Associate Professor Thomas Grewal

Diplom (Honours), PhD, PD (Habilitation)
Associate Professor, Pharmaceutical Chemistry
Research Theme Leader, Cardiovascular and Diabetes

A15 - Pharmacy And Bank Building
The University of Sydney

Telephone +61 2 9351 8496

Biographical details

After completing his PhD on gene regulation in Germany in 1993, Associate Professor Thomas Grewal studied lipoprotein receptors during postdoctoral fellowships at the Heart Research Institute (HRI, Sydney) and the Clinical Research Institute (Montreal, Canada). From 1997-2003, Thomas Grewal led a research group at the University Hospital Eppendorf (Hamburg, Germany) and later (2003-2007) at the Centre for Immunology (CFI, St Vincent’s Hospital, Sydney). Thomas Grewal joined the Faculty of Pharmacy in October 2007. His research examines the link between membrane transport and cell signalling, which regulates spatiotemporal signalling in health and disease. Utilising a multi-disciplinal approach involving biochemistry, molecular cell biology, and state-of-the-art microscopy, he has developed an expertise in scaffolding proteins and cellular cholesterol transport, which coordinates the localisation/activity of signaling complexes and receptors.

Overall he has published 57 manuscripts with more than 1,000 citations, including articles in leading journals (J Biol Chem, Oncogene, Traffic, Mol Biol Cell, Arterio Thromb Vasc Biol, J Cell Sci). He received invitations to present at national/international meetings and seminars, reviews manuscripts and research grants for journals and national/international granting bodies. Collaborations with leading national/international scientists include C Enrich (Barcelona, Spain), J Heeren (Hamburg, Germany) RJ Daly, P Timpson (Garvan), KA Rye, K Gaus (UNSW). Since being in Australia, he received funding from NHMRC, NHF and Cure Cancer Australia.

Research interests

  • Regulation of EGFR/Ras signalling and trafficking.
  • Ras signaling and stimulation of cholesterol efflux in atherosclerosis.
  • Role of Annexin A6 in cholesterol export from late endosomes and caveolae/lipid raft formation.

Teaching and supervision

Associate Professor Thomas Grewal is currently supervising three PhD and one honours student and is Associate Supervisor of three PhD students. Overall he has supervised 17 MD, 10 Honours, four PhD, four postdoctoral scientists and co-supervised 14 PhD and four honours students. He gives lectures and tutorials focusing on drugs targeting signalling molecules and lipids in cardiovascular disease and cancer. He coordinates lectures/tutorial for fourth year Pharmacy students (BPharm), and as postgraduate coordinator (2010-2011), was involved in student consultation, development of under-/postgraduate student programs and student assessments.

Keywords

Pharmaceutical Sciences; Cancer; Cardiovascular diseases

Selected grants

2013

  • Cardiovascular benefits of PCSK9 inhibition; Grewal T, Barter P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2011

  • Annexin A6 - a scaffold to switch off EGF receptor; Grewal T; DVC Research/Bridging Support Grant.
  • Fluorescence microscopy with optical tweezers: imaging cellular responses; Weninger W, Gunning P, Grau G, King N, Grewal T, Soon L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2010

  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Super-resolution fluorescence microscopy; Gaus K, Gandevia S, King N, Allen D, Vadas M, Ammit A, Grewal T, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2008

  • Regulation of EGF receptor signaling; Grewal T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ras signalling and cholesterol efflux from late endosomes; Grewal T; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ras signalling and cholesterol efflux from late endosomes; Grewal T; Heart Foundation of Australia/Grants-in-Aid.

Selected publications

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Book Chapters

  • Tebar, F., Gelabert-Baldrich, M., Hoque, M., Cairns, R., Rentero, C., Pol, A., Grewal, T., Enrich, C. (2014). Annexins and Endosomal Signaling. Methods in Enzymology: Vol 535, Endosome Signaling Part B, (pp. 56-74). San Diego: Elsevier Inc.
  • Grewal, T., Enrich, C., Jaeckle, S. (2003). Role of annexin VI in receptor-mediated endocytosis, membrane trafficking and signal transduction. In Joanna Bandorowicz-Pikula (Eds.), Annexins: Biological Importance and Annexin-Related Pathologies, (pp. 157-164). United States: Landes Biosciences.

