About Professor Steven Meikle
The driver for Steve’s research is the desire to understand human disease processes by extending the capabilities of medical imaging technology.
Professor Steven Meikle is an internationally recognized research leader in the physics of molecular imaging and its applications in pre-clinical research and clinical diagnostics.
Professor Steven Meikle is Head of the Discipline of Medical Radiation Sciences at the University of Sydney and Co-Director of the Ramaciotti Imaging Centre at the Brain and Mind Research Institute which is the Sydney node of the National Imaging Facility. He received his Bachelor of Applied Physics degree (Hons 1 and the University Medal) from the University of Technology, Sydney in 1988 and his Ph.D. degree from the Graduate School of Biomedical Engineering, University of New South Wales in 1995. He was a medical physicist at Royal Prince Alfred Hospital in Sydney (1987-2004), a visiting research associate at the Division of Nuclear Medicine and Biophysics, UCLA School of Medicine in Los Angeles (1991-2) and a post doctoral research scientist at the MRC Cyclotron Unit, Hammersmith Hospital in London (1995-6) before joining the University of Sydney in 2004. Professor Meikle’s research interests include the development of quantitative methodology for single photon emission computed tomography (SPECT) and positron emission tomography (PET) and instrumentation and computational methods development for small animal molecular imaging. He made fundamental contributions to the development of quantitative whole body PET, now widely used in staging and evaluation of treatment response for cancer patients, and developed one of the first multi-pinhole SPECT animal imaging systems. He has published 5 book chapters and more than 60 journal articles attracting over 1,300 citations. He has current grant support for his research of $1.25 million from national competitive grants and is the Australian lead investigator on a large multi-institution grant (4 institutions, US$3.1 million) from the U.S. Department of Energy. Professor Meikle was awarded the Boyce Worthley Prize for distinction in the practice of physical and engineering sciences in medicine from the ACPSEM in 1994, is a Fellow of the Australian Institute of Physics and a Senior Member of the Institute for Electrical and Electronics Engineers (IEEE) and serves on the International Advisory Committee of the IEEE Medical Imaging Conference.
For further information, please see Prof Meikle's staff profile:
http://sydney.edu.au/health_sciences/staff/steven_meikle
Selected publications
- Lehnert W, Meikle SR, Siegel S, Newport D, Banati RB, Rosenfeld AB. Evaluation of transmission methodology and attenuation correction for the microPET Focus 220 animal scanner. Phys Med Biol. 51:4003-4016, 2006. PubMedId: 16885620
- Meikle SR, Kench P, Kassiou M, Banati RB. Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol. 50:R45-R61, 2005. PubMedId: 16264248
- Meikle SR, Eberl S, Fulton RR, Kassiou M, Fulham MJ. The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain. Nucl Med Biol. 27:617-625, 2000. PubMedId: 11056379
- Meikle SR, Matthews JC, Brock CS, Wells P, Harte RJ, Cunningham VJ, Jones T, and Price P, Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study, Cancer Chemother Pharmacol, 42: 183-193, 1998. PubMedId: 9685053
- Meikle SR, Matthews JC, Cunningham VJ, Bailey DL, Livieratos L, Jones T, and Price P, Parametric image reconstruction using spectral analysis of PET projection data, Phys Med Biol, 43: 651-666, 1998. PubMedId: 9533143
- Meikle SR, Bailey DL, Hooper PK, Eberl S, Hutton BF, Jones WF, Fulton RR, and Fulham MJ, Simultaneous emission and transmission measurements for attenuation correction in whole body PET J Nucl Med, 36: 1680-1688, 1995. PubMedId: 7685231
- Meikle SR, Hutton BF, and Bailey DL, A transmission dependent method for scatter correction in SPECT, J Nucl Med, 35: 360-367, 1994. PubMedId: 8295011
- Meikle SR, Hutton BF, Bailey DL, Hooper PK, and Fulham MJ, Accelerated EM reconstruction in total body PET: potential for improving tumour detectability, Phys Med Biol, 39: 1689-1704, 1994. PubMedId: 15551539
- Meikle SR, Dahlbom M, and Cherry SR, Attenuation correction using count-limited transmission data in positron emission tomography, J Nucl Med, 34: 143-150, 1993. PubMedId: 8418258
- Tan P, Bailey DL, Meikle SR, Eberl S, Fulton RR, and Hutton BF, A scanning line source for simultaneous emission and transmission measurements in SPECT, J Nucl Med, 34: 1752-1760, 1993. PubMedId: 8410294