α-Actinin and Skeletal Muscle performance: Role of α-actinin-3 in muscle performance, metabolism, and disease
Summary
The INMR is part of the Children's Hospital at Westmead (CHW), the largest paediatric centre in NSW, providing the most advanced care and treatment options for the children of NSW, Australia, and across the Pacific Rim. The INMR has the best new researchers from Australia, New Zealand, and Europe to lead the challenge of understanding Muscle and Brain disorders and develop therapies to improve the lives of Australian children. The INMR is supported by competitive national and international research grants, with valued contributions from its fundraiser partners. Our scientists are internationally recognised research leaders and foster excellence in postgraduate training.
The INMR is located within the Kids Research Institute, on the Westmead campus, a major hub for research and medicine in NSW. We are affiliated with the University of Sydney and are easily accessible by public transport.
Projects are multi-disciplinary with training in molecular and cellular biology techniques, including gene discovery, PCR and western blotting, protein-protein interactions, animal model phenotyping, live cell imaging, flow cytometry, and immunology. More information can be found on our website
Supervisor(s)
Research Location
Program Type
PHD
Synopsis
To characterise the role of α-actinin-3 in skeletal muscle we have developed a knockout (KO) mouse model which is completely deficient for this protein. Currently we have projects examining the role of α-actinin-3 in skeletal muscle performance, muscle metabolism (obesity and type-2 diabetes) and inherited muscle disease (Duchenne muscular dystrophy).
Additional Information
This opportunity is available on a PhD scholarship with Institute for Neuroscience and Muscle Research. For more information about this research area, please contact Dr Kate Quinlan (kate.quinlan@sydney.edu.au)
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Keywords
α-actinin-3, skeletal muscle, knockout (KO) mouse model, skeletal muscle performance, muscle metabolism, inherited muscle disease
Opportunity ID
The opportunity ID for this research opportunity is: 1446
Other opportunities with Professor Kathryn North