Novel therapies for treating progressive chronic kidney disease
The use of DNA vaccination and regulatory cells to treat progressive kidney disease.
This project is examining the use of regulatory lymphocytes, regulatory macrophages and regulatory dendritic cells as treatments for progressive kidney disease. Regulatory phenotype is achieved by in vitro transduction of regulatory genes, or by application of cytokines which determine the regulatory phenotype. DNA vaccination using genes identified to be important players in the progression of kidney disease will also be used as a novel approach to therapy. The effect on treatment efficacy of vaccination against multiple genes will be examined. These novel therapies are being examined in rodent models of diabetic and non-diabetic kidney disease. It is anticipated that this research will ultimately lead to the definition therapies to be applied to human kidney disease.
Want to find out more?
The opportunity ID for this research opportunity is: 201