The molecular mechanisms of aging bone: lamins as the fountain of youth for the bone
Summary
The molecular mechanisms of aging bone: lamins as the fountain of youth for the bone
Supervisor(s)
Associate Professor Gustavo Duque
Research Location
Nepean Clinical School, Faculty of Medicine
Program Type
PHD
Synopsis
We have obtained recent evidence that lamin A/C, an important protein in the nuclear envelope, is required for the successful differentiation of mesenchymal stem cells (MSC) into either osteoblasts or adipocytes. These observations suggest that lamin A/C may be involved in the bone changes observed in age-related bone loss and that the regulation of lamin A/C might provide a new therapeutic approach for senile osteoporosis. This work has the potential to identify the specific role that lamin A/C has in the differentiation of bone marrow mesenchymal cells down to the osteoblast lineage in the bone microenvironment with the subsequent gain in bone formation.
Additional Information
To elucidate the effect of lamin A/C inhibition/overexpression on MSC differentiation
To assess bone changes in lamin A/C knock out mice
To identify potential therapeutic targets of lamin A/C pathways in order to prevent and treat senile osteoporosis
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Keywords
Lamin, aging, Osteoporosis, osteoblasts, Stem cells, adipocytes, Bone, senile, age-related bone loss, osteoblastogenesis, adipogenesis, Cell Differentiation, therapeutics
Opportunity ID
The opportunity ID for this research opportunity is: 543
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