Mechanism of action of some novel anti-malarial compounds
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We have been investigating the anti-malarial activities of 3 types of molecules and now need to determine the way that they act.
There are over 500 million malaria infections every year worldwide and these result in between 1 and 3 million deaths annually. Most victims are young children in Africa, pregnant women or visitors to malaria-endemic regions of the world. As well as causing great morbidity and mortality, malaria also adversely affects the economic and social fabric of those countries where it is a problem. Around 40% of the world's population live in areas where malaria is endemic. Malaria parasites have become resistant to a number of formerly effective anti-malarial drugs. There is great concern that this resistance may in future extend to the remaining active agents. It therefore is necessary to keep developing new agents that possess anti-malarial activity. We have been working on two such classes of compounds and have preliminary information about their mechanisms of actions that now needs to be examined more precisely.
Approaches: Growing malaria parasites in vitro, biochemistry, molecular biology. Techniques: cell culture, microscopy, gene expression analysis. Other Information: Nick Hunt’s laboratory is in the newly-refurbished Medical Foundation Building. The equipment and other facilities in the building are first class, as are the other research groups located there. His research group contains 3 postdoctoral fellows, 2 PhD students and a part-time technician. The laboratory is well-funded by two National Health and Medical Research Council, one Australian Research Council, and one Sir Zelman Cowen Foundation grant in 2009. Scholarships: Laboratory-funded scholarships may be available for suitably-qualified candidates.
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The opportunity ID for this research opportunity is: 112
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