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Role of Protein Phosphorylation in Cellular Function

Using advances in mass spectrometry-based proteomics this project aims to uncover how phosphorylation affects the function of proteins and cells in both healthy and diseased states. more...

Supervisor(s): James, David (Professor)

How do molecules make memories? Understanding synaptic plasticity at the level of protein pathways and signalling.

This project aims to discover and validate new molecular mechanisms of how synaptic plasticity, which underlies learning and memory, is regulated by protein interactions and phospho more...

Supervisor(s): Graham, Mark (Dr)

Post-translational modifications in bacterial proteins

This project will identify novel proteins that are post-translationally modified in bacterial pathogens and the role of such modification in virulence. more...

Supervisor(s): Cordwell, Stuart (Professor)

How to stop an epileptic seizure - looking for the right molecules to target

Over 400 proteins are implicated in epilepsy. This project involves interrogating models of epilepsy to determine which are the key pathways and molecular mechanisms which could be more...

Supervisor(s): Graham, Mark (Dr)

The role of calcium overload in myocardial ischemia / reperfusion injury

This project aims to identify the biochemical targets of calcium overload responsible for ischemia / reperfusion injury in the heart. more...

Supervisor(s): Cordwell, Stuart (Professor)

Insulin-mediated regulation of adipocyte lipolysis

Insulin, a hormone that is released after a meal, regulates many aspects of metabolism including a process called lipolysis that involves the release of fatty acids into the circula more...

Supervisor(s): James, David (Professor)