Dr Wojtek Chrzanowski
MSc, PhD, DSc
Senior Lecturer, Pharmaceutics
Charles Perkins Centre (Health and Creativity node, Tissue Engineering node)
Visiting Professor, Dankook University
A15 - Pharmacy And Bank Building
The University of Sydney
|Telephone||+61 2 9351 5306|
|Curriculum vitae||Curriculum vitae|
Dr Wojciech Chrzanowski received his PhD from the Silesian University of Technology. In 2006 he was awarded with a prestigious Marie Curie IntraEurpoean Fellowship and moved to University College London, and then to the University of Glasgow to conduct his research in the EU-funded project: Externally Activated Resorbable Materials. In 2014 he received DSc from the Polish Academy of Science.
His research centres around nanomedicine, biointefaces, nanomaterials and nanocharacterisation. His work has made a significant contribution to the development of bionterfaces on biomaterials that are capable of regulating cell responses. A significant proportion of the work focused on smart, shape memory materials. His research is a major contribution to the understanding of the development of novel antimicrobial, self-cleaning materials, bioactive degradable glasses and composites, and surfaces that guide DNA binding. He develops stimuli responsive drug delivery systems that employ different types of nanoparticles to enhance the efficacy of drug therapy (i.e. chemotherapy) and regulated drug release.
Dr Chrzanowski has published his research outcomes in over 70 papers and 50 conference proceedings. He is co-author of two patents and was invited to present his research at several Universities in the USA, UK, Japan, South Korea and Poland.
Biointerface is understood as an interconnection between a synthetic or natural material and tissue, microorganism, cell, virus or biomolecule. Biointerface often refers to the surface of biomaterials that dictates responses of cell and tissue. Therefore, through the engineering of this surface it is possible to regulate biological responses. Dr Chrzanowski's research develops multifunctional surfaces that regulated cell attachment and differentiation. The regulation is achieved using biointerfaces with immobilised protein/peptide that modulated cell responses in a controlled manner.
His work focuses also on drug delivery systems that are capable of modulating drug uptake. In particular his research centres around responsive materials that can target disease and control drug release upon external activation. Drug carriers are design to sensitise cells and upregulate drug adsorption. Nano/molecular characterisation of materials.
In Dr Chrzanowski's laboratory, he uses state-of-art imaging and probing facilities nanoIR (nanoTA, SThM, LCR), Scanning Ion Conductance Microscope and Molecular Probe equipped in nanopro toolbox used for nanocharacterisation of mechanical properties of materials. Both techniques are fully integrated with fluorescence and light microscope to provide unique combination of 2D and 3D integrated images of various types of materials. Current projects look closely on cell mechanics and real time changes to the cell membrane and cells morphology upon specific stimuli.
Teaching and supervision
- Novel Therapeutics, Formulation and Dispensing
- Biomedical Engineering
Current research students
|Project title||Research student|
|The development of novel artificial bone and vascular implants||Callum Arthur Charles STEWART|
|ELECTROSTATICS CHARGING STUDY OF INHALED PHARMACEUTICAL AEROSOLS||Jiaqi YU|
- Editor of Advanced Drug Delivery Reviewissue on ‘Bionics-nature-inspired smart materials’
- Member of:The Australian Research Network for Advanced Materials (ARNAM),STEM Ambassador,Knowledge Transfer Network,European Society for Biomaterials
- Editorial boards: Journal of Tissue Engineering, Journal of Biomaterials Engineering
- Reviewer of: Journal of Biomaterials Applications, Acta Biomaterialia,Surface and Coating Technology, Journal of Materials Processing Technology Advanced Biomaterials, Journal of Biomedical Materials Research: part B – Applied Biomaterials, Materials Science and Engineering C: Materials for Biological Applications
Awards and honours
- Endeavour Executive Award 2012 – fellowship at Harvard-MIT, Harvard Medical School; award funded by The Department of Industry, Innovation, Science, Research and Tertiary Education of Australian Government.
- Winner of ProIMAGE Contest 2012 (NT-MDT) for the image of collagen fibres using atomic force microscopy.
