1), 94-102. [More Information]
  • Alvarez-Guaita, A., Vila de Muga, S., Owen, D., Williamson, D., Magenau, A., Garcia-Melero, A., Reverter, M., Hoque, M., Cairns, R., Cornely, R., Grewal, T., et al (2015). Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. British Journal of Pharmacology, 172(7), 1677-1690. [More Information]
  • Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information]
  • Chan, T., Zheng, J., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2015). Putative Transmembrane Domain 6 of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Influences Transporter Substrate Binding, Protein Trafficking, and Quality Control. Molecular Pharmaceutics, 12(1), 111-119. [More Information]
  • Enrich, C., Rentero, C., Hierro, A., Grewal, T. (2015). Role of cholesterol in SNARE-mediated trafficking on intracellular membranes. Journal of Cell Science, 128(6), 1071-1081. [More Information]
  • Hoque, M., Rentero, C., Conway, J., Murray, R., Timpson, P., Enrich, C., Grewal, T. (2015). The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann Pick Type C1 mutation and altered integrin trafficking. Cell adhesion & migration, 9(5), 384-391. [More Information]
  • Gurgis, F., Yeung, Y., Tang, M., Heng, B., Buckland, M., Ammit, A., Haapasalo, J., Haapasalo, H., Guillemin, G., Grewal, T., Munoz, L. (2015). The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells. Oncogene, 34(22), 2934-2942. [More Information]

2014

  • Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information]
  • Tebar, F., Gelabert-Baldrich, M., Hoque, M., Cairns, R., Rentero, C., Pol, A., Grewal, T., Enrich, C. (2014). Annexins and Endosomal Signaling. In John N Abelson, Melvin I. Simon, Anna Marie Pyle, Gregory L. Verdine (Eds.), Methods in Enzymology, (pp. 55-74). San Diego: Academic Press. [More Information]
  • Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information]

2013

  • Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information]
  • Musiol, A., Gran, S., Ehrhardt, C., Ludwig, S., Grewal, T., Gerke, V., Rescher, U. (2013). Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation. MBIO, 4(6), 1-11. [More Information]
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
  • Poeter, M., Radke, S., Koese, M., Hessner, F., Hegemann, A., Musiol, A., Gerke, V., Grewal, T., Rescher, U. (2013). Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling. Biochimica et Biophysica Acta, 1833 (7), 1700-1711. [More Information]
  • Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]
  • Yeung, Y., McDonald, K., Grewal, T., Munoz, L. (2013). Interleukins in glioblastoma pathophysiology: implications for therapy. British Journal of Pharmacology, 168(3), 591-606. [More Information]

2012

  • Jiang, L., Salao, K., Li, H., Rybicka, J., Yates, R., Luo, X., Shi, X., Kuffner, T., Tsai, V., Husaini, Y., Grewal, T. (2012). Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification. Journal of Cell Science, 125(Pt22), 5479-5488. [More Information]
  • Laatsch, A., Panteli, M., Sornsakrin, M., Hoffzimmer, B., Grewal, T., Heeren, J. (2012). Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. PloS One, 7(1), 1-10. [More Information]
  • Kim, M., Kung, S., Grewal, T., Roufogalis, B. (2012). Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD). Current Pharmaceutical Biotechnology, 13(2), 278-291. [More Information]
  • Roufogalis, B., Grewal, T. (2012). New Methodology and Approaches to Intracellular Lipid Transport in Atherosclerosis and Cardiovascular Disease. Current Pharmaceutical Biotechnology, 13(2), 276-277. [More Information]
  • Yeung, Y., Bryce, N., Adams, S., Braidy, N., Konayagi, M., McDonald, K., Teo, C., Guillemin, G., Grewal, T., Munoz, L. (2012). p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells. Journal of Neuro-Oncology, 109(1), 35-44. [More Information]
  • Mulay, V., Wood, P., Rentero, C., Enrich, C., Grewal, T. (2012). Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport. Current Pharmaceutical Biotechnology, 13(2), 352-364. [More Information]
  • Cornely, R., Grewal, T., Gaus, K. (2012). The actin cytoskeleton and membrane organisation in T lymphocytes. In Maria Kavallaris (Eds.), Cytoskeleton and Human Disease, (pp. 103-121). New York: Humana Press. [More Information]

