Plasmonics for Protein Attachment

Summary

Plasmonics will be used in combination with ellipsometry to investigate the attachment of biomolecules to surfaces. The structure of the attached layers will be investigated using novel optical methods.

Supervisor(s)

Professor David McKenzie

Research Location

School of Physics

Program Type

Masters/PHD

Synopsis

The attachment of biomolecules to surfaces is a research area with many applications in biosensing and medical diagnostics. In a biosensor, a surface is prepared with sites that are specific to the molecular species that is being targeted. The target may be a toxin, an antibody or a protein specific to a disease. The attachment step is detected by means of a sensitive readout technology. In this project, the readout technology is optical and therefore does not interfere with the attachment process. The challenge is to make the detection sensitive enough so that very small amounts of the targeted species can be detected. We will use fundamental principles of optics that relate to the changes in the polarization state of the light that occur upon attachment of the target molecules at an interface. The polarization state of light is measured in a process known as ellipsometry, a technique in which the phase changes as well as the amplitude changes in a light beam are detected after reflection form a surface. In one version of the technique, a surface plasmon is created on a metal surface as a result of the interaction with light, and this gives a high sensitivity to the detection process. We will use both theoretical methods for calculating the effects of adherent layers on the reflected light beams as well as experiments in which the detection process is set up in the laboratory using a flow cell and our state of the art ellipsometer.

Additional Information

The research project is within a collaborative team that includes researchers in physics, biophysics and biochemistry. It will be located in a new purpose built laboratory in the School of Physics that will be opened in Semester 1, 2009. Other researchers including students are working in related fields. The student would learn research techniques in optics, spectroscopy, microscopy and surface analysis. There will be opportunities for publication in high impact factor journals and opportunities to present the results of the work at conferences. There are opportunities for Honours students in the project. A top up scholarship may be available for suitably qualified students.

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Keywords

physics, plasmonics, optical detection, optical physics, biosensors, plasma physics, protein, protein attachment, biomolecules

Opportunity ID

The opportunity ID for this research opportunity is: 823

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