Molecular basis of human heart failure
We are searching for molecular markers that distinguish between failing and non-failing human heart muscle.
In 1989 I began to collaborate with the late Dr Victor Chang, and over the last 18 years I have collaborated with the Heart/Lung Transplant Unit at St Vincent's Hospital, collecting over 14,000 samples from nearly 350 failing human hearts and more than 50 un-used donor (non-failing) hearts. We share these samples with over 30 research groups in nine countries. We have examined these samples using “gene chips” (Harvard, USA and Nantes, France collaborations), using proteomic analyses (Johns Hopkins University, USA; Free University, Amsterdam; Dublin, Ireland), as well as a number of specialist techniques including molecular motility assays (Imperial College, London), single fibre dynamics (King's College, London), titin analysis (Muenster University, Germany), and Spontaneous Oscillatory Contractions (Tokyo, Japan) to name a few. We coordinate these independent research projects with our own research projects. Our projects involve transcriptomics, proteomics and specialized projects involving the proteins in the intercalated disc in health and disease.
Techniques: gene chips, 2-dimensional gel electrophoresis, Western blots, electron microscopy, confocal microscopy, antibody arrays, bioinformatics. Other PhD Topics:
- Using antibody microarrays to examine cancer, autoimmune disease and inflammation
- A bioassay for biotoxic molecules in water
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Idiopathic dilated cardiomyopathy, familial dilated cardiomyopathy, ischaemic cardiomyopathy, hypertrophic cardiomyopathy, peripartum cardiomyopathy, virus-induced cardiomyopathy, Molecular analyses, human heart failure, Cardiovascular & respiratory diseases, Genetic disorders, Cell biology, Health & lifestyle, Heart & circulation
The opportunity ID for this research opportunity is: 239
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