The splicing factor RBM4 in cancer and other diseases
Summary
This project will investigate the role of a new splicing factor, RBM4, in cancer and other diseases.
Supervisor(s)
Research Location
Program Type
Masters/PHD
Synopsis
Normal growth and differentiation of human cells must be regulated precisely. An important process for normal functioning of the cell is splicing, a mechanism that removes the noncoding sequences from the pre-mRNA. Defects in pre-mRNA splicing are responsible for 10–20% of cancers and related diseases. This project will investigate a new alternative splicing factor, RBM4, which we have found is inhibited by the tumour suppressor WT1, a protein which is implicated in pediatric Wilms’ Tumours. The role of RBM4 in cancer and other diseases will be investigated on a genome wide level, by utilizing a very new tool, the exon-microarray. This will show not only which genes and pathways are influenced by RBM4, but precisely which isoforms are controlled by RBM4. The project will also continue from some preliminary results of RBM4’s role in the cell cycle and its diverse localization in the cell.
Additional Information
Our lab uses a wide range of molecular and cellular biology techniques, such as real-time PCR, microarrays, deconvolution microscopy, cell culture, siRNA transfection, protein expression and detection, yeast-2-hybrid screening, cloning.
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Opportunity ID
The opportunity ID for this research opportunity is: 1074
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