Rutledge Group

 

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Publications

 

Papers

 

49.
M. Yu, S. Ast, Q. Yu, A. Lo, R. Flehr, M. Todd, and P.J. Rutledge; Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates. PLoS One, 9(7), e100761-1-e100761-12 (2014). Description: Description: Description: Description: Description: Description: Description: Description: Description: pdf logo

48.

I. J. Clifton, G. Wei, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site; FEBS Lett., 587(16), 2705-2709 (2013).

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47.

M. Yu, N. H. Lim, S. Ellis, H. Nagase, J. A. Triccas, P. J. Rutledge and M. H. Todd; Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity; Chem. Open 2 99–105 (2013).

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46.

A. Daruzzaman, I. J. Clifton, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; The interaction of isopenicillin N synthase with homologated substrate analogues d-(l-a-aminoadipoyl)-l-homocysteinyl-d-Xaa characterised using protein crystallography; ChemBioChem 14 599–606 (2013).

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45.

V. J. Dungan, B. M.-L. Poon, E. Barrett and P. J. Rutledge; L-Proline derived mimics of the non-heme iron active site catalyse allylic oxidation in acetonitrile solutions; Tetrahedron Lett. 54 1236–1238 (2013).

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44.

A. Daruzzaman, I. J. Clifton, R. M. Adlington, J. E. Baldwin and Peter J. Rutledge; The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue; Arch. Biochem. Biophys. 530 48–53 (2013).

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43.

M. Yu, Q. Yu, P. J. Rutledge and M. H. Todd; A fluorescent “allosteric scorpionand” complex visualizes a biological recognition event; ChemBioChem 14 224–229 (2013).

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42.

S. Cheung, V. McCarl, A. J. Holmes, N. V. Coleman and P. J. Rutledge; Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4; Appl. Microbiol. Biotechnol. 97 1131–1140 (2013).

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41.

S. Ast, P. J. Rutledge and M. H. Todd; Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10 fold brighter signal response to Zn2+ in aqueous solution; Eur. J. Inorg. Chem. 2012 5611–5615 (2012).

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40.

V. J. Dungan, H. Mueller-Bunz and P. J. Rutledge; (2S,4S)-3-Benzoyl-4-benzyl-2-(tert-butyl)oxazolidin-5-one; Acta Cryst. E68 o2747 (2012).

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39.

S. M. Barry, H. Mueller-Bunz and P. J. Rutledge; Investigating the oxidation of alkenes by non-heme iron enzyme mimics; Org. Biomol. Chem. 10 7372–7381 (2012).

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38.

V. J. Dungan, S. M. Wong, S. M. Barry and P. J. Rutledge; l-Proline-derived ligands to mimic the ‘2-His-1-carboxylate’ triad of the non-heme iron oxidase active site; Tetrahedron 68 3231–3236 (2012).

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37.

K. D. Beare, M. J. Coster and P. J. Rutledge; Diketoacid inhibitors of HIV-1 integrase: from L-708,906 to raltegravir and beyond; Curr. Med. Chem. 19 1177–1192 (2012).

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36.

M. Yu, J. Price, P. Jensen, T. Shelper, C. Lovitt, S. Duffy, L. Windus, V. Avery, P. J. Rutledge and M. H. Todd; Copper, Nickel and Zinc Cyclam-amino Acid and Cyclam-peptide Complexes may be Synthesized with “Click” Chemistry and are Non-cytotoxic; Inorg. Chem. 50 12823–12835 (2011).

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35.

I. J. Clifton, G. Wei, R. Adlington, J. E. Baldwin and P. J. Rutledge; The Crystal Structure of Isopenicillin N Synthase with d-(l-a-Aminoadipoyl)-l-cysteinyl-d-methionine reveals thioether coordination to iron; Arch. Biochem. Biophys. 516 103–107 (2011).

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34.

A. J. Bridgeman, R. Connor, P. J. Rutledge and M. H. Todd; A Treasure Hunt for Chemistry; J. Chem. Ed. 88 437–439 (2011).

Featured in the journal editorial

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33.

I. J. Clifton, G. Wei, R. Adlington, J. E. Baldwin and P. J. Rutledge; Isopenicillin N Synthase Binds d-(l-a-Aminoadipoyl)-l-cysteinyl-d-thia-allo-isoleucine Through both Sulfur Atoms; ChemBioChem 12 1881–1885 (2011).

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32.

