About Dr Alexandra Sharland

I am committed to improving outcomes in Transplantation by understanding the cellular and molecular mechanisms of transplant rejection and tolerance.

Medical graduate conducting basic and translational research in Transplantation.

Alexandra Sharland leads the Organ and Tissue Replacement research theme of the Bosch Institute. She is a medical graduate, with specialist qualifications in renal medicine, and a longstanding interest in transplantation immunobiology. She attained fellowship of the Royal Australasian College of Physicians in 1995, then embarked upon a career in medical research. Following completion of her PhD, she was awarded both the NHMRC CJ Martin, and Don and Lorraine Jacquot Travelling Fellowships to undertake postdoctoral studies in the Transplantation Biology Research Center at Massachusetts General Hospital and Harvard Medical School, in 2000-2001. During this period, her work centered on developing and testing strategies for inhibiting human anti-pig NK cell-mediated cytotoxicity, with the ultimate aim of facilitating clinical porcine to human xenotransplantation. Dr Sharland returned to Australia at the end of 2001, and in 2004 was appointed Senior Lecturer in Transplantation Immunobiology and Medical Foundation Research Fellow at the University of Sydney. She is a founding member of the Collaborative Transplantation Research Group, which unites teams from Royal Prince Alfred Hospital and the University of Sydney, and of the Sydney University Tissue Engineering Network. Her research interests include the interface between innate and adaptive immunity in allo and xenotransplantation, mechanisms of spontaneous and acquired transplantation tolerance, gene therapy in transplantation, and Tissue Engineering. Alexandra Sharland participates extensively in the teaching and supervision of undergraduate and postgraduate students in the faculties of Medicine and Science at the University of Sydney. Current and completed PhD students have all received scholarship support (APAs to S.Cordoba and P Tran and the highly prestigious Northcott Scholarship to J Laurence). All three have received Young Investigator Awards from TSANZ, and Travel Grants to present their work at international conferences. Shaun Cordoba received the Peter Bancroft Prize for his thesis, submitted in 2006. Dr Sharland contributes widely to professional activities both within and outside her research discipline. She is currently a member of the Council of the Transplantation Society of Australia and New Zealand, and has convened or helped organise a number of highly successful scientific meetings, including the Annual Scientific Meeting of the Transplantation Society in 2004, Gene Therapy in Transplantation Symposium at the Australian Health and Medical Research Congress in 2006, and the inaugural Sydney University Tissue Engineering Symposium. At an international level, Dr Sharland is a member of the Basic Science Programme Committee and the chair of the Postgraduate Course Committee for the 2008 Congress of the International Transplantation Society, and serves on the Editorial Board of the journal Xenotransplantation.

Selected publications

For a comprehensive list of Dr Sharland's publicatons, please visit her Sydney Medical School profile page.