Molecular Clocks

Since its proposal in the 1960s, the molecular clock has become an essential tool in many areas of evolutionary biology, including systematics, molecular ecology, and conservation genetics. The molecular clock hypothesis states that DNA and protein sequences evolve at a rate that is relatively constant over time and among different organisms. A direct consequence of this constancy is that the genetic difference between any two species is proportional to the time since these species last shared a common ancestor.

We are interested in all aspects of molecular clocks, from both theoretical as well as applied angles.

Trends in Genetics
Time-dependent molecular rates
Systematic Biology

Recent projects

  • Testing the impact of calibration on molecular divergence times using a fossil-rich group: The case of Nothofagus (Fagales)
  • Time-dependent rates of molecular evolution
  • A Bayesian phylogenetic method to estimate unknown sequence ages
  • Improved characterisation of among-lineage rate variation in cetacean mitogenomes using codon-partitioned relaxed clocks
  • Accounting for calibration uncertainty in phylogenetic estimation of evolutionary divergence times
  • Evaluating the mitochondrial timescale of human evolution