The Kassiou Research Group

Medicinal Chemistry & Drug Discovery

 

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 Articles in refereed journals.

2013 | 2012 | 2011 | 2010 | 2009-2000 | 1999-1991

 

2013

 

N-Substituted 8-aminopentacyclo[5.4.0.02,6.03,10.05,9]undecanes as σ receptor ligands with potential neuroprotective effects

Banister SD, Manoli M, Barron ML, Werry EL, Kassiou M

Bioorg. Med. Chem. (in press). DOI: 10.1016/j.bmc.2013.07.045

 

A practical synthesis of (1S,4S)-2,5-diazabicyclo[2.2.1]heptanes

Beinat C, Banister SD, McErlean CSP, Kassiou M

Tetrahedron Lett. (in press). DOI: 10.1016/j.tetlet.2013.07.092


Acute Prosocial Effects of Oxytocin and Vasopressin when Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) in Rats: involvement of the V1A receptor

Ramos L, Hicks C, Kevin R, Caminer A, Narlawar R, Kassiou M, McGregor IS

Neuropsychopharmacology (in press). DOI: 10.1038/npp.2013.125

 

The synthesis and pharmacological evaluation of adamantane-derived indoles: novel cannabimimetic drugs of abuse

Banister SD, Wilkinson SM, Longworth M, Stuart J, Apetz N, English K, Brooker L, Goebel C, Hibbs DE, Glass M, Connor M, McGregor IS, Kassiou M

ACS Chem. Neurosci. (2013), 4(7), 1081-1092. DOI: 10.1021/cn400035r

 

The development of CNS-active LRRK2 inhibitors using property-directed optimisation

Kavanagh ME, Doddareddy MR, Kassiou M

Bioorg. Med. Chem. Lett. (2013), 23(13), 3690-3696. DOI: 10.1016/j.bmcl.2013.04.086

 

The translocator protein (TSPO): A novel target for cancer chemotherapy

Austin CJD, Kahlert J, Kassiou M, Rendina LM

Int. J. Biochem. Cell Biol. (2013), 45(7), 1212-1216. DOI: 10.1016/j.biocel.2013.03.004

 

The development of radiotracers for imaging sigma (σ) receptors in the central nervous system (CNS) using positron emission tomography (PET)

Banister SD, Manoli M, Kassiou M

J. Label. Compd. Radiopharm. (2013), 56(3-4), 215-224. DOI: 15-22410.1002/jlcr.3010

 

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats

Boutin H, Prenant C, Maroy R, Galea J, Greenhalgh AD, Smigova A, Cawthorne C, Julyan P, Wilkinson SM, Banister SD, Brown G, Herholz K, Kassiou M, Rothwell NJ

PLoS ONE (2013), 8(2): e56441. DOI: 10.1371/journal.pone.0056441

 

Metabolism and Quantification of [18F]DPA-714, a New TSPO Positron Emission Tomography Radioligand

Peyronneau M-A, Saba W, Goutal S, Damont A, Dolle F, Kassiou M, Bottlaender M, Valette H

Drug Metab. Dispos. (2013), 41(1), 122-131. DOI: 10.1124/dmd.112.046342

 

Improved accessibility to the desoxy analogues of Δ9-tetrahydrocannabinol and cannabidiol

Wilkinson SM, Price J, Kassiou M

Tetrahedron Lett. (2013), 54(1), 52-54. DOI: 10.1016/j.tetlet.2012.10.080

 

 

2012

 

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

Corcia P, Tauber C, Vercoullie J, Arlicot N, Prunier C, Praline J, Nicolas G, Venel Y, Hommet C, Baulieu J-L, Cottier J-P, Roussel C, Kassiou M, Guilloteau D, Ribeiro M-J

PLoS ONE (2012) 7(12): e52941. DOI: 10.1371/journal.pone.0052941

 

A σ1 receptor pharmacophore derived from a series of  N-substituted
4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ols (AHDs)

Banister SD, Manoli M, Doddareddy MR, Hibbs DE, Kassiou M

Bioorg. Med. Chem. Lett. (2012), 22(19), 6053-6058. DOI: 10.1016/j.bmcl.2012.08.046

 

Inhibition of human recombinant T-type calcium channels by N-arachidonoyl serotonin

Gilmore AJ, Heblinski M, Reynolds A, Kassiou M, Connor M

Br. J. Pharmacol. (2012), 167(5), 1076-1088. DOI: 10.1111/j.1476-5381.2012.02047.x

 

Synthesis and Biological Evaluation of Adenosines with Heterobicyclic and Polycyclic N6-Substituents as Adenosine A1 Receptor Agonists

Gosling JI, Baker SP, Haynes JM, Kassiou M, Pouton CW, Warfe L, White PJ, Scammells PJ

ChemMedChem (2012), 7(7), 1191-1201. DOI: 10.1002/cmdc.201200208

 

Exploration of ring size in a series of cyclic vicinal diamines with σ1 receptor affinity

Moussa IA, Banister SD, Manoli M, Doddareddy MR, Cui J, Mach RH, Kassiou M

Bioorg. Med. Chem. Lett. (2012), 22(17), 5493-5497. DOI: 10.1016/j.bmcl.2012.07.026

 

A practical, multigram synthesis of the 2-(2-(4-alkoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of high affinity translocator protein (TSPO) ligands

Banister SD, Wilkinson SM, Hanani R, Reynolds AJ, Hibbs DE, Kassiou M

Tetrahedron Lett. (2012), 53(29), 3780-3783. DOI: 10.1016/j.tetlet.2012.05.044

 

7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands

Banister SD, Rendina LM, Kassiou M

Bioorg. Med. Chem. Lett. (2012), 22(12), 4059-4063. DOI: 10.1016/j.bmcl.2012.04.077

 

The non-peptide oxytocin receptor agonist WAY 267,464: receptor binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats

Hicks C, Jorgensen W, Brown C, Fardell J, Koehbach J, Gruber CW, Kassiou M, Hunt GE, McGregor IS

J. Neuroendocrinol. (2012), 24(7), 1012-1029. DOI: 10.1111/j.1365-2826.2012.02311.x

 

Is There Any Correlation Between Binding and Functional Effects at the Translocator Protein (TSPO) (18 kDa)?

