Post-translational modifications in bacterial proteins

Summary

This project will identify novel proteins that are post-translationally modified in bacterial pathogens and the role of such modification in virulence.

Supervisor(s)

Dr Stuart Cordwell

Research Location

School of Molecular Bioscience

Program Type

Masters/PHD

Synopsis

Post-translational modifications, such as phosphorylation and glycosylation, modify the structure and function of proteins. Furthermore, protein cleavage provides antigenic variation and may dictate novel functions. This project will examine both global protein modifications (e.g. phosphoproteomics) as well as characterize modifications in individual proteins such as the CadF adhesin of Campylobacter jejuni. Oxidative stress, caused by the release of toxic reactive oxygen species (ROS) from inflammatory immune cells, must be overcome by the majority of human pathogens. This project aims to identify how oxidative stress modifies protein expression, as well as determine whether disulfide bond formation is induced under such conditions.

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Keywords

Cystic fibrosis, Gastrointestinal Disease, Guillain-Barre Syndrome, Antibiotic resistance, Proteomics, Phosphorylation, Glycosylation, oxidative stress, mass spectrometry, Infectious diseases, Cell biology, Infection & immunity

Opportunity ID

The opportunity ID for this research opportunity is: 65

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