A. T. S. Lo, N. K. Salam, D. E. Hibbs, P. J. Rutledge and M. H. Todd; Polyamide-scorpion Cyclam Lexitropsins Selectively Bind AT-rich DNA Independently of the Nature of the Coordinated Metal; PLoS ONE 6 e17446 (2011).

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31.

Y. H. Lau, P. J. Rutledge, M. Watkinson and M. H. Todd; Chemical Sensors that Incorporate Click-Derived Triazoles; Chem. Soc. Rev. 40 2848–2866 (2011).

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30.

Y. H. Lau, J. Price, M. H. Todd and P. J. Rutledge; A Click Fluorophore Sensor can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation; Chem. Eur. J. 17 2850–2858 (2011).

Featured in Chemistry Views and selected as the journal frontispiece.

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29.

S. S. Hosseini, M. Bhadbhade, R. J. Clarke, P. J. Rutledge and L. M. Rendina; Synthesis, Carbohydrate- and DNA-Binding Studies of Cationic 2,2’:6’,2”- Terpyridineplatinum(II) Complexes Containing N- and S-donor Boronic Acid Ligands; Dalton Trans. 40 506–513 (2011).

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28.

C. C. G. Scully, P. Jensen and P. J. Rutledge; Synthesis, electrochemistry and metal binding properties of monosubstituted ferrocenoyl peptides with thioether-containing sidechains; J. Organomet. Chem. 696 715–721 (2011).

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27.

D. E. Morrison, F. Issa, M. Bhadbhade, P. K. Witting, L. Groebler, M. Kassiou, P. J. Rutledge and L. M. Rendina; Boronated Phosphonium Salts Containing Arylboronic Acid, Closo- or Nido-Carborane: Synthesis, X-ray Diffraction, In Vitro Cytotoxicity and Cellular Uptake; J. Biol. Inorg. Chem. 15 1305–1318 (2010).

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26.

W. Ge, I. J. Clifton, J. E. Stok, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Crystallographic studies on the binding of selectively deuterated lld- and lll-substrate epimers by isopenicillin N synthase; Biochem. Biophys. Res. Com. 398 659–664 (2010).

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25.

C. C. G. Scully and P. J. Rutledge; Synthesis and electrochemical studies of disubstituted ferrocene-dipeptide conjugates with sulfur-containing side chains; Tetrahedron 66 5653–5659 (2010). Description: Description: Description: Description: Description: Description: Description: Description: Description: http://www.sciencedirect.com/scidirimg/clear.gif

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24.

A. Manos-Turvey, E. M. M. Bulloch, P. J. Rutledge, E. N. Baker, J. S. Lott and R. J. Payne; Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI); ChemMedChem 5 1067–1079 (2010).

Featured on the front cover of the journal.

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23.

V. J. Dungan, Y. Ortin, H. Mueller-Bunz and P. J. Rutledge; Design and synthesis of a tetradentate ‘3-amine-1-carboxylate’ ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site; Org. Biomol. Chem. 8 1666–1673 (2010).

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22.

W. Ge, I. J. Clifton, J. E. Stok, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; The crystal structure of an lll-configured depsipeptide substrate analogue bound in the active site of isopenicillin N synthase; Org. Biomol. Chem. 8 122–127 (2010)

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21.

W. Ge, I. J. Clifton, A. R. Howard-Jones, J. E. Stok, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue; ChemBioChem 10 2025–2031 (2009)

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20.

S. M. Barry and P. J. Rutledge; Cis-Dihydroxylation of alkenes by a non-heme iron enzyme mimic; Synlett 2172–2174 (2008)

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19.

W. Ge, I. J. Clifton, J. E. Stok, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase? J. Am. Chem. Soc. 130 10096–10102 (2008).

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18.

C. C. G. Scully, P. Jensen and P. J. Rutledge; Ferrocenyl peptides incorporating methylsulfide-bearing sidechains selectively bind mercury over other heavy metals; J. Organomet. Chem. 693 2869–2876 (2008).

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17.

S. M. Barry. H. Mueller-Bunz and P. J. Rutledge; tert-Butyldimethylsilanol hemihydrate; Acta Cryst. E64 o1174 (2008).

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16.

A. C. Stewart, I. J. Clifton, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase; ChemBioChem 8 2003–2007 (2007).

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15.

A. R. Howard-Jones, J. M. Elkins, I. J. Clifton, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Interactions of Isopenicillin N Synthase with Cyclopropyl-Containing Substrate Analogues Reveal New Mechanistic Insight; Biochemistry 46 4755–4762 (2007).