Scarf AM, Auman KM, Kassiou M.

Curr. Mol. Med. (2012), 12(4), 387-397. http://bit.ly/KN9ZlT

 

Evidence for Complex Binding Profiles and Species Differences at the Translocator Protein (TSPO) (18 kDa)

Scarf AM, Luus C, Da Pozzo E, Selleri S, Guarino C, Martini CM, Ittner L, Kassiou M

Curr. Mol. Med. (2012), 12(4), 488-493. http://bit.ly/M5l4LM

 

The therapeutic potential of sigma (σ) receptors for the treatment of central nervous system diseases: evaluation of the evidence

Banister SD, Kassiou M

Curr. Pharm. Des. (2012), 18(7), 884-901. DOI: 10.2174/138161212799436539

 

Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333

Beinat C, Banister SD, van Prehn S, Doddareddy MR, Hibbs D, Sako M, Chebib M, Tran T, Al-Muhtasib N, Xiao Y, Kassiou M

Bioorg. Med. Chem. Lett. (2012), 22(7), 2380-2384. DOI:10.1016/j.bmcl.2012.02.052

 

Radiation dosimetry and biodistribution of the TSPO ligand [11C]-DPA-713 in humans

Endres CJ, Coughlin JM, Gage KL, Watkins CC, Kassiou M, Pomper MG

J. Nucl. Med. (2012), 53(2), 330-335. DOI:10.2967/jnumed.111.094565

 

Effects of Translocator Protein (18 kDa) Ligands on Microglial Activation and Neuronal Death in the Quinolinic-Acid-Injected Rat Striatum

Leaver KR, Reynolds A, Bodard S, Guilloteau D, Chalon S, Kassiou M

ACS Chem. Neurosci. (2012), 3(2), 114-119. DOI:10.1021/cn200099e

 

Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation

Arlicot N, Vercouillie J, Ribeiro M-J, Tauber C, Venel Y, Baulieu J-L, Maia S, Corcia P, Stabin MG, Reynolds A, Kassiou M, Guilloteau D

Nucl. Med. Biol. (2012), 39(4), 570-578. DOI: 10.1016/j.nucmedbio.2011.10.012

 

 

2011

 

Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells

Crossley EL, Issa F, Scarf AM, Kassiou M, Rendina LM

Chem. Commun. (2011), 47(44), 12179-12181. DOI:10.1039/c1cc14587h

 

Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine, a novel σ1 receptor PET imaging agent

Moussa IA, Banister SD, Giboureau N, Meikle SR, Kassiou M

Bioorg. Med. Chem. Lett. (2011), 21(22), 6820-6823. DOI:10.1016/j.bmcl.2011.09.028

 

Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazine σ1 receptor ligands

Moussa IA, Banister SD, Akladios FN, Chua SW, Kassiou M

Bioorg. Med. Chem. Lett. (2011), 21(19), 5707-5710. DOI:10.1016/j.bmcl.2011.08.029

 

N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (σ) receptor ligands

Banister SD, Yoo DT, Chua SW, Cui J, Mach RH, Kassiou M

Bioorg. Med. Chem. Lett. (2011), 21(18), 5289-5292. DOI:10.1016/j.bmcl.2011.07.028

 

Synthesis of 6-[18F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET

Damont A, Boisgard R, Kuhnast B, Lemée F, Raggiri G, Scarf AM, Da Pozzo E, Selleri S, Martini C, Tavitian B, Kassiou M, Dollé F

Bioorg. Med. Chem. Lett. (2011), 21(16), 4819-4822. DOI:10.1016/j.bmcl.2011.06.048

 

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

Boucher AA, Arnold JC, Hunt GE, Spiro A, Spencer J, Brown C, McGregor IS, Bennett MR, Kassiou M

Neuroscience (2011), 189, 170-177. DOI:10.1016/j.neuroscience.2011.05.049

 

Brain inflammation is induced by co-morbidities and risk factors for stroke

Drake C, Boutin H, Jones MS, Denes A, McColl BW, Selvarajah JR, Hulme S, Georgiou RF, Hinz R, Gerhard A,

Brain Behav. Immun. (2011), 25(6), 1113-1122. DOI:10.1016/j.bbi.2011.02.008

 

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds

Issa F, Kassiou M, Rendina LM

Chem. Rev. (2011), 111(9), 5701-5722. DOI:10.1021/cr2000866

 

The translocator protein

Scarf AM, Kassiou M

J. Nucl. Med. (2011), 52(5), 677-680. DOI:10.2967/jnumed.110.086629

 

Molecular hybridization of 4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecane-3-ol with sigma (σ) receptor ligands modulates off-target activity and subtype selectivity

Banister SD, Moussa IA, Jorgensen WT, Chua SW, Kassiou M

Bioorg. Med. Chem. Lett. (2011), 21(12), 3622-3626. DOI:10.1016/j.bmcl.2011.04.098

 

Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands

Banister SD, Moussa IA, Beinat C, Reynolds AJ, Schiavini P, Jorgensen WT, Kassiou M

Bioorg. Med. Chem. Lett. (2011), 21(1), 38-41. DOI:10.1016/j.bmcl.2010.11.075

 

Reduced PBR/TSPO Expression After Minocycline Treatment in a Rat Model of Focal Cerebral Ischemia: A PET Study Using [18F]DPA-714

Martín A, Boisgard R, Kassiou M, Dollé F, Tavitian B.

