Genetics of endocrine tumours.
The elucidation of the genetic changes which either predispose or are causal in endocrine tumours and to translate this research into improved patient care.
Our lab is studying the clinical and basic molecular aspects of both hereditary endocrine tumours. We have a bank of over 3000 tumour samples which are an invaluable resource for this work and we have formed a consortium of families and clinicians to study the clinical manifestations of these tumours. We are also performing basic molecular and gene regulatory studies to elucidate the causes and potential therapeutic targets in these tumours.
Cancer Genetics work focuses on the genetics of adrenal, thyroid and brain tumours and PhD projects are possible in these 3 areas in this laboratory.
The Adrenal Group (Head: Professor Bruce Robinson) studies adrenocortical cancer and phaeochromocytomas with specific aims of understanding the benign to malignant progression and the identification of markers to differentiate benign from malignant tumours.
Associate Supervisors: Dr Stan Sidhu, Dr Dindy Benn
Thyroid Cancer and Mineral Laboratory (Head: Dr Rory Clifton-Bligh) studies of PAX8-PPARγ, a fusion protein present in follicular thyroid cancers.
Medullary Thyroid Carcinoma Laboratory (Head: Professor Bruce Robinson): Patients with medullary thyroid carcinoma generally have poor response to chemotherapeutic agents and genetic research in this disease aims to discover gene targets for improved treatment options for these patients.
Associate Supervisors: Dr Stan Sidhu and Dr Marinella Messina.
Brain Cancer Projects are also available.
The Cancer Genetic laboratory established by Professor Bruce Robinson in 1992, has made major contributions over the past 15 years to the understanding of the genetic basis of endocrine tumours. Early work focused on multiple endocrine neoplasia type 2A and the role of the RET gene in medullary thyroid carcinoma with contributions to 2 International Consortia. More recently we have initiated and co ordinated The SDH International Consortium of Phaeochromocytoma /Paraganglioma Familial syndromes, on the clinical phenotype/genotype correlations in this disease. Firm collaborations between surgeons, pathologists, endocrinologists and scientists continue to build our key resource, the large number of endocrine tumours housed in the NeuroEndocrine Tumour Bank which has resulted in 26 publications and contributed to 20 PhD projects.
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The opportunity ID for this research opportunity is: 785