Dr Wojtek Chrzanowski
MSc, PhD, DSc
Australian Institute for Nanoscale Science and Technology, Health and Medicine Theme Leader
Charles Perkins Centre (Health and Creativity node, Tissue Engineering node)
Visiting Professor, Dankook University
A15 - Pharmacy And Bank Building
The University of Sydney
|Telephone||+61 2 9351 5306|
|Curriculum vitae||Curriculum vitae|
Dr Wojciech Chrzanowski received his PhD from the Silesian University of Technology. In 2006 he was awarded with a prestigious Marie Curie Intra European Fellowship and moved to University College London, and then to the University of Glasgow to conduct his research in the EU-funded project: Externally Activated Resorbable Materials. In 2014 he received DSc from the Polish Academy of Science and in 2016 SOAR Fellowship.
His research centres around nanomedicine, nanosafety, nanomaterials and nano-bio-characterisation. His work has made a significant contribution to the understanding interaction of nanomaterials with living cells and tissue-like models assembled using magnetic 3D bioprinting. He develops stimuli responsive drug delivery systems that employ different types of nanoparticles to enhance the efficacy of drug therapy (i.e. chemotherapy) and regulated drug release. He also made a substantial contribution to the development of multifunctional surfaces that are capable of regulating cell responses.
Dr Chrzanowski has published his research outcomes in over 120 peer review papers and 50 conference proceedings. He is co-author of four patents and was invited to present his research at several Universities in the USA, UK, Japan, Hong Kong, Singapore, South Korea and Poland.
Safety of nanomaterials, which are virtually everywhere including cosmetics, toiletries, food products including sweets, chewing gum etc., vitamins, and drugs is of a colossal concern. There is already evidence that nanomaterials may induce seriously health problems and their effects on living organisms are largely unexplored. Dr Chrzanowski research develops functional tissue models of both healthy and diseased tissues to provide a deep understanding of nanomaterial interactions in biological environment. Furthermore, this new knowledge allows him to develop new classes of non-toxic nanomaterials and theranostics that may be used safely for diagnostic and therapeutic application i.e. controlled and targeted drug delivery.
Stem cells and exosomes delivery – a holistic approach for multifaceted lung tissue repair
Dr Chrzanowski laboratory develops a frontier cell- and exosome-based approach targeted at lung diseases. Dr Chrzanowski laboratory develops a frontier cell- and exosome-based approach targeted at lung diseases. In the area of drug delivery,his work is cantered on delivery systems that are capable of modulating drug uptake. In particular his develops stimuli-responsive materials that can target disease tissue and releasetherapeutic cargolocally upon external activation. Drug carriers are design to sensitise cells and upregulate drug adsorption.
Dr Chrzanowski work focuses on drug delivery systems that are capable of modulating drug uptake. In particular his research centres around stimuli-responsive materials that can target disease tissue and release drug locally upon external activation. Drug carriers are design to sensitise cells and upregulate drug adsorption.
Dr Chrzanowski laboratory applies a multifaceted system approach to examine material characteristic at nanoscale to gain fundamental understanding of cellular responses and modulation. He have assembled an unparalleled suite of microscopy systems (of which three are unique to the Asia Pacific region) dedicated to bio-nano-characterisation experiments, which includes: molecular force probe (MFP-3d-BIO), three atomic force microscopes which feature advanced nanomechanical operation modes (PeakForce QNM, Amplitude Modulated Force Microscopy), nano Infra-Red spectroscopy system (nanoIR, ANASYS), Lorenz Contact Resonance microscope, 3D cell explorer (Nanolive), inverse gas chromatography (IGC), ATR-FTIR, qNano (scanning ion occlusion sensing system), Surface Plasmon Resonance spectroscope (SPR), ElastoSensBio2 and surface energy analysers. The facility include also state-of-the-art cell culture laboratory equipped with IncuCyte (build in microscopy system in the incubator for continuous life cell imaging), flow cytometery, high-resolution fluorescent microscopy and qPCR.
Teaching and supervision
- Novel Therapeutics, Formulation and Dispensing
- Biomedical Engineering
Current research students
|Project title||Research student|
|ELECTROSTATICS CHARGING STUDY OF INHALED PHARMACEUTICAL AEROSOLS||Jiaqi YU|
- International Society for Extracellular Vesicles
- Australian Nanotechnology Network
- Australasian Pharmaceutical Science Association
- Editor of Advanced Drug Delivery Reviewissue on ‘Bionics-nature-inspired smart materials’
- Member of:The Australian Research Network for Advanced Materials (ARNAM),STEM Ambassador,Knowledge Transfer Network,European Society for Biomaterials
- Editorial boards: Journal of Tissue Engineering, Journal of Biomaterials Engineering
- Reviewer of: Journal of Biomaterials Applications, Acta Biomaterialia,Surface and Coating Technology, Journal of Materials Processing Technology Advanced Biomaterials, Journal of Biomedical Materials Research: part B – Applied Biomaterials, Materials Science and Engineering C: Materials for Biological Applications
Awards and honours
- SOAR Fellowship (Research Accelertaor Fellowship)
- 2016 Award for Reduction in the Use of Animals in Research
- Endeavour Executive Award 2012 – fellowship at Harvard-MIT, Harvard Medical School; award funded by The Department of Industry, Innovation, Science, Research and Tertiary Education of Australian Government.