Mol. Imaging Biol. (2011) 13, 10-15. DOI: 10.1007/s11307-010-0324-y

 

 

2010

 

Insights into structure-activity relationships and CNS therapeutic applications of NR2B selective antagonists

Beinat C, Banister S, Moussa I, Reynolds AJ, McErlean CSP, Kassiou M

Curr. Med. Chem. (2010), 17(34), 4166-4190. DOI:10.2174/092986710793348572

 

11-{[2-(3-Fluorophenyl)ethyl](methyl)amino}pentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-one

Banister SD, Clegg JK, Hanani R, Kassiou M

Acta Crystallogr., Sect. E: Struct. Rep. Online (2010), E66(10), o2693. DOI:10.1107/S1600536810038523

 

PET radioligands for the vesicular acetylcholine transporter (VAChT)

Giboureau N, Som IM, Boucher-Arnold A, Guilloteau D, Kassiou M

Curr. Top. Med. Chem. (2010), 10(15), 1569-1583.

 

Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO)

Reynolds A, Hanani R, Hibbs D, Damont A, Da Pozzo E, Selleri S, Dolle F, Martini C, Kassiou M

Bioorg. Med. Chem. Lett. (2010), 20(19), 5799-5802. DOI:10.1016/j.bmcl.2010.07.135

 

Development of Vesicular Acetylcholine Transporter Ligands: molecular probes for Alzheimer's disease

Giboureau N, Aumann KM, Beinat C, Kassiou M

Curr. Bioact. Compd. (2010), 6(3), 129-155. DOI:10.2174/157340710793237353

 

Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, x-ray diffraction, in vitro cytotoxicity, and cellular uptake

Morrison DE, Issa F, Bhadbhade M, Groebler L, Witting PK, Kassiou M, Rutledge PJ, Rendina LM

J. Biol. Inorg. Chem. (2010), 15(8), 1305-1318. DOI:10.1007/s00775-010-0690-6

 

Design, Synthesis, and Structure-Affinity Relationships of Regioisomeric N-Benzyl Alkyl Ether Piperazine Derivatives as σ-1 Receptor Ligands

Moussa IA, Banister SD, Beinat C, Giboureau N, Reynolds AJ, Kassiou M

J. Med. Chem. (2010), 53(16), 6228-6239. DOI:10.1021/jm100639f

 

Fluorine-18 chemistry for PET: a concise introduction

Banister S, Roeda D, Dolle F, Kassiou M

Curr. Radiopharm. (2010), 3(2), 68-80. DOI:10.2174/1874471011003020068

 

The development of PET radioligands for imaging the translocator protein (18 kDa): what have we learned?

Luus C, Hanani R, Reynolds A, Kassiou M

J. Label. Compd. Radiopharm. (2010), 53(7), 501-510. DOI:10.1002/jlcr.1752

 

P2X purinergic receptor ligands: recently patented compounds

Gunosewoyo H, Kassiou M

Expert Opin. Ther. Patents (2010), 20(5), 625-646. DOI:10.1517/13543771003702424

 

Evaluation of the PBR/TSPO radioligand [18F]DPA-714 in a rat model of focal cerebral ischemia

Martin A, Boisgard R, Theze B, Van Camp N, Kuhnast B, Damont A, Kassiou M, Dolle F, Tavitian B

J. Cereb. Blood Flow Metab. (2010), 30(1), 230-241. DOI:10.1038/jcbfm.2009.205

 

Oxo-bridged isomers of aza-trishomocubane sigma (σ) receptor ligands: Synthesis, in vitro binding, and molecular modeling

Banister SD, Moussa IA, Jordan MJT, Coster MJ, Kassiou M

Bioorg. Med. Chem. Lett. (2010), 20(1), 145-148. DOI:10.1016/j.bmcl.2009.11.019

 

Attenuation correction for the large non-human primate brain using microPET

Naidoo-Variawa S, Lehnert W, Kassiou M, Banati R, Meikle SR

Phys. Med. Biol. (2010), 55(8), 2351–2363. DOI: 10.1088/0031-9155/55/8/015

 

 

2009

 

Extracellular Loops 2 and 4 of GLYT2 Are Required for N-Arachidonylglycine Inhibition of Glycine Transport

Edington AR, McKinzie AA, Reynolds AJ, Kassiou M, Ryan RM, Vandenberg RJ

J. Biol. Chem. (2009), 284(52), 36424-36430. DOI:10.1074/jbc.M109.017509

 

Recent advances in the Mitsunobu reaction. Modifications and applications to biologically active molecules

Reynolds AJ, Kassiou M

Curr. Org. Chem. (2009), 13(16), 1610-1632.

 

Oral pre-treatment with epigallocatechin gallate in 6-OHDA lesioned rats produces subtle symptomatic relief but not neuroprotection

Leaver KR, Allbutt HN, Creber NJ, Kassiou M, Henderson, JM

Brain Res. Bull. (2009), 80(6), 397-402. DOI:10.1016/j.brainresbull.2009.08.013

 

Water-soluble phosphonium salts containing 1,12-dicarba-closo-dodecaborane

Ioppolo JA, Kassiou M, Rendina LM

Tetrahedron Lett. (2009), 50(47), 6457-6461. DOI:10.1016/j.tetlet.2009.08.112

 

18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors-in vitro binding properties and PET studies in baboons

Valette, Heric; Xiao, Yingxiang; Peyronneau, Marie-Anne; Damont, Annelaure; Kozikowski, Alan P.; Wei, Zhi-Liang; Kassiou, Michael; Kellar, Kenneth J.; Dolle, Frederic; Bottlaender, Michel

J. Nucl. Med. (2009), 50(8), 1349-1355. DOI:10.2967/jnumed.108.061374

 

Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans

Endres CJ, Pomper MG, James M, Uzuner O, Hammoud DA, Watkins CC, Reynolds A, Hilton J, Dannals RF, Kassiou M

J. Nucl. Med. (2009), 50(8), 1276-1282. DOI:10.2967/jnumed.109.062265

 

Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography

Dolle F, Luus C, Reynolds A, Kassiou M

Curr. Med. Chem. (2009), 16(22), 2899-2923. DOI:10.2174/092986709788803150

 

