Research opportunities in metabolism

Summary

Current recent projects:

Breast cancer metabolism - cross talk between different cell types within the breast

This project aims to investigate potential interaction the different cell types within the mammary gland.

Skeletal muscle lipid metabolism in type 2 diabetes and obesity

This project aims to investigate the how lipid within skeletal muscle is pathogenic for type 2 diabetes.

Supervisor(s)

Dr Andrew Hoy

Research Location

Camperdown - School of Medical Sciences - Bosch Institute

Program Type

Masters/PHD

Synopsis

Breast cancer metabolism - cross talk between different cell types within the breast
There is growing evidence of a potential role for metabolic processes regulating and/or sustaining cancer cell growth. This is evident as cancer cells are characterised by a dramatic change in their metabolic profile. Metabolic diseases such as obesity and type diabetes are also characterised by changes in metabolic processes but also changes in inter-tissue signals where the profile of cytokines and hormones released from organs that signal to other organs is deleterious in nature.
Along these lines this project will investigate whether similar relationships between different cell types within the breast exist and whether this interaction is altered in breast cancer. The project will involve cell culture (including primary and immortalised lines) and animal models with outputs including assessment of cellular metabolism by a variety of biochemical techniques and identification of novel secretory proteins through mass spectroscopy.

Skeletal muscle lipid metabolism in type 2 diabetes and obesity

It has been known for over 20 years that excessive amounts of lipid within tissue such as skeletal muscle are deleterious for blood glucose regulation - especially insulin regulation of glucose levels. Insulin is also a major regulator of lipid metabolism yet the role of dysfunctional insulin regulated lipid metabolism has been underappreciated.
Insulin is such as critical regulator of blood glucose and lipid levels. It has long been proposed that lipid accumulation precedes impaired insulin-stimulated glucose metabolism. This project will investigate whether insulin regulated lipid metabolism is a primary event in the generation of insulin resistance.

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Keywords

Cancer, metabolism, Lipid, Adipose, Breast Cancer, Obesity, Type 2 diabetes, Insulin resistance, skeletal muscle, exercise

Opportunity ID

The opportunity ID for this research opportunity is: 1523