- Placement in the prestigious Scottish Crucible 2009 program, funded for 30 leading young researchers in all fields from across Scotland.
- Awarded a Marie Curie Intra European Fellowship (2006) to conduct research at University College London. This was the most highly sought after fellowship program offered by the EU’s FP7.
- Class I Principal Award for Scientific Team (2007), awarded by the Senate of the Silesian University of Technology for scientific research excellence.
Cancer; Biointerfaces; Biomedical engineering
PhD and master's project opportunities
- ElastoSensTM Bio2; Dehghani F, Chrzanowski W, O'Neill G, McConchie R, Chandrawati R; University of Sydney/Equipment Grant.
- 3D cell explorer; Chrzanowski W, King N, Weiss A, George J, Boddy A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Novel Silk based drug carriers targeted for lung cancer; Chrzanowski W; University of Sydney/Sydney Catalyst.
- Cancer invasion and metastasis: how actin networks control cell movement in 3 dimensional environments; O'Neill G, Biro M, Dehghani F, Chrzanowski W, Richardson D; DVC Research/SPARC Implementation - Cancer.
- Australian Government Department of Education and Training Endeavour Research Fellowship; Chrzanowski W; Department of Education/Endeavour Scholarships and Fellowships.
- NanoSafety – new generation of 3D scaffold-free tissue models for high throughput nanotoxicity and drug delivery studies; Chrzanowski W; DVC Research/AINST Accelerator Scheme.
- Multifunctional surfaces for implantable devices; Chrzanowski W; Australian Institute of Nuclear Science and Engineering (AINSE)/Research Projects.
- Kicking, scorching and cooling cells to guide their fate – understanding effects of vibrations and temperatures on a single cell responses using novel micorfuidic devices; Chrzanowski W; Australian Academy of Science/Scientific Visits to Japan.
- Scientific Visits to Japan - JSPS Invitation Fellowships (Short-term); Chrzanowski W; Australian Academy of Science/Japan Society for the Promotion of Science Fellowships.
- Externally activated drug eluting implants/devices; Chrzanowski W; DVC Research/Bridging Support Grant.
- nanoIR - nanoscale bioimaging with continuous mapping of chemical and physical properties; Gomes V, Dehghani F, Gan Y, Chang L, Jabbarzadeh-Khoei A, McKenzie D, Hanaor D, Zhou F, Chrzanowski W, Braet F, Bilek M, Chan K, Perrier S, O'Neill G, Ammit A, Brand-Miller J, McEwan A, Hawkett B, Kondyurin A, Li Q, Burgess J, Li Z; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Clean Technologies for the synthesis and purification of a biohybrid and biodegradable polymer; Chrzanowski W, Dehghani F; BlueScope Steel - Lysaght Technology/Project Support.
- Talking to cells - biointerface as a key parameter in communication with cells; Chrzanowski W, Brown D, Dehghani F, Hibbs D, Ravarian R, Wassef A, Wong J, Yun Y, Lee J, Jang J, Hwang J, Shin S, Shin U, Lee S, Kim H; DVC International/IPDF Grant.
- Clean Technologies for the synthesis and purification of a biohybrid and biodegradable polymer; Dehghani F, Chrzanowski W; Australian Research Council (ARC)/Linkage Projects (LP).
- Molecular force probe for nanoscale bioimaging; Chrzanowski W; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Antimicrobial gallium and strontium implanted materials for tissue engineering and regenerative medicine; Chrzanowski W; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
- The Instron testing material instrument (Model 5943); Dehghani F, Weiss A, Bilek M, Zreiqat H, Dunstan C, Chrzanowski W, Rohanizadeh R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- qNano scanning ion occlusion spectroscopy (SIOS); Chrzanowski W, Bebawy M, Dehghani F, Chan K, Rohanizadeh R, Hawkett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
Biointerfaces: Where Material Meets Biology (Royal Society of Chemistry, 2015)
Engineering Surface Properties of Nickel-Titanium Alloy for Improved Osteointegration (Wydawnictwo Politechniki Slaskiej, 2012)