Purinergic P2X7 receptor antagonists: Chemistry and fundamentals of biological screening

Gunosewoyo H, Coster MJ, Bennett MR, Kassiou M

Bioorg. Med. Chem. (2009), 17(14), 4861-4865. DOI:10.1016/j.bmc.2009.05.083

 

Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation

Chauveau F, Van Camp N, Dolle F, Kuhnast B, Hinnen F, Damont A, Boutin H, James M, Kassiou M, Tavitian B

J. Nucl. Med. (2009), 50(3), 468-476. DOI:10.2967/jnumed.108.058669

 

Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions

Truong L, Allbutt HN, Coster MJ, Kassiou M, Henderson JM

Brain Res. Bull. (2009), 78(2-3), 91-96. DOI:10.1016/j.brainresbull.2008.10.004

 

Evaluation of behavioural effects of a selective NMDA NR1A/2B receptor antagonist in the unilateral 6-OHDA lesion rat model

Warraich ST, Allbutt HN, Billing R, Radford J, Coster MJ, Kassiou M, Henderson JM

Brain Res. Bull. (2009), 78(2-3), 85-90. DOI:10.1016/j.brainresbull.2008.08.023

 

Challenges in molecular imaging of Parkinson's disease: A brief overview

Kassiou M, Banati R, Holsinger RMD, Meikle S

Brain Res. Bull. (2009), 78(2-3), 105-108. DOI:10.1016/j.brainresbull.2008.08.006

 

The Translocator Protein (18 kDa): Central Nervous System Disease and Drug Design

Scarf AM, Ittner LM, Kassiou M

J. Med. Chem. (2009), 52(3), 581-592. DOI:10.1021/jm8011678

 

[11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis.

Doorduin J,  Klein HC, Dierckx RA, James M, Kassiou M, de Vries EFJ.

Mol. Imaging Biol. (2009), 11(6), 386-398. DOI: 10.1007/s11307-009-0211-6

 

 

2008

 

Neuroprotective effects of a selective N-methyl-D-aspartate NR2B receptor antagonist in the 6-hydroxydopamine rat model of Parkinson's disease

Leaver KR, Allbutt HN, Creber NJ, Kassiou M, Henderson JM

Clin. Exptl. Pharmacol. Physiol. (2008), 35(11), 1388-1394. DOI:10.1111/j.1440-1681.2008.05046.x

 

Radiosynthesis of [18F]DPA-714, a selective radioligand for imaging the translocator protein (18 kDa) with PET

Damont A, Hinnen F, Kuhnast B, Schollhorn-Peyronneau M-A, James M, Luus C, Tavitian B, Kassiou M, Dolle F

J. Label. Cmpd. Radiopharm. (2008), 51(7), 286-292. DOI:10.1002/jlcr.1523

 

Dopamine D1 receptor imaging in the rodent and primate brain using the isoquinoline (+)-[11C]A-69024 and positron emission tomography

Besret L, Dolle F, Herard A-S, Guillermier M, Demphel S, Hinnen F, Coulon C, Ottaviani M, Bottlaender M, Hantraye P

J. Pharm. Sci. (2008), 97(7), 2811-2819. DOI:10.1002/jps.21168

 

Synthesis and In Vivo Evaluation of [11C]p-PVP-MEMA as a PET Radioligand for Imaging Nicotinic Receptors

Dolle F, Langle S, Roger G, Fulton RR, Lagnel-de Bruin B, Henderson DJ, Hinnen F, Paine T, Coster, MJ, Valette H

Aust. J. Chem. (2008), 61(6), 438-445. DOI:10.1071/CH08083

 

Cubyl amides: Novel P2X7 receptor antagonists

Gunosewoyo H, Guo JL, Bennett MR, Coster MJ, Kassiou M

Bioorg. Med. Chem. Lett. (2008), 18(13), 3720-3723. DOI:10.1016/j.bmcl.2008.05.062

 

DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization

James ML, Fulton RR, Vercoullie J, Henderson DJ, Garreau L, Chalon S, Dolle F, Selleri S, Guilloteau D, Kassiou M

J. Nucl. Med. (2008), 49(5), 814-822. DOI:10.2967/jnumed.107.046151

 

Behavioural effects of trishomocubanes in rats with unilateral 6-hydroxydopamine lesions

van Dijk, Addy; Johnston, Christopher; Allbutt, Haydn; Kassiou, Michael; Henderson, Jasmine

Behav. Brain Res. (2008), 190(1), 14-21. DOI:10.1016/j.bbr.2008.02.034

 

 

2007

 

(E)-[125I]-5-AOIBV: a SPECT radioligand for the vesicular acetylcholine transporter

Emond P, Mavel S, Zea-Ponce Y, Kassiou M, Garreau L, Bodard S, Drossard M-L, Chalon S, Guilloteau D

Nucl. Med. Biol. (2007), 34(8), 967-971. DOI:10.1016/j.nucmedbio.2007.07.011

 

Ex vivo and in vivo evaluation of (2R,3R)-5-[18F]-fluoroethoxy- and fluoropropoxy-benzovesamicol, as PET radioligands for the vesicular acetylcholine transporter

Giboureau N, Emond P, Fulton RR, Henderson DJ, Chalon S, Garreau L, Roselt P, Eberi S, Mavel S, Bodard S

Synapse (2007), 61(12), 962-970. DOI:10.1002/syn.20450

 

[11C]-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation

Boutin H, Chauveau F, Thominiaux C, Gregoire M-C, James ML, Trebossen R, Hantraye P, Dolle F, Tavitian B, Kassiou M

J. Nucl. Med. (2007), 48(4), 573-581. DOI:10.2967/jnumed.106.036764

 

Positron emission tomography imaging of neuroinflammation

Cagnin A, Kassiou M, Meikle SR, Banati RB

Neurotherapeutics (2007), 4(3), 443-452. DOI:10.1016/j.nurt.2007.04.006

 