Journals

  • Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information]
  • Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information]
  • Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information]
  • Musiol, A., Gran, S., Ehrhardt, C., Ludwig, S., Grewal, T., Gerke, V., Rescher, U. (2013). Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation. MBIO, 4(6), 1-11. [More Information]
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
  • Poeter, M., Radke, S., Koese, M., Hessner, F., Hegemann, A., Musiol, A., Gerke, V., Grewal, T., Rescher, U. (2013). Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1833 (7), 1700-1711. [More Information]
  • Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]
  • Yeung, Y., McDonald, K., Grewal, T., Munoz, L. (2013). Interleukins in glioblastoma pathophysiology: implications for therapy. British Journal of Pharmacology, 168(3), 591-606. [More Information]
  • Jiang, L., Salao, K., Li, H., Rybicka, J., Yates, R., Luo, X., Shi, X., Kuffner, T., Tsai, V., Husaini, Y., Grewal, T. (2012). Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification. Journal of Cell Science, 125(Pt22), 5479-5488. [More Information]
  • Laatsch, A., Panteli, M., Sornsakrin, M., Hoffzimmer, B., Grewal, T., Heeren, J. (2012). Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. PloS One, 7(1), 1-10. [More Information]
  • Kim, M., Kung, S., Grewal, T., Roufogalis, B. (2012). Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD). Current Pharmaceutical Biotechnology, 13(2), 278-291. [More Information]
  • Roufogalis, B., Grewal, T. (2012). New Methodology and Approaches to Intracellular Lipid Transport in Atherosclerosis and Cardiovascular Disease. Current Pharmaceutical Biotechnology, 13(2), 276-277. [More Information]
  • Yeung, Y., Bryce, N., Adams, S., Braidy, N., Konayagi, M., McDonald, K., Teo, C., Guillemin, G., Grewal, T., Munoz, L. (2012). p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells. Journal of Neuro-Oncology, 109(1), 35-44. [More Information]
  • Mulay, V., Wood, P., Rentero, C., Enrich, C., Grewal, T. (2012). Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport. Current Pharmaceutical Biotechnology, 13(2), 352-364. [More Information]
  • Cornely, R., Rentero, C., Enrich, C., Grewal, T., Gaus, K. (2011). Annexin A6 is an Organizer of Membrane Microdomains to Regulate Receptor Localization and Signalling. IUBMB Life, 63(11), 1009-1017. [More Information]
  • Enrich, C., Rentero, C., de Muga, S., Reverter, M., Mulay, V., Wood, P., Koese, M., Grewal, T. (2011). Annexin A6-Linking Ca2+ signaling with cholesterol transport. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1813, 935-947. [More Information]
  • Le Lay, S., Rodriguez, M., Jessup, W., Rentero, C., Li, Q., Cartland, S., Grewal, T., Gaus, K. (2011). Caveolin-1-Mediated Apolipoprotein A-I Membrane Binding Sites Are Not Required for Cholesterol Efflux. PloS One, 6(8), e23353-1-e23353-11. [More Information]
  • Reverter, M., Rentero, C., Vila de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Grewal, T., et al (2011). Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function. Molecular Biology of the Cell, 22(21), 4108-4123. [More Information]
  • Grewal, T., Koese, M., Tebar, F., Enrich, C. (2011). Differential Regulation of RasGAPs in Cancer. Genes and Cancer, 2(3), 288-297. [More Information]
  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, T., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699. [More Information]
  • Wood, P., Mulay, V., Darabi, M., Chan, K., Heeren, J., Pol, A., Lambert, G., Rye, K., Enrich, C., Grewal, T. (2011). RAS/Mitogen-activated Protein Kinase (MAPK) Signalling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI. Journal of Biological Chemistry, 286(26), 23077-23092. [More Information]
  • Grewal, T., Koese, M., Rentero, C., Enrich, C. (2010). Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis. The International Journal of Biochemistry and Cell Biology, 42, 580-584. [More Information]
  • Vila de Muga, S., Timpson, P., Cubells, L., Evans, R., Hayes, T., Rentero, C., Hegemann, A., Reverter, M., Leschner, J., Pol, A., Grewal, T., et al (2009). Annexin A6 inhibits Ras signalling in breast cancer cells. Oncogene, 28(3), 363-377. [More Information]
  • Stogbauer, F., Weigert, J., Neumeier, M., Wanninger, J., Sporrer, D., Weber, M., Schaffler, A., Enrich, C., Wood, P., Grewal, T., et al (2009). Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro. Experimental and Molecular Medicine, 41(7), 501-507. [More Information]
  • Grewal, T., Enrich, C. (2009). Annexins - Modulators of EGF receptor signalling and trafficking. Cellular Signalling, 21(6), 847-858. [More Information]
  • Moreto´, J., Vidal-Quadras, M., Pol, A., Santos, E., Grewal, T., Enrich, C., Tebar, F. (2009). Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling. Cellular Signalling, 21, 1827-1836. [More Information]
