About Associate Professor Arthur Conigrave
Arthur is fascinated by the molecular mechanisms that shape our body's metabolic responses to nutrients.
Prof Arthur Conigrave is an internationally recognized research leader on the links between nutrient-sensing and the metabolic basis of health and disease. He is particularly concerned with the origins of metabolic bone disease including osteoporosis, disorders of calcium metabolism and the impact of dietary nutrients on the control of appetite and weight gain.
Arthur Conigrave is Associate Professor in Medical Biochemistry and Metabolic Medicine at the University of Sydney. He graduated in Medical Science from that university in 1978, in Medicine in 1982, as a Master of Science in 1983 and as a Doctor of Philosophy in 1992. He is a Fellow of the Royal Australasian College of Physicians (1987). He is an Endocrinologist at Royal Prince Alfred Hospital. In 1999-2000, Prof Conigrave was at Harvard Medical School investigating the nutrient sensing properties of a specific family of receptors that is represented in the human genome at an exceptionally high level. This work has led to a major rethink about the molecular mechanisms that underpin nutrient sensing in the body. Prof Conigrave is currently Head of the School of Molecular and Microbial Biosciences which forms an important bridgehead between the Faculties of Science and Medicine. He is currently working to strengthen the links between MMB and other schools of the university that have major research interests in the life and medical sciences. His own research has been enriched by collaborations with Prof Stephen Simpson of the School of Biological Sciences and Professor Rebecca Mason of the School of Medical Sciences.
Selected publications
- A.D. Conigrave and E.M. Brown (2006) Amino acid sensing by calcium sensing receptors: implications for GI physiology. Am. J. Physiol. 291, G753-G761. PubMedId: 17030896
- A.D. Conigrave and D.R. Hampson (2006) Broad-spectrum amino acid sensing by class 3 G-protein coupled receptors. Trends in Endocrinology and Metabolism 17, 398-407. PubMedId: 17085057
- H-C Mun, E. Culverston, A.H. Franks, C.A. Collyer, R. Clifton-Bligh, A.D. Conigrave (2005) A double mutation in the extracellular Ca2+-sensing receptor's Venus Fly Trap domain that selectively disables L-amino acid sensing. J. Biol. Chem., 280, 29067-29072. PubMedId: 15888439
- A.D. Conigrave, H-C Mun, L. Delbridge, S.J. Quinn, M. Wilkinson and E.M. Brown (2004) L-amino acids regulate parathyroid hormone secretion. J. Biol. Chem., 279, 38151-38159. PubMedId: 15234970
- H-C Mun, A.H. Franks, E. Culverston, K. Krapcho, E.F. Nemeth and A.D. Conigrave (2004) The extracellular Ca2+-sensing receptor’s Venus Fly Trap domain is required for L-amino acid sensing. J. Biol. Chem., 279, 51739-51744. PubMedId: 15579475
- A.D. Conigrave, A.H. Franks, E.M. Brown and S.J. Quinn (2002) L-Amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? Eur. J. Clin. Nutr., 56, 1072-1080. PubMedId: 12428172
- A.D. Conigrave, S.J. Quinn and E.M. Brown (2000). L-amino acid sensing by the extracellular Ca2+-sensing receptor. Proceedings of the National Academy of Sciences of the USA., 97, 4814-4819. PubMedId: 10781086
- A.D. Conigrave, S.J. Quinn and E.M. Brown (2000). Cooperative multi-modal sensing and therapeutic implications of the extracellular Ca2+-sensing receptor. Trends in Pharmacological Sciences, 21, 401-407. PubMedId: 11050321
- Case, R.M., Conigrave, A.D., Favaloro, E.J., Novak, I., Thompson, C.H. & Young, J.A. (1982) The role of buffer anions and protons in secretion by the rabbit mandibular salivary gland. Journal of Physiology 322, 273-286. PubMedId: 7069618
- Case, R.M., Conigrave*, A.D., Novak, I. & Young, J.A. (1980) Electrolytes and protein secretion by the perfused rabbit mandibular gland stimulated with acetylcholine or catecholamines. Journal of Physiology 300, 467-487. PubMedId: 7381794