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14.

A. Daruzzaman, I. J. Clifton, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase; ChemBioChem 7 351–358 (2006).

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13.

P. V. Murphy and P. J. Rutledge; Symbiosis in chemistry and biology; Nature Chem. Biol. 2 59–62 (2006).

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12.

A. R. Howard-Jones, P. J. Rutledge, I. J. Clifton, R. M. Adlington and J. E. Baldwin; Unique binding of a non-natural l,l,l-substrate by isopenicillin N synthase; Biochem. Biophys. Res. Com., 336 702–708 (2005).

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11.

A. J. Long, I. J. Clifton, P. L. Roach, J. E. Baldwin, P. J. Rutledge and C. J. Schofield; Structural studies on the reaction of isopenicillin N synthase with substrate analogues d-(l-a-aminoadipoyl)-l-cysteinyl-glycine and d-(l-a-aminoadipoyl)-l-cysteinyl-d-alanine; Biochemistry 44 6619–6628 (2005).

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10.

J. A. Krall, P. J. Rutledge and J. E. Baldwin; Design and synthesis of an isopenicillin N synthase mimic; Tetrahedron 61 137–143 (2005).

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9.

A.R. Grummitt, P.J. Rutledge, I.J. Clifton and J.E. Baldwin; Active site mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase; Biochem. J. 382 659–666 (2004).

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8.

A. C. Ferguson, R. M. Adlington, D. H. Martyres, P. J. Rutledge, A. Cowley and J. E. Baldwin; Total synthesis of a novel 2-thiabicyclo[3.2.0]heptan-6-one analogue of penicillin N; Tetrahedron 59 8233–8243 (2003).

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7.

A. J. Long, I. J. Clifton, P. L. Roach, J. E. Baldwin, C. J. Schofield and P. J. Rutledge; Structural studies on the reaction of isopenicillin N synthase with the substrate analogue d-(l-a-aminoadipoyl)-l-cysteinyl-d-a-aminobutyrate; Biochem J. 372 687–693 (2003).

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6.

J. M. Elkins, P. J. Rutledge, I. J. Clifton, N. I. Burzlaff, P. L. Roach, R. M. Adlington and J. E. Baldwin; Crystallographic investigation of the isopenicillin N synthase reaction with the unsaturated substrate analogue d-(l-a-aminoadipoyl)-l-cysteinyl-d-vinylglycine; Org. Biomol. Chem. 1 1455–1460 (2003).

Featured on the front cover of the journal.

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5.

P. J. Rutledge, N. I. Burzlaff, J. M. Elkins, M. Pickford. J. E. Baldwin and P. L. Roach; Use of hyperbaric oxygenation to promote reaction in enzyme crystals; Anal. Biochem. 308 265–268 (2002).

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4.

J. M. Ogle, I. J. Clifton, P. J. Rutledge, J. M. Elkins, N. I. Burzlaff, R. M. Adlington, P. L. Roach and J. E. Baldwin; Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction; Chem. & Biol. 8 1231–1237 (2001).

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3.

C. S. Hamilton, A. Yasuhara, J. E. Baldwin, M. D. Lloyd and P. J. Rutledge; Contrasting fates for 6-a-methylpenicillin N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/ deacetylcephalosporin C synthase (DAOC/DACS); Bioorg. Med. Chem. Lett. 11 2511–2514 (2001).

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2.

N. I. Burzlaff, P. J. Rutledge, I. J. Clifton, C. M. H. Hensgens, M. Pickford, R. M. Adlington, P. L. Roach and J. E. Baldwin; Observation of the reaction cycle of isopenicillin N synthase by X-ray diffraction; Nature 401 721–724 (1999).

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Book Chapters

1.

P. J. Rutledge, Nitriles with a heteroatom attached to the cyanocarbon; Chapter 5.30 of ‘Comprehensive Organic Functional Group Transformations II’ R. F. C. Jones Editor Volume 5, A. R. Katritzky and R. J. K. Taylor Editors in Chief; Elsevier/Pergamon Press, Oxford 1023–1080 (2005).

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Other Publications

2.

P. J. Rutledge; Changing Up Your Lectures; Teaching@Sydney (2012).

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1.

A. J. Bridgeman and P. J. Rutledge, Getting Personal: Feedback for the masses; Synergy 30 60–68 (2010).

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Rutledge Group

 

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© 2007-2014 Peter J Rutledge

 

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