The Role of Leptin in Modulating Alcohol-Associated Hepatic fibrosis: An in vitro study

Summary

This project will assess whether the hormone leptin, either directly and/or indirectly potentiates alcohol-induced liver injury and fibrosis.

Supervisor(s)

Professor Jacob George

Research Location

Storr Liver Unit, Westmead Millennium Institute

Program Type

Masters/PHD

Synopsis

The studies outlined we anticipate will elucidate the mechanisms whereby overweight and obesity makes the liver more susceptible to alcohol-associated liver disease. We will employ hepatic stellate cells (HSCs), Kupffer cells (KCs) and sinusoidal endothelial cells (SECs) isolated from both normal and Zucker rats (leptin receptor deficient) to determine whether combined treatment with leptin and alcohol (or acetaldehyde) directly and/or indirectly promotes alcohol-induced expression by HSCs of scar tissue components (Collagen I), or of mediators that are well known to drive the production of scar tissue. The relevant intracellular pathways involved in mediating these effects will be analyzed. Zucker rats will be used to clarify whether any observed effects are mediated by the leptin receptor.

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Keywords

Liver fibrosis, Liver and hormonal disorders, Cell biology, hepatic stellate cells, Liver & hormonal disorders, Health & lifestyle, Human body

Opportunity ID

The opportunity ID for this research opportunity is: 202

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