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Dr anna renfrew


Contact Details

ARC DECRA Fellowship
Room 412c
School of Chemistry, Building F11
The University of Sydney, NSW, 2006, Australia
E: anna.renfrew@sydney.edu.au
T: +61-2-9351-4233
F: +61-2-9351-3329

Career Profile:

  • MChem (First Class), The University of York, UK (2002 - 2006)
  • PhD, Ecole Polytechnique Federal de Lausanne, Switzerland (2006 - 2010)
  • Postdoctoral Research Associate, The University of Sydney (2011-2013)
  • Swiss National Science Foundation Postdoctoral Fellow, The University of Sydney (2011-2013)
  • ARC DECRA Fellow, The University of Sydney (2013 - present)

Areas of Interests:

  • Bioinorganic medicinal chemistry
  • Ruthenium-based anticancer agents
  • Light-activated prodrugs
  • Bioconjugation of tumour targeting groups and fluorescent tags

Publications (2009- 2013):

  1. Yamamoto, N; Renfrew, AK; Kim, BJ; Bryce, NS and Hambley, TW. Dual targeting of hypoxic and acidic tumor environments with a cobalt(III) chaperone complex. Journal of Medicinal Chemistry, 55 (24), 11013-11021, 2012. DOI: 10.1021/jm3014713

  2. Govender, P; Renfrew, AK; Clavel, CM; Dyson, PJ; Terrien, B and Smith, GS. Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds. Dalton Transactions, 40, 1158-1167, 2011. DOI: 10.1039/C0DT00761G

  3. Renfrew, AK; Juillerat-Jeanneret, L and Dyson, PJ. Adding diversity to ruthenium(II)-arene anticancer (RAPTA) compounds via click chemistry: the influence of hydrophobic chains. J. Organomet. Chem., 696, 772-779, 2011. DOI: 10.1016/j.jorganchem.2010.09.067

  4. Amouri, H; Moussa, J; Renfrew, AK; Dyson, PJ; Noelle Rager, M and Chamoreau, L-M. Discovery, structure and anticancer activity of an iridium complex of diselenobenoquinone. Angew. Chem. Int. Ed., 49, 7530-7533, 2010. DOI: 10.1002/anie.201002532

  5. Renfrew, AK; Egger, AE; Scopelliti, R; Hartinger, CG and Dyson, PJ. Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(η6-cymene)(PPh2(o-C6H4O)κ2-P,O)(pta)Cl]+ and an investigation of its cytotoxic effect. Comptes Rendus Chimie, 13, 1144-1150, 2010. DOI: 10.1016/j.crci.2010.03.014

  6. Mattsson, J; Zava, O; Renfrew, AK; Sei, Y; Yamaguchi, K; Dyson, PJ and Therrien, B. Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage. Dalton Trans, 8248-8255, 2010. DOI: 10.1039/c0dt00436g

  7. Egger, AE; Hartinger, CG; Renfrew, AK and Dyson, PJ. Metabolization of [Ru(η6-C6H5CF3)(pta)Cl2]: a cytotoxic RAPTA-type complex with a strongly electron-withdrawing ligand. J. Biol. Inorg. Chem., 15, 919-927, 2010. DOI: 10.1007/s00775-010-0654-x

  8. Renfrew, AK; Scopelliti, R and Dyson, PJ. The use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumour targeting. Inorg. Chem., 49, 2239-2246, 2010. DOI: 10.1021/ic9020433

  9. Schulz, J; Renfrew, AK; Cisorova, I; Dyson, PJ and Stepnicka, P. Synthesis and anticancer activity of chalcogenide derivatives and palladium(II) and platinum(II) complexes derived from a polar ferrocene phosphanyl-carboxamide. Appl. Organomet. Chem. 2010, 24, 392-397. J. Organomet. Chem., 694, 3470-3476, 2009. DOI: 10.1002/aoc.1626

  10. Suss-Fink, G; Khan, F-A; Juillerat-Jeanneret, L; Dyson, PJ and Renfrew, AK. Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and nanoparticles. J. Cluster Sci., 21, 313-324, 2010. DOI: 10.1007/s10876-010-0298-6

  11. Govender, P; Antonels, NC; Mattsson, J; Renfrew, AK; Dyson, PJ; Moss, JR; Terrien, B and Smith, GS. Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds. J. Organomet. Chem., 694, 3470-3476, 2009. DOI: 10.1016/j.jorganchem.2009.06.028

  12. Renfrew, AK; Phillips, AD; Tapavicza, E; Scopelliti, R; Rothlisberger, U and Dyson, PJ. Tuning the efficacy of ruthenium(II)-arene (RAPTA) antitumor compounds with fluorinated arene ligands. Organometallics, 28, 5061-5071, 2009. DOI: 10.1021/om900345n

  13. Hartl, F; Renfrew, AK; Lafolet, F; Mahabiersing, T; Calhorda, MJ; Chardon-Noblat, A; Haukka, M and Deronzier, A. soluble redox-active polymetallic chains [{Ru0(CO)(L)(bpy)}m]n (bpy = 2,2'-bipyridine, L = PrCN, Cl-; m = 0, -1): Electrosynthesis and characterization. Inorg. Chem., 4, 8233-8244, 2009. DOI: 10.1021/ic9008043

  14. Mattsson,k J; Govindaswamy, P; Renfrew, AK; Dyson, PJ; Stepnicka, P; Suss-Fink, G and Therrien, B. Synthesis, Molecular structure, and anticancer activity of cationic arene ruthenium metallarectangles. Organometallics, 28, 4350-4357, 2009. DOI: 10.1021/om900359j

  15. Renfrew, A. Ruthenium(II) arene compounds as versatile anticancer agents. Chimia, 63, 217-219, 2009. DOI: 10.2533/chimia.2009.217

  16. Auzias, M; Gueniat, J; Therrien, B; Suss-Fink, G; Renfrew, AK and Dyson, PJ. Arene-ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(η6-arene)(NC5H4CH2NHOC-C5H4FeC5H5)Cl2] and [Ru(η6-arene)(NC3H3N(CH2)2O2C-C5H4FeC5H5)Cl2]. J. Organomet. Chem., 694, 855-861, 2009. DOI: 10.1016/j.jorganchem.2008.08.012

  17. Renfrew, AK; Phillips, AD; Egger, AE; Hartinger, CG; Bosquain, SS; Nazarov, AA; Keppler, BK; Gonsalvi, L; Peruzzini, M and Dyson, PJ. Influence of structural variation on the anticancer activity of RAPTA-type complexes: ptn versus pta. Organometallics, 28, 1165-1172, 2009. DOI: 10.1021/om800899e