Immunological Mechanisms in Atherosclerosis

Summary

This project uses genetically altered mice to study immunological mechanisms underlying the development of arterial atherosclerosis.

Supervisor(s)

Associate Professor Brett Hambly

Research Location

Camperdown - School of Medical Sciences - Bosch Institute

Program Type

Masters/PHD

Synopsis

The immune response is important in modulating the inflammation that occurs in atherosclerosis. We have developed a mouse model of atherosclerosis to examine the process of neointimal proliferation (thickening) of the walls of arteries that have been mechanical damaged. This model allows us to probe immune mechanisms using genetically altered mice. These studies involve the use of microsurgical techniques, immunohistochemistry and mRNA quantitation using real time PCR.

Keywords

Coronary artery disease, Myocardial infarction, atherosclerosis, inflammation, cytokines, Cardiovascular & respiratory diseases, Heart & circulation, Infection & immunity

Opportunity ID

The opportunity ID for this research opportunity is: 33

Other opportunities with Associate Professor Brett Hambly

• Protein defects causing Familial Hypertrophic Cardiomyopathy
• other research opportunities available at Sydney Medical School
• Assessing changes to myocardial proteins subsequent to experimental heart attack