The effect of modafinil on daytime sleepiness, neurobehavioural performance and quality of life in obstructive sleep apnea patients


This study will establish if modafinil can improve neurobehavioural and quality of life outcomes in patients with obstructive sleep apnea.


Professor Ron Grunstein, Associate Professor Peter Liu, Dr Nathaniel Marshall

Research Location

Camperdown - Woolcock Institute of Medical Research

Program Type



Obstructive Sleep Apnea (OSA) is an important cause of impaired quality of life (QOL), neurobehavioural (attention, sleepiness, cognition) and cardiovascular morbidity and mortality. Current scientifically established treatments for OSA (Continuous Positive Airway Pressure, CPAP and oral appliances) are accepted and used long term by only ~50% of patients seeking medical attention for OSA related symptoms. There is a strong need for alternative approaches in mechanical treatment-intolerant OSA patients. In this project, we propose to investigate whether administration of the wakefulness promoter, modafinil, will improve neurobehavioural and QOL outcomes.  

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neurocognitive performance, sleepiness, modafinil, wakefulness promoter, Obstructive Sleep Apnea

Opportunity ID

The opportunity ID for this research opportunity is: 1122

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