NHMRC Project Grants commencing in 2014

Chief Investigator Faculty Project Amount
Allison Abendroth Sydney Medical School Defining key mechanisms that underpin neuropathogenesis of varicella zoster virus during herpes zoster $596,226
Christina  Adler Faculty of Dentistry Determining how genetic and environmental factors influence the developing oral microbiota and drive disease in early childhood

$384,410

Ian Alexander Sydney Medical School Reconstitution of B-cell ontogeny in Btk-deficient patient-derived CD34+ cells in a humanised mouse model: The foundations for an Australian XLA gene therapy trial

$656,226

Ian Alexander Sydney Medical School Development of a novel hybrid rAAV/transposon gene delivery system for life-long correction of metabolic liver disease in infants and children

$489,170

Hisatomi Arima Sydney Medical School Head Position in Stroke Trial (HeadPoST)

$1,709,567

Thomas Balle Pharmacy New positive allosteric modulators of nicotinic acetylcholine receptors for treatment of cognitive impairment in ADHD

$592,228

Janette Burgess Sydney Medical School The central role of Connective Tissue Growth Factor in remodelling of asthmatic airways

$660,757

Steven Chadban Sydney Medical School Targeting Innate Immunity Through Hmgb1 To Prevent Diabetic Nephropathy

$617,562

Hak-Kim (Kim) Chan Pharmacy Novel inhalation formulation of colistin and combination therapy against Gram-negative 'superbugs'

$496,516

Roderick Clifton-Bligh Sydney Medical School Transcription Factor Foxe1 And Thyroid Cancer

$467,565

Rachel Codd Sydney Medical School Lipophilic iron chelators as potential therapeutic agents in Parkinson's disease

$596,226

Mary Collins (Chebib) Pharmacy γ-Hydroxybutyric acid (GHB) and α4-containing GABA-A receptors

$590,558

Tamera Jo Corte Sydney Medical School Novel Methods for the Early Identification of Progressive Disease in Idiopathic Pulmonary Fibrosis

$655,210

Robert Cumming Sydney Medical School Study of the relationship of oral health and oral health service utilisation to the general health of older Australian men

$459,724

Anthony (Tony) Cunningham Sydney Medical School The mechanism of HSV-1 transport in sensory axons and its unique assembly at the axon terminus

$648,222

Andrew Davidson Sydney Medical School NITRO Trial: A randomised phase III trial of adding nitroglycerin to first line chemotherapy for advanced non-small cell lung cancer

$487,974

Michael Dibley Sydney Medical School Long term impact of a community-based cluster randomized controlled trial of peer counselling to improve infant feeding on growth & cognitive function of children up to 5 years in urban Bangladesh

$815,692

Julianne Djordjevic Sydney Medical School Signalling pathways and fungal virulence - the inositol polyphosphate biosynthetic pathway in Cryptococcus neoformans

$527,562

Michael Friedlander Sydney Medical School Does Palliative Chemotherapy Palliate? Measuring symptom benefit in recurrent ovarian cancer using patient reported outcomes: The Symptom Benefit Study

$394,745

David Gottlieb Sydney Medical School A clinical trial of partially HLA-matched unrelated donor microtransplantation for prevention of relapse in patients with acute myeloid leukaemia ineligible for standard haemopoietic stem cell transplantation

$151,148

Maree Hackett Sydney Medical School The validation of a culturally-specific measure to identify depression in Aboriginal and Torres Strait Islander people with or without chronic disease

$641,456

David Harris Sydney Medical School Defining the role of the major subsets of renal mononuclear phogocytes

$593,474

Luke Henderson Sydney Medical School Does a pain-specific pathway exist in humans?

$418,565

Luke Henderson Sydney Medical School Underlying mechanims of thalamocortical dysrhythmia in chronic pain

$382,111

Ian Hickie Sydney Medical School Clinical and neurobiological predictors of onset of major mental disorders (mania, psychosis, severe depression), and associated functional impairment, in adolescent and young adult twins: A prospective longitudinal study

$1,291,586

Edward Holmes Faculty of Science Black Death genomics and the evolution of pathogen virulence

$510,131

David Hunter Sydney Medical School Randomized controlled trial of hip arthroscopy for femoroacetabular impingement

$968,258

Jodie Ingles Sydney Medical School Clinical, Genetic and Psychosocial Aspects of Sudden Cardiac Death

$419,569

Rebecca Ivers Sydney Medical School Understanding burn injuries in Aboriginal and Torres Strait Islander children: treatment, access to services and outcomes.

$872,802

Alicia Jenkins Sydney Medical School Fenofibrate And Microvascular Events in Type 1 Diabetes (FAME 1) Trial

 

Christopher Jolly Sydney Medical School Cell cycle tracking of B cell differentiation and mutation

$695,980

Angela Laird Sydney Medical School Investigating drug treatments for a Machado Joseph disease using transgenic zebrafish

$428,836

Simon Lewis Sydney Medical School Understanding and predicting freezing of gait in Parkinson's Disease.

