Immunological Mechanisms in Atherosclerosis
Summary
This project uses genetically altered mice to study immunological mechanisms underlying the development of arterial atherosclerosis.
Supervisor(s)
Research Location
Program Type
Masters/PHD
Synopsis
The immune response is important in modulating the inflammation that occurs in atherosclerosis. We have developed a mouse model of atherosclerosis to examine the process of neointimal proliferation (thickening) of the walls of arteries that have been mechanical damaged. This model allows us to probe immune mechanisms using genetically altered mice. These studies involve the use of microsurgical techniques, immunohistochemistry and mRNA quantitation using real time PCR.
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Keywords
Coronary artery disease, Myocardial infarction, atherosclerosis, inflammation, cytokines, Cardiovascular & respiratory diseases, Heart & circulation, Infection & immunity
Opportunity ID
The opportunity ID for this research opportunity is: 33
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