2011

  • Cornely, R., Rentero, C., Enrich, C., Grewal, T., Gaus, K. (2011). Annexin A6 is an Organizer of Membrane Microdomains to Regulate Receptor Localization and Signalling. IUBMB Life, 63(11), 1009-1017. [More Information]
  • Enrich, C., Rentero, C., de Muga, S., Reverter, M., Mulay, V., Wood, P., Koese, M., Grewal, T. (2011). Annexin A6-Linking Ca2+ signaling with cholesterol transport. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1813, 935-947. [More Information]
  • Le Lay, S., Rodriguez, M., Jessup, W., Rentero, C., Li, Q., Cartland, S., Grewal, T., Gaus, K. (2011). Caveolin-1-Mediated Apolipoprotein A-I Membrane Binding Sites Are Not Required for Cholesterol Efflux. PloS One, 6(8), e23353-1-e23353-11. [More Information]
  • Reverter, M., Rentero, C., Vila de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Grewal, T., et al (2011). Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function. Molecular Biology of the Cell, 22(21), 4108-4123. [More Information]
  • Grewal, T., Koese, M., Tebar, F., Enrich, C. (2011). Differential Regulation of RasGAPs in Cancer. Genes and Cancer, 2(3), 288-297. [More Information]
  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, T., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699. [More Information]
  • Wood, P., Mulay, V., Darabi, M., Chan, K., Heeren, J., Pol, A., Lambert, G., Rye, K., Enrich, C., Grewal, T. (2011). RAS/Mitogen-activated Protein Kinase (MAPK) Signalling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI. Journal of Biological Chemistry, 286(26), 23077-23092. [More Information]

2010

  • Grewal, T., Koese, M., Rentero, C., Enrich, C. (2010). Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis. The International Journal of Biochemistry and Cell Biology, 42, 580-584. [More Information]

2009

  • Vila de Muga, S., Timpson, P., Cubells, L., Evans, R., Hayes, T., Rentero, C., Hegemann, A., Reverter, M., Leschner, J., Pol, A., Grewal, T., et al (2009). Annexin A6 inhibits Ras signalling in breast cancer cells. Oncogene, 28(3), 363-377. [More Information]
  • Stogbauer, F., Weigert, J., Neumeier, M., Wanninger, J., Sporrer, D., Weber, M., Schaffler, A., Enrich, C., Wood, P., Grewal, T., et al (2009). Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro. Experimental and Molecular Medicine, 41(7), 501-507. [More Information]
  • Grewal, T., Enrich, C. (2009). Annexins - Modulators of EGF receptor signalling and trafficking. Cellular Signalling, 21(6), 847-858. [More Information]
  • Moreto´, J., Vidal-Quadras, M., Pol, A., Santos, E., Grewal, T., Enrich, C., Tebar, F. (2009). Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling. Cellular Signalling, 21, 1827-1836. [More Information]
  • Ingelmo-Torres, M., Gonzales-Moreno, E., Kassan, A., Hanzal-Bayer, M., Tebar, F., Herms, A., Grewal, T., Hancock, J., Enrich, C., Bosch, M., et al (2009). Hydrophobic and Basic Domains Target Proteins to Lipid Droplets. Traffic, 10(12), 1785-1801. [More Information]
  • Laatsch, A., Merkel, M., Talmud, P., Grewal, T., Beisiegel, U., Heeren, J. (2009). Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Atherosclerosis, 204, 105-111. [More Information]
  • Monastyrskaya, K., Babiychuk, E., Hostettler, A., Wood, P., Grewal, T., Draeger, A. (2009). Plasma Membrane-associated Annexin A6 Reduces Ca2+ Entry by Stabilizing the Cortical Actin Cytoskeleton. Journal of Biological Chemistry, 284(25), 17227-17242. [More Information]
  • Ingelmo-Torres, M., Gaus, K., Herms, A., Gonzales-Moreno, E., Kassan, A., Bosch, M., Grewal, T., Tebar, F., Enrich, C., Pol, A. (2009). Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane. Biochemical Journal, 420(3), 373-381. [More Information]