$368,359

Helen Liley Sydney Medical School Preventing Adverse Outcomes of Neonatal Hypoxic Ischaemic Encephalopathy with Erythropoietin: A Randomised Controlled Multicentre Australian Trial

$2,754,608

Nicholas Lintzeris Sydney Medical School Randomised control trial of exercise for the management of cannabis withdrawal in adult humans

$524,507

Wendy Lipworth Sydney Medical School Conflicts of interest in public health and biomedicine: enhancing professional integrity and safeguarding the public's health

$564,553

Joel Mackay Faculty of Science Do transcription factor-RNA interactions represent a new mechanism of gene regulation?

$680,262

Joel Mackay Faculty of Science Structural and functional analysis of a cancer-linked co-regulator complex

$705,558

Rebecca Mason Sydney Medical School Is CYP11A1 critical for the vitamin D photoprotective system in skin?

$500,746

Kirsten McCaffery Sydney Medical School Informing women about over-diagnosis in mammography screening: a randomised trial

$428,447

Jonathan Morris Sydney Medical School Working towards a new therapy for the prevention of restricted fetal growth

$687,942

Sharon Naismith Sydney Medical School A selective prevention trial using novel pharmacotherapies in an older age cohort at risk for depression

$947,670

Matthew Naylor Sydney Medical School A novel role for CBF(B) as a regulator of breast cancer

$659,485

Martin Ng Sydney Medical School Bioengineering Synthetic Elastin Conduits for Arterial Revascularisation

$603,901

Martin Ng Sydney Medical School The protective effects of fenofibrate in diabetes-related susceptibility to ischaemia

$609,505

Christopher O'Neill Sydney Medical School Epigenetic reprogramming within the pluripotent lineage of the early embryo

$641,226

Matthew O'Sullivan Sydney Medical School The true burden of nosocomial staphylococcal disease: Genomic markers of transmission of methicillin-sensitive and - resistant Staphylococcus aureus

$804,619

Sarah Palmer Sydney Medical School Characterising latent HIV reservoirs: examining the effects of treatment initiation, cellular type and patient genetics.

$873,416

Richard Payne Faculty of Science Development of Antimalarial Drug Leads Through Inhibition of Food Vacuole Falcipains

$627,670

Paul Pilowsky Sydney Medical School PACAP, sleep apnoea and high blood pressure

$487,189

John Rasko Sydney Medical School Intron retention regulation in granulopoiesis and leukaemia

$555,506

Roger Reddel Sydney Medical School Activation of TERT gene expression in breast carcinogenesis

$670,124

Desi (Des) Richardson Sydney Medical School Pharmacological Targeting of Integrated Oncogenic and Tumour Suppressive Pathways using Novel Therapeutics

$493,901

Desi (Des) Richardson Sydney Medical School The Physiological Role of Glutathione-S-Transferase in the Intracellular Storage and Transport of Nitric Oxide and its Biomedical Effects

$526,894

Helen Rizos Sydney Medical School Melanoma resistance to combination BRAF and MEK inhibition is driven by reprogramming of MAPK signaling

$720,558

Nicholas Shackel Sydney Medical School The Role of the Hepatocyte and EMMPRIN in Liver Injury

$587,562

Catherine Sherrington Sydney Medical School Does feedback from affordable technology enhance physical activity levels and mobility outcomes in neurological and aged care rehabilitation: an RCT

$1,419,775

Barry Slobedman Sydney Medical School How does human cytomegalovirus control host responses to infection to facilitate human disease?

$596,226

Patrick Tam Sydney Medical School Aberrant mesenchymal-epithelial transition: a pathogenic mechanism in tissue maintenance and differentiation

$505,172

William Tarnow-Mordi Sydney Medical School Should we treat iron deficiency anaemia of pregnancy with lactoferrin? A randomised controlled trial

$2,636,507

Cindy Thamrin Sydney Medical School Prediction of clinical outcomes in COPD from home monitoring of lung function variability

$496,226

Lyndal Trevena Sydney Medical School Should I take low dose aspirin? The 'Optimise' decision aid study

$424,115

Yiping Wang Sydney Medical School Therapeutic potential of peritoneal mononuclear phagocytes from peritoneal dialysis patients

$363,447

Miriam Welgampola Sydney Medical School Optimising balance function in vestibular schwannoma

$263,447

Wolfgang Weninger Sydney Medical School The role of perivascular macrophages in the regulation of skin inflammation

$596,226

Xianjiang Zheng Sydney Medical School The role of Heg-CCM2L signaling in angiogenesis

$643,554