Molecular polymer brushes in nanomedicine
Dr Markus Muellner's recent article on brush nanomedicine has been highlighted in Wiley’s Materials Views. Read more.
Summary: In nanomedicine, we apply nanotechnology to solve persevering issues in prevention, treatment and diagnosis of common diseases. Within this field, polymeric nanoparticles are hot contenders of delivering novel and modular solutions to overcome these issues. Amongst widely used polymer nanoparticles, such as micelles and polymersomes, elaborate polymer architectures are experiencing increasing interest. Molecular polymer brushes (also known as cylindrical polymer brushes or molecular bottlebrushes) are particularly intriguing. Despite being only one giant macromolecule, these molecular heavyweights can easily adopt the size of colloids. This places these unique polymer constructs in a niche between nanoparticles and polymer coils.
Throughout the past decade, these remarkable materials have witnessed an ever-growing interest from many disciplines. The modular build-up of molecular polymer brushes allows for tailoring size and composition simply via polymerisation. Thus, these materials are very appealing in addressing problems where precise tuning of functionality and physicochemical properties is of high importance. Originally considered a molecular playground predominately for synthetic polymer chemists; nowadays, these elaborate nano-constructs find application in many fields of science and engineering.
Open source discovery
Associate Professor Mat Todd was featured in the newsletter of the Australian Society for Parasitology, p16-17. Read more.
In addition, Associate Professor Mat Todd, Dr Robert Don, Dr Jeremy Burrows and Professor Matt Cooper will run the DNDi-MMV Special Symposium: Open Source Drug Discovery at The International Congress for Tropical Medicine and Malaria 2016 in Brisbane where they will examine the successes and challenges of several exemplar projects that have experimented with open source drug discovery.
Professor Thomas Maschmeyer raises $21m in two months
"University of Sydney professor Thomas Maschmeyer has not needed any of the new government help on offer for universities to commercialise inventions, raising $21 million in the last two months to spin out two technologies, one of which could form the basis for the largest biodiesel project in the world.
In April, UK energy investor Armstrong Energy paid $11 million for a commercial prototype of a house whose walls will contain batteries invented by Maschmeyer. The University of Sydney (USyd) spun out the intellectual property in return for equity in a startup named Gelion. The business is developing batteries made with nano-structured gels which claim better performance than lithium ion batteries in their charging and discharging speed, as well as being smaller, safer, more durable and cheaper." Read more.
$10m turns discarded plastics into asset in world first
A month after the launch of the Australian Institute for Nanoscale Science and Technology and the opening of its flagship $150m nanoscience hub, a company co-founded by the Institute’s director Professor Thomas Maschmeyer is announcing that a multi-million dollar contract has been signed to recycle end-of-life plastics, which will provide a solution to the major issue of increasing landfill.
Renewable Chemical Technologies Limited (RCTL) will invest $10m+ into Licella, a start-up of Professor Maschmeyer from the School of Chemistry, to build the world’s first commercial hydrothermal waste upgrading plant. Read more.
Superbugs may kill 10 million people a year by 2050
A recent 18-month review into antimicrobial resistance warns that superbugs may kill 10 million people a year by 2050 if new antibiotics are not forthcoming.
A new paper by Richard Payne’s research group led by Andrew Giltrap and Luke Dowman, together with their collaborators at the Centenary Institute and Simon Fraser University (Canada), reports the first total synthesis of an antibacterial natural product called teixobactin using solid-phase peptide synthesis. Read more.
A more open approach to combating tropical diseases may help to overcome a pharmaceutical market failure
"He didn't know it at the time, but when chemist Matthew Todd posted a request for help on The Synaptic Leap, a website devoted to open-source biomedical research, he was sowing the seeds for a rivalry between an open initiative and a contract-research organization hired by the World Health Organization to reach the same goal." Read more.
Open source removes secrecy in drug research
Traditional research is often a world of secrecy. A small group works on a project and when there’s a result, a paper might be published. Now, the open source approach, familiar in software development, is being used in drug research. As Alice Williamson reports, the collaborative approach of open source science breaks down barriers and facilitates open discussion as projects are underway. Read more.
