Medicinal and Pharmaceutical Chemistry — Design, Synthesis and Testing of New Anti-Bacterial Agents

Summary

This project would appeal to those with interests in pharmaceutical applications of medicinal and protein chemistry.

Supervisor(s)

Professor Paul Groundwater, Dr W Bret Church, Professor David (Dai) Hibbs

Research Location

Pharmacy Research Theme - Cancer

Program Type

Masters/PHD

Synopsis

Pseudomonas aeruginosa is the most common respiratory pathogen in patients with cystic fibrosis and causes systemic infections in patients who are immunosuppressed as a result of severe burns, cancer and AIDS.  This project will build upon our initial results (from a project aimed at developing new agents for the detection of this bacterium [PW Groundwater et al., Org. & Biomol. Chem., 2008, 8, 682; doi: 10.1039/b716978g]) and will aim  to  selectively release specific antibiotics within Pseudomonas aeruginosa, thereby improving their uptake and efficacy.  This project would appeal to those with interests in pharmaceutical applications of medicinal and protein chemistry.

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Keywords

Anti-bacterial, pharmaceutical chemistry, respiratory, Cystic fibrosis, Cancer, antibiotics, protein, synthesis, testing, agents, pharmacy

Opportunity ID

The opportunity ID for this research opportunity is: 938

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