- Winner of ProIMAGE Contest 2012 (NT-MDT) for the image of collagen fibres using atomic force microscopy.
- Placement in the prestigious Scottish Crucible 2009 program, funded for 30 leading young researchers in all fields from across Scotland.
- Awarded a Marie Curie Intra European Fellowship (2006) to conduct research at University College London. This was the most highly sought after fellowship program offered by the EU’s FP7.
- Class I Principal Award for Scientific Team (2007), awarded by the Senate of the Silesian University of Technology for scientific research excellence.
Cancer; Biointerfaces; Biomedical engineering
PhD and master's project opportunities
- Magnetically bioprinted three dimensional scaffold-free liver model for nanotoxicity studies; Khanal D, Zhang F, Song Y, Hau H, Fu D, Ramzan I, Cai W, Chrzanowski W; DVC Research/Award for Reduction in the Use of Animals in Research.
- SOAR Fellowship - Chrzanowski, Wojciech; Chrzanowski W; DVC Research/SOAR Fellowships.
- NanoParticles: Safe or Not Safe?; Chrzanowski W, New E; University of Sydney/Sydney Southeast Asia Centre.
- Ion implanted 'Trojan horse' surfaces with antimicrobial activity; Chrzanowski W; Australian Nuclear Science and Technology Organisation/Research Portal - Access to ANSTO facilities and capabilities.
- ElastoSensTM Bio2; Dehghani F, Chrzanowski W, O'Neill G, McConchie R, Chandrawati R; University of Sydney/Equipment Grant.
- 3D cell explorer; Chrzanowski W, King N, Weiss A, George J, Boddy A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Novel Silk based drug carriers targeted for lung cancer; Chrzanowski W; University of Sydney/Sydney Catalyst.
- Cancer invasion and metastasis: how actin networks control cell movement in 3 dimensional environments; O'Neill G, Biro M, Dehghani F, Chrzanowski W, Richardson D; DVC Research/SPARC Implementation - Cancer.
- Australian Government Department of Education and Training Endeavour Research Fellowship; Chrzanowski W; Department of Education and Training (Federal)/Endeavour Scholarships and Fellowships.
- NanoSafety – new generation of 3D scaffold-free tissue models for high throughput nanotoxicity and drug delivery studies; Chrzanowski W; DVC Research/AINST Accelerator Scheme.
- Multifunctional surfaces for implantable devices; Chrzanowski W; Australian Institute of Nuclear Science and Engineering (AINSE)/Research Projects.
- Kicking, scorching and cooling cells to guide their fate – understanding effects of vibrations and temperatures on a single cell responses using novel micorfuidic devices; Chrzanowski W; Australian Academy of Science/Scientific Visits to Japan.
- Scientific Visits to Japan - JSPS Invitation Fellowships (Short-term); Chrzanowski W; Australian Academy of Science/Japan Society for the Promotion of Science Fellowships.
- Biomedical Engineering. EU Australian cooperation at master level (BEAM); Migliaresi C, Reis R, Groth T, Hutmacher D, Chrzanowski W, Weiss A; EU - Australian Government/EU-ICI ECP Education Cooperation Programme.
- Externally activated drug eluting implants/devices; Chrzanowski W; DVC Research/Bridging Support Grant.
- Clean Technologies for the synthesis and purification of a biohybrid and biodegradable polymer; Dehghani F, Chrzanowski W; Australian Research Council (ARC)/Linkage Projects (LP).
- nanoIR - nanoscale bioimaging with continuous mapping of chemical and physical properties; Gomes V, Dehghani F, Gan Y, Chang L, Jabbarzadeh-Khoei A, McKenzie D, Hanaor D, Zhou F, Chrzanowski W, Braet F, Bilek M, Chan K, Perrier S, O'Neill G, Ammit A, Brand-Miller J, McEwan A, Hawkett B, Kondyurin A, Li Q, Burgess J, Li Z; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Clean Technologies for the synthesis and purification of a biohybrid and biodegradable polymer; Chrzanowski W, Dehghani F; BlueScope Steel - Lysaght Technology/Project Support.
- Molecular force probe for nanoscale bioimaging; Chrzanowski W; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Talking to cells - biointerface as a key parameter in communication with cells; Chrzanowski W, Brown D, Dehghani F, Hibbs D, Ravarian R, Wassef A, Wong J, Yun Y, Lee J, Jang J, Hwang J, Shin S, Shin U, Lee S, Kim H; DVC International/IPDF Grant.
- qNano scanning ion occlusion spectroscopy (SIOS); Chrzanowski W, Bebawy M, Dehghani F, Chan K, Rohanizadeh R, Hawkett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Antimicrobial gallium and strontium implanted materials for tissue engineering and regenerative medicine; Chrzanowski W; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
- The Instron testing material instrument (Model 5943); Dehghani F, Weiss A, Bilek M, Zreiqat H, Dunstan C, Chrzanowski W, Rohanizadeh R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
Biointerfaces: Where Material Meets Biology (Royal Society of Chemistry, 2015)
Engineering Surface Properties of Nickel-Titanium Alloy for Improved Osteointegration (Wydawnictwo Politechniki Slaskiej, 2012)