Onset of oxidative damage in human tissue proteins
Onset of protein oxidation and its implications for protein damage in human tissue proteins.
The accumulated effect of radical damage in biological systems has long been associated with serious disease and aging. The onset of these processes, however, is poorly understood at the molecular level. Radical Probe Mass Spectrometry (PR-MS), pioneered in this laboratory, is being applied to investigate early onset structural damage imparted by radicals on human tissue proteins alone and in aggregate. Long-lived human tissue proteins such as collagen, elastin, and lens crystallins are among those being studies as they are particularly susceptible to oxidative damage due to their low turnover. The research should lead to an improved understanding of the causative mechanisms associated with diseases prevalent in the aged population as diverse as cataract, atherosclerosis, liver damage, to cancer. It willl also aid in the development of preventative treatments and therapies.
Techniques: ESI mass spectrometry, chromatography, protein oxidation chemistry, radical chemistry Ph.D. topics:
- Onset of oxidative damage in crystallins in lens of the eye and the implications for cataractogenesis
- Interactions of crystallins and their role in protecting the lens of the eye from oxidative damage
- Differences in the crystalline populations in the young versus mature eye and their role in conferring stability to the lens of the eye
Want to find out more?
Tissue disease, aging, cataractogenesis, Protein oxidation, disease, imass spectrometry, radicals, tissue, crystallin, Cancer & leukaemia, Cardiovascular & respiratory diseases, Hearing & vision problems, Liver & hormonal disorders, Cell biology, Human body
The opportunity ID for this research opportunity is: 35
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