Genetics Workshop
INTRODUCING GENETICS
CORE CONCEPTS
Please note that not all of the core concepts listed below have been covered in this workshop.
DNA and Chromososmes
- DNA structure
- DNA significance: storage, transmission expression
- Semi-conservative DNA replication
- DNA in eukaryotic chromosomes
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Transcription of the Genetic Code
- The Central Dogma
- RNA structure
- Transcription
- Genes: definition, structure, and regulation.
- Prokaryotic Vs. eukaryotic genes
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Translation of the Gene Message
- The genetic code
- mRNA, tRNA, rRNA: structures and functions
- Ribosomes
- Translation: initiation, elongation, termination.
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Recombinant DNA and Gene Cloning
- Recombinant DNA technology
- Cleavage of DNA and restriction endonucleases
- Repair of DNA and DNA ligase
- Cloning DNA and cloning vectors
- Implications of genetic engineering
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Genes and their Transmission
- Genotype and phenotype
- One gene specifies one polypeptide
- Loci and alleles
- Dominance, incomplete dominance and co-dominance
- The Principle of Segregation
- Crosses
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Inheritance of Combination of Genes
- Dihybrid Crosses
- The Principle of Independent Assortment
- Epistasis
- Quantitative characters
- Linkage and genetic distance
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Sex and the Single Chromosome
- Sex chromosomes Vs. autosomes
- Expected sex ratios
- Male mammal specified by Y chromosome
- X chromosome inactivation
- Sex linked inheritance
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The Gene Pool and Alleles in Populations
- Selfish DNA
- Allele frequencies from phenotype data
- The Hardy Weinberg Principle
- Forces which change expected allele frequencies
- Polymorphisms
- Mutations
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