Detecting cancer metastasis from 5mL of blood

Summary

Microarrays of antibodies can be used to monitor the cellular immune system for signs of inflammation, cancer and cancer metastatic state.

Supervisor(s)

Professor Cris dos Remedios

Research Location

Camperdown - School of Medical Sciences - Bosch Institute

Program Type

PHD

Synopsis

We monitor the surface antigens on white blood cells (leukocytes) looking for markers associated with cancer (particularly melanoma and breast cancer). The search is done by isolating mononuclear cells (or granulocytes) and applying them to an extensive array of antibody dots. Each antibody is directed against known surface marker proteins that are accessible to the extracellular matrix. When a leukocyte (e.g. T lymphocytes) recognizes a non-self protein attached to a non-self cell, it sets in motion a chain of events that result in the destruction of these cells. If this reaction/identification does not occur or is impaired, there will be no inflammatory response. Some cancer patients have the ability prevent metastases, thus stopping the metastatic spread of their cancer) while others do not. We are developing tests that can identify these two groups of patients.

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Keywords

Cancer, melamona, Breast Cancer, bowel cancer, Prostate Cancer, metastatic disease, antibody microarrays, CD antigens, surface protein markers, inflammation, cancer metastasis, secondary cancer, Leukocytes, inflammatory response, test for cancer, cellular immune system, Cancer & leukaemia, Health & lifestyle

Opportunity ID

The opportunity ID for this research opportunity is: 242

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