  • Ingelmo-Torres, M., Gonzales-Moreno, E., Kassan, A., Hanzal-Bayer, M., Tebar, F., Herms, A., Grewal, T., Hancock, J., Enrich, C., Bosch, M., et al (2009). Hydrophobic and Basic Domains Target Proteins to Lipid Droplets. Traffic: the international journal of intracellular transport, 10(12), 1785-1801. [More Information]
  • Laatsch, A., Merkel, M., Talmud, P., Grewal, T., Beisiegel, U., Heeren, J. (2009). Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Atherosclerosis, 204, 105-111. [More Information]
  • Monastyrskaya, K., Babiychuk, E., Hostettler, A., Wood, P., Grewal, T., Draeger, A. (2009). Plasma Membrane-associated Annexin A6 Reduces Ca2+ Entry by Stabilizing the Cortical Actin Cytoskeleton. Journal of Biological Chemistry, 284(25), 17227-17242. [More Information]
  • Ingelmo-Torres, M., Gaus, K., Herms, A., Gonzales-Moreno, E., Kassan, A., Bosch, M., Grewal, T., Tebar, F., Enrich, C., Pol, A. (2009). Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane. Biochemical Journal, 420(3), 373-381. [More Information]
  • Cubells, L., de Muga, S., Tebar, F., Bonventre, J., Balsinde, J., Pol, A., Grewal, T., Enrich, C. (2008). Annexin A6-induced inhibition of cytoplasmic phospholipase A(2) is linked to Caveolin-1 export from the Golgi. Journal of Biological Chemistry, 283(15), 10174-10183. [More Information]
  • Rentero, C., Zech, T., Quinn, C., Engelhardt, K., Williamson, D., Grewal, T., Jessup, W., Harder, T., Gaus, K. (2008). Functional Implications of Plasma Membrane Condensation for T Cell Activation. PloS One, 3(5), e2262-1-e2262-14. [More Information]
  • Llado, A., Timpson, P., de Muga, S., Moreto´, J., Pol, A., Grewal, T., Daly, R., Enrich, C., Tebar, F. (2008). Protein kinase Cδ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Molecular Biology of the Cell, 19(1), 17-29. [More Information]
  • Cubells, L., de Muga, S., Tebar, F., Wood, P., Evans, R., Ingelmo-Torres, M., Calvo, M., Gaus, K., Pol, A., Grewal, T., et al (2007). Annexin a6-Induced alterations in cholesterol transport and caveolin export from the Golgi complex. Traffic: the international journal of intracellular transport, 8(11), 1568-1589.
  • Grewal, T., Hegemann, A., Vila de Muga, S., Enrich, C. (2007). Annexins Regulate EGFR Signaling and Trafficking. Calcium Binding Proteins, 2(1), 11-20.
  • Heeren, J., Beisiegel, U., Grewal, T. (2006). Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 442-448.
  • Turro, S., Ingelmo-Torres, M., Estanyol, J., Tebar, F., Fernandez, M., Albor, C., Gaus, K., Grewal, T., Enrich, C., Pol, A. (2006). Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane-Associated Protein That Resides on Hepatic Lipid Droplets. Traffic: the international journal of intracellular transport, 7, 1254-1269.
  • Rentero, C., Evans, R., Wood, P., Tebar, F., Vila de Muga, S., Cubells, L., de Diego, I., Hayes, T., Hughes, W., Pol, A., Rye, K., Grewal, T., et al (2006). Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells. Cellular Signalling, 18(7), 1006-1016. [More Information]
  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2006). Involvement of Targeting and Scaffolding Proteins in the Regulation of the EGFR/Ras/MAPK Pathway in Oncogenesis. Current Signal Transduction Therapy, 1(2), 147-167.
  • Grewal, T., Enrich, C. (2006). Molecular mechanisms involved in Ras inactivation: the annexin A6-p120GAP complex. BioEssays, 28(12), 1211-1220. [More Information]
  • Grewal, T., Evans, R., Rentero, C., Tebar, F., Cubells, L., de Diego, I., Kirchhoff, M., Hughes, W., Heeren, J., Rye, K., et al (2005). Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. Oncogene, 24, 5809-5820.
  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2004). Annexin A6 and its Role in Ras Signaling. Annexins, 1(1), 62-67.
  • Laatsch, A., Ragozin, S., Grewal, T., Beisiegel, U., Heeren, J. (2004). Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). European Journal of Cell Biology, 83, 113-120.
  • Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K., Beisiegel, U. (2004). Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation. Journal of Biological Chemistry, 279(53), 55483-55492. [More Information]
  • Grewal, T., de Diego, I., Kirchhoff, M., Tebar, F., Heeren, J., Rinninger, F., Enrich, C. (2003). High Density Lipoprotein induced Signaling of the MAPK Pathway Involves Scavenger Receptor Type BI-mediated Activation of Ras. Journal of Biological Chemistry, 278(19), 16478-16481.
  • Heeren, J., Grewal, T., Laatsch, A., Rottke, D., Rinninger, F., Enrich, C., Beisiegel, U. (2003). Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization. Journal of Biological Chemistry, 278(16), 14370-14378.
  • de Diego, I., Schwartz, F., Siegfried, H., Dauterstedt, P., Heeren, J., Beisiegel, U., Enrich, C., Grewal, T. (2002). Cholesterol Modulates the Membrane Binding and Intracellular Distribution of Annexin 6. Journal of Biological Chemistry, 35, 32187-32194.

