About Dr Claire Goldsbury
My research uses a cell biological approach to determine basic mechanisms of neurodegeneration relevant to Alzheimer’s disease with the overall goal of achieving a positive impact into understanding the causes of this disease.
Research in Dr Goldsbury’s laboratory addresses the role of the cytoskeleton in neurodegenerative processes
Claire Goldsbury is a Senior Research Fellow and Group Leader at the Brain and Mind Research Institute, University of Sydney.
The microtubule-associated protein tau is abnormally hyperphosphorylated and accumulates in cell bodies and neurites in Alzheimer’s disease (AD). This occurs concomitantly with the deposition of amyloid plaques in the brain that comprise abnormally folded and aggregated Aβ peptides. Dr Goldsbury’s current research is aimed at delineating mechanisms of tau and Aβ accumulation in neurons. She recently demonstrated that Aβ levels are elevated by exposure of primary neurons in cell culture to oxidative stress and further ongoing work is aimed at determining the mechanism of tau accumulation in stressed neurons. Oxidative stress and energy depletion are characteristic features of mild cognitive impairment and AD and have led to the hypothesis that these characteristics may contribute to Aβ deposition and neuritic tau accumulation.
Dr Goldsbury has also contributed to understanding amyloid fibril structure and assembly. She carried out some of the early work using atomic force microscopy (AFM) to visualize fibril growth and demonstrated the polymorphic nature of amyloid fibrils. Later, she helped demonstrate how tau protein impairs axonal trafficking when over expressed in primary neurons and its relationship to Aβ generation.