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Dr Elizabeth New


Contact Details

ARC DECRA Fellow
Room 543
School of Chemistry, Building F11
The University of Sydney, NSW, 2006, Australia
E: enew@chem.usyd.edu.au
T: +61-2-9351-1993
F: +61-2-9351-3329
W: http://www.chem.usyd.edu.au/~enew/

Career Profile:

  • BSc (Adv, Hons1M), University of Sydney, 2005
  • MSc, University of Sydney, 2007
  • PhD, Durham University, 2009
  • Association of Commonwealth Universities’ Commonwealth Scholarship, 2006-2009
  • Postdoctoral Fellow, University of California at Berkeley, 2010-2011
  • Royal Commission for the Exhibition of 1851 Research Fellow, 2010-2011
  • RSC Dalton Young Researchers Award, 2011
  • ARC DECRA Fellow, 2012-2014

Areas of Interest:

  • Chemical biology
  • Bioinorganic chemistry
  • Molecular imaging
  • Redox sensing
  • Metal ion sensing

Research:

The main research focus of the group is the development of chemical tools to assist the study of biological systems, particularly redox regulation.

Many diseases are associated with perturbations in redox state, so developing ways to measure biological redox state will help us to better understand these diseases and suggest ways to cure or treat them. We are developing probes that allow the monitoring of cellular redox state by MRI or fluorescence microscopy.

Publications (2009- 2013):

  1. Shen, C and New, EJ. Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents. Current Opinion in Chemical Biology, 17 (2), 158-166, 2013. DOI: 10.1016/j.cbpa.2012.10.031

  2. New, EJ. Tools to study distrinct metal pools in biology. Dalton Transactions, 42 (9), 3210-3219, 2013. DOI: 10.1039/c2dt31933k

  3. Que, EL; New, EJ and Chang, CJ. A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model. Chemical Science 3, 1829-1834, 2012. DOI: 10.1039/C2SC20273E

  4. Au-Yeung, H-Y; New, EJ and Chang CJ. A selective reaction-based fluorescent probe for detecting cobalt in living cells. Chemical Communications, 48, 5268-5270, 2012.DOI: 10.1039/C2CC31681A

  5. Yadav, PN; Beveridge, RE; Blay, J; Boyd, AR; Chojnacka, MW; Decken, A; Deshpande, AA; Gardiner, MG; Hambley, TW; Hughes, MJ; Jolly, L; Lavangie, JA; MacInnis, TD; McFarland, SA; New, EJ and Gossage, RA. Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies. MedChemComm 2 (4), 274-7, 2011. DOI: 10.1039/C0MD00211A


  6. Lippert, AR; New, EJ and Chang, CJ. Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. Journal of the American Chemical Society, 133 (26), 10078-10080, 2011. DOI: 10.1021/ja203661j

  7. Dias, DM; Teixeira, JMC; Kuprov, I; New, EJ; Parker, D and Geraldes, C. Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by (1)H STD NMR techniques. Organic & Biomolecular Chemistry, 9, 5047-5050, 2011. DOI: 10.1039/C1OB05524K

  8. New, EJ; Parker, D; Smith, DG and Walton, JW. Development of responsive lanthanide probes for cellular applications. Current Opinion in Chemical Biology, 14 (2), 238-246, 2010. DOI: 10.1016/j.cbpa.2009.10.003

  9. New, EJ; Congreve, A and Parker, D. Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes. Chemical Science, 1, 111-118, 2010. DOI: 10.1039/C0SC00105H

  10. Miller, EW; Taulet, N; Onak, CS; New, EJ; Lanselle, JK; Smelick, GS and Chang, CJ. Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator. Journal of the American Chemical Society, 132 (48), 17071-17073, 2010. DOI: 10.1021/ja107783j

  11. New, EJ; Roche, C; Madawala, R; Zhang, JZ and Hambley, TW. Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells. Journal of Inorganic Biochemistry, 103 (8), 1120-1125, 2009. DOI: 10.1016/j.jinorgbio.2009.05.005

  12. New, EJ; Parker, D and Peacock, RD. Comparative study of the constitution and chiroptical properties of emissive terbium and europium complexes with a common tetraazatriphenylene sensitiser; the nature of the sensitiser determines quenching sensitivity and cellular uptake. Dalton Transactions, 672-679, 2009. DOI: 10.1039/B816173A

  13. New, EJ and Parker, D. The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation. Organic & Biomolecular Chemistry, 7, 851-855, 2009. DOI: 10.1039/B822145F

  14. New, EJ; Duan, R; Zhang, JZ and Hambley, TW. Investigations using fluorescent ligands to monitor platinum(IV) reduction and platinum(II) reactions in cancer cells. Dalton Transactions, 3092-3101, 2009. DOI: 10.1039/B821603G

  15. Montgomery, CP; New, EJ; Palsson, LO; Parker, D; Batsanov, AS and Lamarque, L. Emissive and cell-permeable 3-pyridyl- and 3-pyrazolyl-4-azaxanthone lanthanide complexes and their behaviour in cellulo. Helvetica Chimica Acta, 92, 2186-2213, 2009. DOI: 10.1002/hlca.200900122

  16. Montgomery, CP; Murray, BS; New, EJ; Pal, R and Parker, D. Cell-penetrating metal complex optical probes: Targeted and responsive systems based on lanthanide luminescence. Accounts of Chemical Research, 42, 925-937, 2009. DOI: 10.1021/ar800174z