Defining the molecular role of nutrition in melanoma, breast and prostate cancer

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Summary

We are seeking a motivated PhD student to undertake cutting edge research to determine how nutrition is linked with major cancers such as melanoma, breast and prostate cancer

Supervisor(s)

Dr Jeff Holst

Research Location

Camperdown - Centenary Institute

Program Type

PHD

Synopsis

We are seeking a motivated PhD student to undertake cutting edge research to determine how nutrition is linked with major cancers such as melanoma, breast and prostate cancer.
The importance of lifestyle and environmental factors on development and disease has long been a focus of biomedical research and media attention. Diet in particular is implicated in many different diseases, however quantitative analysis of the effects of nutrition on disease has been restricted to epidemiological and animal studies.
Our laboratory has been examining amino acid transporters that are increased in melanoma, breast and prostate cancer. These transporters bring in essential amino acids such as leucine and glutamine, which are required for cell growth. We have shown that blocking these transporters can inhibit cancer cell growth.
This project aims to determine the role of these amino acid transporters in melanoma, prostate and breast cancer using our laboratories experience in transporter studies, in vitro and in vivo (mouse) models of disease, as well as performing structural studies in order to facilitate drug design.
In the same way as anti-angiogenesis drugs are targeted at reducing the blood supply of nutrients to cancer cells, amino acid transporters might provide a new target for anti-cancer therapies designed to starve the cancer.

Additional Information

Dr Holst joined the Centenary Institute in 2006 after a postdoc in the USA. He is currently Associate Faculty and head of the Origins of Cancer Laboratory at the Centenary Institute, and a Research Fellow at the University of Sydney
Dr Holst's laboratory aims to determine how amino acid transport regulates the development and progression of major cancers including melanoma, breast and prostate cancer, with the ultimate goal to generate therapies designed to block these transporters and starve the cancer

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Keywords

Prostate Cancer, Breast Cancer, melanoma, amino acid transport, signalling pathways, cell metabolism, therapeutic target

Opportunity ID

The opportunity ID for this research opportunity is: 1305