Publications
Research Papers
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46. |
I. J. Clifton, G. Wei, R. M. Adlington,
J. E. Baldwin and P. J. Rutledge; Water
blocks the O2 binding site in the complex of isopenicillin N
synthase with d-(l-a-aminoadipoyl)-l-cysteinyl-O-methyl-d-threonine; submitted. |
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45. |
A. Daruzzaman, I. J. Clifton, R. M.
Adlington, J. E. Baldwin and P. J. Rutledge; The interaction of isopenicillin N synthase with homologated
substrate analogues d-(l-a-aminoadipoyl)-l-homocysteinyl-d-Xaa characterised using protein
crystallography; ChemBioChem accepted 12.12.2012; doi 10.1002/cbic.201200728 (2013). |
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44. |
V. J. Dungan, B. M.-L. Poon, E. Barrett
and P. J. Rutledge; L-Proline derived
mimics of the non-heme iron active site catalyse allylic oxidation in
acetonitrile solutions; Tetrahedron
Lett. 54 1236–1238 (2013). |
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43. |
A. Daruzzaman, I. J. Clifton, R. M. Adlington,
J. E. Baldwin and Peter J. Rutledge;
The crystal structure of isopenicillin N synthase with a dipeptide substrate
analogue; Arch. Biochem. Biophys. 530 48–53 (2013). |
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42. |
M. Yu, Q. Yu, P. J. Rutledge and M. H.
Todd; A fluorescent “allosteric
scorpionate” complex visualizes a biological recognition event; ChemBioChem 14 224–229 (2013). |
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41. |
S. Cheung, V. McCarl, A. J. Holmes, N. V.
Coleman and P. J. Rutledge; Substrate range
and enantioselectivity of epoxidation reactions mediated by the
ethene-oxidising Mycobacterium strain NBB4; Appl. Microbiol. Biotechnol. 97 1131–1140 (2013). |
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40. |
S. Ast, P. J. Rutledge and M. H. Todd; Reversing the triazole topology in a
cyclam-triazole-dye ligand gives a 10 fold brighter signal response to Zn2+
in aqueous solution; Eur. J. Inorg.
Chem. 2012 5611–5615 (2012). |
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39. |
V. J. Dungan, H. Mueller-Bunz and P. J.
Rutledge; (2S,4S)-3-Benzoyl-4-benzyl-2-(tert-butyl)oxazolidin-5-one;
Acta Cryst. E68 o2747
(2012). |
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38. |
S. M. Barry, H. Mueller-Bunz and P. J.
Rutledge; Investigating the oxidation
of alkenes by non-heme iron enzyme mimics; Org. Biomol. Chem. 10 7372–7381 (2012). |
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37. |
V. J. Dungan, S. M. Wong, S.
M. Barry and P. J. Rutledge; l-Proline-derived ligands to mimic the ‘2-His-1-carboxylate’ triad of
the non-heme iron oxidase active site; Tetrahedron 68 3231–3236 (2012). |
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36. |
K. D. Beare, M. J. Coster and P. J.
Rutledge; Diketoacid inhibitors of
HIV-1 integrase: from L-708,906 to raltegravir and beyond; Curr. Med. Chem. 19
1177–1192 (2012). |
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35. |
M. Yu, J. Price, P. Jensen, T. Shelper,
C. Lovitt, S. Duffy, L. Windus, V. Avery, P. J. Rutledge and M. H. Todd; Copper, Nickel and Zinc Cyclam-amino Acid
and Cyclam-peptide Complexes may be Synthesized with “Click” Chemistry and
are Non-cytotoxic; Inorg. Chem. 50 12823–12835 (2011). |
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34. |
I. J. Clifton, G. Wei, R. Adlington, J.
E. Baldwin and P. J. Rutledge; The
Crystal Structure of Isopenicillin N Synthase with d-(l-a-Aminoadipoyl)-l-cysteinyl-d-methionine
reveals thioether coordination to iron; Arch. Biochem. Biophys. 516 103–107 (2011). |
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33. |
I. J.
Clifton, G. Wei, R. Adlington, J. E. Baldwin and P. J. Rutledge; Isopenicillin N Synthase Binds d-(l-a-Aminoadipoyl)-l-cysteinyl-d-thia-allo-isoleucine
