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Dr Matthew H Todd


Contact Details

Senior Lecturer
Honours & Graduate Diploma Coordinator
Room 517
School of Chemistry
The University of Sydney, NSW 2006, Australia
E: matthew.todd@sydney.edu.au
T: +61 (2) 9351-2180
F: +61 (2) 9351-3329
W: http://sydney.edu.au/science/chemistry/~todd_m/
W: http://openwetware.org/wiki/Todd

 

Career Profile

  • Lecturer in Organic Chemistry, Department of Chemistry, Queen Mary, University of London (2001-2005)
  • Fellow in Chemistry, New Hall College, Cambridge (2000-2001)
  • Postdoctoral Fellow, University of California, Berkeley (1999-2000)
  • BA, PhD Queens' College, Cambridge

Research and Selected Publications

For more details on the Group's research, please see the home page.

Publications (2009 - 2013)

  1. Yu, M; Yu, Q; Rutledge, PJ and Todd, MH. A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. ChemBioChem, 14 (2), 224-229, 2013. DOI: 10.1002/cbic.201200637

  2. Ast, S; Rutledge, PJ and Todd, MH. Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10-fold brighter signal response to Zn2+ in aqueous solution. European Journal of Inorganic Chemistry, (34), 5611-5615, 2012. DOI: 10.1002/ejic.201201072

  3. Amarasinghe, NR; Turner, P and Todd, MH. The first catalytic, enantioselective aza-Henry reaction of an unactivated cyclic imine. Advanced Synthesis & Catalysis, 354 (16), 2954-2958, 2012. DOI: 10.1002/adsc.201200558

  4. Ahamed, M; Chan, B; Jensen, P and Todd, MH. The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions. PLOS ONE, 7 (10), e47224, 2012. DOI: 10.1371/journal.pone.0047224

  5. Park, SJ; Price, JR and Todd, MH. Oxidative arylation of isochroman. The Journal of Organic Chemistry, 77 (2), 949-955, 2012. DOI: 10.1021/jo2021373

  6. Yu, M; Price, JR; Jensen, P; Lovitt, CJ; Shelper, T; Duffy, S; Windus, LC; Avery, VM; Rutledge, PJ and Todd, MH. Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with “click” chemistry and are noncytotoxic. Inorganic Chemistry, 50 (24), 12823-12835, 2011. DOI: 10.1021/ic2020012

  7. Woelfle, M; Seerden, J-P; de Gooijer, J; Pouwer, K; Olliaro, P and Todd, MH. Resolution of praziquantel. PLoS Neglected Tropical Diseases, 5 (9), e1260, 2011. DOI: 10.1371/journal.pntd.0001260

  8. Woelfle, M; Olliaro, P and Todd, MH. Open science is a research accelerator. Nature Chemistry, 3 (10), 745-748, 2011.

  9. Lo, ATS; Salam, NK; Hibbs, DE; Rutledge, PJ and Todd, MH. Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal. PLoS one, 6 (5), e17446, 2011. DOI: 10.1371/journal.pone.0017446

  10. Lau, YH; Rutledge, PJ; Watkinson, M and Todd, MH. Chemical sensors that incorporate click-derived triazoles. Chemical Society Reviews, 40 (5), 2848-2866, 2011.DOI: 10.1039/c0cs00143k

  11. Tsang, AS-K; Jensen, P; Hook, JM; Hashmi, ASK and Todd, MH. An oxidative carbon-carbon bond-forming reaction proceeds via an isolable iminium ion. Pure and Applied Chemistry, 83 (3), 655-665, 2011. DOI: 10.1351/PAC-CON-11-01-01

  12. Bridgeman, AJ; Rutledge, PJ; Todd, MH and Connor, R. A treasure hunt for chemistry. Journal of Chemical Education, 88 (4), 437-439, 2011. DOI: 10.1021/ed100867m

  13. Lau, YH; Price, JR; Todd, MH and Rutledge, PJ. A click fluorophore sensor that can distinguish CuII and HgII via selective anion-induced demetallation. Chemistry: A European Journal, 17 (10), 2850-2858, 2011. DOI: 10.1002/chem.201002477

  14. Hashmi, ASK; Ramamurthi, TD; Todd, MH; Tsang, AS-K and Graf, K. Gold-catalysis: Reactions of organogold compounds with electrophiles. Aust. J. Chem., 63 (12), 1619-1626, 2010. DOI: 10.1071/CH10342

  15. Ahamed, M and Todd, MH. Catalytic asymmetric additions of carbon-centered nucleophiles to nitrogen-containing aromatic heterocycles. European Journal of Organic Chemistry, (31),5935-5942, 2010. DOI: 10.1002/ejoc.201000877

  16. Ahamed, M; Thirukkumaran, T; Leung, WY; Jensen, P; Schroers, J and Todd, MH. Aza-Henry reactions of 3,4-dihydroisoquinoline. European Journal of Organic Chemistry, (31), 5980-5988, 2010. DOI: 10.1002/ejoc.201000955

  17. Tamanini, E; Flavin, K; Motevalli, M; Piperno, S; Gheber, LA; Todd, MH and Watkinson, M. Cyclam-based “clickates”: Homogeneous and heterogeneous fluorescent sensors for Zn(II). Inorg. Chem., 49 (8), 3789-3800, 2010. DOI: 10.1021/ic901939x

  18. El-Fayyoumy, S; Todd, MH and Richards, CJ. Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach. Beilstein Journal of Organic Chemistry, 5 (67), 1-6, 2009. DOI: 10.3762/bjoc.5.67

  19. Orti, L; Carbajo, RJ; Pieper, U; Eswar, N; Maurer, SM; Rai, AK; Taylor, G; Todd, MH; Pineda-Lucena, A; Sali, A and Marti-Renom, MA. A kernel for open source drug discovery in tropical diseases. Plos Neglected Tropical Diseases, 3 (4), e418, 2009. DOI: 10.1371/journal.pntd.0000418
  20. Tamanini, E; Rigby, SEJ; Motevalli, M; Todd, MH and Watkinson, M. Responsive metal complexes: A click-based "allosteric scorpionate" complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy. Chemistry-A European Journal, 15 (15), 3720-3728, 2009. DOI: 10.1002/chem.200802425
  21. Orti, L; Carbajo, RJ; Pieper, U; Eswar, N; Maurer, SM; Rai, AK; Taylor, G; Todd, MH; Pineda-Lucena, A; Saili, A and Marti-Renom, MA. A kernel for the tropical disease initiative. Nature Biotechnology, 27 (4), 320-321, 2009. DOI: 10.1038/nbt0409-320

  22. Tsang, ASK and Todd, MH. Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ. Tetrahedron Letters, 50 (11), 1199-1202, 2009. DOI: 10.1016/j.tetlet.2008.12.101
  23. Tamanini, E; Katewa, A; Sedger, LM; Todd, MH and Watkinson, M. A synthetically simple, click-generated cyclam-based zinc(II) sensor. Inorganic Chemistry, 48 (1), 319-324, 2009. DOI: 10.1021/ic8017634