The Long-term Evaluation of Glucosamine Sulphate (LEGS) study.


This randomised controlled clinical trial will evaluate the effectiveness of glucosamine, with or without chondroitin, among people with symptomatic osteoarthritis of the knee.


Associate Professor Marlene Fransen

Research Location

Clinical and Rehabilitation Sciences Research Group

Program Type



A total of 600 patients with knee OA will be randomly allocated to glucosamine or matching placebo capsules and chondroitin or matching placebo capsules for two years. Participants will be required to complete a 7 day symptom and health care costs diary every two months and assessed annually with health status questionnaires, physical performance measures, radiographs and knee MRI. The main outcomes will be the rate of joint space narrowing and symptoms (pain and physical disability). A health economic analysis will be conducted alongside this trial.

Additional Information

Possible PhD topics:

  • Knee radiography
    • All 600 study participants will have a baseline semi-flexed radiograph of both knees, with follow-up at 1 and 2 years. Radiographs will be taken at about 4 radiology centres in Sydney.
  • Knee MRI
    • Baseline and 1 year 3T MRI of the signal knee joint will be conducted in 400 LEGS study participants at 3 different centres.

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osteoarthritis, complementary medicine, Primary Health Care, Medical Imaging, Therapeutics & adverse drug effects, Chronic diseases & ageing, Pharmacology & therapeutics, Public health & social medicine

Opportunity ID

The opportunity ID for this research opportunity is: 45

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