Through both Sulfur Atoms; ChemBioChem
12 1881–1885 (2011). |
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32. |
A. T. S. Lo, N. K. Salam, D. E. Hibbs, P.
J. Rutledge and M. H. Todd; Polyamide-scorpion
Cyclam Lexitropsins Selectively Bind AT-rich DNA Independently of the Nature of
the Coordinated Metal; PLoS ONE 6
e17446 (2011). |
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31. |
Y. H. Lau, P. J. Rutledge, M. Watkinson
and M. H. Todd; Chemical Sensors that
Incorporate Click-Derived Triazoles; Chem. Soc. Rev. 40 2848–2866 (2011). |
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30. |
Y. H. Lau, J. Price, M. H. Todd and P. J.
Rutledge; A Click Fluorophore Sensor
can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation;
Chem. Eur. J. 17 2850–2858 (2011). Featured
in Chemistry Views and selected as the journal
frontispiece. |
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29. |
S. S. Hosseini, M. Bhadbhade, R. J.
Clarke, P. J. Rutledge and L. M. Rendina; Synthesis,
Carbohydrate- and DNA-Binding Studies of Cationic 2,2’:6’,2”-
Terpyridineplatinum(II) Complexes Containing N- and S-donor Boronic Acid
Ligands; Dalton Trans. 40 506–513 (2011). |
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28. |
C. C. G. Scully, P. Jensen and P. J.
Rutledge; Synthesis, electrochemistry and
metal binding properties of monosubstituted ferrocenoyl peptides with
thioether-containing sidechains; J. Organomet. Chem. 696 715–721 (2011). |
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27. |
D. E. Morrison,
F. Issa, M. Bhadbhade, P. K. Witting, L. Groebler, M. Kassiou, P. J. Rutledge
and L. M. Rendina; Boronated
Phosphonium Salts Containing Arylboronic Acid, Closo- or Nido-Carborane:
Synthesis, X-ray Diffraction, In Vitro Cytotoxicity and Cellular Uptake; J. Biol. Inorg. Chem. 15
1305–1318 (2010). |
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26. |
W. Ge, I. J.
Clifton, J. E. Stok, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Crystallographic studies on the binding of
selectively deuterated lld- and lll-substrate epimers by isopenicillin
N synthase; Biochem.
Biophys. Res. Com. 398
659–664 (2010). |
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25. |
C. C. G. Scully and P. J. Rutledge; Synthesis and electrochemical studies of
disubstituted ferrocene-dipeptide conjugates with sulfur-containing side
chains; Tetrahedron 66 5653–5659 (2010). |
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24. |
A. Manos-Turvey, E. M. M.
Bulloch, P. J. Rutledge, E. N. Baker, J. S. Lott and R. J. Payne; Inhibition Studies of Mycobacterium
tuberculosis Salicylate Synthase (MbtI); ChemMedChem 5 1067–1079
(2010). Featured on the front
cover of the journal. |
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23. |
V. J.
Dungan, Y. Ortin, H. Mueller-Bunz and P. J. Rutledge; Design and synthesis of a tetradentate ‘3-amine-1-carboxylate’ ligand
to mimic the metal binding environment at the non-heme iron(II) oxidase
active site; Org. Biomol. Chem.
8 1666–1673 (2010). |
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22. |
W. Ge, I. J.
Clifton, J. E. Stok, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; The crystal structure of an lll-configured depsipeptide substrate
analogue bound in the active site of isopenicillin N synthase; Org. Biomol. Chem. 8 122–127 (2010) |
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21. |
W. Ge, I. J.
Clifton, A. R. Howard-Jones, J. E. Stok, R. M. Adlington, J. E. Baldwin and
P. J. Rutledge; Structural studies on the
reaction of isopenicillin N synthase with a sterically demanding depsipeptide
substrate analogue; ChemBioChem
10 2025–2031 (2009) |
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20. |
S. M. Barry and P. J. Rutledge; Cis-Dihydroxylation of alkenes by a
non-heme iron enzyme mimic; Synlett 2172–2174
(2008) |
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19. |
W. Ge, I. J.
Clifton, J. E. Stok, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Isopenicillin N synthase mediates thiolate
oxidation to sulfenate in a depsipeptide substrate analogue: implications for
oxygen binding and a link to nitrile hydratase? J. Am. Chem. Soc. 130
10096–10102 (2008). |
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18. |
C. C. G. Scully,
P. Jensen and P. J. Rutledge; Ferrocenyl
peptides incorporating methylsulfide-bearing sidechains selectively bind
mercury over other heavy metals; J.
Organomet. Chem. 693
2869–2876 (2008). |
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17. |
S. M. Barry. H.
Mueller-Bunz and P. J. Rutledge; tert-Butyldimethylsilanol
hemihydrate; Acta Cryst. E64 o1174
(2008). |
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16. |
A. C. Stewart, I.
J. Clifton, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; A
cyclobutanone analogue mimics penicillin in binding to isopenicillin N
synthase; ChemBioChem 8 2003–2007 (2007). |
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15. |
A. R.
Howard-Jones, J. M. Elkins, I. J. Clifton, R. M. Adlington, J. E. Baldwin and
P. J. Rutledge; Interactions of Isopenicillin N Synthase with
Cyclopropyl-Containing Substrate Analogues Reveal New Mechanistic Insight;
Biochemistry 46 4755–4762 (2007). |
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14. |
A. Daruzzaman, I.
J. Clifton, R. M. Adlington, J. E. Baldwin and P. J. Rutledge; Unexpected
oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N
synthase; ChemBioChem 7 351–358 (2006). |
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13. |
P. V. Murphy and
P. J. Rutledge; Symbiosis in chemistry
and biology; Nature Chem. Biol. 2 59–62 (2006). |
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12. |
A. R.
Howard-Jones, P. J. Rutledge, I. J. Clifton, R. M. Adlington and J. E.