2014

  • Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information]
  • Tebar, F., Gelabert-Baldrich, M., Hoque, M., Cairns, R., Rentero, C., Pol, A., Grewal, T., Enrich, C. (2014). Annexins and Endosomal Signaling. Methods in Enzymology: Vol 535, Endosome Signaling Part B, (pp. 56-74). San Diego: Elsevier Inc.
  • Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information]

2013

  • Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information]
  • Musiol, A., Gran, S., Ehrhardt, C., Ludwig, S., Grewal, T., Gerke, V., Rescher, U. (2013). Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation. MBIO, 4(6), 1-11. [More Information]
  • Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
  • Poeter, M., Radke, S., Koese, M., Hessner, F., Hegemann, A., Musiol, A., Gerke, V., Grewal, T., Rescher, U. (2013). Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1833 (7), 1700-1711. [More Information]
  • Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]
  • Yeung, Y., McDonald, K., Grewal, T., Munoz, L. (2013). Interleukins in glioblastoma pathophysiology: implications for therapy. British Journal of Pharmacology, 168(3), 591-606. [More Information]

2012

  • Jiang, L., Salao, K., Li, H., Rybicka, J., Yates, R., Luo, X., Shi, X., Kuffner, T., Tsai, V., Husaini, Y., Grewal, T. (2012). Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification. Journal of Cell Science, 125(Pt22), 5479-5488. [More Information]
  • Laatsch, A., Panteli, M., Sornsakrin, M., Hoffzimmer, B., Grewal, T., Heeren, J. (2012). Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. PloS One, 7(1), 1-10. [More Information]
  • Kim, M., Kung, S., Grewal, T., Roufogalis, B. (2012). Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD). Current Pharmaceutical Biotechnology, 13(2), 278-291. [More Information]
  • Roufogalis, B., Grewal, T. (2012). New Methodology and Approaches to Intracellular Lipid Transport in Atherosclerosis and Cardiovascular Disease. Current Pharmaceutical Biotechnology, 13(2), 276-277. [More Information]
  • Yeung, Y., Bryce, N., Adams, S., Braidy, N., Konayagi, M., McDonald, K., Teo, C., Guillemin, G., Grewal, T., Munoz, L. (2012). p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells. Journal of Neuro-Oncology, 109(1), 35-44. [More Information]
  • Mulay, V., Wood, P., Rentero, C., Enrich, C., Grewal, T. (2012). Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport. Current Pharmaceutical Biotechnology, 13(2), 352-364. [More Information]

