Does dieting cause cannabinoid re-intoxication in humans?
Summary
Does dieting cause cannabinoid re-intoxication in humans?
Supervisor(s)
Research Location
Camperdown - School of Medical Sciences - Bosch Institute
Program Type
Masters/PHD
Synopsis
The main psychoactive constituent of cannabis, THC, is stored in fat for significant periods of time which explains its long elimination half-life. We have recently demonstrated in THC-treated rats that dieting or stress, by promoting fat breakdown, cause THC to be released back into the blood. Accordingly, it is possible that individuals who have kicked their cannabis habit for some time, who decide to go on a diet, may experience a sufficient increase in THC blood levels causing them to be “spontaneously” intoxicated. This phenomenon we have termed “re-intoxication” and it has significant implications for cannabis-related medicolegal cases. This project aims to demonstrate cannabis re-intoxication in human users. Cannabis withdrawing patients will undergo 24 hours of dieting and we will measure whether this increases THC blood levels that correlates with neuropsychological impairment.
Additional Information
Techniques: human study, neuropsychological tests, analytical techniques (HPLC and GCMS)
Want to find out more?
Contact us to find out what’s involved in applying for a PhD.
Contact Research Expert to find out more about participating in this opportunity.
Browse for other opportunities within the Camperdown - School of Medical Sciences - Bosch Institute .
Keywords
Opportunity ID
The opportunity ID for this research opportunity is: 1181
Other opportunities with Dr Jonathon Arnold