Metal Ion Sensors for Medicinal and Environmental Applications

Summary

Metal cations like Zn(II), Cu and K(I) play a raft of important signalling roles in our bodies; others such as Hg(II), Cd(II) and Pb(II) are toxic pollutants in the environment. We are developing new sensors to selectively image these ions inside cells (as tools for diagnosing diseases like diabetes and Alzheimer’s disease) and in the environment. Now we want to increase the responsiveness of our sensors by (i) attaching them to optical fibres, and (ii) incorporating fluorescent nanoparticles.

Supervisor(s)

Associate Professor Peter Rutledge, Professor John Canning, Associate Professor Matthew Todd

Research Location

School of Chemistry

Program Type

Masters/PHD

Synopsis

Metal cations like Zn(II), Cu and K(I) play a raft of important signalling roles in our bodies; others such as Hg(II), Cd(II) and Pb(II) are toxic pollutants in the environment. We are developing new sensors to selectively image these ions inside cells (as tools for diagnosing diseases like diabetes and Alzheimer’s disease) and in the environment. Now we want to increase the responsiveness of our sensors by (i) attaching them to optical fibres, and (ii) incorporating fluorescent nanoparticles.

Additional Information

Working on this project, you will use organic synthesis, spectroscopic techniques including 1H and 13C NMR, IR and mass spectroscopy and chromatography. You will also have the opportunity to develop further skills in coordination chemistry, crystallography, nanotechnology and photonics. Prior experience in one or more of these areas would be an advantage but is not required.Laboratory costs (chemicals, consumables, spectroscopy) will be covered through existing funding in the group, however direct funding for fees or scholarships is not currently available from within the group. Australian and New Zealand citizens should apply for an Australian Postgraduate Award, International Students should apply for scholarship funding through the International Office and Science Faculty schemes.

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Keywords

Keywords :click reaction, fluorescence, macrocycles, molecular probes, sensors, synthesis

Opportunity ID

The opportunity ID for this research opportunity is: 1550

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