2011

  • Cornely, R., Rentero, C., Enrich, C., Grewal, T., Gaus, K. (2011). Annexin A6 is an Organizer of Membrane Microdomains to Regulate Receptor Localization and Signalling. IUBMB Life, 63(11), 1009-1017. [More Information]
  • Enrich, C., Rentero, C., de Muga, S., Reverter, M., Mulay, V., Wood, P., Koese, M., Grewal, T. (2011). Annexin A6-Linking Ca2+ signaling with cholesterol transport. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1813, 935-947. [More Information]
  • Le Lay, S., Rodriguez, M., Jessup, W., Rentero, C., Li, Q., Cartland, S., Grewal, T., Gaus, K. (2011). Caveolin-1-Mediated Apolipoprotein A-I Membrane Binding Sites Are Not Required for Cholesterol Efflux. PloS One, 6(8), e23353-1-e23353-11. [More Information]
  • Reverter, M., Rentero, C., Vila de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Grewal, T., et al (2011). Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function. Molecular Biology of the Cell, 22(21), 4108-4123. [More Information]
  • Grewal, T., Koese, M., Tebar, F., Enrich, C. (2011). Differential Regulation of RasGAPs in Cancer. Genes and Cancer, 2(3), 288-297. [More Information]
  • Toh, S., Murray, M., Tan, K., Mulay, V., Grewal, T., Lee, E., Zhou, F. (2011). Functional analysis of pharmacogenetic variants of human organic cation/carnitine transporter 2 (hOCTN2) identified in Singaporean populations. Biochemical Pharmacology, 82(11), 1692-1699. [More Information]
  • Wood, P., Mulay, V., Darabi, M., Chan, K., Heeren, J., Pol, A., Lambert, G., Rye, K., Enrich, C., Grewal, T. (2011). RAS/Mitogen-activated Protein Kinase (MAPK) Signalling Modulates Protein Stability and Cell Surface Expression of Scavenger Receptor SR-BI. Journal of Biological Chemistry, 286(26), 23077-23092. [More Information]

2010

  • Grewal, T., Koese, M., Rentero, C., Enrich, C. (2010). Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis. The International Journal of Biochemistry and Cell Biology, 42, 580-584. [More Information]

2009

  • Vila de Muga, S., Timpson, P., Cubells, L., Evans, R., Hayes, T., Rentero, C., Hegemann, A., Reverter, M., Leschner, J., Pol, A., Grewal, T., et al (2009). Annexin A6 inhibits Ras signalling in breast cancer cells. Oncogene, 28(3), 363-377. [More Information]
  • Stogbauer, F., Weigert, J., Neumeier, M., Wanninger, J., Sporrer, D., Weber, M., Schaffler, A., Enrich, C., Wood, P., Grewal, T., et al (2009). Annexin A6 is highly abundant in monocytes of obese and type 2 diabetic individuals and is downregulated by adiponectin in vitro. Experimental and Molecular Medicine, 41(7), 501-507. [More Information]
  • Grewal, T., Enrich, C. (2009). Annexins - Modulators of EGF receptor signalling and trafficking. Cellular Signalling, 21(6), 847-858. [More Information]
  • Moreto´, J., Vidal-Quadras, M., Pol, A., Santos, E., Grewal, T., Enrich, C., Tebar, F. (2009). Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling. Cellular Signalling, 21, 1827-1836. [More Information]
  • Ingelmo-Torres, M., Gonzales-Moreno, E., Kassan, A., Hanzal-Bayer, M., Tebar, F., Herms, A., Grewal, T., Hancock, J., Enrich, C., Bosch, M., et al (2009). Hydrophobic and Basic Domains Target Proteins to Lipid Droplets. Traffic: the international journal of intracellular transport, 10(12), 1785-1801. [More Information]
  • Laatsch, A., Merkel, M., Talmud, P., Grewal, T., Beisiegel, U., Heeren, J. (2009). Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance. Atherosclerosis, 204, 105-111. [More Information]
  • Monastyrskaya, K., Babiychuk, E., Hostettler, A., Wood, P., Grewal, T., Draeger, A. (2009). Plasma Membrane-associated Annexin A6 Reduces Ca2+ Entry by Stabilizing the Cortical Actin Cytoskeleton. Journal of Biological Chemistry, 284(25), 17227-17242. [More Information]
  • Ingelmo-Torres, M., Gaus, K., Herms, A., Gonzales-Moreno, E., Kassan, A., Bosch, M., Grewal, T., Tebar, F., Enrich, C., Pol, A. (2009). Triton X-100 promotes a cholesterol-dependent condensation of the plasma membrane. Biochemical Journal, 420(3), 373-381. [More Information]

2008

  • Cubells, L., de Muga, S., Tebar, F., Bonventre, J., Balsinde, J., Pol, A., Grewal, T., Enrich, C. (2008). Annexin A6-induced inhibition of cytoplasmic phospholipase A(2) is linked to Caveolin-1 export from the Golgi. Journal of Biological Chemistry, 283(15), 10174-10183. [More Information]
  • Rentero, C., Zech, T., Quinn, C., Engelhardt, K., Williamson, D., Grewal, T., Jessup, W., Harder, T., Gaus, K. (2008). Functional Implications of Plasma Membrane Condensation for T Cell Activation. PloS One, 3(5), e2262-1-e2262-14. [More Information]
  • Llado, A., Timpson, P., de Muga, S., Moreto´, J., Pol, A., Grewal, T., Daly, R., Enrich, C., Tebar, F. (2008). Protein kinase Cδ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Molecular Biology of the Cell, 19(1), 17-29. [More Information]

