The Molecular Genetics Lab

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Multiresistant strains of the bacterial pathogen Staphylococcus aureus ("Golden Staph") are a frequent cause of hospital-acquired infections worldwide. One reason for the success of S. aureus as a hospital pathogen is the resistance of some strains to up to twenty different antimicrobial compounds, e.g., antibiotics, antiseptics and disinfectants. In the Molecular Genetics Lab we use genetical, molecular biology, biochemical, biophysical, cell biology, genomics, functional genomics and bioinformatic methods to gain an understanding of the genetic basis, mechanisms, and evolution of resistance in staphylococci. Our research has been funded by Project Grants from NHMRC, Discovery Grants from ARC, and R&D Grants from the University of Sydney.