Can open-source drug development deliver?
Open-source drug development involves open data sharing, collaboration, and results sharing. The aim is to produce new drugs for neglected diseases. But can it work? Read more.
$11m UK investment in nano start-up boon for eco energy
An ambitious plan to make commercially viable, nanostructured, gel-based batteries to lead the renewable electricity revolution is closer to becoming a reality, with the multimillion-dollar investment by the UK’s major utility-scale solar energy company into a pioneering University of Sydney start-up.
“The idea is to build houses with batteries inherently included as part of their structure, ready to take advantage of rapidly improving, solar energy technology and also to serve as a buffer for the grid, enabling an ever greater share of renewables to be connected, while grid stability is maintained” Professor Maschmeyer, from the School of Chemistry said. Read more.
Inaugural Westpac Bicentennial Foundation Research Fellowship
Dr Liz New has been named inaugural recipient of the Westpac Bicentennial Foundation Research Fellowship. The Research Fellowship recognises outstanding early career researchers in technology and innovation; strengthening Australia-Asia ties; and enabling positive social change. It is valued at up to $460,000 over three years. Read more.
David McDonald at the HOPE meeting in Japan
PhD candidate David McDonald attended the 8th HOPE meeting in Tsukuba Japan in March 2016 enabling him to have an amazing experience hearing lectures from many Nobel Prize laureates and meeting many other young enthusiastic scientists. Read more.
K computer provides new insights into fullerenes
The University of Sydney in collaboration with a group of Scientists from the RIKEN Advanced Institute for Computational Science (AICS) in Japan have made use of the tremendous power of the K computer to provide new insights into the properties of fullerenes. Dr Bun Chan from the School of Chemistry at Sydney University and author of the study describes the important contribution this study has made to the study of nanomaterials. Read more.
Superhydrophobicity is child’s play
A team of chemical researchers from The University of Sydney have developed a new robust nanostructured material that is extremely repellent to water droplets due to its highly wrinkled surface.
The team in the School of Chemistry, led by A/Prof Chiara Neto, developed a surface with a special roughness, combining micro-scale and nanoscale features, which mimics the surface structure of the leaf of the Sacred lotus. Droplets of water placed on the Sacred lotus leaf bead up in a spherical shape, a sign that the petal is highly water-repellent; the droplets roll off the petals very easily, and in doing so remove contaminants and dust from the surface. The mechanism behind this behaviour is due to the special surface structure of the lotus leaf, made up of micrometric bumps covered with even smaller nanometric ones, engineered to trap air on the surface and therefore repel water. Read more.
Photo insert: A scanning electron micrograph shows a crinkled, water-repellent layer of Teflon deposited on polyolefin. (Credit Chiara Neto).
Gold nanoparticles riddle solved – offering medical hope
Products based on nanoparticles are not new, with gold nanoparticles used by the Ancient Egyptians to make paints lasting for millennia - but they are promising to deliver a wide range of new medical imaging and treatment technologies.
An international group of researchers including the University of Sydney have solved the riddle in work published today in The Proceedings of the National Academy of Science of the United States of America. It is all in the glue that binds the surface of the gold nanoparticles to keep potentially destructive chemicals out of contact range. Read more.
Research raises concerns over long-term use of chromium diet pills
Concerns have been raised over the long-term use of nutritional supplements containing chromium, after an Australian research team found the supplement is partially converted into a carcinogenic form when it enters cells.
The team, led by Professor Peter Lay from the University of Sydney’s School of Chemistry and Dr Lindsay Wu, now with UNSW’s School of Medical Sciences, travelled near to Chicago to Argonne National Laboratory to perform the experiments in collaboration with colleagues at Argonne’s, the Advanced Photon Source, a US Department of Energy Office of Science User Facility that generates ultra-bright, high-energy x-rays. Read more.
Women making strides in chemistry
Women in STEM: On UN International Day of Women and Girls in Science, meet five scientists making strides, including our very own Postdoctoral Research Associate, Dr Alice Williamson. Read more.
Alice was also named one of ABC’s RN and UNSW’s ‘Top 5 Under 40’ - a nationwide competition to find the next generation of passionate science communicators. Read more.