Molecular probes for P2X7 receptor studies

Gunosewoyo H, Coster MJ, Kassiou M

Curr. Med. Chem. (2007), 14(14), 1505-1523. DOI:10.2174/092986707780831023

 

Acetylenic pyridines for use in PET imaging of nicotinic receptors

Kozikowski AP, Chellappan SK, Henderson D, Fulton R, Giboureau N, Xiao Y, Wei Z-L, Guilloteau D, Emond P, Dolle F

ChemMedChem (2007), 2(1), 54-57. DOI:10.1002/cmdc.200600220

 

Decreased vesicular acetylcholine transporter and α4β2 nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning

Quinlivan M, Chalon S, Vergote J, Henderson J, Katsifis A, Kassiou M, Guilloteau D

Neurosci. Lett. (2007), 415(2), 97-101. DOI:10.1016/j.neulet.2006.08.065

 

High resolution imaging of the large non-human primate brain using microPET: A feasibility study

Naidoo-Variawa S, Hey-Cunningham AJ, Lehnert W, Kench PL, Kassiou M, Banati R, Meikle SR

Phys. Med. Biol. (2007), 52(22), 6627-6638. DOI: 10.1088/0031-9155/52/22/005

 

Imaging sigma receptors: applications in drug development

Collier TL, Waterhouse RN, Kassiou M

Curr. Pharm. Des. (2007), 13(1), 51-72.

 

Molecular imaging in drug development

Kassiou, M

Curr. Pharm. Des. (2007), 13(1), 1.

 

(1R,2S,3R,6S,7R,8S)-Tricyclo[6.2.1.02,7]undeca-4,9-diene-3,6-diol

Banister SD, Clegg JK, Coster MJ, Jolliffe KA, Kassiou M

Acta Crystallogr., Sect. E: Struct. Rep. Online (2007), E63(1), o92-o93. DOI:10.1107/S1600536806051002

 

Trishomocubanes: Novel σ ligands modulate cocaine-induced behavioral effects

Liu X, Banister SD, Christie MJ, Banati R, Meikle S, Coster MJ, Kassiou M

Eur. J. Pharmacol. (2007), 555(1), 37-42. DOI:10.1016/j.ejphar.2006.10.020

 

 

2006

 

Development of ligands for the peripheral benzodiazepine receptor

James ML, Selleri S, Kassiou M

Curr. Med. Chem. (2006), 13(17), 1991-2001. DOI:10.2174/092986706777584979

 

Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands

Assaad T, Mavel S, Parsons SM, Kruse S, Galineau L, Allouchi H, Kassiou M, Chalon S, Guilloteau D, Emond P

Bioorg. Med. Chem. Lett. (2006), 16(10), 2654-2657. DOI:10.1016/j.bmcl.2006.02.033

 

Improved synthesis of the peripheral benzodiazepine receptor ligand [11C]DPA-713 using [11C]methyl triflate

Thominiaux C, Dolle F, James ML, Bramoulle Y, Boutin H, Besret L, Gregoire M-C, Valette H, Bottlaender M, Tavitian, B

Appl. Rad. Isotop. (2006), 64(5), 570-573. DOI:10.1016/j.apradiso.2005.12.003

 

Developing a preclinical model of Parkinson's disease: A study of behaviour in rats with graded 6-OHDA lesions

Truong L, Allbutt H, Kassiou M, Henderson JM

Behav. Brain Res. (2006), 169(1), 1-9. DOI:10.1016/j.bbr.2005.11.026

 

Synthesis and Radiolabelling of Ipratropium and Tiotropium for Use as PET Ligands in the Study of Inhaled Drug Deposition

Issa F, Kassiou M, Chan H-K, McLeod MD

Aust. J. Chem. (2006), 59(1), 53-58. DOI:10.1071/CH05303

 

Synthesis and in vitro evaluation of novel derivatives of diphenyl sulfide as serotonin transporter ligands

Vercouillie J, Mavel S, Galineau L, Ragusa T, Innis R, Kassiou M, Chalon S, Dolle F, Besnard J-C, Guilloteau D

Bioorg. Med. Chem. Lett. (2006), 16(5), 1297-1300. DOI:10.1016/j.bmcl.2005.11.066

 

Radiosynthesis of (E)-N-(2-[11C]methoxybenzyl)-3-phenyl-acrylamidine, a novel subnanomolar NR2B subtype-selective NMDA receptor antagonist

Thominiaux C, de Bruin B, Bramoulle Y, Hinnen F, Demphel S, Valette H, Bottlaender M, Besret L, Kassiou M, Dolle F

Appl. Rad. Isotop. (2006), 64(3), 348-354. DOI:10.1016/j.apradiso.2005.08.005

 

Clinical evidences of microglial activation in neurodegenerative dementia

Cagnin A, Kassiou M, Meikle SR, Banati RB

Acta. Neurologic. Scand. (2006), 114(S185), 107-114. DOI: 10.1111/j.1600-0404.2006.00694.x

 

 

2005

 

Sequential 123I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and 18F-FDG PET imaging)

Mohamed A, Eberl S, Fulham MJ, Kassiou M, Zaman A, Henderson D, Beveridge S, Constable C, Lo SK

Eur. J. Nuc. Med. Mol. Imaging (2005), 32(2), 180-185. DOI: 10.1007/s00259-004-1654-2

 

Small animal SPECT and its place in the matrix of molecular imaging technologies

Meikle SR, Kench P, Kassiou M, Banati RB

Phys. Med. Biol. (2005), 50(22), R45-R61. DOI:10.1088/0031-9155/50/22/R01

 

Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand

James ML, Fulton RR, Henderson DJ, Eberl S, Meikle SR, Thomson S, Allan RD, Dolle F, Fulham MJ, Kassiou M

Bioorg. Med. Chem. (2005), 13(22), 6188-6194. DOI:10.1016/j.bmc.2005.06.030

 

Synthesis and in vivo evaluation of a new PET radioligand for studying sigma-2 receptors

