Does physical activity and exercise modify the cardiovascular , metabolic, and hepatic effects of alcohol intake on the human body?


The proposed research project will examine how physical activity and exercise modify the acute and long-term physiological effects of alcohol intake on cardio-metabolic and hepatic health. The specific objectives will address the role of duration of exposure, timing and intensity of physical activity in relation to alcohol intake. Depending on the interests of the candidate, this project offers opportunities for epidemiological work, controlled experiments, or a combination of both.


Associate Professor Emmanuel Stamatakis, Dr Nathan Johnson

Research Location

Exercise, Health and Performance Research Group

Program Type



It is well-established that physical activity and exercise have multiple cardio-protective and general health benefits. Although the effect of physical activity on liver function remains unclear, high levels of habitual physical activity have been shown to be associated with a reduced incidence of non-alcoholic fatty liver disease, and short-term exercise interventions have proven to be effective in lowering liver fat levels. On the other hand, moderate consumption of alcohol is considered beneficial for cardiovascular health but high alcohol consumption is linked to poor cardiovascular health and increased risk for various severe liver disorders including alcoholic liver disease, liver cirrhosis, and alcoholic hepatitis. Recent longitudinal epidemiological studies suggest that among those who have high levels of physical activity and high cardiorespiratory fitness, alcohol intake is not associated with increased risk for cardiovascular mortality. These observational studies imply that regular exercise may, to some extent, protect against the health risks associated with alcohol drinking, although there a paucity of studies in controlled settings.

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physical activity, Liver disease, Liver, hepatic, Blood pressure, Randomised Controlled Trial, RCT, Health behaviour, cardiovascular, metabolic, diabetes, cardiometabolic, behaviour change, prevention, Alcohol, ethanol, physiology, lifestyle, controlled trial, moderator, epidemiology, effect modification, cardiorespiratory fitness, aerobic capacity

Opportunity ID

The opportunity ID for this research opportunity is: 1894

Other opportunities with Associate Professor Emmanuel Stamatakis

Other opportunities with Dr Nathan Johnson