The role of a newly discovered enzyme, indoleamine dioxygenase-2, in health and in disease
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We have discovered the existence of a new enzyme, called indoleamine dioxygenase-2, and where it is located; now we need to find out what it does in the body, which probably relates to the control of blood pressure and male reproductive fertility.
The essential amino acid tryptophan is metabolised in only three ways:
- Incorporated into proteins
- Converted to 5-hydroxytryptamine
- Converted to kynurenine and other metabolites.
- Role in the kidney
- Role in male reproduction
- Role in immunoregulation
Approaches: molecular biology, biochemistry, pathology, physiology. Techniques: cell culture, immunohistochemistry, microscopy, quantitative RT-PCR, epithelial transport studies, sperm motility studies, enzyme kinetics. Other Information: Nick Hunt’s laboratory is in the newly-refurbished Medical Foundation Building. The equipment and other facilities in the building are first class, as are the other research groups located there. His research group contains 3 postdoctoral fellows, 2 PhD students and a part-time technician. The laboratory is well-funded by two National Health and Medical Research Council, one Australian Research Council and one Sir Zelman Cowen Foundation grant in 2009. Scholarhips: Laboratory-funded scholarships may be available for suitably-qualified candidates.
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Browse for other opportunities within the Camperdown - School of Medical Sciences - Bosch Institute .
Hypertension, infertility, diabetes, indoleamine dioxygenase, tryptophan, kynurenine, sodium transport, spermatozoa, kidney function, Cardiovascular & respiratory diseases, Infertility & developmental problems, Cell biology, Genes in biology & medicine, Human body, Reproduction & development
The opportunity ID for this research opportunity is: 114
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