Kassiou M, Dannals RF, Liu X, Wong DF, Ravert HT, Scheffel UA

Bioorg. Med. Chem. (2005), 13(11), 3623-3626. DOI:10.1016/j.bmc.2005.03.039

 

Ligands for peripheral benzodiazepine binding sites in glial cells

Kassiou M, Meikle SR, Banati RB

Brain Res. Rev. (2005), 48(2), 207-210. DOI:10.1016/j.brainresrev.2004.12.010

 

Influence of trishomocubanes on sigma receptor binding of N-(1-benzyl-piperidin-4-yl)-4-[123I]iodobenzamide in vivo in the rat brain

Liu X, Mattner F, Katsifis A, Christie M, Kassiou M

Med. Chem. (2005), 1(1), 31-38. DOI:10.2174/1573406053402541

 

Synthesis and in vitro evaluation of new benzovesamicol analogs as potential imaging probes for the vesicular acetylcholine transporter

Zea-Ponce Y, Mavel S, Assaad T, Kruse SE, Parsons SM, Emond P, Chalon S, Giboureau N, Kassiou M, Guilloteau D

Bioorg. Med. Chem. (2005), 13(3), 745-753. DOI:10.1016/j.bmc.2004.10.043

 

 

2004

 

Radiosynthesis and in vivo evaluation of [11C]Ro-647312: A novel NR1/2B subtype selective NMDA receptor radioligand

Dolle F, Valette H, Demphel S, Coulon C, Ottaviani M, Bottlaender M, Kassiou M

J. Label. Cmpd. Radiopharm. (2004), 47(13), 911-920.

 

Development of radioligands for in vivo imaging of GABAA-benzodiazepine receptors

Katsifis A, Kassiou M

Mini-Rev. Med. Chem. (2004), 4(8), 909-921.

 

Radiosynthesis and pharmacological evaluation of [11C]EMD-95885: a high affinity ligand for NR2B-containing NMDA receptors

Roger G, Dolle F, de Bruin B, Liu X, Besret L, Bramoulle Y, Coulon C, Ottaviani M, Bottlaender M, Valette H

Bioorg. Med. Chem. (2004), 12(12), 3229-3237. DOI:10.1016/j.bmc.2004.03.065

 

The role of positron emission tomography in the discovery and development of new drugs; As studied in laboratory animals

Roselt P, Meikle S, Kassiou M

Eur. J. Drug Metab. Pharmacokinet. (2004), 29(1), 1-6. DOI:10.1007/BF03190567

 

3-Pyridyl ethers as SPECT radioligands for imaging nicotinic acetylcholine receptors

Henderson DJ, Eberl S, Thomson S, Smith A, Allan RD, Fulham MJ, Loiacono R, Kassiou M

Appl. Rad. Isotop. (2004), 60(5), 669-676. DOI:10.1016/j.apradiso.2004.01.002

 

 

2003

 

Synthesis, radiosynthesis and In vivo evaluation of 5-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer

Roger G, Lagnel B, Besret L, Bramoulle Y, Coulon C, Ottaviani M, Kassiou M, Bottlaender M, Valette H, Dolle F

Bioorg. Med. Chem. (2003), 11(24), 5401-5408. DOI:10.1016/j.bmc.2003.09.036

 

Synthesis and evaluation of iodine-123 labelled tricyclic tropanes as radioligands for the serotonin transporter

Quinlivan M, Mattner F, Papazian V, Zhou J, Katsifis A, Emond P, Chalon S, Kozikowski A, Guilloteau D, Kassiou M

Nucl. Med. Biol. (2003), 30(7), 741-746. DOI:10.1016/S0969-8051(03)00076-3

 

PET radiochemistry in drug development and evaluation

Kassiou M, Katsifis A

Chem. Aust. (2003), 70(5), 10-12.

 

Pharmacological evaluation of (S)-8-[123I]iodobretazenil: a radioligand for in vivo studies of central benzodiazepine receptors

Katsifis A, Mardon K, Mattner F, Loc'h C, McPhee ME, Dikic B, Kassiou M, Ridley DD

Nucl. Med. Biol. (2003), 30(2), 191-198. DOI:10.1016/S0969-8051(02)00394-3

 

 

2002

 

Preparation of a bromine-76 labelled analogue of epibatidine: a potent ligand for nicotinic acetylcholine receptor studies

Kassiou M, Loc'h C, Dolle F, Musachio JL, Dolci L, Crouzel C, Dannals RF, Maziere B

Appl. Rad. Isotop. (2002), 57(5), 713-717. DOI:10.1016/S0969-8043(02)00187-2

 

Pharmacological evaluation of a Br-76 analog of epibatidine: A potent ligand for studying brain nicotinic acetylcholine receptors

Kassiou M, Bottlaender M, Loc'h C, Dolle F, Musachio JL, Coulon C, Ottaviani M, Dannals RF, Maziere B

Synapse (2002), 45(2), 95-104. DOI:10.1002/syn.10087

 

(+)-[76Br]A-69024: a non-benzazepine radioligand for studies of dopamine D1 receptors using PET

Kassiou M, Loc'h C, Bottlaender M, Mardon K, Ottaviani M, Coulon C, Katsifis A, Maziere B

Nucl. Med. Biol. (2002), 29(3), 295-302. DOI:10.1016/S0969-8051(01)00306-7

 

 

2001

 

In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT

Kassiou M, Eberl S, Meikle SR, Birrell A, Constable C, Fulham MJ, Wong DF, Musachio J

Nucl. Med. Biol. (2001), 28(2), 165-175. DOI:10.1016/S0969-8051(00)00206-7

 

Trishomocubanes: Requirements for σ receptor binding and subtype selectivity

Liu X, Kassiou M, Christie MJ Hambley, TW

Aust. J. Chem. (2001), 54(1), 31-36.