2007

  • Cubells, L., de Muga, S., Tebar, F., Wood, P., Evans, R., Ingelmo-Torres, M., Calvo, M., Gaus, K., Pol, A., Grewal, T., et al (2007). Annexin a6-Induced alterations in cholesterol transport and caveolin export from the Golgi complex. Traffic: the international journal of intracellular transport, 8(11), 1568-1589.
  • Grewal, T., Hegemann, A., Vila de Muga, S., Enrich, C. (2007). Annexins Regulate EGFR Signaling and Trafficking. Calcium Binding Proteins, 2(1), 11-20.

2006

  • Heeren, J., Beisiegel, U., Grewal, T. (2006). Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 442-448.
  • Turro, S., Ingelmo-Torres, M., Estanyol, J., Tebar, F., Fernandez, M., Albor, C., Gaus, K., Grewal, T., Enrich, C., Pol, A. (2006). Identification and Characterization of Associated with Lipid Droplet Protein 1: A Novel Membrane-Associated Protein That Resides on Hepatic Lipid Droplets. Traffic: the international journal of intracellular transport, 7, 1254-1269.
  • Rentero, C., Evans, R., Wood, P., Tebar, F., Vila de Muga, S., Cubells, L., de Diego, I., Hayes, T., Hughes, W., Pol, A., Rye, K., Grewal, T., et al (2006). Inhibition of H-Ras and MAPK is compensated by PKC-dependent pathways in annexin A6 expressing cells. Cellular Signalling, 18(7), 1006-1016. [More Information]
  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2006). Involvement of Targeting and Scaffolding Proteins in the Regulation of the EGFR/Ras/MAPK Pathway in Oncogenesis. Current Signal Transduction Therapy, 1(2), 147-167.
  • Grewal, T., Enrich, C. (2006). Molecular mechanisms involved in Ras inactivation: the annexin A6-p120GAP complex. BioEssays, 28(12), 1211-1220. [More Information]

2005

  • Grewal, T., Evans, R., Rentero, C., Tebar, F., Cubells, L., de Diego, I., Kirchhoff, M., Hughes, W., Heeren, J., Rye, K., et al (2005). Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity. Oncogene, 24, 5809-5820.

2004

  • Grewal, T., Tebar, F., Pol, A., Enrich, C. (2004). Annexin A6 and its Role in Ras Signaling. Annexins, 1(1), 62-67.
  • Laatsch, A., Ragozin, S., Grewal, T., Beisiegel, U., Heeren, J. (2004). Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). European Journal of Cell Biology, 83, 113-120.
  • Heeren, J., Grewal, T., Laatsch, A., Becker, N., Rinninger, F., Rye, K., Beisiegel, U. (2004). Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation. Journal of Biological Chemistry, 279(53), 55483-55492. [More Information]

2003

  • Grewal, T., de Diego, I., Kirchhoff, M., Tebar, F., Heeren, J., Rinninger, F., Enrich, C. (2003). High Density Lipoprotein induced Signaling of the MAPK Pathway Involves Scavenger Receptor Type BI-mediated Activation of Ras. Journal of Biological Chemistry, 278(19), 16478-16481.
  • Heeren, J., Grewal, T., Laatsch, A., Rottke, D., Rinninger, F., Enrich, C., Beisiegel, U. (2003). Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization. Journal of Biological Chemistry, 278(16), 14370-14378.
  • Grewal, T., Enrich, C., Jaeckle, S. (2003). Role of annexin VI in receptor-mediated endocytosis, membrane trafficking and signal transduction. In Joanna Bandorowicz-Pikula (Eds.), Annexins: Biological Importance and Annexin-Related Pathologies, (pp. 157-164). United States: Landes Biosciences.

2002

  • de Diego, I., Schwartz, F., Siegfried, H., Dauterstedt, P., Heeren, J., Beisiegel, U., Enrich, C., Grewal, T. (2002). Cholesterol Modulates the Membrane Binding and Intracellular Distribution of Annexin 6. Journal of Biological Chemistry, 35, 32187-32194.

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