2008

  • Cubells, L., de Muga, S., Tebar, F., Bonventre, J., Balsinde, J., Pol, A., Grewal, T., Enrich, C. (2008). Annexin A6-induced inhibition of cytoplasmic phospholipase A(2) is linked to Caveolin-1 export from the Golgi. Journal of Biological Chemistry, 283(15), 10174-10183. [More Information]
  • Rentero, C., Zech, T., Quinn, C., Engelhardt, K., Williamson, D., Grewal, T., Jessup, W., Harder, T., Gaus, K. (2008). Functional Implications of Plasma Membrane Condensation for T Cell Activation. PloS One, 3(5), e2262-1-e2262-14. [More Information]
  • Llado, A., Timpson, P., de Muga, S., Moreto´, J., Pol, A., Grewal, T., Daly, R., Enrich, C., Tebar, F. (2008). Protein kinase Cδ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Molecular Biology of the Cell, 19(1), 17-29. [More Information]

2007

  • Cubells, L., de Muga, S., Tebar, F., Wood, P., Evans, R., Ingelmo-Torres, M., Calvo, M., Gaus, K., Pol, A., Grewal, T., et al (2007). Annexin a6-Induced alterations in cholesterol transport and caveolin export from the Golgi complex. Traffic, 8(11), 1568-1589. [More Information]
  • Grewal, T., Hegemann, A., Vila de Muga, S., Enrich, C. (2007). Annexins Regulate EGFR Signaling and Trafficking. Calcium Binding Proteins, 2(1), 11-20.

2006

  • Heeren, J., Beisiegel, U., Grewal, T. (2006). Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 442-448. [More Information]
  • Turro, S., Ingelmo-Torres, M., Estanyol, J., Tebar, F., Fernandez, M., Albor, C., Gaus, K., Grewal, T., Enrich, C., Pol, A. (2006). Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane-Associated Protein That Resides on Hepatic Lipid Droplets. Traffic, 7, 1254-1269. [More Information]
  • Rentero, C., Evans, R., Wood, P., Tebar, F., Vila de Muga, S., Cubells, L., de Diego, I., Hayes, T., Hughes, W., Pol, A., Rye, K., Grewal, T., et al (2006). Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells. Cellular Signalling, 18(7), 1006-1016. [More Information]
  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2006). Involvement of Targeting and Scaffolding Proteins in the Regulation of the EGFR/Ras/MAPK Pathway in Oncogenesis. Current Signal Transduction Therapy, 1(2), 147-167.
  • Grewal, T., Enrich, C. (2006). Molecular mechanisms involved in Ras inactivation: the annexin A6-p120GAP complex. BioEssays, 28(12), 1211-1220. [More Information]

2005

  • Grewal, T., Evans, R., Rentero, C., Tebar, F., Cubells, L., de Diego, I., Kirchhoff, M., Hughes, W., Heeren, J., Rye, K., et al (2005). Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. Oncogene, 24, 5809-5820. [More Information]

2004

  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2004). Annexin A6 and its Role in Ras Signaling. Annexins, 1(1), 62-67.
  • Laatsch, A., Ragozin, S., Grewal, T., Beisiegel, U., Heeren, J. (2004). Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). European Journal of Cell Biology, 83, 113-120. [More Information]
  • Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K., Beisiegel, U. (2004). Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation. Journal of Biological Chemistry, 279(53), 55483-55492. [More Information]

2003

  • Grewal, T., de Diego, I., Kirchhoff, M., Tebar, F., Heeren, J., Rinninger, F., Enrich, C. (2003). High Density Lipoprotein induced Signaling of the MAPK Pathway Involves Scavenger Receptor Type BI-mediated Activation of Ras. Journal of Biological Chemistry, 278(19), 16478-16481. [More Information]
  • Heeren, J., Grewal, T., Laatsch, A., Rottke, D., Rinninger, F., Enrich, C., Beisiegel, U. (2003). Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization. Journal of Biological Chemistry, 278(16), 14370-14378. [More Information]
  • Grewal, T., Enrich, C., Jaeckle, S. (2003). Role of annexin VI in receptor-mediated endocytosis, membrane trafficking and signal transduction. In Joanna Bandorowicz-Pikula (Eds.), Annexins: Biological Importance and Annexin-Related Pathologies, (pp. 157-164). United States: Landes Biosciences.

2002

  • de Diego, I., Schwartz, F., Siegfried, H., Dauterstedt, P., Heeren, J., Beisiegel, U., Enrich, C., Grewal, T. (2002). Cholesterol Modulates the Membrane Binding and Intracellular Distribution of Annexin 6. Journal of Biological Chemistry, 35, 32187-32194.

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