 

Pharmacological evaluation of (+)-2-[123I]A-69024 A radioligand for in vivo studies of dopamine D1 receptors

Kassiou M, Mardon K, Mattner F, Katsifis A, Dikic B

Life Sci. (2001), 69(6), 669-675. DOI:10.1016/S0024-3205(01)01156-0

 

Trishomocubanes: novel σ-receptor ligands modulate amphetamine-stimulated [3H]dopamine release

Liu X, Samer N, Christie MJ, Kassiou M, Werling LL

Eur. J. Pharmacol. (2001), 422(1-3), 39-45. DOI:10.1016/S0014-2999(01)01071-8

 

 

2000

 

X-ray crystallographic structures of biologically active trishomocubanes of the types pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines and 4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecane

Hambley, TW, Knott R, Kassiou M, Christie MJ

Aust. J. Chem. (2000), 53(11 & 12), 899-904.

 

Radiosynthesis of bromine-76 and iodine-123 labelled enantiomers of A-69024: radioligands for dopamine D1 receptor studies using PET and SPECT

Kassiou M, Loc'h C, Katsifis A, Papazian V, Mattner F, Dikic B, Maziere B

J. Label. Cmpd. Radiopharm. (2000), 43(4), 339-346.

DOI:10.1002/(SICI)1099-1344(20000330)43:4<339::AID-JLCR321>3.0.CO;2-6

 

The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies in the rat brain

Miekle SR, Eberl S, Fulton RR, Kassiou M, Fulham MJ

Nucl. Med. Biol. (2000), 27(6), 617-625. DOI: 10.1016/S0969-8051(00)00105-0

 

 

1999

 

Effects of streptozotocin-induced diabetes on neuronal sigma receptors in the rat brain

Mardon K, Kassiou M, Donald A

Life Sci. (1999), 65(23), PL281-PL286. DOI:10.1016/S0024-3205(99)00521-4

 

Synthesis and binding studies of trishomocubanes: novel ligands for σ binding sites

Liu X, Kassiou M, Christie MJ

Aust. J. Chem. (1999), 52(7), 653-656. DOI:10.1071/CH99010

 

A study of myocardial muscarinic receptors in streptozotocin-induced diabetic rats using iodine-123 N-methyl-4-iododexetimide

Mardon K, Kassiou M, Katsifis A, Najdovski L

Eur. J. Nucl. Med. (1999), 26(7), 743-749. DOI:10.1007/s002590050445

 

In vitro and in vivo characterization of [3H]ANSTO-14 binding to the σ1 binding sites

Nguyen VH, Mardon K, Kassiou M, Christie MJ

Nucl. Med. Biol. (1999), 26(2), 209-215. DOI:10.1016/S0969-8051(98)00095-X

 

 

1998

 

σ-Binding site ligands inhibit K+ currents in rat locus coeruleus neurons in vitro

Nguyen VH, Ingram SL, Kassiou M, Christie MJ

Eur. J. Pharmacol. (1998), 361(1), 157-163. DOI:10.1016/S0014-2999(98)00706-7

 

Pharmacological evaluation of [11C]A-84543: an enantioselective ligand for in vivo studies of neuronal nicotinic acetylcholine receptors

Kassiou M, Scheffel UA, Ravert HT, Mathews WB, Musachio JL, London ED, Dannals RF

Life Sci. (1998), 63(1), PL13-PL18. DOI:10.1016/S0024-3205(98)00240-9

 

 

1997

 

Synthesis of 3-[(1-[11C]methyl-2(S)-pyrrolidinyl)methoxy]pyridine and 3-[(1-[11C]methyl-2(R)-pyrrolidinyl)methoxy]pyridine: radioligands for in vivo studies of neuronal nicotinic acetylcholine receptors

Kassiou M, Ravert HT, Mathews WB, Musachio JL, London ED, Dannals RF

J. Label. Cmpd. Radiopharm. (1997), 39(5), 425-431.

DOI:10.1002/(SICI)1099-1344(199705)39:5<425::AID-JLCR984>3.0.CO;2-R

 

Synthesis and evaluation of halogenated dibenzodiazepines as muscarinic receptor ligands

Kassiou M, Read R, Shi X-Q

Bioorg. Med.Chem. Lett. (1997), 7(7), 799-804. DOI:10.1016/S0960-894X(97)00109-1

 

 

1996

 

Synthesis of iodine-123 labeled analogs of imidazenil and ethylimidazenil for studying benzodiazepine receptors using SPECT

Katsifis A, Mattner F, Dikic B, Najdovski L, Kassiou M

J. Label. Cmpd. Radiopharm. (1996), 38(12), 1121-1132.

DOI:10.1002/(SICI)1099-1344(199612)38:12<1121::AID-JLCR948>3.0.CO;2-V

 

Comparison of binding parameters of σ1 and σ2 binding sites in rat and guinea pig brain membranes: novel subtype-selective trishomocubanes

Nguyen VH, Kassiou M, Johnston GAR, Christie MJ

Eur. J. Pharmacol. (1996), 311(2-3), 233-240. DOI:10.1016/0014-2999(96)00395-0

 

Synthesis of iodine-123 labeled analogs of the partial agonist (S)- and (R)-bretazenil for the study of CNS benzodiazepine receptors using SPECT

Katsifis A, Mattner F, McPhee M, Kassiou M, Najdovski L, Dikic B

J. Label. Cmpd. Radiopharm. (1996), 38(9), 835-845.

DOI:10.1002/(SICI)1099-1344(199609)38:9<835::AID-JLCR898>3.0.CO;2-Z

 

Pharmacological characterization and positron emission tomography evaluation of 4-[76Br]bromodexetimide and 4-[76Br]bromolevetimide for investigations of central muscarinic cholinergic receptors

Loc’h C, Kassiou M, Strijckmans V, Bottlaender M, Katsifis A, Schmid L, Maziere M, Lambrecht RM, Maziere B

Nucl. Med. Biol. (1996), 23(3), 235-243. DOI:10.1016/0969-8051(95)02052-7

 

