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Molecular and cellular mechanisms in neuroinflammatory disease

Molecular genetic and functional genomic approaches will be used to determine how immune hormones termed cytokines and chemokines communicate with cells in the central nervous syste more...

Supervisor(s): Campbell, Iain (Professor)

How do gingipains recognise their host cell targets?

Porphyromonas gingivalis is a gram-negative, rod-shaped anaerobic pathogenic bacterium that found in the oral cavity. more...

Supervisor(s): Collyer, Charles (Associate Professor)

Link between ATP supply and consumption in the maintenance of the shape of the red blood cell in normal and disease states

The link between the main energy supply (ATP from glycolysis) and its consumption by the cytoskeleton will be studied by using nuclear magnetic resonance (NMR) spectroscopy, compute more...

Supervisor(s): Kuchel, Philip (Professor)

Protein self-assembly in nature and disease

The project aims to understand the self-assembly of proteins into stable, fibrillar beta-sheet structures which underlies many amyloid diseases, such as Alzheimer’s disease, a more...

Supervisor(s): Sunde, Margaret (Dr)

Regulatory Proteins in Development and Disease

PhD projects in this laboratory are focused on understanding how key proteins can lead to both normal development and disease, and using this knowledge to develop reagents to inhibi more...

Supervisor(s): Matthews, Jacqui (Dr)

Protein and peptide biomarkers of myocardial ischemia

This project will identify novel biomarkers (diagnostics) of ischemia / reperfusion injury in the heart. more...

Supervisor(s): Cordwell, Stuart (Dr)

The role of calcium overload in myocardial ischemia / reperfusion injury

This project aims to identify the biochemical targets of calcium overload responsible for ischemia / reperfusion injury in the heart. more...

Supervisor(s): Cordwell, Stuart (Dr)

Identification of proteins specific to transmissible Pseudomonas aeruginosa in cystic fibrosis infection

This project will characterize the molecular basis for increased infectivity caused by an epidemic strain of Pseudomonas aeruginosa (AES-1) which infects many patients treated in cy more...

Supervisor(s): Cordwell, Stuart (Dr)

Post-translational modifications in bacterial proteins

This project will identify novel proteins that are post-translationally modified in bacterial pathogens and the role of such modification in virulence. more...

Supervisor(s): Cordwell, Stuart (Dr)

Studying gene regulation using the model organism Caenorhabditis elegans

This project aims to characterise the biological roles of CtBP, a protein implicated in control of cell death and cancer metastasis, and to identify the molecules that function with more...

Supervisor(s): Nicholas, Hannah (Dr)