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Understanding how Flaviviruses interact with the host immune system to cause disease

This laboratory is investigating the interaction of neurotropic Flaviviruses with the vertebrate host immune system to discover how it causes immune-mediated disease (immunopatholog more...

Supervisor(s): King, Nicholas (Professor)

Dendritic cells and control of T cell immune responses

DCs are unique antigen-presenting cells that can initiate (prime) CD4 T cell responses, as well as controlling the progression and subsequent reduction of the immune response, devel more...

Supervisor(s): Fazekas, Barbara (Professor)

An investigation into the mechanisms of immune evasion in metastatic melanoma patients treated with molecular or immune checkpoint inhibitors.

The aim of this project is to characterise the immune reaction and prevalence of immune inhibitory mechanisms present in metastatic melanoma patient tumours whilst on immune checkpo more...

Supervisor(s): Scolyer, Richard (Professor), Long, Georgina (Professor)

Genetic Modulation of the host response to pulmonary tuberculosis

This project will investigate alternative therapies to treat tuberculosis utilising viral vectors to overexpress immunological genes of interest to try and increase immunity to tube more...

Supervisor(s): Saunders, Bernadette (Dr)

Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D

Role of NKG2D in the human cellular immune response against porcine xenotransplants. more...

Supervisor(s): Sharland, Alexandra (Dr)

Clinical utility of MS molecular phenotypes of MS

My group at the Centre for Immunology aims to translate immunogenetic findings from discovery to clinical practice. We have used genome wide association studies to identify genetic more...

Supervisor(s): Booth, David (Associate Professor)

MS-risk genes and EBV or other virus infection

My group at the Centre for Immunology aims to translate immunogenetic findings from discovery to clinical practice. We have used genome wide association studies to identify genetic more...

Supervisor(s): Booth, David (Associate Professor)

Genetic control of resistance and susceptibility to tuberculosis

Both environmental and genetic factors influence susceptibility to tuberculosis; this project will identify and investigate polymorphisms in genes that may increase susceptibility t more...

Supervisor(s): Saunders, Bernadette (Dr)

Phosphate homeostasis and fungal virulence

Inorganic phosphate (Pi) is an important macronutrient for all living organisms including yeast, and is essential for ATP, phospholipid and protein synthesis, metabolism and signall more...

Supervisor(s): Djordjevic, Julianne (Dr), Sorrell, Tania (Professor)

How do gingipains recognise their host cell targets?

Porphyromonas gingivalis is a gram-negative, rod-shaped anaerobic pathogenic bacterium that found in the oral cavity. more...

Supervisor(s): Collyer, Charles (Associate Professor)