Radiosynthesis of [123I]N-methyl-4-iododexetimide and [123I]N-methyl-4-iodolevetimide: In vitro and in vivo characterization of binding to muscarinic receptors in the rat heart

Kassiou M, Mardon M, Katsifis A, Najdovski L, Dikic D, Mattner F, Lambrecht RM, Hicks RJ, Eu P, Loc’h C

Nucl. Med. Biol. (1996), 23(2), 147-53. DOI:10.1016/0969-8051(95)02045-4

 

Trishomocubanes, a new class of selective and high affinity ligands for the sigma binding site

Kassiou M, Nguyen V, Knott R, Christie MJ, Hambley T

Bioorg. Med. Chem. Lett. (1996), 6(6), 595-600. DOI:10.1016/0960-894X(96)00067-4

 

Localization of temporal lobe epileptic foci with iodine-123 iododexetimide cholinergic neuroreceptor single-photon emission computed tomography

Boundy K, Rowe CC, Black AB, Kitchener MI, Barden L, Sebben R, Kassiou M, Katsifis A, Lambrecht RM

Neurology (1996), 47(4), 1015-1020.

 

In vitro pharmacological properties of 4-bromodexetimide for muscarinic receptors

Strijckmans V, Coulon C, Kassiou M, Loc’h C, Maziere B

Life Sci. (1996), 58(23), PL337-344. DOI: 10.1016/0024-3205(96)00212-3

 

 

1995

 

[3H]A-69024: a non-benzazepine ligand for in vitro and in vivo studies of dopamine D1 receptors

Kassiou M, Scheffel U, Ravert HT, Mathews WB, Musachio JL, Lambrecht RM, Dannals RF

Nucl. Med. Biol. (1995), 57(23), PL367-PL372. DOI:10.1016/0024-3205(95)02212-2

 

Human dosimetry and biodistribution of iodine-123-iododexetimide: A SPECT imaging agent for cholinergic muscarinic neuroreceptors

Boundy KL, Barnden LR, Rowe CC, Reid M, Kassiou M, Katsifis A, Lambrecht RM

J. Nucl. Med. (1995), 36(7), 1332-1338.

 

[11C]A-69024: a potent and selective non-benzazepine radiotracer for in vivo studies of dopamine D1 receptors

Kassiou M, Scheffel U, Ravert H, Mathews WB, Musachio JL, Lambrecht RM, Dannals RF

Nucl. Med. Biol. (1995), 22(2), 221-6. DOI:10.1016/0969-8051(94)00086-Y

 

Synthesis of [76Br]4-bromodexetimide and [76Br]4-bromolevetimide: radiotracers for studying muscarinic cholinergic receptors using PET

Kassiou M, Loc’h C, Strijckmans V, Katsifis A, Lambrecht RM, Maziere M, Maziere B

J. Label. Cmpd. Radiopharm. (1995), 36(3), 259-66. DOI:10.1002/jlcr.2580360308

 

Iodine-123 N-methyl-4-iododexetimide: a new radioligand for SPET imaging of myocardial muscarinic receptors

Hicks RJ, Kassiou M, Eu P, Katsifis A, Garra M, Power J, Najdovski L, Lambrecht RM

Eur. J. Nucl. Med. Mol. Imaging (1995), 22(4), 339-345. DOI: 10.1007/BF00941851

 

 

1994

 

Radiosynthesis of (±)-1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-[11C]-methyl-1,2,3,4-tetrahydroisoquinoline, [11C]A-69024: a non-benzazepine antagonist for studying dopamine D1 receptors in vivo using PET

Kassiou M, Mathews WB, Musachio JL, Ravert HT, Lambrecht RM, Dannals RF

J. Label. Cmpd. Radiopharm. (1994), 34(5), 431-437. DOI:10.1002/jlcr.2580340505

 

Synthesis and stereochemical assignment of 2,5-trans-2',5'-trans-5,5'-dimethylperhydro-2,2'-bipyrimidine and heterocycles derived from its condensation with formaldehyde

Kassiou M, Read RW

Tetrahedron (1994), 50(8), 2497-2506. DOI:10.1016/S0040-4020(01)86966-0

 

 

1993

 

Reactions of perhydro-2,2'-bipyrimidines with carbonyl compounds bearing α-carbonyl functionality

Craig DC, Doughty A, Kassiou M, MacIntosh M, Read RW

J. Org. Chem. (1993), 58(21), 5753-5758. DOI:10.1021/jo00073a039

 

 

1992

 

Synthesis and stereochemical assignment of heterocycles derived from (2S*,2'S*,4R*,4'R*,6S*,6'S*)-4,4',6,6'-tetramethylperhydro-2,2'-bipyrimidine

Craig DC, Kassiou M, Read RW

J. Org. Chem. (1992), 57(14), 3901-3905. DOI:10.1021/jo00040a033

 

 

1991

 

Unexpected formation of 5,12-dimethyl-3,7,10,14,15,16-tetraazapentacyclo[7.5.1.12,8.15,16.112,15]octadecane, a novel caged nitrogen heterocycle, and preparation and x-ray crystal structure of its copper(II) chloride complex

Craig DC, Kassiou M, Read RW

J. Chem. Soc., Chem. Commun. (1991), (8), 607-608. DOI:10.1039/c39910000607

 

Evidence for equatorial bridging in 2,2'-bis(hexahydropyrimidines), perhydro-4,5,8a,9a-tetraazafluorenes, and perhydro-3a,4a,7a,8a-tetraazacyclopentanofluorenes through one-bond carbon-hydrogen coupling

Black DSC, Kassiou M, Read RW

J. Org. Chem. (1991), 56(13), 4308-4312. DOI:10.1021/jo00013a046

 

Preferred equatorial linkages of hexahydropyrimidine rings in dodecahydro-2,2'-bipyrimidines

Black DSC, Craig DC, Kassiou M, Read RW

Aust. J. Chem. (1991), 44(1), 143-149. DOI:10.1071/CH9910143

 

 

 

 Description: BD10219_