Baldwin; Unique binding of a non-natural l,l,l-substrate
by isopenicillin N synthase; Biochem.
Biophys. Res. Com., 336
702–708 (2005). |
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11. |
A. J. Long, I. J.
Clifton, P. L. Roach, J. E. Baldwin, P. J. Rutledge and C. J. Schofield; Structural studies on the reaction of
isopenicillin N synthase with substrate analogues d-(l-a-aminoadipoyl)-l-cysteinyl-glycine and d-(l-a-aminoadipoyl)-l-cysteinyl-d-alanine; Biochemistry 44
6619–6628 (2005). |
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10. |
J. A. Krall, P.
J. Rutledge and J. E. Baldwin; Design and synthesis of an isopenicillin N
synthase mimic; Tetrahedron 61 137–143 (2005). |
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9. |
A.R. Grummitt, P.J.
Rutledge, I.J. Clifton and J.E. Baldwin; Active site mediated elimination
of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N
synthase; Biochem. J. 382
659–666 (2004). |
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8. |
A. C. Ferguson,
R. M. Adlington, D. H. Martyres, P. J. Rutledge, A. Cowley and J. E. Baldwin;
Total synthesis of a novel 2-thiabicyclo[3.2.0]heptan-6-one analogue of
penicillin N; Tetrahedron 59 8233–8243 (2003). |
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7. |
A. J. Long, I. J.
Clifton, P. L. Roach, J. E. Baldwin, C. J. Schofield and P. J. Rutledge; Structural studies on the reaction of isopenicillin
N synthase with the substrate analogue d-(l-a-aminoadipoyl)-l-cysteinyl-d-a-aminobutyrate; Biochem
J. 372 687–693 (2003). |
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6. |
J. M. Elkins, P.
J. Rutledge, I. J. Clifton, N. I. Burzlaff, P. L. Roach, R. M. Adlington and
J. E. Baldwin; Crystallographic
investigation of the isopenicillin N synthase reaction with the unsaturated
substrate analogue d-(l-a-aminoadipoyl)-l-cysteinyl-d-vinylglycine; Org. Biomol.
Chem. 1 1455–1460 (2003). Featured on the front
cover of the journal. |
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5. |
P. J. Rutledge,
N. I. Burzlaff, J. M. Elkins, M. Pickford. J. E. Baldwin and P. L. Roach; Use of hyperbaric oxygenation to promote
reaction in enzyme crystals; Anal. Biochem. 308 265–268 (2002). |
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4. |
J. M. Ogle, I. J.
Clifton, P. J. Rutledge, J. M. Elkins, N. I. Burzlaff, R. M. Adlington, P. L.
Roach and J. E. Baldwin; Alternative oxidation
by isopenicillin N synthase observed by X-ray diffraction; Chem. & Biol. 8 1231–1237 (2001). |
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3. |
C. S. Hamilton,
A. Yasuhara, J. E. Baldwin, M. D. Lloyd and P. J. Rutledge; Contrasting fates for 6-a-methylpenicillin
N upon oxidation by deacetoxycephalosporin C synthase (DAOCS) and deacetoxy/
deacetylcephalosporin C synthase (DAOC/DACS); Bioorg. Med. Chem. Lett. 11 2511–2514 (2001). |
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2. |
N. I. Burzlaff, P. J. Rutledge, I. J. Clifton, C. M.
H. Hensgens, M. Pickford, R. M. Adlington, P. L. Roach and J. E. Baldwin; Observation of the reaction cycle of
isopenicillin N synthase by X-ray diffraction; Nature 401 721–724 (1999). |
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Book Chapters
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1. |
P. J. Rutledge, Nitriles
with a heteroatom attached to the cyanocarbon; Chapter 5.30 of ‘Comprehensive
Organic Functional Group Transformations II’ R. F. C. Jones Editor Volume 5,
A. R. Katritzky and R. J. K. Taylor Editors in Chief; Elsevier/Pergamon Press, Oxford 1023–1080 (2005). |
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Teaching Papers & Articles
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3. |
P. J. Rutledge; Changing Up Your Lectures; Teaching@Sydney (2012). |
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2. |
A. J. Bridgeman, R. Connor, P. J.
Rutledge and M. H. Todd; A Treasure
Hunt for Chemistry; J. Chem. Ed. 88
437–439 (2011). Featured in the journal editorial |
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1. |
A. J. Bridgeman and P. J. Rutledge, Getting Personal: Feedback for the masses;
Synergy 30 60–68 (2010). |
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Sydney
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